Carla Baan

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi request reprint The impact of transforming growth factor-beta1 gene polymorphism on end-stage renal failure after heart transplantation
    Jacqueline van de Wetering
    Department of Internal Medicine, Erasmus MC, University Hospital Rotterdam, The Netherlands
    Transplantation 82:1744-8. 2006
  2. ncbi request reprint Interleukin-21: an interleukin-2 dependent player in rejection processes
    Carla C Baan
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Transplantation 83:1485-92. 2007
  3. ncbi request reprint Fundamental role for HO-1 in the self-protection of renal allografts
    Carla Baan
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Am J Transplant 4:811-8. 2004
  4. ncbi request reprint Differential effect of calcineurin inhibitors, anti-CD25 antibodies and rapamycin on the induction of FOXP3 in human T cells
    Carla C Baan
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Transplantation 80:110-7. 2005
  5. ncbi request reprint Functional CD25(bright+) alloresponsive T cells in fully immunosuppressed renal allograft recipients
    Carla C Baan
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Clin Transplant 21:63-71. 2007
  6. pmc Uremia causes premature ageing of the T cell compartment in end-stage renal disease patients
    Ruud Wj Meijers
    Department of Internal Medicine, section Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, The Netherlands
    Immun Ageing 9:19. 2012
  7. pmc Phospho-specific flow cytometry for pharmacodynamic monitoring of immunosuppressive therapy in transplantation
    Carla Baan
    Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Transplant Res 1:20. 2012
  8. pmc FoxP3 T cells and the pathophysiologic effects of brain death and warm ischemia in donor kidneys
    Carla C Baan
    Department of Internal Medicine, Erasmus Medical Center, University Medical Center, Rotterdam, The Netherlands
    Clin J Am Soc Nephrol 7:1481-9. 2012
  9. doi request reprint Regulatory T cells in alloreactivity after clinical heart transplantation
    Carla C Baan
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Curr Opin Organ Transplant 14:577-82. 2009
  10. ncbi request reprint Anti-CD25 monoclonal antibody therapy affects the death signals of graft-infiltrating cells after clinical heart transplantation
    C C Baan
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Transplantation 75:1704-10. 2003

Collaborators

Detail Information

Publications70

  1. ncbi request reprint The impact of transforming growth factor-beta1 gene polymorphism on end-stage renal failure after heart transplantation
    Jacqueline van de Wetering
    Department of Internal Medicine, Erasmus MC, University Hospital Rotterdam, The Netherlands
    Transplantation 82:1744-8. 2006
    ....
  2. ncbi request reprint Interleukin-21: an interleukin-2 dependent player in rejection processes
    Carla C Baan
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Transplantation 83:1485-92. 2007
    ..Interleukin (IL)-21 is the most recently described cytokine that signals via the common cytokine receptor (gammac), is produced by activated CD4+ T-cells, and regulates expansion and effector function of CD8+ T-cells...
  3. ncbi request reprint Fundamental role for HO-1 in the self-protection of renal allografts
    Carla Baan
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Am J Transplant 4:811-8. 2004
    ..50, 95% CI 0.27-0.93, p = 0.03). Kidneys that are carriers of HO-1 S-allele are less vulnerable to tissue injury resulting in less CAN and better graft survival...
  4. ncbi request reprint Differential effect of calcineurin inhibitors, anti-CD25 antibodies and rapamycin on the induction of FOXP3 in human T cells
    Carla C Baan
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Transplantation 80:110-7. 2005
    ..The transcription factor FOXP3 has been identified as the molecule associated with the regulatory function of CD25+ T cells...
  5. ncbi request reprint Functional CD25(bright+) alloresponsive T cells in fully immunosuppressed renal allograft recipients
    Carla C Baan
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Clin Transplant 21:63-71. 2007
    ..Evidence from animal studies indicate a crucial role for CD25(bright+) regulatory T cells in transplantation tolerance...
  6. pmc Uremia causes premature ageing of the T cell compartment in end-stage renal disease patients
    Ruud Wj Meijers
    Department of Internal Medicine, section Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, The Netherlands
    Immun Ageing 9:19. 2012
    ..abstract:..
