C W J Oomens

Summary

Affiliation: Eindhoven University of Technology
Country: The Netherlands

Publications

  1. doi request reprint A numerical study to analyse the risk for pressure ulcer development on a spine board
    C W J Oomens
    Biomedical Engineering Department, Eindhoven University of Technology, Eindhoven, The Netherlands Electronic address
    Clin Biomech (Bristol, Avon) 28:736-42. 2013
  2. doi request reprint The importance of internal strain as opposed to interface pressure in the prevention of pressure related deep tissue injury
    C W J Oomens
    Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513 5600 MB Eindhoven, The Netherlands
    J Tissue Viability 19:35-42. 2010
  3. ncbi request reprint Can loaded interface characteristics influence strain distributions in muscle adjacent to bony prominences?
    C W J Oomens
    Eindhoven University of Technology, Eindhoven, The Netherlands
    Comput Methods Biomech Biomed Engin 6:171-80. 2003
  4. pmc Finite element modelling of contracting skeletal muscle
    C W J Oomens
    Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands
    Philos Trans R Soc Lond B Biol Sci 358:1453-60. 2003
  5. ncbi request reprint The relative contributions of different skin layers to the mechanical behavior of human skin in vivo using suction experiments
    F M Hendriks
    Eindhoven University of Technology, Department of Biomedical Engineering, P O Box 513, 5600 MB Eindhoven, The Netherlands
    Med Eng Phys 28:259-66. 2006
  6. doi request reprint Heat shocks enhance procollagen type I and III expression in fibroblasts in ex vivo human skin
    S D Dams
    Philips Research Eindhoven, Eindhoven, The Netherlands
    Skin Res Technol 17:167-80. 2011
  7. doi request reprint Validation of a numerical model of skeletal muscle compression with MR tagging: a contribution to pressure ulcer research
    K K Ceelen
    Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513, 5600 MB Eindhoven, The Netherlands
    J Biomech Eng 130:061015. 2008
  8. doi request reprint Compression-induced damage and internal tissue strains are related
    K K Ceelen
    Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513, Building W hoog 4 11, 5600 MB Eindhoven, The Netherlands
    J Biomech 41:3399-404. 2008
  9. ncbi request reprint Mechanical and failure properties of single attached cells under compression
    E A G Peeters
    Department of Biomedical Engineering, Eindhoven University of Technology, Den Dolech 2, P O Box 513, 5600 MB Eindhoven, The Netherlands
    J Biomech 38:1685-93. 2005
  10. ncbi request reprint Influence of hydration and experimental length scale on the mechanical response of human skin in vivo, using optical coherence tomography
    F M Hendriks
    Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Skin Res Technol 10:231-41. 2004

