M M B Breteler

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. pmc Heart failure and the risk of stroke: the Rotterdam Study
    V P Alberts
    Department of Epidemiology, Erasmus MC University Medical Center, Dr Molewaterplein 50, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Eur J Epidemiol 25:807-12. 2010
  2. pmc Retinopathy and risk of dementia: the Rotterdam Study
    Elisabeth M C Schrijvers
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Neurology 79:365-70. 2012
  3. pmc The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project
    Onofre Combarros
    Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Marqués de Valdecilla University Hospital University of Cantabria, 39008 Santander, Spain
    BMC Med Genet 11:162. 2010
  4. ncbi Incidence and prognosis of transient neurological attacks
    Michiel J Bos
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Dr Molewaterplein 50, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    JAMA 298:2877-85. 2007
  5. ncbi Dietary folate, vitamin B12, and vitamin B6 and the risk of Parkinson disease
    L M L de Lau
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurology 67:315-8. 2006
  6. ncbi Association between blood pressure, white matter lesions, and atrophy of the medial temporal lobe
    T den Heijer
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurology 64:263-7. 2005
  7. ncbi The impact of APOE on myocardial infarction, stroke, and dementia: the Rotterdam Study
    A J C Slooter
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurology 62:1196-8. 2004
  8. doi Genetic risk factors for cerebral small-vessel disease in hypertensive patients from a genetically isolated population
    M Schuur
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 82:41-4. 2011
  9. ncbi Unrecognized myocardial infarction and the risk of stroke: the Rotterdam Study
    M A Ikram
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Neurology 67:1635-9. 2006
  10. doi Structural and diffusion MRI measures of the hippocampus and memory performance
    T den Heijer
    Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
    Neuroimage 63:1782-9. 2012

Collaborators

Detail Information

Publications146 found, 100 shown here

  1. pmc Heart failure and the risk of stroke: the Rotterdam Study
    V P Alberts
    Department of Epidemiology, Erasmus MC University Medical Center, Dr Molewaterplein 50, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Eur J Epidemiol 25:807-12. 2010
    ..In conclusion, the risk of ischemic stroke is strongly increased shortly after the diagnosis of heart failure but returns to normal within 6 months after onset of heart failure...
  2. pmc Retinopathy and risk of dementia: the Rotterdam Study
    Elisabeth M C Schrijvers
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Neurology 79:365-70. 2012
    ..To investigate the relation between retinopathy and the risk of dementia...
  3. pmc The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project
    Onofre Combarros
    Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Marqués de Valdecilla University Hospital University of Cantabria, 39008 Santander, Spain
    BMC Med Genet 11:162. 2010
    ..We therefore examined the associations with AD of the DBH -1021T allele and of the above interactions in the Epistasis Project, with 1757 cases of AD and 6294 elderly controls...
  4. ncbi Incidence and prognosis of transient neurological attacks
    Michiel J Bos
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Dr Molewaterplein 50, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    JAMA 298:2877-85. 2007
    ..Conversely, hardly anything is known about the prognostic significance of TNAs with nonfocal or mixed symptoms...
  5. ncbi Dietary folate, vitamin B12, and vitamin B6 and the risk of Parkinson disease
    L M L de Lau
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurology 67:315-8. 2006
    ..Moreover, vitamin B6 might influence the risk of PD through antioxidant effects unrelated to homocysteine metabolism and through its role in dopamine synthesis...
  6. ncbi Association between blood pressure, white matter lesions, and atrophy of the medial temporal lobe
    T den Heijer
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurology 64:263-7. 2005
    ..Alternatively, in persons with high blood pressure, increased numbers of neurofibrillary tangles and amyloid plaques at autopsy have also been observed, suggesting direct links between blood pressure and AD...
  7. ncbi The impact of APOE on myocardial infarction, stroke, and dementia: the Rotterdam Study
    A J C Slooter
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurology 62:1196-8. 2004
    ..8% higher. Risk estimates of dementia, specified for age, sex, and APOE, are provided for counseling. APOE is not strongly related to vascular diseases, but contributes substantially to dementia incidence...
  8. doi Genetic risk factors for cerebral small-vessel disease in hypertensive patients from a genetically isolated population
    M Schuur
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 82:41-4. 2011
    ..We examined the role of a series of candidate genes involved in blood pressure regulation and amyloid metabolism...
