Research Topics
Genomes and GenesSpecies | Michiel G H BetjesSummaryAffiliation: Erasmus MC Country: The Netherlands Publications
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Publications
The pathology of jaundice-related renal insufficiency: cholemic nephrosis revisitedMichiel G H Betjes
Division of Nephrology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
J Nephrol 19:229-33. 2006..In conclusion, jaundice-related nephropathy is essentially a tubulopathy, but the exact nature of the Pathogenesis is still uncertain...- Regional citrate versus heparin anticoagulation during venovenous hemofiltration in patients at low risk for bleeding: similar hemofilter survival but significantly less bleedingMichiel G H Betjes
Division of Nephrology, Department of Internal Medicine, Erasmus Medical Center, Dijkzigt Rotterdam, Rotterdam The Netherlands
J Nephrol 20:602-8. 2007..RCA does not increase the risk of bleeding, but carries the risk of metabolic derangements. Clotting-free circuit survival may be increased with RCA... - IL-2 producing memory CD4+ T lymphocytes are closely associated with the generation of IgG-secreting plasma cellsNicolle H R Litjens
Department of Internal Medicine, Division of Nephrology, Erasmus Medical Center, Rotterdam, The Netherlands
J Immunol 181:3665-73. 2008..Based on these findings, we conclude that the development of Ag-specific IL-2-producing memory T cells appears to be essential for the development of IgG-secreting plasma cells in humans... 
Prevention of catheter-related bloodstream infection in patients on hemodialysisMichiel G H Betjes
Division of Nephrology, Department of Internal Medicine, Erasmus Medical Center, s Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands
Nat Rev Nephrol 7:257-65. 2011..Adherence to a meticulous catheter care protocol can achieve a CRBSI incidence well below one episode per 1,000 catheter days, even without the need for antimicrobial ointments or lock solutions...- Terminally differentiated CD8+ Temra cells are associated with the risk for acute kidney allograft rejectionMichiel G H Betjes
Division of Nephrology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
Transplantation 94:63-9. 2012..This may cause a relevant reduction in T-cell immunity, yielding a lowered risk for acute rejection (AR) of kidney allografts... - A killer on the road: circulating CD4(+)CD28null T cells as cardiovascular risk factor in ESRD patientsMichiel G H Betjes
Division of Nephrology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
J Nephrol 25:183-91. 2012.... 
Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsetsNicolle Hr Litjens
Department of Internal Medicine, Division of Nephrology, Erasmus Medical Center, Rotterdam, The Netherlands
Immun Ageing 8:2. 2011..In conclusion, CMV-seropositivity markedly alters the homeostasis of circulating T cells in healthy individuals and aggravates the T cell dysregulation observed in ESRD patients...- Decreased antigen-specific T-cell proliferation by moDC among hepatitis B vaccine non-responders on haemodialysisM A Verkade
Department of Internal Medicine, Division of Nephrology, Bd336, Erasmus Medical Center, Dr Molewater plein 40, 3015 GD Rotterdam, The Netherlands
Clin Exp Med 7:65-71. 2007..Our results indicate that impairment of moDC to stimulate antigen-specific T cells provides an explanation for the clinical immunodeficiency of patients with end-stage kidney disease... - Circulating pro-inflammatory CD4posCD28null T cells are independently associated with cardiovascular disease in ESRD patientsMichiel G H Betjes
Erasmus Medical Center, Department of Internal Medicine, Division of Nephrology, Rotterdam, The Netherlands
Nephrol Dial Transplant 25:3640-6. 2010..Circulating pro-inflammatory CD4posCD28null T cells are expanded in cytomegalovirus-seropositive ESRD patients and potentially could mediate atherosclerotic plaque instability and rupture... - Expansion of cytolytic CD4+CD28- T cells in end-stage renal diseaseMichiel G H Betjes
Division of Nephrology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
