Jan J Cornelissen

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. pmc Tissue-specific DNA methylation profiles in newborns
    Emilie Herzog
    Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Centre Rotterdam, Dr, Molewaterplein 50, Rotterdam, GE 3015, The Netherlands
    Clin Epigenetics 5:8. 2013
  2. doi request reprint The European LeukemiaNet AML Working Party consensus statement on allogeneic HSCT for patients with AML in remission: an integrated-risk adapted approach
    Jan J Cornelissen
    Department of Hematology, Erasmus University Medical Center, Groene Hilledijk 301, 3075 EA, Rotterdam, The Netherlands
    Nat Rev Clin Oncol 9:579-90. 2012
  3. ncbi request reprint Comparative analysis of the value of allogeneic hematopoietic stem-cell transplantation in acute myeloid leukemia with monosomal karyotype versus other cytogenetic risk categories
    Jan J Cornelissen
    Erasmus University Medical Center, Rotterdam, The Netherlands
    J Clin Oncol 30:2140-6. 2012
  4. ncbi request reprint A randomized multicenter comparison of CD34(+)-selected progenitor cells from blood vs from bone marrow in recipients of HLA-identical allogeneic transplants for hematological malignancies
    Jan J Cornelissen
    Department of Hematology, Erasmus MC Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Exp Hematol 31:855-64. 2003
  5. ncbi request reprint Results of a HOVON/SAKK donor versus no-donor analysis of myeloablative HLA-identical sibling stem cell transplantation in first remission acute myeloid leukemia in young and middle-aged adults: benefits for whom?
    Jan J Cornelissen
    Department of Hematology, Erasmus University Medical Center, Groene Hilledijk 301, 3075 EA Rotterdam, The Netherlands
    Blood 109:3658-66. 2007
  6. doi request reprint Myeloablative allogeneic versus autologous stem cell transplantation in adult patients with acute lymphoblastic leukemia in first remission: a prospective sibling donor versus no-donor comparison
    Jan J Cornelissen
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Blood 113:1375-82. 2009
  7. ncbi request reprint IL-7-mediated protection against minor-antigen-mismatched allograft rejection is associated with enhanced recovery of regulatory T cells
    Annoek E C Broers
    Department of Hematology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Haematologica 92:1099-106. 2007
  8. ncbi request reprint Flt3 ligand expands lymphoid progenitors prior to recovery of thymopoiesis and accelerates T cell reconstitution after bone marrow transplantation
    Evert Jan Wils
    Department of Hematology, Erasmus Medical Center Daniel den Hoed Cancer Center, Groene Hilledijk 301, 3071 EA Amsterdam, The Netherlands
    J Immunol 178:3551-7. 2007
  9. doi request reprint Lenalidomide maintenance after nonmyeloablative allogeneic stem cell transplantation in multiple myeloma is not feasible: results of the HOVON 76 Trial
    Evelien Kneppers
    Department of Hematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Blood 118:2413-9. 2011
  10. pmc Efficacy of escalated imatinib combined with cytarabine in newly diagnosed patients with chronic myeloid leukemia
    Wendy Deenik
    Erasmus University Medical Center, Rotterdam, The Netherlands
    Haematologica 95:914-21. 2010

Detail Information

Publications60

  1. pmc Tissue-specific DNA methylation profiles in newborns
    Emilie Herzog
    Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Centre Rotterdam, Dr, Molewaterplein 50, Rotterdam, GE 3015, The Netherlands
    Clin Epigenetics 5:8. 2013
    ....
  2. doi request reprint The European LeukemiaNet AML Working Party consensus statement on allogeneic HSCT for patients with AML in remission: an integrated-risk adapted approach
    Jan J Cornelissen
    Department of Hematology, Erasmus University Medical Center, Groene Hilledijk 301, 3075 EA, Rotterdam, The Netherlands
    Nat Rev Clin Oncol 9:579-90. 2012
    ....
  3. ncbi request reprint Comparative analysis of the value of allogeneic hematopoietic stem-cell transplantation in acute myeloid leukemia with monosomal karyotype versus other cytogenetic risk categories
    Jan J Cornelissen
    Erasmus University Medical Center, Rotterdam, The Netherlands
    J Clin Oncol 30:2140-6. 2012
    ....