  9. ncbi Unrecognized myocardial infarction and the risk of stroke: the Rotterdam Study
    M A Ikram
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Neurology 67:1635-9. 2006
    ..To investigate the relationship between unrecognized myocardial infarction and the risk of stroke in a population-based cohort study...
  10. doi Structural and diffusion MRI measures of the hippocampus and memory performance
    T den Heijer
    Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
    Neuroimage 63:1782-9. 2012
    ..Follow-up studies will be needed to determine whether higher MD of hippocampus at younger ages could be an earlier marker of incident Alzheimer's disease than hippocampal volume...
  11. ncbi Retinal vessel diameters and risk of stroke: the Rotterdam Study
    M K Ikram
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurology 66:1339-43. 2006
    ..A smaller ratio of the retinal arteriolar-to-venular diameters reportedly predicts the risk of stroke. It is unclear if this is due to arteriolar narrowing or venular dilation...
  12. doi Cerebral microbleeds are associated with worse cognitive function: the Rotterdam Scan Study
    M M F Poels
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Neurology 78:326-33. 2012
    ..Cerebral microbleeds are frequently found in the general elderly population and may reflect underlying vascular disease, but their role in cognitive function is unknown...
  13. doi Superficial siderosis in the general population
    M W Vernooij
    Department of Epidemiology, Erasmus MC UniversityMedical Center, 3015 CE Rotterdam, The Netherlands
    Neurology 73:202-5. 2009
    ..All previously reported cases of superficial siderosis were detected because of overt clinical symptoms. We studied the occurrence of superficial siderosis on brain MRI in a general population of nondemented elderly...
  14. doi Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study
    M W Vernooij
    Department of Epidemiology and Biostatistics, Erasmus MC University Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Neurology 70:1208-14. 2008
    ..We investigated the prevalence of and risk factors for microbleeds in the general population aged 60 years and older...
  15. doi Risk factors for coronary, aortic arch and carotid calcification; The Rotterdam Study
    A E Odink
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Hum Hypertens 24:86-92. 2010
    ....
  16. doi Genetic determinants of von Willebrand factor plasma levels and the risk of stroke: the Rotterdam Study
    M C VAN Schie
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Thromb Haemost 10:550-6. 2012
    ..Whether these SNPs are associated with stroke risk is not known. The aim of our study was to investigate the association between genetic determinants of VWF levels and stroke risk...
  17. doi Plasma vitamin B12 status and cerebral white-matter lesions
    L M L de Lau
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 80:149-57. 2009
    ..This study examined the association of several markers of vitamin B(12) status with cerebral white-matter lesions, infarcts and cognition...
  18. ncbi Diuretic-gene interaction and the risk of myocardial infarction and stroke
    H Schelleman
    Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands
    Pharmacogenomics J 7:346-52. 2007
    ..51; 95% CI: 0.23-1.15), whereas no interaction on the risk of stroke was found (SI: 0.84; 95% CI: 0.46-1.56)...
  19. pmc Polymorphisms of the renin-angiotensin system are associated with blood pressure, atherosclerosis and cerebral white matter pathology
    M J E van Rijn
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 78:1083-7. 2007
    ..We studied the association between the M235T polymorphism of the angiotensinogen gene (AGT) and the C573T polymorphism of the angiotensin II type 1 receptor (AT1R) and blood pressure, carotid atherosclerosis and cerebrovascular disease...
  20. doi Interaction between polymorphisms in the renin-angiotensin-system and angiotensin-converting enzyme inhibitor or beta-blocker use and the risk of myocardial infarction and stroke
    H Schelleman
    Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands
    Pharmacogenomics J 8:400-7. 2008
    ..52) or in beta-blocker users. Also, no significant drug-gene interaction was found with the ACE I/D polymorphism. In conclusion, subjects with at least one copy of the AGTR1 573C allele might have more benefit from ACE inhibitor therapy...
  21. ncbi Variations in estrogen receptor alpha gene and risk of dementia, and brain volumes on MRI
    T den Heijer
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    Mol Psychiatry 9:1129-35. 2004
    ..50 (SE 0.10) in PP genotype, 4.45 (SE 0.06) in Pp genotype, and 4.18 ml (SE 0.08) in pp genotype (P trend=0.008). Further studies are required to investigate whether this smaller amygdalar volume has functional significance...
  22. ncbi C-reactive protein and cerebral small-vessel disease: the Rotterdam Scan Study
    E J van Dijk
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, PO Box 1738, 3000DR Rotterdam, The Netherlands
    Circulation 112:900-5. 2005
    ..These lesions are associated with an increased risk of stroke and dementia. We assessed whether higher C-reactive protein (CRP) levels were related to white matter lesion and lacunar infarcts...
