Research Topics
Species | Carla BaanSummaryAffiliation: Erasmus MC Country: The Netherlands Publications
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Detail Information
Publications
The impact of transforming growth factor-beta1 gene polymorphism on end-stage renal failure after heart transplantationJacqueline van de Wetering
Department of Internal Medicine, Erasmus MC, University Hospital Rotterdam, The Netherlands
Transplantation 82:1744-8. 2006....
Phospho-specific flow cytometry for pharmacodynamic monitoring of immunosuppressive therapy in transplantationCarla Baan
Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
Transplant Res 1:20. 2012..Through this tool the efficacy of immunosuppressive medication can be assessed, novel targets can be identified, and differences in drug sensitivity between cells and patients can be clarified...- FoxP3 T cells and the pathophysiologic effects of brain death and warm ischemia in donor kidneysCarla C Baan
Department of Internal Medicine, Erasmus Medical Center, University Medical Center, Rotterdam, The Netherlands
Clin J Am Soc Nephrol 7:1481-9. 2012..Additionally, the interaction between forkhead box P3+ T cells and kidney injury molecule-1 by activated primary tubular epithelial cells was studied... - Fundamental role for HO-1 in the self-protection of renal allograftsCarla Baan
Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Am J Transplant 4:811-8. 2004..50, 95% CI 0.27-0.93, p = 0.03). Kidneys that are carriers of HO-1 S-allele are less vulnerable to tissue injury resulting in less CAN and better graft survival... - Differential effect of calcineurin inhibitors, anti-CD25 antibodies and rapamycin on the induction of FOXP3 in human T cellsCarla C Baan
Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands
Transplantation 80:110-7. 2005..The transcription factor FOXP3 has been identified as the molecule associated with the regulatory function of CD25+ T cells... - Functional CD25(bright+) alloresponsive T cells in fully immunosuppressed renal allograft recipientsCarla C Baan
Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Clin Transplant 21:63-71. 2007..Evidence from animal studies indicate a crucial role for CD25(bright+) regulatory T cells in transplantation tolerance... - Interleukin-21: an interleukin-2 dependent player in rejection processesCarla C Baan
Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands
Transplantation 83:1485-92. 2007..Interleukin (IL)-21 is the most recently described cytokine that signals via the common cytokine receptor (gammac), is produced by activated CD4+ T-cells, and regulates expansion and effector function of CD8+ T-cells... - Anti-CD25 monoclonal antibody therapy affects the death signals of graft-infiltrating cells after clinical heart transplantationC C Baan
Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
Transplantation 75:1704-10. 2003.... 
Regulatory T cells in alloreactivity after clinical heart transplantationCarla C Baan
Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands
Curr Opin Organ Transplant 14:577-82. 2009..This review focuses on the function of regulatory T cells in the peripheral blood and the transplanted organ of patients after heart transplantation during immunological quiescence and rejection...- Clinical rejection and persistent immune regulation in kidney transplant patientsT K Hendrikx
Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands
Transpl Immunol 21:129-35. 2009..The majority of these patients experienced an acute rejection episode, which suggests that immune activation is required for persistent immunoregulatory function... - IL-15R alpha-chain expression during anti-CD25 treatment of cardiac allograft recipientsC C Baan
Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
Transplant Proc 34:3243-5. 2002 - Living kidney donors and hypoxia-inducible factor-1alphaCarla Baan
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
Transplantation 75:570-1. 2003..We speculate that prolonged ischemia and hypoxia time leads to the production of HIF-1alpha, which in turn induces the production of fibrogenic cytokines in the graft... - Inhibition of the IL-15 pathway in anti-CD25 mAb treated renal allograft recipientsC C Baan
Department of Internal Medicine, University Hospital Rotterdam Dijkzigt, The Netherlands
