Research Topics
| Irma A J M Bakker-WoudenbergSummaryAffiliation: Erasmus University Country: The Netherlands Publications
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Detail Information
Publications
Improved efficacy of ciprofloxacin administered in polyethylene glycol-coated liposomes for treatment of Klebsiella pneumoniae pneumonia in ratsI A Bakker-Woudenberg
Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, 3000 DR Rotterdam, The Netherlands
Antimicrob Agents Chemother 45:1487-92. 2001..PEG-coated liposomal ciprofloxacin was well tolerated in relatively high doses, permitting once daily administration with relatively low ciprofloxacin clearance and without compromising therapeutic efficacy...
Long-circulating sterically stabilized liposomes as carriers of agents for treatment of infection or for imaging infectious fociIrma A J M Bakker-Woudenberg
Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, P O Box 1738, 3000 DR, The Netherlands
Int J Antimicrob Agents 19:299-311. 2002..In addition, radiolabelled SSL are used to image infectious and inflammatory foci...- Ciprofloxacin in polyethylene glycol-coated liposomes: efficacy in rat models of acute or chronic Pseudomonas aeruginosa infectionIrma A J M Bakker-Woudenberg
Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
Antimicrob Agents Chemother 46:2575-81. 2002..Complete bacterial eradication is never observed... - Scintigraphic imaging using 99mTc-labeled PEG liposomes allows early detection of experimental invasive pulmonary aspergillosis in neutropenic ratsMartin J Becker
Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, 3015 GE Rotterdam, 50, The, Dr Molewaterplein, Netherlands
Nucl Med Biol 29:177-84. 2002.... - Enhanced antifungal efficacy in experimental invasive pulmonary aspergillosis by combination of AmBisome with Fungizone as assessed by several parameters of antifungal responseMartin J Becker
Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Centre, PO Box 1738, 3000 DR Rotterdam, The Netherlands
J Antimicrob Chemother 49:813-20. 2002..This is probably a result of active amphotericin B being immediately available in the lung at the start of treatment... - Caspofungin: antifungal activity in vitro, pharmacokinetics, and effects on fungal load and animal survival in neutropenic rats with invasive pulmonary aspergillosisWim van Vianen
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, The Netherlands
J Antimicrob Chemother 57:732-40. 2006..Evaluation of the potential of caspofungin, in relation to pharmacokinetics, in order to optimize its use in the treatment of filamentous fungal infections... 
The effects of antifungal agents to conidial and hyphal forms of Aspergillus fumigatusWendy W J van de Sande
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Med Mycol 48:48-55. 2010..Antifungal susceptibility of conidia was also determined using the E-test in which it was found that the XTT assaygave comparable ICs for amphotericin B, itraconazole and voriconazole but not for caspofungin...- Effect of amphotericin B treatment on kinetics of cytokines and parameters of fungal load in neutropenic rats with invasive pulmonary aspergillosisMartin J Becker
Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
J Antimicrob Chemother 52:428-34. 2003..The kinetics of various parameters of fungal load and cytokines were investigated, in order to acquire insight into the pathogenesis of invasive pulmonary aspergillosis (IPA) during antifungal treatment with amphotericin B... - Caspofungin prolongs survival of transiently neutropenic rats with advanced-stage invasive pulmonary aspergillosisWendy W J van de Sande
Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, s Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands
Antimicrob Agents Chemother 52:1345-50. 2008..In this model, the administration of high-dose-step-down treatment was as effective as treatment with high doses for the whole treatment period... - Antimycobacterial agents differ with respect to their bacteriostatic versus bactericidal activities in relation to time of exposure, mycobacterial growth phase, and their use in combinationIrma A J M Bakker-Woudenberg
Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
Antimicrob Agents Chemother 49:2387-98. 2005..The combination of amikacin and amoxicillin-clavulanic acid exhibited synergistic antimycobacterial activity. Towards MAC at low growth rates, only the quinolones exhibited a bactericidal effect... - Consequences of noncompliance for therapy efficacy and emergence of resistance in murine tuberculosis caused by the Beijing genotype of Mycobacterium tuberculosisJurriaan E M de Steenwinkel
Erasmus MC, University Medical Centre Rotterdam, Department of Medical Microbiology and Infectious Diseases, Rotterdam, The Netherlands