  23. pmc Retinal vascular caliber and risk of dementia: the Rotterdam study
    F J De Jong
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Neurology 76:816-21. 2011
    ..Whether retinal vessel calibers are related to dementia remains unclear...
  24. doi Duration of antihypertensive drug use and risk of dementia: A prospective cohort study
    M D M Haag
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurology 72:1727-34. 2009
    ..Duration of follow-up was limited and relied mainly on baseline drug exposure data without information on duration of use. We investigated the association between the duration of antihypertensive use and risk of dementia...
  25. doi White matter atrophy and lesion formation explain the loss of structural integrity of white matter in aging
    M W Vernooij
    Department of Epidemiology, Erasmus MC University Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Neuroimage 43:470-7. 2008
    ..Furthermore, white matter atrophy and white matter lesion formation relate to loss of integrity in distinct brain regions, indicating the two processes are pathophysiologically different...
  26. ncbi Homocysteine and brain atrophy on MRI of non-demented elderly
    T den Heijer
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Brain 126:170-5. 2003
    ..These results support the hypothesis that higher plasma homocysteine levels are associated with more atrophy of the hippocampus and cortical regions in elderly at risk of Alzheimer's disease...
  27. ncbi Dietary antioxidants and the risk of ischemic stroke: the Rotterdam Study
    Z Voko
    Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, The Netherlands
    Neurology 61:1273-5. 2003
    ..These results agree with the view that high dietary intake of antioxidants, in particular vitamin C and--in smokers--vitamin E, reduces the risk of stroke...
  28. ncbi ACE gene is associated with Alzheimer's disease and atrophy of hippocampus and amygdala
    Kristel Sleegers
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurobiol Aging 26:1153-9. 2005
    ..Vascular pathology was not significantly associated with ACE. This suggests a modest but significant increase in risk of AD and early AD pathology in women homozygous for the ACE I-allele independent of vascular factors...
  29. pmc Insulin-like growth factor I promoter polymorphism, risk of stroke, and survival after stroke: the Rotterdam study
    M J E van Rijn
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 77:24-7. 2006
    ..Non-carriers of the 192 bp allele have lower levels of IGF-I compared with 192 bp allele carriers. We studied the IGF-I polymorphism in relation to the risk of stroke and survival after stroke...
  30. doi Is dementia incidence declining?: Trends in dementia incidence since 1990 in the Rotterdam Study
    E M C Schrijvers
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Neurology 78:1456-63. 2012
    ..To investigate whether dementia incidence has changed over the last 2 decades...
  31. pmc Arterial oxygen saturation, COPD, and cerebral small vessel disease
    E J van Dijk
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre, The Netherlands
    J Neurol Neurosurg Psychiatry 75:733-6. 2004
    ..To study whether lower arterial oxygen saturation (SaO(2)) and chronic obstructive pulmonary disease (COPD) are associated with cerebral white matter lesions and lacunar infarcts...
  32. pmc Insulin metabolism and the risk of Alzheimer disease: the Rotterdam Study
    E M C Schrijvers
    Department of Epidemiology, Erasmus MC University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Neurology 75:1982-7. 2010
    ..We investigated whether fasting glucose and insulin levels and insulin resistance are associated with the risk of AD and whether this risk is constant over time...
  33. ncbi Dietary fatty acids and the risk of Parkinson disease: the Rotterdam study
    L M L de Lau
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurology 64:2040-5. 2005
    ..Unsaturated fatty acids are important constituents of neuronal cell membranes and have neuroprotective, antioxidant, and anti-inflammatory properties...
  34. ncbi Retinal vessel diameters and cerebral small vessel disease: the Rotterdam Scan Study
    M Kamran Ikram
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Brain 129:182-8. 2006
    ..The mechanisms underlying venular dilatation deserve more attention, as they may provide new clues into the pathophysiology of cerebral small vessel disease...
  35. ncbi Relation between smoking and risk of dementia and Alzheimer disease: the Rotterdam Study
    C Reitz
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurology 69:998-1005. 2007
    ....
  36. ncbi Incidence of parkinsonism and Parkinson disease in a general population: the Rotterdam Study
    L M L de Lau
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurology 63:1240-4. 2004
    ..To investigate the incidence of parkinsonism and Parkinson disease (PD) in the general population using in-person screening along with clinical data...