  4. ncbi request reprint A randomized multicenter comparison of CD34(+)-selected progenitor cells from blood vs from bone marrow in recipients of HLA-identical allogeneic transplants for hematological malignancies
    Jan J Cornelissen
    Department of Hematology, Erasmus MC Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Exp Hematol 31:855-64. 2003
    ..We performed a prospective randomized trial comparing bone marrow transplantation (BMT) vs PBPC transplantation (PBPCT) using CD34(+) selection for T-cell depletion (TCD) in both study arms...
  5. ncbi request reprint Results of a HOVON/SAKK donor versus no-donor analysis of myeloablative HLA-identical sibling stem cell transplantation in first remission acute myeloid leukemia in young and middle-aged adults: benefits for whom?
    Jan J Cornelissen
    Department of Hematology, Erasmus University Medical Center, Groene Hilledijk 301, 3075 EA Rotterdam, The Netherlands
    Blood 109:3658-66. 2007
    ....
  6. doi request reprint Myeloablative allogeneic versus autologous stem cell transplantation in adult patients with acute lymphoblastic leukemia in first remission: a prospective sibling donor versus no-donor comparison
    Jan J Cornelissen
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Blood 113:1375-82. 2009
    ..This trial is registered with http://www.trialregister.nl under trial ID NTR228...
  7. ncbi request reprint IL-7-mediated protection against minor-antigen-mismatched allograft rejection is associated with enhanced recovery of regulatory T cells
    Annoek E C Broers
    Department of Hematology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Haematologica 92:1099-106. 2007
    ..A major concern of IL-7 is its possible aggravating effect on graft-versus-host and host-versus-graft reactivity...
  8. ncbi request reprint Flt3 ligand expands lymphoid progenitors prior to recovery of thymopoiesis and accelerates T cell reconstitution after bone marrow transplantation
    Evert Jan Wils
    Department of Hematology, Erasmus Medical Center Daniel den Hoed Cancer Center, Groene Hilledijk 301, 3071 EA Amsterdam, The Netherlands
    J Immunol 178:3551-7. 2007
    ..Collectively, our data suggest that FL promotes T cell recovery by enhanced thymopoiesis and by expansion of lymphoid progenitors...
  9. doi request reprint Lenalidomide maintenance after nonmyeloablative allogeneic stem cell transplantation in multiple myeloma is not feasible: results of the HOVON 76 Trial
    Evelien Kneppers
    Department of Hematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Blood 118:2413-9. 2011
    ..This trial was registered at www.trialregister.nl as #NTR1645...
  10. pmc Efficacy of escalated imatinib combined with cytarabine in newly diagnosed patients with chronic myeloid leukemia
    Wendy Deenik
    Erasmus University Medical Center, Rotterdam, The Netherlands
    Haematologica 95:914-21. 2010
    ....
  11. pmc Insufficient recovery of thymopoiesis predicts for opportunistic infections in allogeneic hematopoietic stem cell transplant recipients
    Evert Jan Wils
    Erasmus MC Daniel den Hoed Cancer Center, Department of Hematology, EA Rotterdam, The Netherlands
    Haematologica 96:1846-54. 2011
    ..However, it is still unclear to what extent insufficient recovery of thymopoiesis predicts for subsequent opportunistic infections and non-relapse mortality...
  12. doi request reprint Autologous peripheral blood stem cell transplantation for acute myeloid leukemia
    Edo Vellenga
    Department of Hematology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands
    Blood 118:6037-42. 2011
    ..This trial is registered at www.trialregister.nl as #NTR230 and #NTR291...
  13. doi request reprint Donor versus no-donor comparison of newly diagnosed myeloma patients included in the HOVON-50 multiple myeloma study
    Henk M Lokhorst
    Department of Hematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Blood 119:6219-25; quiz 6399. 2012
    ..These results do not support a general application of allo-SCT in all myeloma patients as part of first-line therapy...