Antimicrob Agents Chemother 56:4937-44. 2012..These results suggest that genotype diversity of M. tuberculosis may be involved in emergence of resistance and indicates that genotype-tailor-made treatment should be investigated... - Pathophysiology of unilateral pulmonary aspergillosis in an experimental rat modelMartin J Becker
Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, The Netherlands
Med Mycol 44:133-9. 2006..Loss of left lung function was probably compensated by the uninfected right lung, even in a late stage of the disease. Circulatory failure was a major feature in the terminal phase of the infection... - A murine model of Madurella mycetomatis eumycetomaAbdalla O Ahmed
Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands
FEMS Immunol Med Microbiol 37:29-36. 2003..This model will enable further studies on the pathogenesis as well as prevention and treatment of the fungal infection... - Time-kill kinetics of anti-tuberculosis drugs, and emergence of resistance, in relation to metabolic activity of Mycobacterium tuberculosisJurriaan E M de Steenwinkel
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
J Antimicrob Chemother 65:2582-9. 2010.... - Nebulization of four commercially available amphotericin B formulations in persistently granulocytopenic rats with invasive pulmonary aspergillosis: evidence for long-term biological activityElisabeth J Ruijgrok
Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands
J Pharm Pharmacol 57:1289-95. 2005..All commercially available amphotericin B preparations could be nebulized efficiently and may be of value in the prophylactic treatment of invasive pulmonary aspergillosis... - Reshuffling of Aspergillus fumigatus cell wall components chitin and β-glucan under the influence of caspofungin or nikkomycin Z alone or in combinationPatricia E B Verwer
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
Antimicrob Agents Chemother 56:1595-8. 2012..This could explain the synergistic activity of this combination of drugs... - Effect of treatment duration on pharmacokinetic/pharmacodynamic indices correlating with therapeutic efficacy of ceftazidime in experimental Klebsiella pneumoniae lung infectionIrma A J M Bakker-Woudenberg
Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
Antimicrob Agents Chemother 50:2919-25. 2006..The effect of long-term treatment should be studied more extensively in other models of infection... - Long-circulating sterically stabilized liposomes in the treatment of infectionsIrma A J M Bakker-Woudenberg
Department of Medical Microbiology and Infectious Diseases, Erasmus University Rotterdam, Rotterdam, The Netherlands
Methods Enzymol 391:228-60. 2005..Host-related factors focused on the components of the inflammatory response... - Biodistribution of long-circulating PEG-liposomes in a murine model of established subcutaneous abscessesLorna E T Stearne
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, P O Box 1738, 3000 DR, Netherlands
Biochim Biophys Acta 1561:91-7. 2002..We conclude that PEG-liposomes localise to a significant degree at the infection focus in our mouse model and may provide a new approach to the antimicrobial treatment of intra-abdominal abscesses... - Targeted drug delivery to enhance efficacy and shorten treatment duration in disseminated Mycobacterium avium infection in miceJurriaan E M de Steenwinkel
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
J Antimicrob Chemother 60:1064-73. 2007..Improvement of the efficacy of drug treatment in mycobacterial infection by the development and application of targeted drug delivery... - Therapeutic efficacy of liposomal gentamicin in clinically relevant rat modelsR M Schiffelers
Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
Int J Pharm 214:103-5. 2001..Survival rates demonstrate the valuable therapeutic properties of the liposome-encapsulated drug in these clinically relevant animal models... - Relapse of tuberculosis versus primary tuberculosis; course, pathogenesis and therapy in miceJurriaan E M de Steenwinkel
Erasmus MC, University Medical Centre Rotterdam, Department of Medical Microbiology and Infectious Diseases, P O Box 2040, 3000 CA Rotterdam, The Netherlands
Tuberculosis (Edinb) 93:213-21. 2013..Treatment response in relapse of TB is as good as the treatment response in primary TB; thereby no supportive evidence could be given for the recommended longer treatment duration in case of relapse of TB... - Rifampicin-induced transcriptome response in rifampicin-resistant Mycobacterium tuberculosisGerjo J de Knegt
Erasmus MC, University Medical Centre Rotterdam, Department of Medical Microbiology and Infectious Diseases, P O Box 2040, 3000 CA Rotterdam, The Netherlands
