B A Ellenbroek

Summary

Country: The Netherlands

Publications

  1. ncbi Animal models in the genomic era: possibilities and limitations with special emphasis on schizophrenia
    B A Ellenbroek
    Department of Psychoneuropharmacology, Nijmegen, The Netherlands
    Behav Pharmacol 14:409-17. 2003
  2. ncbi Early maternal deprivation and prepulse inhibition: the role of the postdeprivation environment
    Bart A Ellenbroek
    Department Psychoneuropharmacology, University of Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Pharmacol Biochem Behav 73:177-84. 2002
  3. ncbi The effects of an early stressful life event on sensorimotor gating in adult rats
    B A Ellenbroek
    University of Nijmegen, Department of Psychoneuropharmacology, The Netherlands
    Schizophr Res 30:251-60. 1998
  4. ncbi The role of hippocampal dopamine receptors in prepulse inhibition
    Bart A Ellenbroek
    Department of Psychoneuropharmacology, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur J Neurosci 15:1237-43. 2002
  5. ncbi Animal models for the negative symptoms of schizophrenia
    B A Ellenbroek
    Department of Psychoneuropharmacology, University of Nijmegen, The Netherlands
    Behav Pharmacol 11:223-33. 2000
  6. ncbi Sensory gating in rats: lack of correlation between auditory evoked potential gating and prepulse inhibition
    B A Ellenbroek
    Department of Psychoneuropharmacology, University of Nijmegen, The Netherlands
    Schizophr Bull 25:777-88. 1999
  7. ncbi Hippocampal and cortical sensory gating in rats: effects of quinpirole microinjections in nucleus accumbens core and shell
    N M de Bruin
    NICI Department of Psychoneuropharmacology, University of Nijmegen, The Netherlands
    Neuroscience 105:169-80. 2001
  8. ncbi Dopamine characteristics in different rat genotypes: the relation to absence epilepsy
    N M de Bruin
    NICI Department of Psychoneuropharmacology, University of Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Neurosci Res 38:165-73. 2000
  9. doi Serotonin transporter deficiency in rats contributes to impaired object memory
    J D A Olivier
    Donders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience, Molecular Neurobiology and Psychoneuropharmacology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Genes Brain Behav 8:829-34. 2009
  10. ncbi Auditory information processing in rat genotypes with different dopaminergic properties
    N M de Bruin
    Department of Psychoneuropharmacology, University of Nijmegen, The Netherlands
    Psychopharmacology (Berl) 156:352-9. 2001

Collaborators

  • A R Cools
  • Gilles van Luijtelaar
  • J D A Olivier
  • A M Coenen
  • L A W Jans
  • F Sluyter
  • K E Stevens
  • S M Korte
  • J G Veening
  • W H Drinkenburg
  • F G Zitman
  • Bart De Strooper
  • Guo Zhang Jin
  • M M M Verheij
  • Hans J Berger
  • N M de Bruin
  • Martine C J van der Elst
  • E L van Luijtelaar
  • Elizabeth L van der Kam
  • Femke Streijger
  • Dimitri van der Linden
  • M W Coolen
  • Bart M G Smits
  • Marcel W Coolen
  • Eric W Roubos
  • E L van der Kam
  • S B Degen
  • Frank Oerlemans
  • Be Wieringa
  • Catharina E E M Van der Zee
  • Carolina R Jost
  • T A Sontag
  • Bart W Smits
  • Marc A T Teunis
  • Jean François Liégeois
  • Marja G Lanser
  • M G Lanser
  • E P Prinssen
  • Yvette S Wunderink
  • Stijn A A Massar
  • Judith Homberg
  • G J M Martens
  • Arnt F A Schellekens
  • Edwin Cuppen
  • Victor Guryev
  • K M J van Loo
  • Erik J C M Coolen
  • Mark Verheul
  • Ronald H A Plasterk
  • Josine B Mudde
  • Robbert Jan Verkes
  • Jose van de Belt
  • J C M Coolen
  • V M Wiegant
  • Karen M J Van Loo
  • Gerard J M Martens
  • David J Pulford
  • Lutgarde Serneels
  • Nick N H M Van Bakel
  • Pascal Carato
  • Joseph Géczy
  • Jacques Bruhwyler
  • Helene L M Siero
  • Cobi J Heijnen
  • Laurence Eyrolles
  • Joost M Bakker
  • Christel Lejeune
  • Gerard A Rongen
  • Jacques Delarge
  • Niels P Riksen
  • Frans G M Russel
  • Jacques Damas
  • Emile Voest
  • Paul Smits
  • Annemieke Kavelaars
  • Joop M P M Borggreven
  • W J van Schaijk
  • D J Heeren
  • S J Jansen
  • C A Miller
  • B Stamatovic

Detail Information

Publications50

  1. ncbi Animal models in the genomic era: possibilities and limitations with special emphasis on schizophrenia
    B A Ellenbroek
    Department of Psychoneuropharmacology, Nijmegen, The Netherlands
    Behav Pharmacol 14:409-17. 2003
    ....