  7. pmc Phospho-specific flow cytometry for pharmacodynamic monitoring of immunosuppressive therapy in transplantation
    Carla Baan
    Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Transplant Res 1:20. 2012
    ..Through this tool the efficacy of immunosuppressive medication can be assessed, novel targets can be identified, and differences in drug sensitivity between cells and patients can be clarified...
  8. pmc FoxP3 T cells and the pathophysiologic effects of brain death and warm ischemia in donor kidneys
    Carla C Baan
    Department of Internal Medicine, Erasmus Medical Center, University Medical Center, Rotterdam, The Netherlands
    Clin J Am Soc Nephrol 7:1481-9. 2012
    ..Additionally, the interaction between forkhead box P3+ T cells and kidney injury molecule-1 by activated primary tubular epithelial cells was studied...
  9. doi request reprint Regulatory T cells in alloreactivity after clinical heart transplantation
    Carla C Baan
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Curr Opin Organ Transplant 14:577-82. 2009
    ..This review focuses on the function of regulatory T cells in the peripheral blood and the transplanted organ of patients after heart transplantation during immunological quiescence and rejection...
  10. ncbi request reprint Anti-CD25 monoclonal antibody therapy affects the death signals of graft-infiltrating cells after clinical heart transplantation
    C C Baan
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Transplantation 75:1704-10. 2003
    ....
  11. ncbi request reprint IL-15R alpha-chain expression during anti-CD25 treatment of cardiac allograft recipients
    C C Baan
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Transplant Proc 34:3243-5. 2002
  12. doi request reprint Clinical rejection and persistent immune regulation in kidney transplant patients
    T K Hendrikx
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Transpl Immunol 21:129-35. 2009
    ..The majority of these patients experienced an acute rejection episode, which suggests that immune activation is required for persistent immunoregulatory function...
  13. ncbi request reprint Living kidney donors and hypoxia-inducible factor-1alpha
    Carla Baan
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Transplantation 75:570-1. 2003
    ..We speculate that prolonged ischemia and hypoxia time leads to the production of HIF-1alpha, which in turn induces the production of fibrogenic cytokines in the graft...
  14. ncbi request reprint Inhibition of the IL-15 pathway in anti-CD25 mAb treated renal allograft recipients
    C C Baan
    Department of Internal Medicine, University Hospital Rotterdam Dijkzigt, The Netherlands
    Transpl Immunol 10:81-7. 2002
    ..In conclusion, therapy with anti-CD25 mAb's affect T-cell-dependent allogeneic immune responses, not only by blocking IL-2 signaling but also by impairing IL-15 signaling through downregulating the IL-2/IL-15 receptor beta-chain...
  15. ncbi request reprint Report of the second joint meeting of ESOT and AST: current pipelines in biotech and pharma
    Teun van Gelder
    Erasmus MC, Rotterdam, The Netherlands
    Transpl Int 26:938-48. 2013
    ..Thus, the topic of this second meeting "Transformational therapies and diagnostics in transplantation" was devised and a summary of this meeting follows. ..
  16. ncbi request reprint Anti-CD25 therapy impairs donor-specific Th1 and Th2 cytokine-producing peripheral blood cells after clinical heart transplantation
    N M van Besouw
    Department of Internal Medicine, University Hospital Rotterdam Dijkzigt, Rotterdam, The Netherlands
    Transplant Proc 34:2942-3. 2002
  17. ncbi request reprint Failure to down-regulate intragraft cytokine mRNA expression shortly after clinical heart transplantation is associated with high incidence of acute rejection
    H A de Groot-Kruseman
    Department of Internal Medicine, University Hospital Rotterdam Dijkzigt, Rotterdam, The Netherlands
    J Heart Lung Transplant 20:503-10. 2001
    ..Therefore, we evaluated intragraft cytokine mRNA expression at an early stage after clinical heart transplantation and related these data to ischemia, immunosuppression, and rejection...
  18. pmc Inflammatory conditions affect gene expression and function of human adipose tissue-derived mesenchymal stem cells
    M J Crop
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Clin Exp Immunol 162:474-86. 2010
    ..Therefore, in vitro preconditioning provides ASC with improved properties for immediate clinical immune therapy...