Transpl Immunol 10:81-7. 2002..In conclusion, therapy with anti-CD25 mAb's affect T-cell-dependent allogeneic immune responses, not only by blocking IL-2 signaling but also by impairing IL-15 signaling through downregulating the IL-2/IL-15 receptor beta-chain... - Failure to down-regulate intragraft cytokine mRNA expression shortly after clinical heart transplantation is associated with high incidence of acute rejectionH A de Groot-Kruseman
Department of Internal Medicine, University Hospital Rotterdam Dijkzigt, Rotterdam, The Netherlands
J Heart Lung Transplant 20:503-10. 2001..Therefore, we evaluated intragraft cytokine mRNA expression at an early stage after clinical heart transplantation and related these data to ischemia, immunosuppression, and rejection... - Anti-CD25 therapy impairs donor-specific Th1 and Th2 cytokine-producing peripheral blood cells after clinical heart transplantationN M van Besouw
Department of Internal Medicine, University Hospital Rotterdam-Dijkzigt, Rotterdam, The Netherlands
Transplant Proc 34:2942-3. 2002 - Apoptotic death of infiltrating cells in human cardiac allografts is regulated by IL-2, FASL, and FLIPH A de Groot-Kruseman
Department of Internal Medicine, University Medical Center Utrecht, The Netherlands
Transplant Proc 36:3143-8. 2004..In vitro studies have shown that apoptotic cell death is triggered by a IL-2-dependent activation of the Fas-FasL pathway and that this pathway can be inhibited by FLIP... - Inflammatory conditions affect gene expression and function of human adipose tissue-derived mesenchymal stem cellsM J Crop
Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
Clin Exp Immunol 162:474-86. 2010..Therefore, in vitro preconditioning provides ASC with improved properties for immediate clinical immune therapy... - The effects of renal transplantation on circulating dendritic cellsD A Hesselink
Department of Internal Medicine, Renal Transplant Unit, Room Ee 563 A, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
Clin Exp Immunol 140:384-93. 2005..Immunosuppressive drugs have important additional in vivo effects on this cell type and impair the reconstitution of the myeloid DC subset in peripheral blood after renal transplantation... - The control of anti-donor immune responses by regulatory T cells in organ transplant patientsI E Dijke
Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Transplant Proc 40:1249-52. 2008..Subsequently, monitoring regulatory T cells may help us to identify patients in whom the anti-donor reactivity is actively suppressed... - CD4+CD25bright+ regulatory T cells can mediate donor nonreactivity in long-term immunosuppressed kidney allograft patientsJ H L Velthuis
Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
Am J Transplant 6:2955-64. 2006..Altogether, we conclude that in long-term immunosuppressed kidney allograft patients functional regulatory CD4+ CD25bright+ T cells circulate but that these cells mediate donor non reactivity only in a subset of patients... - Human heart, spleen, and perirenal fat-derived mesenchymal stem cells have immunomodulatory capacitiesM J Hoogduijn
Department of Internal Medicine, Transplantation Laboratory, Erasmus Medical Center, 3000 CA, Rotterdam, The Netherlands
Stem Cells Dev 16:597-604. 2007..The results of this study demonstrate that MSCs from various tissues have similar immunophenotypes, in vitro immunosuppressive properties, and differentiation potential... - Kinetic analysis reveals potency of CD4+ CD25bright+ regulatory T-cells in kidney transplant patientsJ H L Velthuis
Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
Transpl Immunol 18:159-65. 2007..Thus, we conclude that the potency of Tregs to suppress reactivity to specific antigens should be determined by reconstitution to ongoing reactions... - Donor-derived mesenchymal stem cells remain present and functional in the transplanted human heartM J Hoogduijn
Deparmtent of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
Am J Transplant 9:222-30. 2009..In conclusion, functional MSC of donor origin remain present in the heart for several years after transplantation... - Quantitative flow cytometry shows activation of the TNF-alpha system but not of the IL-2 system at the single cell level in renal replacement therapyI C van Riemsdijk-van Overbeeke
Department of Internal Medicine, University Hospital Rotterdam-Dijkzigt, The Netherlands