  37. ncbi Diet and risk of dementia: Does fat matter?: The Rotterdam Study
    M J Engelhart
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurology 59:1915-21. 2002
    ....
  38. ncbi Silent brain infarcts and white matter lesions increase stroke risk in the general population: the Rotterdam Scan Study
    Sarah E Vermeer
    Dept of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Stroke 34:1126-9. 2003
    ..In healthy elderly people, silent brain infarcts and white matter lesions are common, but little is known about their relevance. We examined the risk of stroke associated with these lesions in the general population...
  39. doi Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study
    M D M Haag
    Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 80:13-7. 2009
    ..Prospective studies have provided inconsistent evidence. Moreover, it is unclear whether the association differs for lipophilic statins, those that could more easily pass the blood-brain barrier and hydrophilic statins...
  40. pmc Incidence, risk, and case fatality of first ever stroke in the elderly population. The Rotterdam Study
    M Hollander
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 74:317-21. 2003
    ..To estimate the incidence, survival, and lifetime risk of stroke in the elderly population...
  41. doi Depressive symptoms and risk of stroke: the Rotterdam Study
    M J Bos
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre, 3000 CA Rotterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 79:997-1001. 2008
    ..This study examines the association between depressive symptoms, depressive disorder and the risk of stroke in the general population...
  42. ncbi Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI
    T den Heijer
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Dr Molewaterplein 50, PO Box 1738, 3000 DR, Rotterdam, The Netherlands
    Diabetologia 46:1604-10. 2003
    ..We investigated the association between diabetes mellitus, insulin resistance and the degree of hippocampal and amygdalar atrophy on magnetic resonance imaging (MRI) accounting for vascular pathology...
  43. ncbi Haplotypes of the fibrinogen gene and cerebral small vessel disease: the Rotterdam scan study
    M van Oijen
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 79:799-803. 2008
    ....
  44. ncbi Measuring progression of cerebral white matter lesions on MRI: visual rating and volumetrics
    N D Prins
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurology 62:1533-9. 2004
    ..To evaluate the concordance of a volumetric method for measuring white matter lesion (WML) change with visual rating scales...
  45. ncbi Matrix metalloproteinase 3 haplotypes and dementia and Alzheimer's disease. The Rotterdam Study
    Christiane Reitz
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, P O Box 1738, 3000DR Rotterdam, The Netherlands
    Neurobiol Aging 29:874-81. 2008
    ..These associations did not differ between strata of APOEepsilon4 genotype. Our observations do not suggest that variation in the MMP3 gene is causally involved in dementia or AD...
  46. doi Unrecognized myocardial infarction in relation to risk of dementia and cerebral small vessel disease
    M Arfan Ikram
    Department of Epidemiology and Biostatistics, Erasmus MC University Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Stroke 39:1421-6. 2008
    ..We investigated whether unrecognized MI is also a risk factor for dementia and cerebral small vessel disease (white matter lesions and brain infarction) in 2 population-based cohort studies...
  47. ncbi A longitudinal population-based study of prothrombotic factors in elderly subjects with atrial fibrillation: the Rotterdam Study 1990-1999
    J Heeringa
    Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands
    J Thromb Haemost 4:1944-9. 2006
    ..A prothrombotic or hypercoagulable state in atrial fibrillation may contribute to stroke and thromboembolism. Results of longitudinal population-based studies in elderly people with atrial fibrillation are not yet available...
  48. ncbi Hippocampal, amygdalar, and global brain atrophy in different apolipoprotein E genotypes
    T den Heijer
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurology 59:746-8. 2002
    ..Carriers of epsilon4 had significantly more hippocampal and amygdalar atrophy than epsilon3epsilon3 subjects, but not more global brain atrophy. Carriers of epsilon2 did not have less brain atrophy than epsilon3epsilon3 subjects...
  49. ncbi A clinical-genetic study of Parkinson's disease in a genetically isolated community
    M C J Dekker
    Genetic Epidemiologic Unit, Dept of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
    J Neurol 250:1056-62. 2003
    ..The finding of a common ancestor in 41 idiopathic-PD patients along with the exclusion of known PD genes and loci suggests the presence of at least one other, yet unknown, susceptibility gene involved in PD in this population...