  14. ncbi request reprint A comparison of postengraftment infectious morbidity and mortality after allogeneic partially T cell-depleted peripheral blood progenitor cell transplantation versus T cell-depleted bone marrow transplantation
    Annoek E C Broers
    Department of Hematology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    Exp Hematol 33:912-9. 2005
    ..We set out to evaluate and compare the incidence, cause, and outcome of postengraftment infections following HLA-identical sibling T cell-depleted PBPCT vs T cell-depleted BMT between days 30 and 365 posttransplant...
  15. ncbi request reprint High-dose imatinib versus high-dose imatinib in combination with intermediate-dose cytarabine in patients with first chronic phase myeloid leukemia: a randomized phase III trial of the Dutch-Belgian HOVON study group
    Noortje Thielen
    Department of Hematology, VU University Medical Center, De Boelelaan 1117, Amsterdam, The Netherlands
    Ann Hematol 92:1049-56. 2013
    ..However, the underpowering of the study precludes any definitive conclusions. This trial is registered at www.trialregister.nl (NTR674). ..
  16. doi request reprint Stem cell factor consistently improves thymopoiesis after experimental transplantation of murine or human hematopoietic stem cells in immunodeficient mice
    Evert Jan Wils
    Department of Hematology, Erasmus Medical Center, Rotterdam 3075 EA, The Netherlands
    J Immunol 187:2974-81. 2011
    ....
  17. ncbi request reprint Monitoring cytomegalovirus IE-1 and pp65-specific CD4+ and CD8+ T-cell responses after allogeneic stem cell transplantation may identify patients at risk for recurrent CMV reactivations
    Jan W Gratama
    Department of Internal Oncology, Erasmus MC, Rotterdam, The Netherlands
    Cytometry B Clin Cytom 74:211-20. 2008
    ..Thus, monitoring of particular CMV-specific CD4+ and CD8+ T-cell responses after allogeneic SCT may identify patients at risk for recurrent CMV reactivations...
  18. ncbi request reprint Impaired recovery of Epstein-Barr virus (EBV)--specific CD8+ T lymphocytes after partially T-depleted allogeneic stem cell transplantation may identify patients at very high risk for progressive EBV reactivation and lymphoproliferative disease
    Pauline Meij
    Department of Internal Oncology, Erasmus MC, Rotterdam, The Netherlands
    Blood 101:4290-7. 2003
    ....
  19. doi request reprint Keratinocyte growth factor improves allogeneic bone marrow engraftment through a CD4+Foxp3+ regulatory T cell-dependent mechanism
    Marieke Bruinsma
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Immunol 182:7364-9. 2009
    ..These data demonstrate that administration of KGF to the T cell provider mice improves engraftment of allogeneic BM through a CD4(+)Foxp3(+) Treg-dependent mechanism...
  20. ncbi request reprint Immune monitoring with iTAg MHC Tetramers for prediction of recurrent or persistent cytomegalovirus infection or disease in allogeneic hematopoietic stem cell transplant recipients: a prospective multicenter study
    Jan W Gratama
    Department of Clinical and Tumor Immunology, Erasmus Medical Center Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Blood 116:1655-62. 2010
    ..004). CMV tetramer-based immune monitoring, in conjunction with virologic monitoring, can be an important new tool to assess risk of CMV-related complications and to guide preemptive therapeutic choices...
  21. ncbi request reprint Neurocognitive functions and quality of life in haematological patients receiving haematopoietic stem cell grafts: a one-year follow-up pilot study
    Helena Harder
    Department of Neuro Oncology, Erasmus MC Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    J Clin Exp Neuropsychol 28:283-93. 2006
    ..These preliminary results emphasize the significance of a pre-treatment assessment and the need of a large baseline sample in future longitudinal studies to overcome the expected dropout rate of more than 50%...
  22. ncbi request reprint Resolution of EBV(+) CNS lymphoma with appearance of CSF EBV-specific T cells
    Janet W de Beukelaar
    Department of Medical Oncology, Erasmus MC, Rotterdam, The Netherlands
    Ann Neurol 58:788-92. 2005
    ..The appearance of EBV-specific CD8(+) T cells in CSF and blood correlated with neurological improvement and disappearance of EBV-LPD. These observations suggest a role for EBV-specific CD8(+) T cells in the control of EBV-LPD in the CNS...