Nephrol Dial Transplant 16:1430-5. 2001..These findings support the hypothesis that the interaction between the TNF-alpha and IL-2 cytokine systems is disturbed... - Donor-specific immune regulation by CD8 lymphocytes expanded from rejecting human cardiac allograftsI E Dijke
Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands
Am J Transplant 9:397-403. 2009..We suggest that during acute cellular rejection, GLs may not only consist of graft-destructing effector T cells, but also of cells of the CD8(+) type with the potential to specifically inhibit antidonor immune reactivity... - Improvement of cardiovascular risk factors in heart transplant recipients after conversion from cyclosporine to tacrolimus: a role of the TGF-beta systemI C van Riemsdijk
Department of Internal Medicine, Erasmus University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
Transplant Proc 34:1864-5. 2002 - The calcineurin inhibitor tacrolimus allows the induction of functional CD4CD25 regulatory T cells by rabbit anti-thymocyte globulinsV D K D Sewgobind
Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
Clin Exp Immunol 161:364-77. 2010.... - Intragraft interleukin 2 mRNA expression during acute cellular rejection and left ventricular total wall thickness after heart transplantationH A de Groot-Kruseman
Department of Internal Medicine, University Hospital Rotterdam, Rotterdam, Netherlands
Heart 87:363-7. 2002..To assess whether diastolic graft function is influenced by intragraft interleukin 2 (IL-2) messenger RNA (mRNA) expression in rejecting cardiac allografts... - Conversion from cyclosporin A to tacrolimus is safe and decreases blood pressure, cholesterol levels and TGF-beta 1 type I receptor expressionC C Baan
Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
Clin Transplant 15:276-83. 2001..Conversion from CsA to TAC results in improvement of blood pressure and cholesterol levels and does not induce immune activation. These beneficial effects were accompanied with lower TGF-beta 1 type I receptor expression... - The nature of acute rejection is associated with development of graft vascular disease after clinical heart transplantationC C Baan
Department of Internal Medicine 1, University Hospital Rotterdam Dijkzigt, Rotterdam, The Netherlands
J Heart Lung Transplant 17:363-73. 1998..To determine mechanisms that trigger graft vascular disease (GVD) after heart transplantation, we studied parameters that reflect both early and late intragraft allogeneic reactions... - Quantitative flow cytometry to measure the TNF-alpha and IL-2 system after heart transplantationI C van Riemsdijk
Department of Internal Medicine 1, University Hospital Rotterdam Dijkzigt, Rotterdam, The Netherlands
Transpl Int 13:S212-5. 2000.... - Evaluation of the new EMIT enzyme immunoassay for the determination of whole-blood tacrolimus concentrations in kidney, heart, and liver transplant recipientsC J Hesse
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
Transplant Proc 34:2988-90. 2002 - Potential of mesenchymal stem cells as immune therapy in solid-organ transplantationMeindert Crop
Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
Transpl Int 22:365-76. 2009..We discuss these topics and assess the feasibility of MSCs therapy in organ transplantation... - T cells activate the tumor necrosis factor-alpha system during hemodialysis, resulting in tachyphylaxisI C van Riemsdijk
Department of Internal Medicine, University Hospital Rotterdam Dijkzigt, Rotterdam, The Netherlands
Kidney Int 59:883-92. 2001.... - Recipient gene polymorphisms in the Th-1 cytokines IL-2 and IFN-gamma in relation to acute rejection and graft vascular disease after clinical heart transplantationC T J Holweg
Erasmus MC, Department of Internal Medicine, Room Ee 563a, PO Box 1738, 3000 DR Rotterdam, The Netherlands
Transpl Immunol 11:121-7. 2003..63). In conclusion, we did not detect an association between the IL-2 T-330G promoter polymorphism and CA repeat polymorphism in the first intron of the IFN-gamma gene and AR or GVD after heart transplantation... - Renal failure after clinical heart transplantation is associated with the TGF-beta 1 codon 10 gene polymorphismC C Baan
Department of Internal Medicine, University Hospital Rotterdam Dijkzigt, Rotterdam, The Netherlands
J Heart Lung Transplant 19:866-72. 2000.... - The immunomodulatory properties of mesenchymal stem cells and their use for immunotherapyMartin J Hoogduijn
Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
Int Immunopharmacol 10:1496-500. 2010.... - Increased intragraft IL-15 mRNA expression after liver transplantationC C Baan
Department of Internal Medicine, University Hospital Rotterdam Dijkzigt, The Netherlands
Clin Transplant 12:212-8. 1998..The overall high IL-15 mRNA levels in sites of immune responses suggests that the macrophage-derived mediator IL-15 is involved in a constant flow of T-cells from the circulation into the graft... - The Jak inhibitor CP-690,550 preserves the function of CD4CD25FoxP3 regulatory T cells and inhibits effector T cellsV D K D Sewgobind
Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
Am J Transplant 10:1785-95. 2010..Our findings show that CP-690,550 effectively inhibits Teff function but preserves the suppressive activity of CD4(+)CD25(bright) regulatory T cells... - Patients on chronic hemodialysis have no intrinsic lymphocyte defect upon stimulation with interleukin-2, interleukin-15 or tumor necrosis factor-alphaI C van Riemsdijk
Department of Internal Medicine, Erasmus University Medical Center Rotterdam, The Netherlands
Blood Purif 21:158-62. 2003..Although various abnormalities in T cell function of HD patients have been described, it remains unclear whether this is due to an intrinsic T cell defect... - Redundancy of the cytokine network in the development of rejection after clinical heart transplantationC C Baan
Department of Internal Medicine, University Hospital Rotterdam Dijkzigt, The Netherlands
Transpl Int 11:S512-4. 1998..This study demonstrates that therapeutic intervention within the IL-2-dependent T-cell activation cascade does not completely prevent rejection. Other cytokines, such as IL-15, may participate in IL-2-independent rejections... - The transforming growth factor-beta1 codon 10 gene polymorphism and accelerated graft vascular disease after clinical heart transplantationC T Holweg
University Hospital Rotterdam Dijkzigt, Department of Internal Medicine, Room Bd293, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
Transplantation 71:1463-7. 2001..We investigated whether these polymorphisms are risk factors for the development of GVD after clinical heart transplantation... - Intragraft platelet-derived growth factor-alpha and transforming growth factor-beta1 during the development of accelerated graft vascular disease after clinical heart transplantationH A de Groot-Kruseman
Department of Internal Medicine I, University Hospital Rotterdam Dijkzigt, Rotterdam, The Netherlands
Transpl Immunol 7:201-5. 1999..These results suggest that intragraft PDGF-alpha and TGF-beta1 play a role in the pathogenesis of accelerated GVD after clinical heart transplantation... - TGF-beta1 gene polymorphisms in patients with end-stage heart failureC T Holweg
Department of Internal Medicine, University Hospital Rotterdam Dijkzigt, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands
J Heart Lung Transplant 20:979-84. 2001..We investigated whether these polymorphisms are associated with end-stage heart failure caused by dilated cardiomyopathy (CMP) or ischemic heart disease (IHD)... - FOXP3 mRNA expression analysis in the peripheral blood and allograft of heart transplant patientsI Esmé Dijke
Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands
Transpl Immunol 18:250-4. 2008.... - Hepatitis B vaccine-specific CD4(+) T cells can be detected and characterised at the single cell level: limited usefulness of dendritic cells as signal enhancersNicolle H R Litjens
Department of Internal Medicine, Division of Nephrology, Erasmus Medical Center, Rotterdam, The Netherlands
J Immunol Methods 330:1-11. 2008..T cell responses associated with (in-) adequate hepatitis B vaccination can now be analysed in more detail... - Ficoll-separated mononuclear cells from sepsis patients are contaminated with granulocytesErica L T Van Den Akker
Department of Pediatric Endocrinology, Office sp 1536, Erasmus MC, PO Box 2060, 3000 CB Rotterdam, The Netherlands
Intensive Care Med 34:912-6. 2008..To determine the cell content and purity of Ficoll-separated peripheral blood mononuclear cells and granulocyte isolates in sepsis patients compared to healthy controls... - After discontinuation of calcineurin inhibitors, tapering of mycophenolate mofetil further impairs donor-directed cytotoxicityNicole M van Besouw
