Marcel J C Bijvelds
Affiliation: Erasmus MC
Country: The Netherlands
- Bijvelds M, Bot A, Escher J, de Jonge H. Activation of intestinal Cl- secretion by lubiprostone requires the cystic fibrosis transmembrane conductance regulator. Gastroenterology. 2009;137:976-85 pubmed publisher..Lubiprostone enhances intestinal Cl(-) and fluid secretion via prostanoid receptor signaling, triggering activation of CFTR. Therefore, it is of limited use for treatment of CF-related intestinal disease. ..
- Ikpa P, Sleddens H, Steinbrecher K, Peppelenbosch M, de Jonge H, Smits R, et al. Guanylin and uroguanylin are produced by mouse intestinal epithelial cells of columnar and secretory lineage. Histochem Cell Biol. 2016;146:445-55 pubmed publisher..Our study reveals novel aspects of the cellular localization of the GCC signaling axis that, apart from its role in the regulation of fluid balance, link it to pH regulation, cell cycle control, and host defense. ..
- Bijvelds M, Jorna H, Verkade H, Bot A, Hofmann F, Agellon L, et al. Activation of CFTR by ASBT-mediated bile salt absorption. Am J Physiol Gastrointest Liver Physiol. 2005;289:G870-9 pubmed..We conclude that active BS absorption in the ileum triggers CFTR activation and, consequently, local salt and water secretion, which may serve to prevent intestinal obstruction in the postprandial state. ..