  23. ncbi request reprint Interleukin-7 improves T-cell recovery after experimental T-cell-depleted bone marrow transplantation in T-cell-deficient mice by strong expansion of recent thymic emigrants
    Annoek E C Broers
    Department of Hematology, Erasmus MC Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Blood 102:1534-40. 2003
    ..These results suggest that peripheral expansion of recent thymic emigrants or mature T cells may be a preferential mechanism by which IL-7 enhances T-cell recovery after BMT...
  24. doi request reprint Keratinocyte growth factor and stem cell factor to improve thymopoiesis after autologous CD34+ cell transplantation in rhesus macaques
    Evert Jan Wils
    Department of Hematology, Erasmus Medical Center, Rotterdam, The Netherlands
    Biol Blood Marrow Transplant 18:55-65. 2012
    ..Animals treated with KGF and SCF experienced severe adverse events that precluded evaluation of thymopoiesis and T cell recovery. Collectively, our data confirm that KGF may enhance thymopoiesis...
  25. ncbi request reprint Antithymocyteglobulin as prophylaxis of graft failure and graft-versus-host disease in recipients of partially T-cell-depleted grafts from matched unrelated donors: a dose-finding study
    Ellen Meijer
    Department of Hematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Exp Hematol 31:1026-30. 2003
    ....
  26. ncbi request reprint The impact of CD4+Foxp3+ Treg on immunity to murine cytomegalovirus after bone marrow transplantation depends on the peripheral or thymic source of T cell regeneration
    Marieke Bruinsma
    Department of Haematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Transpl Immunol 24:9-16. 2010
    ..e. lymphopenia-induced proliferation (LIP) of mature T cells and generation of T cells through thymopoiesis...
  27. ncbi request reprint Keratinocyte growth factor induces expansion of murine peripheral CD4+Foxp3+ regulatory T cells and increases their thymic output
    Marieke Bruinsma
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Immunol 179:7424-30. 2007
    ..First by selective peripheral expansion of Treg and thereafter by enhanced thymic output of newly developed Treg...
  28. ncbi request reprint Partially T-cell-depleted allogeneic stem-cell transplantation for first-line treatment of multiple myeloma: a prospective evaluation of patients treated in the phase III study HOVON 24 MM
    Henk M Lokhorst
    Department of Hematology, University Medical Center Utrecht, HP G03 647, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Clin Oncol 21:1728-33. 2003
    ..To determine in a prospective study the efficacy, toxicity, and long-term outcome of up-front allogeneic stem-cell transplantation (allo-SCT) in multiple myeloma (MM)...
  29. ncbi request reprint Allogeneic stem cell transplantation in acute myeloid leukemia in first or subsequent remission: weighing prognostic markers predicting relapse and risk factors for non-relapse mortality
    Ellen Meijer
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Semin Oncol 35:449-57. 2008
    ..We discuss how these recent developments may affect our decision-making about whether and when to proceed to alloSCT...
  30. ncbi request reprint Prevention of Epstein-Barr virus-lymphoproliferative disease by molecular monitoring and preemptive rituximab in high-risk patients after allogeneic stem cell transplantation
    Joost W J van Esser
    Department of Hematology, Erasmus Medical Center Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Blood 99:4364-9. 2002
    ..04) at 6 months from EBV-DNA more than or equal to 1000 geq/mL. Frequent quantitative monitoring of EBV reactivation and preemptive therapy by rituximab improves outcome in patients at high risk of EBV-LPD. (Blood. 2002;99:4364-4369)..
  31. ncbi request reprint Allogeneic stem cell transplantation in acute myeloid leukemia: a risk-adapted approach
    Tom Lodewyck
    Department of Hematology, Erasmus University Medical Center Daniel Den Hoed, Rotterdam, The Netherlands
    Blood Rev 22:293-302. 2008
    ..Here, we discuss how recent findings that have identified and validated specific prognostic factors may affect our decision making for which category of AML-patients alloSCT may especially be indicated...