Kidney Int 74:760-7. 2008..These findings are highly suggestive of repetitive antigenic stimulation of the immune system in patients with end stage disease by subclinical CMV reactivation which might contribute to increased atherosclerotic risk... - Premature aging of circulating T cells in patients with end-stage renal diseaseMichiel G H Betjes
Division of Nephrology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
Kidney Int 80:208-17. 2011..Thus, our results are compatible with premature aging of the T-cell system of patients with ESRD comparable with that of healthy individuals 20-30 years older... - CMV seropositivity determines epoetin dose and hemoglobin levels in patients with CKDMichiel G H Betjes
Erasmus Medical Center, Department of Internal Medicine, Division of Nephrology, Dr Molewaterplein 40, Rotterdam, Netherlands
J Am Soc Nephrol 20:2661-6. 2009..In conclusion, expansion of CD4(+)CD28null T cells in CMV-seropositive patients with ESRD associates with increased demand for epoetin... - Seropositivity for cytomegalovirus in patients with end-stage renal disease is strongly associated with atherosclerotic diseaseMichiel G H Betjes
Erasmus Medical Center, Department of Internal Medicine, Division of Nephrology, Dr Molewater plein 40 3015 GD Rotterdam, The Netherlands
Nephrol Dial Transplant 22:3298-303. 2007..The possible contribution of CMV seropositivity to the hugely increased risk for cardiovascular disease in patients with ESRD is not clear... - Prevention of dialysis catheter-related sepsis with a citrate-taurolidine-containing lock solutionMichiel G H Betjes
Department of Internal Medicine, Division of Nephrology, Erasmus Medical Center, Dijkzigt Rotterdam, Dr Molewater plein 40, 3015 GD Rotterdam, The Netherlands
Nephrol Dial Transplant 19:1546-51. 2004..The use of a catheter lock solution containing the antimicrobial taurolidine might prevent bacterial colonization, thereby reducing the incidence of catheter-related sepsis... - Vitamin E-coated dialyzer membranes downregulate expression of monocyte adhesion and co-stimulatory moleculesMichiel G H Betjes
Erasmus Medical Center, Dijkzigt Rotterdam, Department of Internal Medicine, Division of Nephrology, Rotterdam, The Netherlands
Blood Purif 22:510-7. 2004..In this study we investigated if the vitamin E-coated dialyzer membrane could reduce monocyte activation thereby improving cellular immunity... - Resolution of IgM nephropathy after rituximab treatmentMichiel G H Betjes
Department of Internal Medicine, Division of Nephrology, Erasmus Medical Center, Rotterdam, The Netherlands
Am J Kidney Dis 53:1059-62. 2009..One year after rituximab treatment, the patient has stable kidney function, normal urinary sediment, and no proteinuria. Rituximab may be a valuable novel therapeutic drug for the treatment of patients with IgM nephropathy... - Hepatitis B vaccine-specific CD4(+) T cells can be detected and characterised at the single cell level: limited usefulness of dendritic cells as signal enhancersNicolle H R Litjens
Department of Internal Medicine, Division of Nephrology, Erasmus Medical Center, Rotterdam, The Netherlands
J Immunol Methods 330:1-11. 2008..T cell responses associated with (in-) adequate hepatitis B vaccination can now be analysed in more detail... - Risk factors associated with encapsulating peritoneal sclerosis in Dutch EPS studyMario R Korte
Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, Netherlands
Perit Dial Int 31:269-78. 2011..The aim of the present study was to evaluate the independent associations of PD duration, age, dialysis fluids, and kidney transplantation with EPS... - The effects of chronic kidney disease and renal replacement therapy on circulating dendritic cellsDennis A Hesselink
Department of Internal Medicine, Division of Nephrology and Renal Transplantation, Room Ee 563 A, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
Nephrol Dial Transplant 20:1868-73. 2005..In this study, we analysed whether this reduction resulted from CKD or from renal replacement therapy (RRT)... - Peripheral blood dendritic cells and GM-CSF as an adjuvant for hepatitis B vaccination in hemodialysis patientsMartijn A Verkade
Erasmus Medical Center, Department of Internal Medicine, Division of Nephrology, Dijkzigt Rottterdam, The Netherlands