Department of Internal Medicine Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Clin Transplant 22:129-35. 2008.... - Impact of immunosuppressive drugs on CD4+CD25+FOXP3+ regulatory T cells: does in vitro evidence translate to the clinical setting?Ahmet Demirkiran
Department of Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Transplantation 85:783-9. 2008..A greater understanding of the impact of immunosuppression on Treg may help to create future opportunities to manipulate the host allo-immune response and achieve operational tolerance in transplantation... - Intragraft heme oxygenase-1 and coronary artery disease after heart transplantationCecile T J Holweg
Erasmus MC, University Medical Center Rotterdam, Department of Internal Medicine, Room Ee559, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
Transpl Immunol 13:265-72. 2004..Our results suggest that a higher HO-1 by macrophages in our patient population might be an adaptive response to tissue injury and inflammation, reflecting damage due to the transplantation procedure that finally results in TCAD... - Functional heme oxygenase-1 promoter polymorphism in relation to heart failure and cardiac transplantationCecile T J Holweg
Department of Internal Medicine, University Medical Center Rotterdam, Rotterdam, The Netherlands
J Heart Lung Transplant 24:493-7. 2005..No influence of the polymorphism on the development of heart failure, graft survival, acute rejection, or transplant atherosclerosis was found... - Differential expression of heme oxygenase-1 and vascular endothelial growth factor in cadaveric and living donor kidneys after ischemia-reperfusionFrancine B C Lemos
Departments of Internal Medicine, Surgery, and Pathology, Erasmus Medical Center, Rotterdam, The Netherlands
J Am Soc Nephrol 14:3278-87. 2003..It is concluded that the lower expression of HO-1, VEGF(165), and Bcl-2 in cadaveric donor kidneys can reflect a defective adaptation against ischemia-reperfusion injury that may affect their function in the short term... - Tapering immunosuppression in recipients of living donor kidney transplantsWillem Weimar
Department of Internal Medicine, Section of Transplantation, Room D 410, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
Nephrol Dial Transplant 19:iv61-3. 2004..Only in one patient, who had stopped all his medication, was a rejection episode diagnosed. We conclude that in patients with a low donor-specific CTLp frequency it is safe to reduce the immunosuppression... - Clinical impact of cytokine gene polymorphisms in heart and lung transplantationCecile T J Holweg
Department of Internal Medicine, Erasmus Medical Center, University Medical Center Rotterdam, The Netherlands
J Heart Lung Transplant 23:1017-26. 2004 - Differential intragraft cytokine messenger RNA profiles during rejection and repair of clinical heart transplants. A longitudinal studyHester A de Groot-Kruseman
Department of Internal Medicine, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands
Transpl Int 16:9-14. 2003..Elevated growth factor expression levels indicate repair responses after tissue damage due to either the transplantation procedure (surgery, ischemia, reperfusion) or acute allograft rejection... - Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infectionJeroen N Stoop
Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands
Hepatology 41:771-8. 2005..T(reg) have an immunosuppressive effect on HBV-specific T helper cells. The presence of HBV-specific T(reg) could contribute to an inadequate immune response against the virus, leading to chronic infection... - Sequential monitoring of intragraft cytokine mRNA expression in relation to diastolic left ventricular wall thickness and function early after heart transplantationHester A de Groot-Kruseman
Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
Clin Transplant 16:433-41. 2002..Our data suggest that the improvement in diastolic left ventricular function is associated with a general reduction of inflammation within the allograft, rather than related to a specific cytokine expression pattern... - Ten-year follow-up of recipients of a kidney or heart transplant who received induction therapy with a monoclonal antibody against the interleukin-2 receptorMarike Wabbijn
Departments of Internal Medicine and Cardiology, Erasmus Medical Centre Rotterdam, 3000 CA Rottterdam, The Netherlands