  32. ncbi request reprint Allogeneic stem cell transplantation for patients with acute myeloid leukemia or myelodysplastic syndrome who have chromosome 5 and/or 7 abnormalities
    Hanneke M van der Straaten
    Department of Hematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Haematologica 90:1339-45. 2005
    ..As data on allogeneic SCT in this context are limited we did a retrospective study of allogeneic SCT in patients with AML or MDS who had chromosome 5 and/or 7 abnormalities...
  33. pmc Paradoxical effects of interleukin-10 on the maturation of murine myeloid dendritic cells
    Dianne L Commeren
    Department of Hematology, Erasmus MC, Rotterdam, The Netherlands
    Immunology 110:188-96. 2003
    ..These DC lack T-cell stimulatory capacity, suggesting a role for IL-10 in conferring tolerogenic properties on murine myeloid DC...
  34. doi request reprint Epstein-Barr virus-associated lymphoproliferative disease after allogeneic haematopoietic stem cell transplantation: molecular monitoring and early treatment of high-risk patients
    Ellen Meijer
    Department of Haematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Curr Opin Hematol 15:576-85. 2008
    ..Epstein-Barr virus-associated lymphoproliferative disease (EBV-LPD) is a rare but serious complication in recipients of allogeneic stem cell transplants. An overview is given of the incidence, monitoring and (early) treatment of EBV-LPD...
  35. ncbi request reprint Hepatitis E virus: an underestimated opportunistic pathogen in recipients of allogeneic hematopoietic stem cell transplantation
    Jurjen Versluis
    Department of Hematology, Erasmus Medical Center, Gravendijkwal 230, Rotterdam, The Netherlands
    Blood 122:1079-86. 2013
    ..Therefore, alloHSCT recipients should be screened pretransplantation by HEV serology and RNA. Furthermore, a differential diagnosis including hepatitis E is mandatory in all alloHSCT patients with severe liver enzyme abnormalities. ..
  36. doi request reprint Characterization of Lgr5-positive epithelial cells in the murine thymus
    Eric Vroegindeweij
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Eur J Immunol 43:1243-51. 2013
    ..In sum, we show that presence of the Lgr5 protein is not a prerequisite for proper thymus organogenesis...
  37. ncbi request reprint Thymopoiesis following allogeneic stem cell transplantation: new possibilities for improvement
    Evert Jan Wils
    Department of Hematology, Erasmus University Medical Center Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Blood Rev 19:89-98. 2005
    ..KGF has been evaluated clinically in the setting of autologous stem cell transplantation and studies in the setting of allo-SCT are awaited in the near future...
  38. ncbi request reprint Dose-finding study of imatinib in combination with intravenous cytarabine: feasibility in newly diagnosed patients with chronic myeloid leukemia
    Wendy Deenik
    Department of Hematology, Erasmus University Medical Center, Groene Hilledijk 301, Rotterdam, The Netherlands
    Blood 111:2581-8. 2008
    ..We conclude that combination therapy of escalating dosages of imatinib and cytarabine is feasible. This study was registered at www.kankerbestrijding.nl as no. CKTO-2001-03...
  39. ncbi request reprint Intermediate-dose melphalan compared with myeloablative treatment in multiple myeloma: long-term follow-up of the Dutch Cooperative Group HOVON 24 trial
    Pieter Sonneveld
    Erasmus Medical Center Rotterdam, The Netherlands
    Haematologica 92:928-35. 2007
    ..The Dutch-Belgian HOVON group performed a randomized phase 3 trial to compare single non-myeloablative intensive treatment with double, intensive treatment in previously untreated patients with multiple myeloma (MM)...
  40. ncbi request reprint Hepatitis E virus infection in hematopoietic stem cell transplant recipients
    Annemiek A van der Eijk
    aDepartment of Viroscience bDepartment of Hematology cDepartment of Hepatogastroenterology, Erasmus Medical Center, Rotterdam, The Netherlands
    Curr Opin Infect Dis 27:309-15. 2014
    ..We review the incidence, sequela, extrahepatic manifestations, and treatment of hepatitis due to HEV infection in allogeneic hematopoietic stem cell transplantation (alloHSCT) recipients...