  19. ncbi request reprint CD4+CD25bright+ regulatory T cells can mediate donor nonreactivity in long-term immunosuppressed kidney allograft patients
    J H L Velthuis
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Am J Transplant 6:2955-64. 2006
    ..Altogether, we conclude that in long-term immunosuppressed kidney allograft patients functional regulatory CD4+ CD25bright+ T cells circulate but that these cells mediate donor non reactivity only in a subset of patients...
  20. doi request reprint Donor-specific immune regulation by CD8 lymphocytes expanded from rejecting human cardiac allografts
    I E Dijke
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Am J Transplant 9:397-403. 2009
    ..We suggest that during acute cellular rejection, GLs may not only consist of graft-destructing effector T cells, but also of cells of the CD8(+) type with the potential to specifically inhibit antidonor immune reactivity...
  21. doi request reprint Donor-derived mesenchymal stem cells remain present and functional in the transplanted human heart
    M J Hoogduijn
    Deparmtent of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Am J Transplant 9:222-30. 2009
    ..In conclusion, functional MSC of donor origin remain present in the heart for several years after transplantation...
  22. ncbi request reprint Apoptotic death of infiltrating cells in human cardiac allografts is regulated by IL-2, FASL, and FLIP
    H A de Groot-Kruseman
    Department of Internal Medicine, University Medical Center Utrecht, The Netherlands
    Transplant Proc 36:3143-8. 2004
    ..In vitro studies have shown that apoptotic cell death is triggered by a IL-2-dependent activation of the Fas-FasL pathway and that this pathway can be inhibited by FLIP...
  23. ncbi request reprint Kinetic analysis reveals potency of CD4+ CD25bright+ regulatory T-cells in kidney transplant patients
    J H L Velthuis
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Transpl Immunol 18:159-65. 2007
    ..Thus, we conclude that the potency of Tregs to suppress reactivity to specific antigens should be determined by reconstitution to ongoing reactions...
  24. pmc The effects of renal transplantation on circulating dendritic cells
    D A Hesselink
    Department of Internal Medicine, Renal Transplant Unit, Room Ee 563 A, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Clin Exp Immunol 140:384-93. 2005
    ..Immunosuppressive drugs have important additional in vivo effects on this cell type and impair the reconstitution of the myeloid DC subset in peripheral blood after renal transplantation...
  25. doi request reprint The control of anti-donor immune responses by regulatory T cells in organ transplant patients
    I E Dijke
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Transplant Proc 40:1249-52. 2008
    ..Subsequently, monitoring regulatory T cells may help us to identify patients in whom the anti-donor reactivity is actively suppressed...
  26. ncbi request reprint Human heart, spleen, and perirenal fat-derived mesenchymal stem cells have immunomodulatory capacities
    M J Hoogduijn
    Department of Internal Medicine, Transplantation Laboratory, Erasmus Medical Center, 3000 CA, Rotterdam, The Netherlands
    Stem Cells Dev 16:597-604. 2007
    ..The results of this study demonstrate that MSCs from various tissues have similar immunophenotypes, in vitro immunosuppressive properties, and differentiation potential...
  27. ncbi request reprint Quantitative flow cytometry shows activation of the TNF-alpha system but not of the IL-2 system at the single cell level in renal replacement therapy
    I C van Riemsdijk-van Overbeeke
    Department of Internal Medicine, University Hospital Rotterdam-Dijkzigt, The Netherlands
    Nephrol Dial Transplant 16:1430-5. 2001
    ..These findings support the hypothesis that the interaction between the TNF-alpha and IL-2 cytokine systems is disturbed...
  28. ncbi request reprint Improvement of cardiovascular risk factors in heart transplant recipients after conversion from cyclosporine to tacrolimus: a role of the TGF-beta system
    I C van Riemsdijk
    Department of Internal Medicine, Erasmus University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Transplant Proc 34:1864-5. 2002
  29. ncbi request reprint Evaluation of the new EMIT enzyme immunoassay for the determination of whole-blood tacrolimus concentrations in kidney, heart, and liver transplant recipients
    C J Hesse
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Transplant Proc 34:2988-90. 2002
  30. pmc The calcineurin inhibitor tacrolimus allows the induction of functional CD4CD25 regulatory T cells by rabbit anti-thymocyte globulins
    V D K D Sewgobind
    Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Clin Exp Immunol 161:364-77. 2010
    ....