Tuberculosis (Edinb) 93:96-101. 2013..tuberculosis. Further investigation of Rv0559c and Rv0560c is needed to reveal function and mechanism of both genes that were triggered upon rifampicin exposure... - Distinctive cytokines as biomarkers predicting fatal outcome of severe Staphylococcus aureus bacteremia in miceSanne van den Berg
Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Centre, Rotterdam, The Netherlands
PLoS ONE 8:e59107. 2013..KC was a biomarker elevated irrespective the progression of infection, which is very interesting regarding clinical application in view of the heterogeneity of patients experiencing bacteraemia in this respect... - Activity of liposomal amphotericin B with prolonged circulation in blood versus those of AmBisome and fungizone against intracellular Candida albicans in murine peritoneal macrophagesE W Van Etten
Department of Medical Microbiology and Infectious Diseases, Erasmus University Rotterdam, Rotterdam, The Netherlands
Antimicrob Agents Chemother 42:2437-9. 1998..Previous exposure of uninfected macrophages to PEG-AMB-LIP or AmBisome is advantageous for intracellular antifungal activity... - Superior efficacy of liposomal amphotericin B with prolonged circulation in blood in the treatment of severe candidiasis in leukopenic miceE W Van Etten
Department of Medical Microbiology and Infectious Diseases, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands
Antimicrob Agents Chemother 42:2431-3. 1998..day). When the first of five daily doses of AmBisome was combined with a single low dose of Fungizone (0.1 mg of AMB/kg), the efficacy was equal to that of PEG-AMB-LIP... - Differential nitric oxide and TNF-alpha production of murine Kupffer cell subfractions upon priming with IFN-gamma and TNF-alphaT L ten Hagen
Dept Clinical Microbiology and Antimicrobial Therapy, Erasmus University Rotterdam, The Netherlands
Liver 18:299-305. 1998..We have previously shown a striking heterogeneity of naive murine Kupffer cells (KC) that depends on cell size... - Localization of sterically stabilized liposomes in Klebsiella pneumoniae-infected rat lung tissue: influence of liposome characteristicsR M Schiffelers
Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, P O BOX 80082, 3508 TB, Utrecht, The Netherlands
Biochim Biophys Acta 1421:329-39. 1999..These properties seem to be a direct consequence of the presence of the polymer coating operating as a repulsive steric barrier opposing interactions with biological components... - Administration of liposomal agents and blood clearance capacity of the mononuclear phagocyte systemE W Van Etten
Department of Medical Microbiology and Infectious Diseases, Erasmus University Rotterdam, The Netherlands
Antimicrob Agents Chemother 42:1677-81. 1998..The bacterial blood clearance capacity was never impaired, not even after prolonged treatment with AmBisome administered in a clinically relevant regimen... - Involvement of T cells in enhanced resistance to Klebsiella pneumoniae septicemia in mice treated with liposome-encapsulated muramyl tripeptide phosphatidylethanolamine or gamma interferonT L ten Hagen
Department of Clinical Microbiology and Antimicrobial Therapy, Erasmus University Rotterdam, The Netherlands
Infect Immun 66:1962-7. 1998..These findings indicate that immunomodulation with liposomal MTPPE and IFN-gamma favors Th1 and NK cell activation... - Efficacy of liposomal amphotericin B with prolonged circulation in blood in treatment of severe pulmonary aspergillosis in leukopenic ratsE W Van Etten
Department of Medical Microbiology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
Antimicrob Agents Chemother 44:540-5. 2000..For temporarily leukopenic rats no major advances in efficacy were achieved compared to those for persistently leukopenic rats, probably because the leukocyte numbers in blood were restored too late in the course of infection... - Host factors influencing the preferential localization of sterically stabilized liposomes in Klebsiella pneumoniae-infected rat lung tissueR M Schiffelers
Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, The Netherlands
Pharm Res 18:780-7. 2001..To gain insight into the host factors influencing liposome localization at sites of bacterial infection... - Quantitative galactomannan detection is superior to PCR in diagnosing and monitoring invasive pulmonary aspergillosis in an experimental rat modelM J Becker
Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center Rotterdam, 3000 DR Rotterdam, The Netherlands
J Clin Microbiol 38:1434-8. 2000..0001). It was concluded that, in this model, quantitative galactomannan detection is superior to PCR in diagnosing and monitoring invasive pulmonary aspergillosis... - Localization of sterically stabilized liposomes in experimental rat Klebsiella pneumoniae pneumonia: dependence on circulation kinetics and presence of poly(ethylene)glycol coatingR M Schiffelers
Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
Biochim Biophys Acta 1468:253-61. 2000..This finding is discussed in relation to the equation of Kedem and Katchalsky, which describes protein influx into sites of infection or inflammation... - The therapeutic effect of tigecycline, unlike that of Ceftazidime, is not influenced by whether the Klebsiella pneumoniae strain produces extended-spectrum β-lactamases in experimental pneumonia in ratsWil H F Goessens
Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
Antimicrob Agents Chemother 57:643-6. 2013..In contrast, tigecycline at 6.25, 12.5, or 25 mg/kg b.i.d. showed dosage-dependent efficacy up to 100% rat survival irrespective of the ESBL character of the infecting organism... - Testing of the in vitro susceptibilities of Madurella mycetomatis to six antifungal agents by using the Sensititre system in comparison with a viability-based 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5- [(phenylamino)carbonyl]-2H-tetrazolium hydroxide (XTWendy W J van de Sande
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
Antimicrob Agents Chemother 49:1364-8. 2005..Based on the relatively broad range of MICs obtained for the antifungal agents, routine testing of M. mycetomatis isolates for susceptibility to antifungal agents seems to be relevant to adequate therapeutic management... - Combination therapy of advanced invasive pulmonary aspergillosis in transiently neutropenic rats using human pharmacokinetic equivalent doses of voriconazole and anidulafunginWendy W J van de Sande
Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
Antimicrob Agents Chemother 53:2005-13. 2009..In conclusion, VOR monotherapy is therapeutically effective in the treatment of advanced-stage IPA and superior to the use of ANI. Combining both agents does not significantly improve the therapeutic outcome... - Experimental models of pulmonary infectionIrma A J M Bakker-Woudenberg
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
J Microbiol Methods 54:295-313. 2003..Examples of pulmonary infection models caused by bacteria, fungi, viruses or parasites in experimental animals with intact or impaired host defense mechanisms are shortly summarized including key-references... - In vivo synergistic interaction of liposome-coencapsulated gentamicin and ceftazidimeR M Schiffelers
Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
J Pharmacol Exp Ther 298:369-75. 2001..Liposomal coencapsulation of synergistic antibiotics may open new perspectives in the treatment of severe infections... - A multiplex assay for the quantification of antibody responses in Staphylococcus aureus infections in miceSanne van den Berg
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, 3015 CE Rotterdam, The Netherlands
J Immunol Methods 365:142-8. 2011..aureus antibody assay can be successfully applied to determine the immunogenicity of different S. aureus proteins in relation to the site of infection and the S. aureus strain causing the infection... - Nebulized amphotericin B combined with intravenous amphotericin B in rats with severe invasive pulmonary aspergillosisElisabeth J Ruijgrok
Department of Clinical Pharmacy, Medical Center Rijnmond Zuid, Olympiaweg 350, 3078 HT Rotterdam, The Netherlands
Antimicrob Agents Chemother 50:1852-4. 2006..Nebulized liposomal AMB in addition to intravenous AMB resulted in significantly prolonged survival compared to controls... - Liposome-enabled synergistic interaction of antimicrobial agentsRaymond M Schiffelers
Dept of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands
J Liposome Res 12:121-7. 2002..In this presentation therapeutic efficacy of liposome-co-encapsulated gentamicin (GN) and ceftazidime (CZ) will be shown in a GN-CZ-susceptible and GN-CZ-resistant Klebsiella pneumoniae-pneumonia in rats... - In vitro susceptibilities of Madurella mycetomatis to itraconazole and amphotericin B assessed by a modified NCCLS method and a viability-based 2,3-Bis(2-methoxy-4-nitro-5- sulfophenyl)-5-[(phenylamino)carbonyl]-2H-tetrazolium hydroxide (XTT) assayAbdalla O A Ahmed
Mycetoma Research Group, Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan
Antimicrob Agents Chemother 48:2742-6. 2004..The XTT assay was reproducible and sensitive for both antifungals. Itraconazole (MIC at which 50% of the isolates tested are inhibited [MIC(50)]) of 0.06 to 0.13 mg/liter) was superior to amphotericin B (MIC(50) of 0.5 to 1.0 mg/liter)... - Apolipoprotein CI stimulates the response to lipopolysaccharide and reduces mortality in gram-negative sepsisJimmy F P Berbee
Department of Biomedical Research, TNO Quality of Life, Leiden, The Netherlands
FASEB J 20:2162-4. 2006....