  41. ncbi request reprint Quantification of newly developed T cells in mice by real-time quantitative PCR of T-cell receptor rearrangement excision circles
    Annoek E C Broers
    Department of Hematology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Exp Hematol 30:745-50. 2002
    ..We developed and evaluated a real-time quantitative PCR (RQ-PCR) to detect and quantify dRec-psiJa sjTRECs in murine peripheral blood leukocytes for estimation of thymic output of newly developed ab T cells in mice...
  42. doi request reprint Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells
    Tom Cupedo
    Department of Hematology, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands
    Nat Immunol 10:66-74. 2009
    ..Our data indicate that lymph node organogenesis is controlled by an NK cell precursor population with adaptive immune features and demonstrate a previously unappreciated link between the innate and adaptive immune systems...
  43. ncbi request reprint Pharmacokinetics of mycophenolate mofetil in hematopoietic stem cell transplant recipients
    Reinier M van Hest
    Department of Hospital Pharmacy Clinical Pharmacology Unit, Erasmus MC, Rotterdam, The Netherlands
    Ther Drug Monit 29:353-60. 2007
    ..Exposure may be improved in HCT recipients by higher or more frequent MMF dosing...
  44. ncbi request reprint Prevalence and clinical symptoms of human metapneumovirus infection in hospitalized patients
    Bernadette G van den Hoogen
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Infect Dis 188:1571-7. 2003
    ..Treatment with antibiotics and corticosteroids was reported more frequently in hMPV-infected children. From these data, we conclude that hMPV is an important pathogen associated with RTI...
  45. doi request reprint Aerosolized liposomal amphotericin B for the prevention of invasive pulmonary aspergillosis during prolonged neutropenia: a randomized, placebo-controlled trial
    Bart J Rijnders
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Clin Infect Dis 46:1401-8. 2008
    ..Because pulmonary deposition of conidia is the first step in developing IPA, we hypothesized that inhalation of liposomal amphotericin B would prevent IPA...
  46. ncbi request reprint Clinical utility of tetramer-based immune monitoring in allogeneic stem cell transplantation
    Jan W Gratama
    Laboratory for Clinical and Tumor Immunology, Department of Medical Oncology, Erasmus MC Daniel den Hoed, Rotterdam, The Netherlands
    BioDrugs 17:325-38. 2003
    ....
  47. ncbi request reprint Cognitive functioning and quality of life in long-term adult survivors of bone marrow transplantation
    Helena Harder
    Department of Neuro Oncology, University Hospital Rotterdam Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Cancer 95:183-92. 2002
    ..The late neurotoxic effects of bone marrow transplantation (BMT) on cognitive functioning and quality of life (QOL) were investigated in a consecutively treated cohort of long-term adult survivors...
  48. ncbi request reprint Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
    Brian J Druker
    Oregon Health and Science University Cancer Institute, L592, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    N Engl J Med 355:2408-17. 2006
    ..Imatinib inhibits this kinase, and in a short-term study was superior to interferon alfa plus cytarabine for newly diagnosed CML in the chronic phase. For 5 years, we followed patients with CML who received imatinib as initial therapy...
  49. ncbi request reprint Retrospective comparison of bone marrow and granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells for allogeneic stem cell transplantation using HLA identical sibling donors in myelodysplastic syndromes
    Philippe Guardiola
    Service de Greffe de Moelle, Hopital Saint Louis, Paris, France
    Blood 99:4370-8. 2002
    ....
  50. ncbi request reprint Associations among Epstein-Barr virus subtypes, human leukocyte antigen class I alleles, and the development of posttransplantation lymphoproliferative disorder in bone marrow transplant recipients
    Irene Görzer
    Institute of Virology, Medical University of Vienna, Austria
    Clin Infect Dis 44:693-5. 2007
    ..This study provides, to our knowledge, the first evidence that the human leukocyte antigen B51 allele might predispose bone marrow transplant recipients to Epstein-Barr virus-associated posttransplantation lymphoproliferative disorder...