  31. ncbi request reprint Quantitative flow cytometry to measure the TNF-alpha and IL-2 system after heart transplantation
    I C van Riemsdijk
    Department of Internal Medicine 1, University Hospital Rotterdam Dijkzigt, Rotterdam, The Netherlands
    Transpl Int 13:S212-5. 2000
    ....
  32. ncbi request reprint Conversion from cyclosporin A to tacrolimus is safe and decreases blood pressure, cholesterol levels and TGF-beta 1 type I receptor expression
    C C Baan
    Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
    Clin Transplant 15:276-83. 2001
    ..Conversion from CsA to TAC results in improvement of blood pressure and cholesterol levels and does not induce immune activation. These beneficial effects were accompanied with lower TGF-beta 1 type I receptor expression...
  33. pmc Intragraft interleukin 2 mRNA expression during acute cellular rejection and left ventricular total wall thickness after heart transplantation
    H A de Groot-Kruseman
    Department of Internal Medicine, University Hospital Rotterdam, Rotterdam, Netherlands
    Heart 87:363-7. 2002
    ..To assess whether diastolic graft function is influenced by intragraft interleukin 2 (IL-2) messenger RNA (mRNA) expression in rejecting cardiac allografts...
  34. ncbi request reprint The nature of acute rejection is associated with development of graft vascular disease after clinical heart transplantation
    C C Baan
    Department of Internal Medicine 1, University Hospital Rotterdam Dijkzigt, Rotterdam, The Netherlands
    J Heart Lung Transplant 17:363-73. 1998
    ..To determine mechanisms that trigger graft vascular disease (GVD) after heart transplantation, we studied parameters that reflect both early and late intragraft allogeneic reactions...
  35. doi request reprint Potential of mesenchymal stem cells as immune therapy in solid-organ transplantation
    Meindert Crop
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Transpl Int 22:365-76. 2009
    ..We discuss these topics and assess the feasibility of MSCs therapy in organ transplantation...
  36. ncbi request reprint T cells activate the tumor necrosis factor-alpha system during hemodialysis, resulting in tachyphylaxis
    I C van Riemsdijk
    Department of Internal Medicine, University Hospital Rotterdam Dijkzigt, Rotterdam, The Netherlands
    Kidney Int 59:883-92. 2001
    ....
  37. ncbi request reprint Renal failure after clinical heart transplantation is associated with the TGF-beta 1 codon 10 gene polymorphism
    C C Baan
    Department of Internal Medicine, University Hospital Rotterdam Dijkzigt, Rotterdam, The Netherlands
    J Heart Lung Transplant 19:866-72. 2000
    ....
  38. ncbi request reprint Recipient gene polymorphisms in the Th-1 cytokines IL-2 and IFN-gamma in relation to acute rejection and graft vascular disease after clinical heart transplantation
    C T J Holweg
    Erasmus MC, Department of Internal Medicine, Room Ee 563a, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Transpl Immunol 11:121-7. 2003
    ..63). In conclusion, we did not detect an association between the IL-2 T-330G promoter polymorphism and CA repeat polymorphism in the first intron of the IFN-gamma gene and AR or GVD after heart transplantation...
  39. doi request reprint The immunomodulatory properties of mesenchymal stem cells and their use for immunotherapy
    Martin J Hoogduijn
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Int Immunopharmacol 10:1496-500. 2010
    ....
  40. ncbi request reprint The Jak inhibitor CP-690,550 preserves the function of CD4CD25FoxP3 regulatory T cells and inhibits effector T cells
    V D K D Sewgobind
    Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
    Am J Transplant 10:1785-95. 2010
    ..Our findings show that CP-690,550 effectively inhibits Teff function but preserves the suppressive activity of CD4(+)CD25(bright) regulatory T cells...