  2. ncbi Early maternal deprivation and prepulse inhibition: the role of the postdeprivation environment
    Bart A Ellenbroek
    Department Psychoneuropharmacology, University of Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Pharmacol Biochem Behav 73:177-84. 2002
    ..We present a working model in order to explain the long-term behavioural consequences of maternal deprivation...
  3. ncbi The effects of an early stressful life event on sensorimotor gating in adult rats
    B A Ellenbroek
    University of Nijmegen, Department of Psychoneuropharmacology, The Netherlands
    Schizophr Res 30:251-60. 1998
    ....
  4. ncbi The role of hippocampal dopamine receptors in prepulse inhibition
    Bart A Ellenbroek
    Department of Psychoneuropharmacology, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur J Neurosci 15:1237-43. 2002
    ..Because quinpirole has a much higher affinity for the D3 receptor than does sulpiride, it is suggested that the D3 receptor might be involved in this effect...
  5. ncbi Animal models for the negative symptoms of schizophrenia
    B A Ellenbroek
    Department of Psychoneuropharmacology, University of Nijmegen, The Netherlands
    Behav Pharmacol 11:223-33. 2000
    ..The general conclusion is that very few models have so far been adequately tested. The lack of currently effective treatment further hampers the study of such validation...
  6. ncbi Sensory gating in rats: lack of correlation between auditory evoked potential gating and prepulse inhibition
    B A Ellenbroek
    Department of Psychoneuropharmacology, University of Nijmegen, The Netherlands
    Schizophr Bull 25:777-88. 1999
    ....
  7. ncbi Hippocampal and cortical sensory gating in rats: effects of quinpirole microinjections in nucleus accumbens core and shell
    N M de Bruin
    NICI Department of Psychoneuropharmacology, University of Nijmegen, The Netherlands
    Neuroscience 105:169-80. 2001
    ..This casts doubt on whether dopamine receptor activation affects the putative inhibitory process between the first and the second stimulus...
  8. ncbi Dopamine characteristics in different rat genotypes: the relation to absence epilepsy
    N M de Bruin
    NICI Department of Psychoneuropharmacology, University of Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Neurosci Res 38:165-73. 2000
    ..Finally, further research is required to provide evidence in favor of the hypothesis that the relative dominance of the dopaminergic mesolimbic system is smaller in WAG/Rij than in APO-SUS...
  9. doi Serotonin transporter deficiency in rats contributes to impaired object memory
    J D A Olivier
    Donders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience, Molecular Neurobiology and Psychoneuropharmacology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Genes Brain Behav 8:829-34. 2009
    ..Given its resemblance with the human SERT-linked polymorphic region and propensity to develop depression-like symptoms, our findings may contribute to further understanding of mechanisms underlying cognitive deficits in depression...
  10. ncbi Auditory information processing in rat genotypes with different dopaminergic properties
    N M de Bruin
    Department of Psychoneuropharmacology, University of Nijmegen, The Netherlands
    Psychopharmacology (Berl) 156:352-9. 2001
    ..These effects have been linked to DA hyperactivity in the mesolimbic system. A non-invasive approach in studying the role of the DA system in PPI and AEP gating is to compare rat genotypes that are marked by distinct DA systems...