  50. ncbi MR spectroscopy of brain white matter in the prediction of dementia
    T den Heijer
    Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands
    Neurology 66:540-4. 2006
    ..Given the long prodromal period of Alzheimer disease (AD), the authors sought to investigate whether biochemical changes can be observed also in the preclinical period...
  51. ncbi Hippocampal head size associated with verbal memory performance in nondemented elderly
    V H Hackert
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Neuroimage 17:1365-72. 2002
    ..06, 0.59)). Our data suggest selective involvement of the hippocampal head in verbal memory, and add to recent findings of functional segregation along the longitudinal axis of the hippocampus...
  52. ncbi Homocysteine and cognitive function in the elderly: the Rotterdam Scan Study
    N D Prins
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurology 59:1375-80. 2002
    ..Elevated plasma total homocysteine (tHcy) concentrations are associated with AD and vascular dementia, but the relation with cognitive performance in nondemented elderly people is not known...
  53. ncbi Polymorphisms and haplotypes in the C-reactive protein gene and risk of dementia
    Marieke van Oijen
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Neurobiol Aging 28:1361-6. 2007
    ..Since serum levels of C-reactive protein are partly determined by genetic factors, we examined the association between genetic variation in the C-reactive protein gene with dementia and AD...
  54. ncbi Mutations in the hemochromatosis gene (HFE) and stroke
    Omer T Njajou
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands
    Stroke 33:2363-6. 2002
    ..Carriers of HFE C282Y and H63D mutations have elevated serum iron levels and may have an increased risk for stroke. We studied the association between HFE gene mutations, carotid atherosclerosis, and stroke...
  55. ncbi Thyroid hormones, dementia, and atrophy of the medial temporal lobe
    Frank Jan de Jong
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 91:2569-73. 2006
    ..Thyroid function has been related to Alzheimer disease (AD), but it remains unclear whether thyroid dysfunction results from or contributes to developing AD...
  56. ncbi Prognosis of Parkinson disease: risk of dementia and mortality: the Rotterdam Study
    Lonneke M L de Lau
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Arch Neurol 62:1265-9. 2005
    ..Most prognostic studies on Parkinson disease have been hospital based or have applied register-based case-finding methods. Potential under-representation of mild cases may have given biased results...
  57. doi Gait patterns in a community-dwelling population aged 50 years and older
    V J A Verlinden
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Gait Posture 37:500-5. 2013
    ..Future research should further investigate how these gait factors relate with gait-related diseases in their earliest stages...
  58. ncbi Carotid plaques increase the risk of stroke and subtypes of cerebral infarction in asymptomatic elderly: the Rotterdam study
    M Hollander
    Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, and Julius Center for General Practice and Patient Oriented Research, University Medical Center Utrecht, The Netherlands
    Circulation 105:2872-7. 2002
    ..1 to 4.9]). A >10-fold increased risk of lacunar infarction was found in subjects with severe plaques (RR 10.8 [95% CI, 1.7 to 69.7]). No clear difference in risk estimates was seen between ipsilateral and contralateral infarction...
  59. ncbi Pharmacologic agents associated with a preventive effect on Alzheimer's disease: a review of the epidemiologic evidence
    B A in 't Veld
    Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Epidemiol Rev 24:248-68. 2002
  60. ncbi Prevalence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study
    Sarah E Vermeer
    Department of Epidemiology, Erasmus Medical Centre Rotterdam, The Netherlands
    Stroke 33:21-5. 2002
    ..It is unclear whether risk factors for silent infarcts differ from those for symptomatic stroke. We investigated the prevalence of, and cardiovascular risk factors for, silent brain infarcts...
  61. doi Use of antithrombotic drugs and the presence of cerebral microbleeds: the Rotterdam Scan Study
    Meike W Vernooij
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Arch Neurol 66:714-20. 2009
    ..Cerebral microbleeds are hemosiderin deposits in the brain that are indicative of microangiopathy. Microbleeds in strictly lobar brain locations have been related to cerebral amyloid angiopathy, a bleeding-prone disease state...
  62. ncbi Prestroke cognitive performance, incident stroke, and risk of dementia: the Rotterdam Study
    Christiane Reitz
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, PO Box 2040, 3000CA Rotterdam, The Netherlands
    Stroke 39:36-41. 2008
    ..We explored in a prospective cohort study whether stroke occurrence was related to a higher risk of subsequent dementia and whether this association was dependent on prestroke slope of cognitive function...