  41. ncbi request reprint Increased intragraft IL-15 mRNA expression after liver transplantation
    C C Baan
    Department of Internal Medicine, University Hospital Rotterdam Dijkzigt, The Netherlands
    Clin Transplant 12:212-8. 1998
    ..The overall high IL-15 mRNA levels in sites of immune responses suggests that the macrophage-derived mediator IL-15 is involved in a constant flow of T-cells from the circulation into the graft...
  42. ncbi request reprint Redundancy of the cytokine network in the development of rejection after clinical heart transplantation
    C C Baan
    Department of Internal Medicine, University Hospital Rotterdam Dijkzigt, The Netherlands
    Transpl Int 11:S512-4. 1998
    ..This study demonstrates that therapeutic intervention within the IL-2-dependent T-cell activation cascade does not completely prevent rejection. Other cytokines, such as IL-15, may participate in IL-2-independent rejections...
  43. ncbi request reprint The transforming growth factor-beta1 codon 10 gene polymorphism and accelerated graft vascular disease after clinical heart transplantation
    C T Holweg
    University Hospital Rotterdam Dijkzigt, Department of Internal Medicine, Room Bd293, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Transplantation 71:1463-7. 2001
    ..We investigated whether these polymorphisms are risk factors for the development of GVD after clinical heart transplantation...
  44. ncbi request reprint Patients on chronic hemodialysis have no intrinsic lymphocyte defect upon stimulation with interleukin-2, interleukin-15 or tumor necrosis factor-alpha
    I C van Riemsdijk
    Department of Internal Medicine, Erasmus University Medical Center Rotterdam, The Netherlands
    Blood Purif 21:158-62. 2003
    ..Although various abnormalities in T cell function of HD patients have been described, it remains unclear whether this is due to an intrinsic T cell defect...
  45. ncbi request reprint TGF-beta1 gene polymorphisms in patients with end-stage heart failure
    C T Holweg
    Department of Internal Medicine, University Hospital Rotterdam Dijkzigt, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands
    J Heart Lung Transplant 20:979-84. 2001
    ..We investigated whether these polymorphisms are associated with end-stage heart failure caused by dilated cardiomyopathy (CMP) or ischemic heart disease (IHD)...
  46. ncbi request reprint Intragraft platelet-derived growth factor-alpha and transforming growth factor-beta1 during the development of accelerated graft vascular disease after clinical heart transplantation
    H A de Groot-Kruseman
    Department of Internal Medicine I, University Hospital Rotterdam Dijkzigt, Rotterdam, The Netherlands
    Transpl Immunol 7:201-5. 1999
    ..These results suggest that intragraft PDGF-alpha and TGF-beta1 play a role in the pathogenesis of accelerated GVD after clinical heart transplantation...
  47. ncbi request reprint Ten-year follow-up of recipients of a kidney or heart transplant who received induction therapy with a monoclonal antibody against the interleukin-2 receptor
    Marike Wabbijn
    Departments of Internal Medicine and Cardiology, Erasmus Medical Centre Rotterdam, 3000 CA Rottterdam, The Netherlands
    Exp Clin Transplant 2:201-7. 2004
    ..We analyzed the long-term safety and efficacy data from all 120 patients who participated in the two randomized trials after kidney and heart transplantation 10 years ago...
  48. ncbi request reprint Clinical impact of cytokine gene polymorphisms in heart and lung transplantation
    Cecile T J Holweg
    Department of Internal Medicine, Erasmus Medical Center, University Medical Center Rotterdam, The Netherlands
    J Heart Lung Transplant 23:1017-26. 2004
  49. ncbi request reprint Functional heme oxygenase-1 promoter polymorphism in relation to heart failure and cardiac transplantation
    Cecile T J Holweg
    Department of Internal Medicine, University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Heart Lung Transplant 24:493-7. 2005
    ..No influence of the polymorphism on the development of heart failure, graft survival, acute rejection, or transplant atherosclerosis was found...