  11. ncbi Dopamine characteristics in rat genotypes with distinct susceptibility to epileptic activity: apomorphine-induced stereotyped gnawing and novelty/amphetamine-induced locomotor stimulation
    N M de Bruin
    NICI Department of Psychoneuropharmacology, University of Nijmegen, Nijmegen, The Netherlands
    Behav Pharmacol 12:517-25. 2001
    ..It is suggested that the functional dopaminergic mesolimbic dominance is an important factor in the susceptibility to show spontaneously occurring spike-wave discharges...
  12. ncbi Role of striatal dopamine D2 receptors in the paw test, an animal model for the therapeutic efficacy and extrapyramidal side effects of neuroleptic drugs
    E P Prinssen
    Department of Psychoneuropharmacology, University of Nijmegen, The Netherlands
    Brain Res 673:283-9. 1995
    ..However, the data also suggest that the generally held view that the dorsal striatum is solely responsible for the extrapyramidal side effects of neuroleptic drugs is too simple...
  13. ncbi The development of various somatic markers is retarded in an animal model for schizophrenia, namely apomorphine-susceptible rats
    S B Degen
    Department of Psychoneuropharmacology, University of Nijmegen, P O Box 9101, NL 6500 HB Nijmegen, The Netherlands
    Behav Brain Res 157:369-77. 2005
    ..The impact of these data for APO-SUS rats as a model for schizophrenia is discussed...
  14. ncbi Effects of JL13, a pyridobenzoxazepine with potential atypical antipsychotic activity, in animal models for schizophrenia
    B A Ellenbroek
    Department of Psychoneuropharmacology, University of Nijmegen, The Netherlands
    J Pharmacol Exp Ther 298:386-91. 2001
    ..Taken together, these data suggest that JL13 may be an effective antipsychotic drug, with a profile similar to clozapine...
  15. ncbi The role of medial prefrontal cortical dopamine in spontaneous flexibility in the rat
    M G Lanser
    Department of Psychoneuropharmacology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Behav Pharmacol 12:163-71. 2001
    ..Amphetamine had a similar effect to the DA antagonists. It is suggested that this is most likely due to an amphetamine-induced increase in extracellular DA, leading to a suboptimal level of mPFC DA...
  16. ncbi The role of genetic and early environmental factors in determining apomorphine susceptibility
    B A Ellenbroek
    Department of Psychoneuropharmacology, University of Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Psychopharmacology (Berl) 148:124-31. 2000
    ..There is ample evidence that rats show large individual differences in their response to dopaminergic drugs, such as apomorphine...
  17. ncbi Differential effects of ketamine on gating of auditory evoked potentials and prepulse inhibition in rats
    N M de Bruin
    NICI Department of Comparative and Physiological Psychology, University of Nijmegen, The Netherlands
    Psychopharmacology (Berl) 142:9-17. 1999
    ..Secondly, PPI and the C-T paradigm reflect distinct inhibitory sensory processes, since both paradigms are differentially influenced by ketamine...
  18. ncbi Neural correlates of sensory gating in the rat: decreased Fos induction in the lateral septum
    G van Luijtelaar
    NICI, Department of Psychology, University of Nijmegen, Nijmegen, The Netherlands
    Brain Res Bull 54:145-51. 2001
    ..The results might be relevant for theories on sensory gating deficits in schizophrenia...
  19. doi Acute tryptophan depletion dose dependently impairs object memory in serotonin transporter knockout rats
    J D A Olivier
    Department of Cognitive Neuroscience Psychoneuropharmacology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Psychopharmacology (Berl) 200:243-54. 2008
    ..Acute tryptophan depletion (ATD) transiently lowers central serotonin levels and can induce depressive mood states and cognitive defects. Previous studies have shown that ATD impairs object recognition in rats...
  20. ncbi Differential effects of non-REM and REM sleep on sensory gating in rats
    E L van Luijtelaar
    NICI Department of Psychology, University of Nijmegen, The Netherlands
    Acta Neurobiol Exp (Wars) 58:263-70. 1998
    ..Finally, results were discussed in terms of neuronal properties of thalamic relay cells and it is suggested that firing properties of thalamic relay cells are not involved in this type of sensory gating...
  21. ncbi Differences in vulnerability and susceptibility to dexamphetamine in Nijmegen high and low responders to novelty: a dose-effect analysis of spatio-temporal programming of behaviour
    A R Cools
    Department of Psychoneuropharmacology, University of Nijmegen, The Netherlands
    Psychopharmacology (Berl) 132:181-7. 1997
    ....