Kidney Int 66:614-21. 2004.... - Progressive loss of renal function is associated with activation and depletion of naive T lymphocytesNicolle H R Litjens
Department of Internal Medicine, Division of Nephrology, Room Ee 551, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
Clin Immunol 118:83-91. 2006..IL-7 but not IL-15 plasma concentrations were lowered in patients with end-stage renal disease as compared to healthy controls... - The human alloreactive CD4+ T-cell repertoire is biased to a Th17 response and the frequency is inversely related to the number of HLA class II mismatchesNicolle H R Litjens
Department of Internal Medicine, Division of Nephrology, Erasmus Medical Center, Rotterdam, The Netherlands
Blood 114:3947-55. 2009..Alloreactive HLA-identical T cells did not proliferate or express cytokines, but were driven to proliferation in the presence of exogenous IL-2... - Identification of circulating human antigen-reactive CD4+ FOXP3+ natural regulatory T cellsNicolle H R Litjens
Division of Nephrology and Transplantation, Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
J Immunol 188:1083-90. 2012..Isolation and expansion of functional Ag-reactive nTregs is possible and of potential benefit for specific therapeutic goals... - Hypernatraemia in critically ill patients: too little water and too much saltEwout J Hoorn
Erasmus Medical Center, Dialysis Unit, Room Bd 391, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
Nephrol Dial Transplant 23:1562-8. 2008..Our objective was to study the risk factors and mechanisms of hypernatraemia in critically ill patients, a common and potentially serious problem... - Hydroxyethylstarch solutions versus saline for the treatment of intradialytic hypotensionMagda Konings
Department of Internal Medicine, Division of Nephrology, Rotterdam, The Netherlands
J Ren Care 33:130-3. 2007..It is unknown whether the colloid solutions hydroxyethylstarch (HES) 6% and 10% are equally effective as compared to saline alone for the treatment of intradialytic hypotension... - Posttransplant encapsulating peritoneal sclerosis: a worrying new trend?Marien W J A Fieren
Nephrology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
Perit Dial Int 27:619-24. 2007..Transfer from PD to hemodialysis should be under serious consideration in patients eligible for kidney transplantation as soon as there are indications of ultrafiltration failure... - Reversible renal failure due to bilateral renal sarcoma in a patient with acute myeloid leukemiaWim Rüger
Department of Nephrology, Erasmus Medical Center, Rotterdam, The Netherlands
Ren Fail 31:606-9. 2009..This report shows that renal failure, enlargement of the kidneys, and tubule dysfunction in the course of AML infiltrating the kidneys can be reversed by treatment of the hematological disease... - Encapsulating peritoneal sclerosis: the state of affairsMario R Korte
Albert Schweitzer Hospital, Department of Internal Medicine, PO Box 444, 3300 AK Dordrecht, The Netherlands
Nat Rev Nephrol 7:528-38. 2011.... - Tamoxifen is associated with lower mortality of encapsulating peritoneal sclerosis: results of the Dutch Multicentre EPS StudyMario R Korte
Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, The Netherlands
Nephrol Dial Transplant 26:691-7. 2011..At present, there is no evidence for the effect of tamoxifen treatment in EPS patients. This study investigates the effect of treatment with tamoxifen on survival in EPS patients... - Mesenchymal stem cells derived from adipose tissue are not affected by renal diseaseMarieke Roemeling-van Rhijn
Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
Kidney Int 82:748-58. 2012..Hence, our results indicate the feasibility of their use in autologous cell therapy in patients with renal disease... - Stable improvement of renal function after initiation of highly active anti-retroviral therapy in patients with HIV-1-associated nephropathyMichiel G H Betjes
Academic Hospital Rotterdam, Dijkzigt, Department of Internal Medicine, Division of Nephrology, Rotterdam, The Netherlands
Nephrol Dial Transplant 17:1836-9. 2002 - Increasing incidence of severe encapsulating peritoneal sclerosis after kidney transplantationMario R Korte
Nephrol Dial Transplant 22:2412-4. 2007