  50. ncbi request reprint Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection
    Jeroen N Stoop
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands
    Hepatology 41:771-8. 2005
    ..T(reg) have an immunosuppressive effect on HBV-specific T helper cells. The presence of HBV-specific T(reg) could contribute to an inadequate immune response against the virus, leading to chronic infection...
  51. ncbi request reprint Intragraft heme oxygenase-1 and coronary artery disease after heart transplantation
    Cecile T J Holweg
    Erasmus MC, University Medical Center Rotterdam, Department of Internal Medicine, Room Ee559, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Transpl Immunol 13:265-72. 2004
    ..Our results suggest that a higher HO-1 by macrophages in our patient population might be an adaptive response to tissue injury and inflammation, reflecting damage due to the transplantation procedure that finally results in TCAD...
  52. ncbi request reprint Tapering immunosuppression in recipients of living donor kidney transplants
    Willem Weimar
    Department of Internal Medicine, Section of Transplantation, Room D 410, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Nephrol Dial Transplant 19:iv61-3. 2004
    ..Only in one patient, who had stopped all his medication, was a rejection episode diagnosed. We conclude that in patients with a low donor-specific CTLp frequency it is safe to reduce the immunosuppression...
  53. ncbi request reprint Intragraft FOXP3 mRNA expression reflects antidonor immune reactivity in cardiac allograft patients
    I Esmé Dijke
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Transplantation 83:1477-84. 2007
    ..Therefore, we analyzed the gene expression profiles of regulatory and effector T-cell markers during immunological quiescence and acute rejection...
  54. ncbi request reprint Sequential monitoring of intragraft cytokine mRNA expression in relation to diastolic left ventricular wall thickness and function early after heart transplantation
    Hester A de Groot-Kruseman
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Clin Transplant 16:433-41. 2002
    ..Our data suggest that the improvement in diastolic left ventricular function is associated with a general reduction of inflammation within the allograft, rather than related to a specific cytokine expression pattern...
  55. ncbi request reprint Differential intragraft cytokine messenger RNA profiles during rejection and repair of clinical heart transplants. A longitudinal study
    Hester A de Groot-Kruseman
    Department of Internal Medicine, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Transpl Int 16:9-14. 2003
    ..Elevated growth factor expression levels indicate repair responses after tissue damage due to either the transplantation procedure (surgery, ischemia, reperfusion) or acute allograft rejection...
  56. ncbi request reprint The beneficial effects of recipient-derived vascular endothelial growth factor on graft survival after kidney transplantation
    Francine B C Lemos
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Transplantation 79:1221-5. 2005
    ..Vascular endothelial growth factor (VEGF) is crucial for preservation of microvasculature and contributes to cytoprotection of the graft after kidney transplantation...
  57. ncbi request reprint The effects of chronic kidney disease and renal replacement therapy on circulating dendritic cells
    Dennis A Hesselink
    Department of Internal Medicine, Division of Nephrology and Renal Transplantation, Room Ee 563 A, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Nephrol Dial Transplant 20:1868-73. 2005
    ..In this study, we analysed whether this reduction resulted from CKD or from renal replacement therapy (RRT)...
  58. doi request reprint Impact of immunosuppressive drugs on CD4+CD25+FOXP3+ regulatory T cells: does in vitro evidence translate to the clinical setting?
    Ahmet Demirkiran
    Department of Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Transplantation 85:783-9. 2008
    ..A greater understanding of the impact of immunosuppression on Treg may help to create future opportunities to manipulate the host allo-immune response and achieve operational tolerance in transplantation...
  59. ncbi request reprint Differential expression of heme oxygenase-1 and vascular endothelial growth factor in cadaveric and living donor kidneys after ischemia-reperfusion
    Francine B C Lemos
    Departments of Internal Medicine, Surgery, and Pathology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Am Soc Nephrol 14:3278-87. 2003
    ..It is concluded that the lower expression of HO-1, VEGF(165), and Bcl-2 in cadaveric donor kidneys can reflect a defective adaptation against ischemia-reperfusion injury that may affect their function in the short term...