  22. ncbi The role of mesolimbic and nigrostriatal dopamine in latent inhibition as measured with the conditioned taste aversion paradigm
    B A Ellenbroek
    Department of Psychoneuropharmacology, University of Nijmegen, The Netherlands
    Psychopharmacology (Berl) 129:112-20. 1997
    ..A possible mechanism by which the dorsal striatum might influence latent inhibition is discussed...
  23. ncbi Sensory gating of auditory evoked potentials in rats: effects of repetitive stimulation and the interstimulus interval
    N M de Bruin
    NICI Department of Psychoneuropharmacology, University of Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Biol Psychol 55:195-213. 2001
    ..The ISI effects on gating are due to an increase of the amplitude to S2. The results have implications for the discussion about the rat homologue of the human P50...
  24. ncbi Ontogenic reduction of Aph-1b mRNA and gamma-secretase activity in rats with a complex neurodevelopmental phenotype
    M W Coolen
    Department of Molecular Animal Physiology, Nijmegen Center for Molecular Life Sciences NCMLS, Radboud University, Nijmegen, The Netherlands
    Mol Psychiatry 11:787-93. 2006
    ..We conclude that the low levels of Aph-1b mRNA and gamma-secretase activity observed in the I/I and II/II rats during the entire developmental period may well underlie their complex phenotype...
  25. pmc Peripheral and central adrenoceptor modulation of the behavioural effects of clozapine in the paw test
    E P Prinssen
    Department of Psycho and Neuropharmacology, University of Nijmegen, The Netherlands
    Br J Pharmacol 112:769-74. 1994
    ..Given the predictive validity of the paw test, the presented data suggest that the alpha 1-adrenoceptor antagonist properties of clozapine are important for its therapeutic effects, but not for its lack of extrapyramidal side-effects...
  26. ncbi The effects of stress on alcohol consumption: mild acute and sub-chronic stressors differentially affect apomorphine susceptible and unsusceptible rats
    E L van der Kam
    Department of Psychoneuropharmacology 234, Nijmegen Institute of Neuroscience, UMC St Radboud, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Life Sci 76:1759-70. 2005
    ..The APO-SUS/ APO-UNSUS rats represent a good model to study the interaction between genetic factors and stress on directing alcohol consumption...
  27. ncbi Removal of short-term isolation stress differentially influences prepulse inhibition in APO-SUS and APO-UNSUS rats
    T A Sontag
    Department of Psychoneuropharmacology, University of Nijmegen, P O Box 9190, 6500 HB, Nijmegen, The Netherlands
    Behav Brain Res 141:171-5. 2003
    ..It is suggested that the differential stress-induced change in the dopaminergic and the noradrenergic system influences the reaction of APO-SUS and APO-UNSUS rats on ppi...
  28. doi A study in male and female 5-HT transporter knockout rats: an animal model for anxiety and depression disorders
    J D A Olivier
    Department of Cognitive Neuroscience Psychoneuropharmacology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Neuroscience 152:573-84. 2008
    ..This knockout rat model may provide a valuable model to study anxiety- and depression-related disorders in male and female rats...
  29. ncbi A single exposure to novelty differentially affects the accumbal dopaminergic system of apomorphine-susceptible and apomorphine-unsusceptible rats
    Martine C J van der Elst
    Department of Psychoneuropharmacology, Nijmegen Institute for Neurosciences, University, of Nijmegen, The Netherlands
    Life Sci 76:1391-406. 2005
    ....
  30. ncbi Gene dosage effect on gamma-secretase component Aph-1b in a rat model for neurodevelopmental disorders
    Marcel W Coolen
    Department of Molecular Animal Physiology, Nijmegen Center for Molecular Life Sciences, Institute for Neuroscience, Radboud University Nijmegen, 6525 GA Nijmegen, The Netherlands
    Neuron 45:497-503. 2005
    ..Thus, a subtle imbalance in the expression of a single, developmentally important protein may be sufficient to cause a complex phenotype...
