Irma A J M Bakker-Woudenberg

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi request reprint Experimental models of pulmonary infection
    Irma A J M Bakker-Woudenberg
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Microbiol Methods 54:295-313. 2003
  2. pmc Antimycobacterial agents differ with respect to their bacteriostatic versus bactericidal activities in relation to time of exposure, mycobacterial growth phase, and their use in combination
    Irma A J M Bakker-Woudenberg
    Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Antimicrob Agents Chemother 49:2387-98. 2005
  3. pmc Effect of treatment duration on pharmacokinetic/pharmacodynamic indices correlating with therapeutic efficacy of ceftazidime in experimental Klebsiella pneumoniae lung infection
    Irma A J M Bakker-Woudenberg
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Antimicrob Agents Chemother 50:2919-25. 2006
  4. ncbi request reprint Scintigraphic imaging using 99mTc-labeled PEG liposomes allows early detection of experimental invasive pulmonary aspergillosis in neutropenic rats
    Martin J Becker
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, 3015 GE Rotterdam, 50, The, Dr Molewaterplein, Netherlands
    Nucl Med Biol 29:177-84. 2002
  5. ncbi request reprint Enhanced antifungal efficacy in experimental invasive pulmonary aspergillosis by combination of AmBisome with Fungizone as assessed by several parameters of antifungal response
    Martin J Becker
    Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Centre, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    J Antimicrob Chemother 49:813-20. 2002
  6. doi request reprint Relapse of tuberculosis versus primary tuberculosis; course, pathogenesis and therapy in mice
    Jurriaan E M de Steenwinkel
    Erasmus MC, University Medical Centre Rotterdam, Department of Medical Microbiology and Infectious Diseases, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Tuberculosis (Edinb) 93:213-21. 2013
  7. ncbi request reprint Caspofungin: antifungal activity in vitro, pharmacokinetics, and effects on fungal load and animal survival in neutropenic rats with invasive pulmonary aspergillosis
    Wim van Vianen
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    J Antimicrob Chemother 57:732-40. 2006
  8. doi request reprint Optimization of the rifampin dosage to improve the therapeutic efficacy in tuberculosis treatment using a murine model
    Jurriaan E M de Steenwinkel
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Am J Respir Crit Care Med 187:1127-34. 2013
  9. doi request reprint The effects of antifungal agents to conidial and hyphal forms of Aspergillus fumigatus
    Wendy W J van de Sande
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Med Mycol 48:48-55. 2010
  10. ncbi request reprint Targeted drug delivery to enhance efficacy and shorten treatment duration in disseminated Mycobacterium avium infection in mice
    Jurriaan E M de Steenwinkel
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Antimicrob Chemother 60:1064-73. 2007

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Experimental models of pulmonary infection
    Irma A J M Bakker-Woudenberg
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Microbiol Methods 54:295-313. 2003
    ..Examples of pulmonary infection models caused by bacteria, fungi, viruses or parasites in experimental animals with intact or impaired host defense mechanisms are shortly summarized including key-references...
  2. pmc Antimycobacterial agents differ with respect to their bacteriostatic versus bactericidal activities in relation to time of exposure, mycobacterial growth phase, and their use in combination
    Irma A J M Bakker-Woudenberg
    Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Antimicrob Agents Chemother 49:2387-98. 2005
    ..The combination of amikacin and amoxicillin-clavulanic acid exhibited synergistic antimycobacterial activity. Towards MAC at low growth rates, only the quinolones exhibited a bactericidal effect...
  3. pmc Effect of treatment duration on pharmacokinetic/pharmacodynamic indices correlating with therapeutic efficacy of ceftazidime in experimental Klebsiella pneumoniae lung infection
    Irma A J M Bakker-Woudenberg
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Antimicrob Agents Chemother 50:2919-25. 2006
    ..The effect of long-term treatment should be studied more extensively in other models of infection...
  4. ncbi request reprint Scintigraphic imaging using 99mTc-labeled PEG liposomes allows early detection of experimental invasive pulmonary aspergillosis in neutropenic rats
    Martin J Becker
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, 3015 GE Rotterdam, 50, The, Dr Molewaterplein, Netherlands
    Nucl Med Biol 29:177-84. 2002
    ....