  63. pmc Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk
    ELIZABETH E DEVORE
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands
    Am J Clin Nutr 90:170-6. 2009
    ..Greater fish and omega-3 (n-3) polyunsaturated fatty acid (PUFA) intake may reduce dementia risk; however, previous studies have reported conflicting results, which were largely based on short-term follow-up...
  64. ncbi Use of hippocampal and amygdalar volumes on magnetic resonance imaging to predict dementia in cognitively intact elderly people
    Tom den Heijer
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Arch Gen Psychiatry 63:57-62. 2006
    ..Whether atrophy of these structures is also present in persons without cognitive impairment who later develop dementia is unknown...
  65. doi Familial aggregation of parkinsonism in progressive supranuclear palsy
    L Donker Kaat
    Erasmus University Medical Center Rotterdam, Department of Neurology, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Neurology 73:98-105. 2009
    ..In this case-control study, we compared the occurrence of dementia and parkinsonism among first-degree relatives of patients with PSP with an age- and sex-matched control group...
  66. doi Matrix metalloproteinase 3 haplotypes and plasma amyloid beta levels: the Rotterdam Study
    Christiane Reitz
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurobiol Aging 31:715-8. 2010
    ..Factors modulating secretion or activity of MMP-3 may have the potential to influence the amount of Abeta concentration and deposition in the brain...
  67. ncbi Plasma levels of antioxidants are not associated with Alzheimer's disease or cognitive decline
    Marianne J Engelhart
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Dement Geriatr Cogn Disord 19:134-9. 2005
    ..87 (95% CI 0.64-1.19) for vitamin A and 0.94 (95% CI 0.60-1.48) for vitamin E. Antioxidants were not related to CD in non-demented subjects. Our findings suggest no association between plasma levels of vitamin A and E and AD or CD...
  68. doi Accuracy and reproducibility study of automatic MRI brain tissue segmentation methods
    Renske de Boer
    Department of Radiology and Medical Informatics, Erasmus MC, Rotterdam, The Netherlands
    Neuroimage 51:1047-56. 2010
    ..Example sample size calculations demonstrate a rather large effect of the choice of segmentation method on the required number of subjects...
  69. ncbi Methylenetetrahydrofolate reductase C677T genotype and PD
    Lonneke M L de Lau
    Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    Ann Neurol 57:927-30. 2005
    ..Our findings support the hypothesis that homocysteine plays a role in the pathogenesis of Parkinson's disease...
  70. ncbi A multivariate score objectively assessed health of depressed elderly
    Henning Tiemeier
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    J Clin Epidemiol 58:1134-41. 2005
    ..The self-report health measures commonly used may be biased in depressed persons. We introduce a method to assess physical health objectively in prospective studies of elderly persons...
  71. ncbi Polymorphisms in the interleukin 6 and transforming growth factor beta1 gene and risk of dementia. The Rotterdam Study
    Marieke van Oijen
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Neurosci Lett 402:113-7. 2006
    ..Associations did not differ across APOE genotypes. Our findings do not suggest involvement of genetic variance in IL-6 and TGFbeta1 in the development of dementia...
  72. ncbi Iterative co-linearity filtering and parameterization of fiber tracts in the entire cingulum
    Marius de Groot
    Biomedical Imaging Group Rotterdam, Department of Radiology, Erasmus MC, Rotterdam, The Netherlands
    Med Image Comput Comput Assist Interv 12:853-60. 2009
    ..Our asymmetry analysis shows a higher fractional anisotropy in the left anterior part of the cingulum compared to the right side, and the opposite effect in the posterior part...
  73. ncbi Decreased glomerular filtration rate is a risk factor for hemorrhagic but not for ischemic stroke: the Rotterdam Study
    Michiel J Bos
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Dr Molewaterplein 50, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Stroke 38:3127-32. 2007
    ..It is unclear whether decreased GFR is a risk factor for stroke. We assessed the association between GFR and stroke in a prospective population-based cohort study...
  74. pmc The Rotterdam Study: objectives and design update
    Albert Hofman
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Epidemiol 22:819-29. 2007
    ..epib.nl/rotterdamstudy). This article gives the reasons for the study and its design. It also presents a summary of the major findings and an update of the objectives and methods...
  75. doi Measuring cognitive function with age: the influence of selection by health and survival
    Sjoerd M Euser
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlandes
    Epidemiology 19:440-7. 2008
    ..Research into the pathophysiology of age-associated cognitive function and decline requires a valid estimate of cognitive function. However, this estimation can be grossly influenced by a selective loss to follow-up...
