M M Breteler

Summary

Affiliation: Erasmus University
Country: The Netherlands

Publications

  1. ncbi request reprint The new epidemic: frequency of dementia in the Rotterdam Study
    M M Breteler
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Haemostasis 28:117-23. 1998
  2. ncbi request reprint Vascular risk factors for Alzheimer's disease: an epidemiologic perspective
    M M Breteler
    Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, PO Box 1738, 3000 DR, Rotterdam, The Netherlands
    Neurobiol Aging 21:153-60. 2000
  3. ncbi request reprint Risk factors for vascular disease and dementia
    M M Breteler
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Haemostasis 28:167-73. 1998
  4. ncbi request reprint Insulin and cognitive function in an elderly population. The Rotterdam Study
    R P Stolk
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Diabetes Care 20:792-5. 1997
  5. ncbi request reprint Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study
    A J Slooter
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Arch Neurol 55:964-8. 1998
  6. ncbi request reprint Coagulation and fibrinolysis markers and risk of dementia. The Dutch Vascular Factors in Dementia Study
    M L Bots
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Haemostasis 28:216-22. 1998
  7. ncbi request reprint Atrial fibrillation and dementia in a population-based study. The Rotterdam Study
    A Ott
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Stroke 28:316-21. 1997
  8. ncbi request reprint Response to activated protein C in subjects with and without dementia. The Dutch Vascular Factors in Dementia Study
    M L Bots
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Haemostasis 28:209-15. 1998
  9. ncbi request reprint Apolipoprotein E genotype and progression of Alzheimer's disease: the Rotterdam Study
    A J Slooter
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    J Neurol 246:304-8. 1999
  10. ncbi request reprint Education and the incidence of dementia in a large population-based study: the Rotterdam Study
    A Ott
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Neurology 52:663-6. 1999