  5. ncbi request reprint Enhanced antifungal efficacy in experimental invasive pulmonary aspergillosis by combination of AmBisome with Fungizone as assessed by several parameters of antifungal response
    Martin J Becker
    Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Centre, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    J Antimicrob Chemother 49:813-20. 2002
    ..This is probably a result of active amphotericin B being immediately available in the lung at the start of treatment...
  6. doi request reprint Relapse of tuberculosis versus primary tuberculosis; course, pathogenesis and therapy in mice
    Jurriaan E M de Steenwinkel
    Erasmus MC, University Medical Centre Rotterdam, Department of Medical Microbiology and Infectious Diseases, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Tuberculosis (Edinb) 93:213-21. 2013
    ..Treatment response in relapse of TB is as good as the treatment response in primary TB; thereby no supportive evidence could be given for the recommended longer treatment duration in case of relapse of TB...
  7. ncbi request reprint Caspofungin: antifungal activity in vitro, pharmacokinetics, and effects on fungal load and animal survival in neutropenic rats with invasive pulmonary aspergillosis
    Wim van Vianen
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    J Antimicrob Chemother 57:732-40. 2006
    ..Evaluation of the potential of caspofungin, in relation to pharmacokinetics, in order to optimize its use in the treatment of filamentous fungal infections...
  8. doi request reprint Optimization of the rifampin dosage to improve the therapeutic efficacy in tuberculosis treatment using a murine model
    Jurriaan E M de Steenwinkel
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Am J Respir Crit Care Med 187:1127-34. 2013
    ..The dosage of 10 mg/kg/d rifampin, as currently used in the treatment of tuberculosis (TB), is not an optimal dose. Shortening of treatment duration might be achievable using an increased rifampin dose...
  9. doi request reprint The effects of antifungal agents to conidial and hyphal forms of Aspergillus fumigatus
    Wendy W J van de Sande
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Med Mycol 48:48-55. 2010
    ..Antifungal susceptibility of conidia was also determined using the E-test in which it was found that the XTT assaygave comparable ICs for amphotericin B, itraconazole and voriconazole but not for caspofungin...
  10. ncbi request reprint Targeted drug delivery to enhance efficacy and shorten treatment duration in disseminated Mycobacterium avium infection in mice
    Jurriaan E M de Steenwinkel
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Antimicrob Chemother 60:1064-73. 2007
    ..Improvement of the efficacy of drug treatment in mycobacterial infection by the development and application of targeted drug delivery...
  11. ncbi request reprint Effect of amphotericin B treatment on kinetics of cytokines and parameters of fungal load in neutropenic rats with invasive pulmonary aspergillosis
    Martin J Becker
    Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    J Antimicrob Chemother 52:428-34. 2003
    ..The kinetics of various parameters of fungal load and cytokines were investigated, in order to acquire insight into the pathogenesis of invasive pulmonary aspergillosis (IPA) during antifungal treatment with amphotericin B...
  12. pmc The therapeutic effect of tigecycline, unlike that of Ceftazidime, is not influenced by whether the Klebsiella pneumoniae strain produces extended-spectrum β-lactamases in experimental pneumonia in rats
    Wil H F Goessens
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Antimicrob Agents Chemother 57:643-6. 2013
    ..In contrast, tigecycline at 6.25, 12.5, or 25 mg/kg b.i.d. showed dosage-dependent efficacy up to 100% rat survival irrespective of the ESBL character of the infecting organism...
  13. pmc Caspofungin prolongs survival of transiently neutropenic rats with advanced-stage invasive pulmonary aspergillosis
    Wendy W J van de Sande
    Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, s Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands
    Antimicrob Agents Chemother 52:1345-50. 2008
    ..In this model, the administration of high-dose-step-down treatment was as effective as treatment with high doses for the whole treatment period...
  14. pmc Ciprofloxacin in polyethylene glycol-coated liposomes: efficacy in rat models of acute or chronic Pseudomonas aeruginosa infection
    Irma A J M Bakker-Woudenberg
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Antimicrob Agents Chemother 46:2575-81. 2002
    ..Complete bacterial eradication is never observed...