  31. ncbi Early maternal deprivation retards neurodevelopment in Wistar rats
    Bart A Ellenbroek
    Radboud University Nijmegen, Department of Psychoneuropharmacology, Nijmegen, The Netherlands
    Stress 8:247-57. 2005
    ..These data clearly show that early MD delays development, especially of the dopaminergic system and confirm our hypothesis that MD may represent an interesting animal model for the neurodevelopmental hypothesis of schizophrenia...
  32. ncbi Differences in the cellular mechanism underlying the effects of amphetamine on prepulse inhibition in apomorphine-susceptible and apomorphine-unsusceptible rats
    Martine C J van der Elst
    Molecular Neurobiology Section, Department of Cognitive Neurosciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Psychopharmacology (Berl) 190:93-102. 2007
    ..Amphetamine is often used to mimic certain aspects of schizophrenia in laboratory animals, such as a decreased prepulse inhibition...
  33. ncbi Cocaine strongly reduces prepulse inhibition in apomorphine-susceptible rats, but not in apomorphine-unsusceptible rats: regulation by dopamine D2 receptors
    Martine C J van der Elst
    Department of Cognitive Neurosciences, Section Molecular Neurobiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Behav Brain Res 175:392-8. 2006
    ..The effects of cocaine on prepulse inhibition in apomorphine-susceptible rats were mediated by D2-receptors, but not by 5-HT2-receptors or alpha-1 adrenoceptors...
  34. ncbi Apomorphine susceptibility and animal models for psychopathology: genes and environment
    Bart A Ellenbroek
    Department of Psychoneuropharmacology, HB Nijmegen, The Netherlands
    Behav Genet 32:349-61. 2002
    ..Because schizophrenia is also likely to result from an interaction between genetic and early stressful life events, the APO-SUS rat might represent a promising animal model for studying this severe mental disorder...
  35. ncbi Pre-attentive processing and schizophrenia: animal studies
    Bart A Ellenbroek
    Department of Psychoneuropharmacology 234, University of Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Psychopharmacology (Berl) 174:65-74. 2004
    ..The advantage of these two paradigms is that they can be used in humans and animals with virtually identical methods...
  36. ncbi The effects of early maternal deprivation on auditory information processing in adult Wistar rats
    Bart A Ellenbroek
    Department of Psychoneuropharmacology, Nijmegen Institute for Cognition and Information, Nijmegen, The Netherlands
    Biol Psychiatry 55:701-7. 2004
    ..The present set of experiments was designed to further characterize the information processing deficits of maternally deprived Wistar rats...
  37. ncbi Gene - environment interactions determine the individual variability in cocaine self-administration
    Elizabeth L van der Kam
    Department of Psychoneuropharmacology, Nijmegen Institute of Neuroscience, Radboud University Nijmegen Medical Center, The Netherlands
    Neuropharmacology 48:685-95. 2005
    ....
  38. ncbi Effects of (-)stepholidine in animal models for schizophrenia
    Bart A Ellenbroek
    Department of Cognitive Neurosciences, Section Molecular Neurobiology, University of Nijmegen, 6500 HB Nijmegen, The Netherlands
    Acta Pharmacol Sin 27:1111-8. 2006
    ..The present study aimed to investigate the antipsychotic properties of SPD in two animal models for schizophrenia...
  39. ncbi New pyridobenzodiazepine derivatives: modifications of the basic side chain differentially modulate binding to dopamine (D(4.2), D(2L)) and serotonin (5-HT(2A)) receptors
    Jean François Liégeois
    Natural and Synthetic Drugs Research Center, Laboratory of Medicinal Chemistry, University of Liege, Avenue de l Hopital 1 B36, Belgium
    J Med Chem 45:5136-49. 2002
    ..2) and 5-HT(2A) affinity (K(i) = 40 and 103 nM, respectively) did not induce cataleptic phenomenon in the paw test in rats but significantly reduced the immobility time in Porsolt's test in mice suggesting antidepressant properties...
  40. ncbi Structural and behavioural consequences of double deficiency for creatine kinases BCK and UbCKmit
    Femke Streijger
    Department of Cell Biology, NCMLS, UMC Radboud, University of Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Behav Brain Res 157:219-34. 2005
    ..These results suggest that lack of both brain specific creatine kinase isoforms renders the synaptic circuitry in adult brain less efficient in coping with sensory or cognitive activity related challenges...