  76. doi Cerebral microbleeds: accelerated 3D T2*-weighted GRE MR imaging versus conventional 2D T2*-weighted GRE MR imaging for detection
    Meike W Vernooij
    Department of Epidemiology and Biostatistics, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Radiology 248:272-7. 2008
    ..In conclusion, accelerated 3D T2*-weighted GRE images depict more microbleeds than do conventional 2D T2*-weighted GRE images...
  77. doi Amino-terminal pro-B-type natriuretic peptide improves cardiovascular and cerebrovascular risk prediction in the population: the Rotterdam study
    Joost H W Rutten
    Department of Internal Medicine, Room D432, Erasmus Medical Center, 3015 CE Rotterdam, The Netherlands
    Hypertension 55:785-91. 2010
    ....
  78. doi White matter microstructural integrity and cognitive function in a general elderly population
    Meike W Vernooij
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Arch Gen Psychiatry 66:545-53. 2009
    ..Measures reflecting white matter microstructural integrity may provide additional information to investigate the relation between white matter changes and cognition...
  79. ncbi Homocysteine levels and the risk of osteoporotic fracture
    Joyce B J van Meurs
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    N Engl J Med 350:2033-41. 2004
    ..We therefore hypothesized that mildly elevated homocysteine levels might be related to age-related osteoporotic fractures...
  80. doi White matter lesion extension to automatic brain tissue segmentation on MRI
    Renske de Boer
    Biomedical Imaging Group Rotterdam, Departments of Radiology and Medical Informatics, Erasmus MC, Rotterdam, The Netherlands
    Neuroimage 45:1151-61. 2009
    ..The results indicated that the automatic segmentation accuracy is close to the interobserver variability of manual segmentations...
  81. doi The GAB2 gene and the risk of Alzheimer's disease: replication and meta-analysis
    M Arfan Ikram
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam 3000 CA, The Netherlands
    Biol Psychiatry 65:995-9. 2009
    ..Recently, GAB2 has been suggested to modify the risk of late-onset Alzheimer's disease (AD) among APOEepsilon4 carriers. However, replication data are inconsistent...
  82. ncbi Blood pressure components and cardiovascular events in older adults: the Rotterdam study
    Francesco U S Mattace-Raso
    Section of Geriatric Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Am Geriatr Soc 52:1538-42. 2004
    ..To compare the strength of the relative risks of systolic (SBP) diastolic blood pressure (DBP) and pulse pressure (PP) as predictors of myocardial infarction and stroke in older adults...
  83. ncbi Alcohol intake in relation to brain magnetic resonance imaging findings in older persons without dementia
    Tom den Heijer
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, Netherlands
    Am J Clin Nutr 80:992-7. 2004
    ..However, a low concentration of alcohol may also have direct effects on the hippocampus, a brain structure highly affected by Alzheimer disease...
  84. ncbi Mutations in the hemochromatosis gene (HFE), Parkinson's disease and parkinsonism
    Marieke C J Dekker
    Department of Epidemiology and Biostatistics, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Neurosci Lett 348:117-9. 2003
    ..009, P=0.006, respectively). Our data are hampered by small numbers, yet suggest that the C282Y mutation increases the risk of PD and non-PD PS. The rarity of this genotype requires a large series of patients to prove our hypothesis...
  85. pmc The Rotterdam Study: 2010 objectives and design update
    Albert Hofman
    Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam The Netherlands
    Eur J Epidemiol 24:553-72. 2009
    ..epib.nl/rotterdamstudy). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods...
  86. doi Cigarette smoking and risk of MS in multiplex families
    Naghmeh Jafari
    Department of Neurology, MS Centre ErasMS, Erasmus MC, Rotterdam, The Netherlands
    Mult Scler 15:1363-7. 2009
    ..However, more intense exposure and women showed higher odds ratios, although non-significant. Association studies in families with relatively high genetic loading are unlikely to be confounded by smoking history...
  87. pmc Predicting survival and morbidity-free survival to very old age
    Rachel S Newson
    Department of Epidemiology, Erasmus University Medical Centre, P O Box 2040, 3000 CA Rotterdam, Netherlands
    Age (Dordr) 32:521-34. 2010
    ....
  88. pmc Thyroid function, the risk of dementia and neuropathologic changes: the Honolulu-Asia aging study
    Frank Jan de Jong
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Neurobiol Aging 30:600-6. 2009
    ..No associations were found for thyrotropin. Our findings suggest that higher thyroxine levels are present with Alzheimer clinical disease and neuropathology...