  15. pmc Distinctive cytokines as biomarkers predicting fatal outcome of severe Staphylococcus aureus bacteremia in mice
    Sanne van den Berg
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Centre, Rotterdam, The Netherlands
    PLoS ONE 8:e59107. 2013
    ..KC was a biomarker elevated irrespective the progression of infection, which is very interesting regarding clinical application in view of the heterogeneity of patients experiencing bacteraemia in this respect...
  16. pmc Consequences of noncompliance for therapy efficacy and emergence of resistance in murine tuberculosis caused by the Beijing genotype of Mycobacterium tuberculosis
    Jurriaan E M de Steenwinkel
    Erasmus MC, University Medical Centre Rotterdam, Department of Medical Microbiology and Infectious Diseases, Rotterdam, The Netherlands
    Antimicrob Agents Chemother 56:4937-44. 2012
    ..These results suggest that genotype diversity of M. tuberculosis may be involved in emergence of resistance and indicates that genotype-tailor-made treatment should be investigated...
  17. ncbi request reprint Pathophysiology of unilateral pulmonary aspergillosis in an experimental rat model
    Martin J Becker
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, The Netherlands
    Med Mycol 44:133-9. 2006
    ..Loss of left lung function was probably compensated by the uninfected right lung, even in a late stage of the disease. Circulatory failure was a major feature in the terminal phase of the infection...
  18. ncbi request reprint A murine model of Madurella mycetomatis eumycetoma
    Abdalla O Ahmed
    Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands
    FEMS Immunol Med Microbiol 37:29-36. 2003
    ..This model will enable further studies on the pathogenesis as well as prevention and treatment of the fungal infection...
  19. pmc Madurella mycetomatis is not susceptible to the echinocandin class of antifungal agents
    Wendy W J van de Sande
    Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases CE Rotterdam, The Netherlands
    Antimicrob Agents Chemother 54:2738-40. 2010
    ..As a comparator fungus, Aspergillus fumigatus was used. Minimal effective concentrations (MECs) and MICs were assessed and compared to those of ketoconazole. M. mycetomatis isolates were not susceptible to the echinocandins...
  20. doi request reprint Time-kill kinetics of anti-tuberculosis drugs, and emergence of resistance, in relation to metabolic activity of Mycobacterium tuberculosis
    Jurriaan E M de Steenwinkel
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
    J Antimicrob Chemother 65:2582-9. 2010
    ....
  21. pmc Evidence supporting a role for mammalian chitinases in efficacy of caspofungin against experimental aspergillosis in immunocompromised rats
    Patricia E B Verwer
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands
    PLoS ONE 8:e75848. 2013
    ..Mammals produce two chitinases, chitotriosidase and AMCase, which can hydrolyse chitin. We hypothesized that the mammalian chitinases play a role in the in vivo efficacy of caspofungin...
  22. ncbi request reprint Rifampicin-induced transcriptome response in rifampicin-resistant Mycobacterium tuberculosis
    Gerjo J de Knegt
    Erasmus MC, University Medical Centre Rotterdam, Department of Medical Microbiology and Infectious Diseases, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Tuberculosis (Edinb) 93:96-101. 2013
    ..tuberculosis. Further investigation of Rv0559c and Rv0560c is needed to reveal function and mechanism of both genes that were triggered upon rifampicin exposure...
  23. ncbi request reprint Long-circulating sterically stabilized liposomes as carriers of agents for treatment of infection or for imaging infectious foci
    Irma A J M Bakker-Woudenberg
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, P O Box 1738, 3000 DR, The Netherlands
    Int J Antimicrob Agents 19:299-311. 2002
    ..In addition, radiolabelled SSL are used to image infectious and inflammatory foci...
  24. ncbi request reprint Nebulization of four commercially available amphotericin B formulations in persistently granulocytopenic rats with invasive pulmonary aspergillosis: evidence for long-term biological activity
    Elisabeth J Ruijgrok
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands
    J Pharm Pharmacol 57:1289-95. 2005
    ..All commercially available amphotericin B preparations could be nebulized efficiently and may be of value in the prophylactic treatment of invasive pulmonary aspergillosis...
  25. pmc Reshuffling of Aspergillus fumigatus cell wall components chitin and β-glucan under the influence of caspofungin or nikkomycin Z alone or in combination
    Patricia E B Verwer
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Antimicrob Agents Chemother 56:1595-8. 2012
    ..This could explain the synergistic activity of this combination of drugs...