Exp Clin Transplant 2:201-7. 2004..Patient and graft survival appear to be excellent in both the BT563-treated patients and the control groups. BT563 treatment was not associated with an increased likelihood of developing infections or malignancies... - The beneficial effects of recipient-derived vascular endothelial growth factor on graft survival after kidney transplantationFrancine B C Lemos
Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Transplantation 79:1221-5. 2005..Vascular endothelial growth factor (VEGF) is crucial for preservation of microvasculature and contributes to cytoprotection of the graft after kidney transplantation... - The effects of chronic kidney disease and renal replacement therapy on circulating dendritic cellsDennis A Hesselink
Department of Internal Medicine, Division of Nephrology and Renal Transplantation, Room Ee 563 A, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
Nephrol Dial Transplant 20:1868-73. 2005..In this study, we analysed whether this reduction resulted from CKD or from renal replacement therapy (RRT)... - Donor-specific cytotoxic hyporesponsiveness associated with high interleukin-10 messenger RNA expression in cardiac allograft patientsI Esmé Dijke
Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
J Heart Lung Transplant 25:955-64. 2006..In this study, we determined whether cardiac allograft recipients show donor-specific hyporesponsiveness and studied the underlying mechanisms... - The chemokine and chemokine receptor profile of infiltrating cells in the wall of arteries with cardiac allograft vasculopathy is indicative of a memory T-helper 1 responseJorg van Loosdregt
Department of Pathology, University Medical Center Utrecht, Heidelberglaan 100, PO Box 85500, 3508 GA Utrecht, The Netherlands
Circulation 114:1599-607. 2006..CONCLUSIONS: In coronary arteries with CAV, most T cells are CD4+ and express human leukocyte antigen DR. These activated TH cells are mainly memory TH1 cells on the basis of their C+CR profile and cytokine expression... - The presence of immune stimulatory cells in fresh and cryopreserved donor aortic and pulmonary valve allograftsFrans B S Oei
Department of Cardio-Thoracic Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands
J Heart Valve Dis 11:315-24; discussion 325. 2002.... - Effect of HLA-DR matching on acute rejection after clinical heart transplantation might be influenced by an IL-2 gene polymorphismCecile T J Holweg
Department of Internal Medicine, Cardiology, Diagnostic Institute of Molecular Biology, and Thoracic Surgery, University Hospital Rotterdam Dijkzigt, The Netherlands
Transplantation 73:1353-6. 2002..To examine whether genetic factors are involved in the development of acute rejection (AR), we investigated a (CA)m(CT)n repeat in the 3'-flanking region of the interleukin (IL)-2 gene... - Intrahepatic detection of FOXP3 gene expression after liver transplantation using minimally invasive aspiration biopsyAhmet Demirkiran
Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Transplantation 83:819-23. 2007..Differences in gene expression between the graft and blood underline the importance of local immune monitoring... - Allosuppressive donor CD4+CD25+ regulatory T cells detach from the graft and circulate in recipients after liver transplantationAhmet Demirkiran
Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
J Immunol 178:6066-72. 2007..These donor Tregs suppress the direct pathway alloresponses and may in vivo contribute to chimerism-associated tolerance early after liver Tx... - Intragraft FOXP3 mRNA expression reflects antidonor immune reactivity in cardiac allograft patientsI Esmé Dijke
Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands
Transplantation 83:1477-84. 2007..Therefore, we analyzed the gene expression profiles of regulatory and effector T-cell markers during immunological quiescence and acute rejection... - Prediction of mortality in heart transplant recipients by stress technetium-99m tetrofosmin myocardial perfusion imagingAbdou Elhendy
Heart Transplant Unit, Thoraxcenter, Rotterdam, The Netherlands
Am J Cardiol 89:964-8. 2002..01). It is concluded that stress myocardial perfusion imaging with technetium-99m tetrofosmin single-photon emission computed tomography provides incremental data for the prediction of cardiac death in heart transplant recipients...