  60. ncbi request reprint Effect of HLA-DR matching on acute rejection after clinical heart transplantation might be influenced by an IL-2 gene polymorphism
    Cecile T J Holweg
    Department of Internal Medicine, Cardiology, Diagnostic Institute of Molecular Biology, and Thoracic Surgery, University Hospital Rotterdam Dijkzigt, The Netherlands
    Transplantation 73:1353-6. 2002
    ..To examine whether genetic factors are involved in the development of acute rejection (AR), we investigated a (CA)m(CT)n repeat in the 3'-flanking region of the interleukin (IL)-2 gene...
  61. ncbi request reprint Intrahepatic detection of FOXP3 gene expression after liver transplantation using minimally invasive aspiration biopsy
    Ahmet Demirkiran
    Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Transplantation 83:819-23. 2007
    ..Differences in gene expression between the graft and blood underline the importance of local immune monitoring...
  62. ncbi request reprint Allosuppressive donor CD4+CD25+ regulatory T cells detach from the graft and circulate in recipients after liver transplantation
    Ahmet Demirkiran
    Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    J Immunol 178:6066-72. 2007
    ..These donor Tregs suppress the direct pathway alloresponses and may in vivo contribute to chimerism-associated tolerance early after liver Tx...
  63. ncbi request reprint The chemokine and chemokine receptor profile of infiltrating cells in the wall of arteries with cardiac allograft vasculopathy is indicative of a memory T-helper 1 response
    Jorg van Loosdregt
    Department of Pathology, University Medical Center Utrecht, Heidelberglaan 100, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Circulation 114:1599-607. 2006
    ..Cytokines and chemokines are considered to play an important role in CAV development...
  64. doi request reprint Ficoll-separated mononuclear cells from sepsis patients are contaminated with granulocytes
    Erica L T Van Den Akker
    Department of Pediatric Endocrinology, Office sp 1536, Erasmus MC, PO Box 2060, 3000 CB Rotterdam, The Netherlands
    Intensive Care Med 34:912-6. 2008
    ..To determine the cell content and purity of Ficoll-separated peripheral blood mononuclear cells and granulocyte isolates in sepsis patients compared to healthy controls...
  65. ncbi request reprint Donor-specific cytotoxic hyporesponsiveness associated with high interleukin-10 messenger RNA expression in cardiac allograft patients
    I Esmé Dijke
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Heart Lung Transplant 25:955-64. 2006
    ..In this study, we determined whether cardiac allograft recipients show donor-specific hyporesponsiveness and studied the underlying mechanisms...
  66. ncbi request reprint The presence of immune stimulatory cells in fresh and cryopreserved donor aortic and pulmonary valve allografts
    Frans B S Oei
    Department of Cardio Thoracic Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Heart Valve Dis 11:315-24; discussion 325. 2002
    ..The presence and distribution of these cells in both aortic and pulmonary HVA, before and after cryopreservation, was analyzed immunohistochemically...
  67. ncbi request reprint FOXP3 mRNA expression analysis in the peripheral blood and allograft of heart transplant patients
    I Esmé Dijke
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Transpl Immunol 18:250-4. 2008
    ....
  68. ncbi request reprint Hepatitis B vaccine-specific CD4(+) T cells can be detected and characterised at the single cell level: limited usefulness of dendritic cells as signal enhancers
    Nicolle H R Litjens
    Department of Internal Medicine, Division of Nephrology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Immunol Methods 330:1-11. 2008
    ..T cell responses associated with (in-) adequate hepatitis B vaccination can now be analysed in more detail...
  69. doi request reprint After discontinuation of calcineurin inhibitors, tapering of mycophenolate mofetil further impairs donor-directed cytotoxicity
    Nicole M van Besouw
    Department of Internal Medicine Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Clin Transplant 22:129-35. 2008
    ....
  70. ncbi request reprint Prediction of mortality in heart transplant recipients by stress technetium-99m tetrofosmin myocardial perfusion imaging
    Abdou Elhendy
    Heart Transplant Unit, Thoraxcenter, Rotterdam, The Netherlands
    Am J Cardiol 89:964-8. 2002
    ..01). It is concluded that stress myocardial perfusion imaging with technetium-99m tetrofosmin single-photon emission computed tomography provides incremental data for the prediction of cardiac death in heart transplant recipients...