  26. ncbi request reprint Biodistribution of long-circulating PEG-liposomes in a murine model of established subcutaneous abscesses
    Lorna E T Stearne
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, P O Box 1738, 3000 DR, Netherlands
    Biochim Biophys Acta 1561:91-7. 2002
    ..We conclude that PEG-liposomes localise to a significant degree at the infection focus in our mouse model and may provide a new approach to the antimicrobial treatment of intra-abdominal abscesses...
  27. pmc Combination therapy of advanced invasive pulmonary aspergillosis in transiently neutropenic rats using human pharmacokinetic equivalent doses of voriconazole and anidulafungin
    Wendy W J van de Sande
    Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Antimicrob Agents Chemother 53:2005-13. 2009
    ..In conclusion, VOR monotherapy is therapeutically effective in the treatment of advanced-stage IPA and superior to the use of ANI. Combining both agents does not significantly improve the therapeutic outcome...
  28. pmc Testing of the in vitro susceptibilities of Madurella mycetomatis to six antifungal agents by using the Sensititre system in comparison with a viability-based 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5- [(phenylamino)carbonyl]-2H-tetrazolium hydroxide (XT
    Wendy W J van de Sande
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Antimicrob Agents Chemother 49:1364-8. 2005
    ..Based on the relatively broad range of MICs obtained for the antifungal agents, routine testing of M. mycetomatis isolates for susceptibility to antifungal agents seems to be relevant to adequate therapeutic management...
  29. ncbi request reprint Long-circulating sterically stabilized liposomes in the treatment of infections
    Irma A J M Bakker-Woudenberg
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Methods Enzymol 391:228-60. 2005
    ..Host-related factors focused on the components of the inflammatory response...
  30. doi request reprint A multiplex assay for the quantification of antibody responses in Staphylococcus aureus infections in mice
    Sanne van den Berg
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, 3015 CE Rotterdam, The Netherlands
    J Immunol Methods 365:142-8. 2011
    ..aureus antibody assay can be successfully applied to determine the immunogenicity of different S. aureus proteins in relation to the site of infection and the S. aureus strain causing the infection...
  31. pmc In vitro susceptibilities of Madurella mycetomatis to itraconazole and amphotericin B assessed by a modified NCCLS method and a viability-based 2,3-Bis(2-methoxy-4-nitro-5- sulfophenyl)-5-[(phenylamino)carbonyl]-2H-tetrazolium hydroxide (XTT) assay
    Abdalla O A Ahmed
    Mycetoma Research Group, Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan
    Antimicrob Agents Chemother 48:2742-6. 2004
    ..The XTT assay was reproducible and sensitive for both antifungals. Itraconazole (MIC at which 50% of the isolates tested are inhibited [MIC(50)]) of 0.06 to 0.13 mg/liter) was superior to amphotericin B (MIC(50) of 0.5 to 1.0 mg/liter)...
  32. ncbi request reprint Liposome-enabled synergistic interaction of antimicrobial agents
    Raymond M Schiffelers
    Dept of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands
    J Liposome Res 12:121-7. 2002
    ..In this presentation therapeutic efficacy of liposome-co-encapsulated gentamicin (GN) and ceftazidime (CZ) will be shown in a GN-CZ-susceptible and GN-CZ-resistant Klebsiella pneumoniae-pneumonia in rats...
  33. pmc Nebulized amphotericin B combined with intravenous amphotericin B in rats with severe invasive pulmonary aspergillosis
    Elisabeth J Ruijgrok
    Department of Clinical Pharmacy, Medical Center Rijnmond Zuid, Olympiaweg 350, 3078 HT Rotterdam, The Netherlands
    Antimicrob Agents Chemother 50:1852-4. 2006
    ..Nebulized liposomal AMB in addition to intravenous AMB resulted in significantly prolonged survival compared to controls...
  34. ncbi request reprint Apolipoprotein CI stimulates the response to lipopolysaccharide and reduces mortality in gram-negative sepsis
    Jimmy F P Berbee
    Department of Biomedical Research, TNO Quality of Life, Leiden, The Netherlands
    FASEB J 20:2162-4. 2006
    ....