  41. ncbi Perseveration in schizophrenia: failure to generate a plan and relationship with the psychomotor poverty subsyndrome
    Marja G Lanser
    Department of Psychoneuropharmacology, University Medical Centre St Radboud, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Psychiatry Res 112:13-26. 2002
    ..Type of antipsychotic medication used (atypical vs. typical) proved not relevant. The results are discussed in the light of evidence for involvement of the dorsolateral prefrontal cortex in perseveration in schizophrenia...
  42. ncbi Reduced tumor growth, experimental metastasis formation, and angiogenesis in rats with a hyperreactive dopaminergic system
    Marc A T Teunis
    Laboratory for Psychoneuroimmunology, University Medical Center Utrecht, The Netherlands
    FASEB J 16:1465-7. 2002
    ..These results suggest a novel link between dopaminergic reactivity, angiogenesis, and tumor development and may explain part of the individual differences in cancer progression...
  43. ncbi JL 13, an atypical antipsychotic: a preclinical review
    Bart A Ellenbroek
    University of Nijmegen, Department of Psychoneuropharmacology, The Netherlands
    CNS Drug Rev 9:41-56. 2003
    ..Moreover, its electrooxidation potential was close to that of loxapine and far from that of clozapine. Taking all these preclinical data into account, it appears that JL 13 is a promising atypical antipsychotic drug...
  44. ncbi Disrupted sensorimotor gating due to mental fatigue: preliminary evidence
    Dimitri van der Linden
    Radboud University, Department of Work and Organizational Psychology, Montessorilaan 3, 6525 HR Nijmegen, The Netherlands
    Int J Psychophysiol 62:168-74. 2006
    ..These findings are linked to theories about compromised cognitive control under fatigue and to recent ideas about the role of dopamine in fatigue as well as in the regulation of PPI...
  45. ncbi Stress susceptibility as a determinant of the response to adrenergic stimuli in mesenteric resistance arteries of the rat
    Bart W Smits
    Department of Pharmacology Toxicology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Cardiovasc Pharmacol 40:678-83. 2002
    ..An unopposed vasoconstrictor action of norepinephrine may place the APO-SUS rats at increased risk for the development of hypertension, insulin resistance, and atherosclerosis...
  46. ncbi Generation of gene knockouts and mutant models in the laboratory rat by ENU-driven target-selected mutagenesis
    Bart M G Smits
    Hubrecht Laboratory, Utrecht, The Netherlands
    Pharmacogenet Genomics 16:159-69. 2006
    ..This study aims to provide the tools to manipulate the rat genome in a more directed way...
  47. ncbi Individual differences in drug dependence in rats: the role of genetic factors and life events
    Bart A Ellenbroek
    Department of Psychoneuropharmacology, University of Nijmegen, P O Box 9101, The Netherlands
    Eur J Pharmacol 526:251-8. 2005
    ..We finally propose a theoretical model which can explain this gene-environment interaction...
  48. ncbi Mice lacking the UbCKmit isoform of creatine kinase reveal slower spatial learning acquisition, diminished exploration and habituation, and reduced acoustic startle reflex responses
    Femke Streijger
    Department of Cell Biology NCMLS, University Medical Center UMC, University of Nijmegen, The Netherlands
    Mol Cell Biochem 256:305-18. 2004
    ....
  49. ncbi Apomorphine-susceptible rats and apomorphine-unsusceptible rats differ in the tyrosine hydroxylase-immunoreactive network in the nucleus accumbens core and shell
    Martine C J van der Elst
    Department of Psychoneuropharmacology, Nijmegen Institute for Neurosciences, University of Nijmegen, Nijmegen, The Netherlands
    Exp Brain Res 160:418-23. 2005
    ..These data provide a basis for further studying the structural and neurochemical properties of the nucleus accumbens contributing to individual differences in response to stressors such as novelty and drugs of abuse...
  50. ncbi Expression of cocaine-induced conditioned place preference in apomorphine susceptible and unsusceptible rats
    Elizabeth L van der Kam
    Department of Psychoneuropharmacology, Nijmegen Institute of Neuroscience, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Behav Pharmacol 17:331-40. 2006
    ....