Detail Information

Publications26

  1. ncbi request reprint The new epidemic: frequency of dementia in the Rotterdam Study
    M M Breteler
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Haemostasis 28:117-23. 1998
    ..Typical incidence estimates for age 65, 75 and 95 are 1 per 1,000, 1 per 100 and 1 per 10 person-years. One in 6 men, and almost 1 in 3 women, will suffer at least some of their lifetime from dementia...
  2. ncbi request reprint Vascular risk factors for Alzheimer's disease: an epidemiologic perspective
    M M Breteler
    Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, PO Box 1738, 3000 DR, Rotterdam, The Netherlands
    Neurobiol Aging 21:153-60. 2000
    ..In this paper, current knowledge on the relation between vascular risk factors and risk indicators and Alzheimer's disease will be reviewed...
  3. ncbi request reprint Risk factors for vascular disease and dementia
    M M Breteler
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Haemostasis 28:167-73. 1998
    ....
  4. ncbi request reprint Insulin and cognitive function in an elderly population. The Rotterdam Study
    R P Stolk
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Diabetes Care 20:792-5. 1997
    ..To examine the association between insulin and cognitive function in the population-based Rotterdam Study...
  5. ncbi request reprint Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study
    A J Slooter
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Arch Neurol 55:964-8. 1998
    ..To provide risk estimates of dementia and Alzheimer disease as a function of the apolipoprotein E (APOE) genotypes and to assess the proportion of dementia that is attributable to the APOE genotypes...
  6. ncbi request reprint Coagulation and fibrinolysis markers and risk of dementia. The Dutch Vascular Factors in Dementia Study
    M L Bots
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Haemostasis 28:216-22. 1998
    ..Additional stratified analyses indicated that an increased TAT level was the primary factor related to dementia. The present study provides evidence that predominantly increased thrombin generation is associated with dementia...
  7. ncbi request reprint Atrial fibrillation and dementia in a population-based study. The Rotterdam Study
    A Ott
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Stroke 28:316-21. 1997
    ..We investigated the association of atrial fibrillation with dementia and cognitive impairment in a large cross-sectional, population-based study in the elderly...
  8. ncbi request reprint Response to activated protein C in subjects with and without dementia. The Dutch Vascular Factors in Dementia Study
    M L Bots
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Haemostasis 28:209-15. 1998
    ..82-5.63), respectively. No association was found for APC response. We showed a nonsignificant twofold increased risk of dementia among subjects with factor V Leiden. The association appeared to be stronger for vascular dementia...
  9. ncbi request reprint Apolipoprotein E genotype and progression of Alzheimer's disease: the Rotterdam Study
    A J Slooter
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    J Neurol 246:304-8. 1999
    ..As change in cognitive function and severity of dementia are similar for AD patients with and without APOE*4, our study suggests that progression of AD is not related to the APOE*4 allele...
  10. ncbi request reprint Education and the incidence of dementia in a large population-based study: the Rotterdam Study
    A Ott
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Neurology 52:663-6. 1999
    ..Our data indicate that cross-sectional studies may overrate the association between education and risk of dementia...
  11. ncbi request reprint Serum apolipoprotein E level is not increased in Alzheimer's disease: the Rotterdam study
    A J Slooter
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Neurosci Lett 248:21-4. 1998
    ..Our population-based study suggests that the differences in serum apoE level between Alzheimer patients and controls are mainly the result of differences in the distribution of the APOE genotype...
  12. ncbi request reprint Antihypertensive drugs and incidence of dementia: the Rotterdam Study
    A Ruitenberg
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurobiol Aging 22:407-12. 2001
    ..87, not significant. Dementia may be prevented by antihypertensive treatment. In order to confirm any relation in Alzheimer's disease larger observational studies with longer follow-up are needed...
  13. ncbi request reprint Reproductive period and risk of dementia in postmenopausal women
    M I Geerlings
    Department of Epidemiology and Biostatistics, Erasmus University Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    JAMA 285:1475-81. 2001
    ..Exogenous estrogen use may lower risk of dementia in postmenopausal women. A relationship between long-term exposure to endogenous estrogens and incident dementia has been hypothesized but not studied...
  14. ncbi request reprint Serum carotenoids and cerebral white matter lesions: the Rotterdam scan study
    T den Heijer
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    J Am Geriatr Soc 49:642-6. 2001
    ..Longitudinal studies with repeated measurements of both carotenoids and WMLs are necessary to explore this hypothesis further...
  15. ncbi request reprint HFE variants, APOE and Alzheimer's disease: findings from the population-based Rotterdam study
    B Z Alizadeh
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands
    Neurobiol Aging 30:330-2. 2009
    ..2+/-2.1 versus 78.7+/-1.6, p=0.05). Our results suggest that HFE variants are not strong determinants of AD in the general population but may modify the age of onset...
  16. ncbi request reprint Regional cerebral blood flow and cerebrovascular risk factors in the elderly population
    J J Claus
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Neurobiol Aging 19:57-64. 1998
    ..Reduced contractility of the vascular muscle wall with increasing age resulting from atherosclerosis may be the underlying mechanism...
  17. ncbi request reprint Prognosis of Alzheimer's disease: the Rotterdam Study
    A Ruitenberg
    Department of Epidemiology and Biostatistics, Erasmus University, Rotterdam, The Netherlands
    Neuroepidemiology 20:188-95. 2001
    ..These prognostic risk functions can provide information on the decline of Alzheimer patients and might be used to better evaluate the effect of treatments for AD...
  18. ncbi request reprint Incidence of dementia: does gender make a difference?
    A Ruitenberg
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurobiol Aging 22:575-80. 2001
    ..After 90 years of age the incidence of Alzheimer's disease is higher for women than for men. The incidence of vascular dementia is higher for men than for women in all age groups...
  19. ncbi request reprint Cerebral white matter lesions and subjective cognitive dysfunction: the Rotterdam Scan Study
    J C de Groot
    Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, The Netherlands
    Neurology 56:1539-45. 2001
    ..To determine the relationship between cerebral white matter lesions (WML) and subjective cognitive dysfunction...
  20. ncbi request reprint Markers of inflammation and cellular adhesion molecules in relation to insulin resistance in nondiabetic elderly: the Rotterdam study
    A E Hak
    Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 86:4398-405. 2001
    ..These factors may contribute to the well-known relationship between insulin resistance and cardiovascular disease risk and might potentially become therapeutic targets in insulin resistant subjects...
  21. ncbi request reprint Is carotid intima-media thickness useful in cardiovascular disease risk assessment? The Rotterdam Study
    A I del Sol
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Stroke 32:1532-8. 2001
    ..We determined the contribution of common carotid intima-media thickness (IMT) in the prediction of future coronary heart disease and cerebrovascular disease when added to established risk factors...
  22. ncbi request reprint The cost of treatment of Alzheimer's disease in The Netherlands: a regression-based simulation model
    J McDonnell
    Institute for Medical Technology Assessment, Erasmus University, Rotterdam, The Netherlands
    Pharmacoeconomics 19:379-90. 2001
    ..To examine the potential economic impact of treatment of Alzheimer's disease...
  23. ncbi request reprint Aspirin use and risk of stroke in the elderly: the Rotterdam Study
    Z Voko
    Department of Epidemiology and Biostatistics, University Medical Center Utrecht, The Netherlands
    Neuroepidemiology 20:40-4. 2001
    ..99, 95% CI 0.56-1.73). Our findings suggest that aspirin use may increase the risk of stroke in elderly subjects free from vascular disease...
  24. ncbi request reprint CASCADE: a European collaborative study on vascular determinants of brain lesions. Study design and objectives
    L J Launer
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Neuroepidemiology 19:113-20. 2000
    ..The objectives and design of the CASCADE project are described...
  25. ncbi request reprint Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease
    A Ruitenberg
    Department of Epidemiology and Biostatistics, Eramus Medical Center, Rotterdam, The Netherlands
    N Engl J Med 345:1515-21. 2001
    ..The use of NSAIDs was not associated with a reduction in the risk of vascular dementia. CONCLUSIONS: The long-term use of NSAIDs may protect against Alzheimer's disease but not against vascular dementia...
  26. ncbi request reprint CYP2D6 polymorphism in Parkinson's disease: the Rotterdam Study
    B S Harhangi
    Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, The Netherlands
    Mov Disord 16:290-3. 2001
    ..Our result supports the hypothesis that the CYP2D6 gene is not a major gene responsible for PD...