  89. ncbi Plasma pterins and folate in late life depression: the Rotterdam Study
    Henning Tiemeier
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands
    Psychiatry Res 145:199-206. 2006
    ..17, 0.03, P=0.18). The interaction between depressive symptoms, folate and neopterin was significant (P=0.03). The study suggests that the relation between folate and pterins is altered in the depressed elderly...
  90. ncbi Dietary intake of antioxidants and risk of Alzheimer disease
    Marianne J Engelhart
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    JAMA 287:3223-9. 2002
    ..Therefore, the risk of Alzheimer disease might be reduced by intake of antioxidants that counteract the detrimental effects of oxidative stress...
  91. doi Genetic variation in homocysteine metabolism, cognition, and white matter lesions
    Lonneke M L de Lau
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurobiol Aging 31:2020-2. 2010
    ..No significant relationship was observed for any of the polymorphisms with cognitive performance or severity of cerebral white matter lesions...
  92. ncbi Glucocorticoid receptor variant and risk of dementia and white matter lesions
    Elisabeth F C van Rossum
    Department of Internal Medicine, Erasmus Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Neurobiol Aging 29:716-23. 2008
    ..A glucocorticoid receptor gene variant (ER22/23EK) is related to relative glucocorticoid resistance. We investigated whether the ER22/23EK allele is associated with dementia and structural brain abnormalities...
  93. ncbi Uric acid is a risk factor for myocardial infarction and stroke: the Rotterdam study
    Michiel J Bos
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Stroke 37:1503-7. 2006
    ..We investigated the association between serum uric acid and coronary heart disease and stroke in a large prospective population-based study...
  94. doi Hippocampus segmentation in MR images using atlas registration, voxel classification, and graph cuts
    Fedde van der Lijn
    Department of Radiology, Erasmus MC, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Neuroimage 43:708-20. 2008
    ..Finally, direct quantitative and qualitative comparisons showed that the proposed method outperforms a multi-atlas based segmentation method...
  95. doi Incidence of cerebral microbleeds in the general population: the Rotterdam Scan Study
    Mariëlle M F Poels
    Department of Radiology, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Stroke 42:656-61. 2011
    ..Cerebral microbleeds are frequently seen in the general elderly population, but it is unknown at what rate they occur with aging and whether once present can disappear over time...
  96. ncbi Angiotensinogen M235T polymorphism and the risk of myocardial infarction and stroke among hypertensive patients on ACE-inhibitors or beta-blockers
    Hedi Schelleman
    Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands
    Eur J Hum Genet 15:478-84. 2007
    ..ACE-inhibitor users with at least one copy of the 235T-allele of the AGT gene might have an increased risk of MI and stroke...
  97. ncbi Incidence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study
    Sarah E Vermeer
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Stroke 34:392-6. 2003
    ..The incidence of silent brain infarcts is unknown. We investigated the incidence and cardiovascular risk factors for silent brain infarcts...
  98. doi Fetal growth retardation and risk of febrile seizures
    Annemarie M Visser
    Generation R Study Group, Erasmus University Medical Center, Department of Neurology, PO Box 2040, 3000 CA Rotterdam, Netherlands
    Pediatrics 126:e919-25. 2010
    ..The goal was to examine the associations between fetal growth characteristics in different trimesters of pregnancy and the occurrence of febrile seizures in early childhood...
  99. ncbi Endogenous estradiol and risk of dementia in women and men: the Rotterdam Study
    Mirjam I Geerlings
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Ann Neurol 53:607-15. 2003
    ..The findings do not support the hypothesis that higher levels of endogenous estradiol reduce risk of dementia, neither in women nor in men...
  100. doi Prevalence and risk factors of cerebral microbleeds: an update of the Rotterdam scan study
    Mariëlle M F Poels
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Stroke 41:S103-6. 2010
    ..We examined the prevalence and determinants of microbleeds in this larger and younger cohort from the general population...
  101. ncbi Multi-spectral brain tissue segmentation using automatically trained k-Nearest-Neighbor classification
    Henri A Vrooman
    Department of Radiology, Erasmus MC, P O Box 1738, Rotterdam, The Netherlands
    Neuroimage 37:71-81. 2007
    ..It can be concluded that our fully automated method using non-rigid registration may replace manual segmentation, and thus that automated brain tissue segmentation without laborious manual training is feasible...