  51. ncbi request reprint Assessment of pre-treatment cognitive performance in adult bone marrow or haematopoietic stem cell transplantation patients: a comparative study
    Helena Harder
    Department of Neuro Oncology, Erasmus Medical Center, Daniel den Hoed Cancer Center, PO Box 5201, 3008 AE Rotterdam, The Netherlands
    Eur J Cancer 41:1007-16. 2005
    ..This study showed impaired cognitive performance prior to SCT. Haematological patients treated with non-myeloablative cancer therapies proved to be a reliable reference group for longitudinal studies...
  52. pmc Mapping MHC-resident transplantation determinants
    Mari Malkki
    The Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Biol Blood Marrow Transplant 13:986-95. 2007
    ..67; 95% confidence interval, 0.45-0.98; P=.04). These results suggest that Msats may be informative for mapping MHC-resident genetic variation of clinical importance in HCT...
  53. ncbi request reprint The occurrence of graft-versus-host disease is the major predictive factor for response to donor lymphocyte infusions in multiple myeloma
    Henk M Lokhorst
    University Medical Center Utrecht, Department of Haematology, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Blood 103:4362-4. 2004
    ....
  54. ncbi request reprint Overall and event-free survival are not improved by the use of myeloablative therapy following intensified chemotherapy in previously untreated patients with multiple myeloma: a prospective randomized phase 3 study
    Christine M Segeren
    Erasmus Medical Center Rotterdam, The Netherlands
    Blood 101:2144-51. 2003
    ..However, it did not result in a better EFS and OS...
  55. ncbi request reprint Galactomannan detection in computerized tomography-based broncho-alveolar lavage fluid and serum in haematological patients at risk for invasive pulmonary aspergillosis
    Martin J Becker
    Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Centre Rotterdam, The Netherlands
    Br J Haematol 121:448-57. 2003
    ..These results indicate that, when CT is used systematically and at an early stage, GM detection in CT-based BAL fluid has a high PPV for diagnosing IPA early in untreated patients...
  56. ncbi request reprint Case-referent comparison of cognitive functions in patients receiving haematopoietic stem-cell transplantation for haematological malignancies: two-year follow-up results
    Helena Harder
    Department of Neuro Oncology, Erasmus Medical Center, Daniel den Hoed Cancer Center, PO Box 5201, 3008 AE Rotterdam, The Netherlands
    Eur J Cancer 43:2052-9. 2007
    ..Our results suggest limited HSCT-related cognitive dysfunctions. Additional follow-up is necessary to assess long-term effects...
  57. ncbi request reprint Reduced-intensity conditioning compared with conventional allogeneic stem-cell transplantation in relapsed or refractory Hodgkin's lymphoma: an analysis from the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation
    Anna Sureda
    Clinical Hematology Division, Hospital de la Santa Creu i Sant Pau, Antoni Maria i Claret, 167, 08025 Barcelona, Spain
    J Clin Oncol 26:455-62. 2008
    ....
  58. doi request reprint Results of hematopoietic stem cell transplantation after treatment with different high-dose total-body irradiation regimens in five Dutch centers
    M Loes van Kempen-Harteveld
    Department of Radiotherapy, University Medical Center, Utrecht, The Netherlands
    Int J Radiat Oncol Biol Phys 71:1444-54. 2008
    ..To evaluate results of high-dose total-body irradiation (TBI) regimens for hematopoietic stem cell transplantation...
  59. ncbi request reprint Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
    Stephen G O'Brien
    University of Newcastle, Newcastle, United Kingdom
    N Engl J Med 348:994-1004. 2003
    ..We compared the efficacy of imatinib with that of interferon alfa combined with low-dose cytarabine in newly diagnosed chronic-phase CML...
  60. ncbi request reprint Characterization of Epstein-Barr virus Type I variants based on linked polymorphism among EBNA3A, -3B, and -3C genes
    Irene Görzer
    Medical University of Vienna, Institute of Virology, Kinderspitalgasse 15, A 1095 Vienna, Austria
    Virus Res 118:105-14. 2006
    ..Thus, a combination of more than one polymorphic site in the EBV genome might be involved in determining disease characteristics...