Detail Information

Publications36

  1. doi request reprint A numerical study to analyse the risk for pressure ulcer development on a spine board
    C W J Oomens
    Biomedical Engineering Department, Eindhoven University of Technology, Eindhoven, The Netherlands Electronic address
    Clin Biomech (Bristol, Avon) 28:736-42. 2013
    ..Thus in order to minimise the risk of pressure ulcer development during prolonged loading, a new soft-layered long spine board has been designed...
  2. doi request reprint The importance of internal strain as opposed to interface pressure in the prevention of pressure related deep tissue injury
    C W J Oomens
    Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513 5600 MB Eindhoven, The Netherlands
    J Tissue Viability 19:35-42. 2010
    ..The paper reveals that it may be possible to identify a damage threshold for healthy skeletal muscle tissue based on local internal deformations...
  3. ncbi request reprint Can loaded interface characteristics influence strain distributions in muscle adjacent to bony prominences?
    C W J Oomens
    Eindhoven University of Technology, Eindhoven, The Netherlands
    Comput Methods Biomech Biomed Engin 6:171-80. 2003
    ....
  4. pmc Finite element modelling of contracting skeletal muscle
    C W J Oomens
    Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands
    Philos Trans R Soc Lond B Biol Sci 358:1453-60. 2003
    ..The results have been compared with experimentally determined strains at the surface of the muscle. Qualitatively there is good agreement between measured and calculated strains, but the measured strains were higher...
  5. ncbi request reprint The relative contributions of different skin layers to the mechanical behavior of human skin in vivo using suction experiments
    F M Hendriks
    Eindhoven University of Technology, Department of Biomedical Engineering, P O Box 513, 5600 MB Eindhoven, The Netherlands
    Med Eng Phys 28:259-66. 2006
    ..11 kPa for the top-layer and C(10,rd) = 0.16 MPa for the reticular dermis. This unexpected, extreme stiffness ratio of the material parameters let to convergence problems of the finite element software for most of the individuals...
  6. doi request reprint Heat shocks enhance procollagen type I and III expression in fibroblasts in ex vivo human skin
    S D Dams
    Philips Research Eindhoven, Eindhoven, The Netherlands
    Skin Res Technol 17:167-80. 2011
    ..Aged dermis, in fact, has a degenerated collagen matrix. To regenerate this matrix, fibroblasts need to be stimulated into synthesizing new collagen...
  7. doi request reprint Validation of a numerical model of skeletal muscle compression with MR tagging: a contribution to pressure ulcer research
    K K Ceelen
    Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513, 5600 MB Eindhoven, The Netherlands
    J Biomech Eng 130:061015. 2008
    ..It was concluded that the model was suitable for calculating strains in skeletal muscle tissues in which damage is measured due to compression...
  8. doi request reprint Compression-induced damage and internal tissue strains are related
    K K Ceelen
    Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513, Building W hoog 4 11, 5600 MB Eindhoven, The Netherlands
    J Biomech 41:3399-404. 2008
    ..Using dedicated finite element modeling, a considerable reduction in the inherent biological variation was obtained, leading to the proposal that muscle deformation can prove a generic predictive indicator of damage...
  9. ncbi request reprint Mechanical and failure properties of single attached cells under compression
    E A G Peeters
    Department of Biomedical Engineering, Eindhoven University of Technology, Den Dolech 2, P O Box 513, 5600 MB Eindhoven, The Netherlands
    J Biomech 38:1685-93. 2005
    ..14+/-0.32 kpa...
  10. ncbi request reprint Influence of hydration and experimental length scale on the mechanical response of human skin in vivo, using optical coherence tomography
    F M Hendriks
    Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Skin Res Technol 10:231-41. 2004
    ..For suction, this means that a large aperture diameter reflects the behaviour of mainly dermis, whereas a very small diameter reflects the behaviour of only the top layer of the skin...
  11. doi request reprint A reaction-diffusion model to predict the influence of neo-matrix on the subsequent development of tissue-engineered cartilage
    C C van Donkelaar
    Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Comput Methods Biomech Biomed Engin 14:425-32. 2011
    ..In conclusion, non-constant diffusion renders significant effects on both the microscopic ECM development and the macroscopic mechanical properties of developing tissue-engineered cartilage...
  12. doi request reprint The effects of deformation, ischemia, and reperfusion on the development of muscle damage during prolonged loading
    S Loerakker
    Soft Tissue Biomechanics and Engineering, Dept of Biomedical Engineering, Eindhoven Univ of Technology, P O Box 513, 5600 MB Eindhoven, The Netherlands
    J Appl Physiol 111:1168-77. 2011
    ..These variations are related to intrinsic factors, such as pathological state, which partly explain the individual susceptibility to the development of DTI and highlight the need for regular assessments of individual subjects...
  13. pmc Temporal effects of mechanical loading on deformation-induced damage in skeletal muscle tissue
    S Loerakker
    Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513, Building W Hoog 4 108, 5600 MB, Eindhoven, The Netherlands
    Ann Biomed Eng 38:2577-87. 2010
    ..Temporary load reliefs were inefficient in reducing deformation-induced damage, but may still influence the development of ischemia-induced damage during longer loading periods...
  14. ncbi request reprint Computational modeling to predict the temporal regulation of chondrocyte metabolism in response to various dynamic compression regimens
    B G Sengers
    Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513, 5600, MB, Eindhoven, The Netherlands
    Biomech Model Mechanobiol 5:111-22. 2006
    ..The mechanisms behind this inhibitory effect and the computational implementation, however, require further investigation...
  15. ncbi request reprint A new MR-compatible loading device to study in vivo muscle damage development in rats due to compressive loading
    A Stekelenburg
    Department of Materials Technology, Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513, 5600 MB Eindhoven, The Netherlands
    Med Eng Phys 28:331-8. 2006
    ..With this new set-up, the different factors that may play a role in the onset of muscle damage can be studied, what we believe will lead to a better understanding of the contributing factors to pressure ulcer development...
  16. pmc Microstructural analysis of deformation-induced hypoxic damage in skeletal muscle
    K K Ceelen
    Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513, 5600 MB, Eindhoven, The Netherlands
    Biomech Model Mechanobiol 7:277-84. 2008
    ..The results show that weakening of dead cells indeed affects the damage accumulation in other cells. Further, the fact that cells stop consuming oxygen after they have died, delays cell death of other cells...
  17. ncbi request reprint Compression-induced deep tissue injury examined with magnetic resonance imaging and histology
    A Stekelenburg
    Eindhoven University of Technology, Department of Materials Technology, PO Box 513, Den Dolech 2, 5600 MB Eindhoven, The Netherlands
    J Appl Physiol 100:1946-54. 2006
    ..Differences in damage development distal and proximal to the indenter position suggested a contribution of perfusion status in the measured tissue changes that, however, appeared be to reversible...
  18. ncbi request reprint A numerical-experimental method to characterize the non-linear mechanical behaviour of human skin
    F M Hendriks
    Eindhoven University of Technology, Department of Biomedical Engineering, Eindhoven, The Netherlands
    Skin Res Technol 9:274-83. 2003
    ..A numerical-experimental method was developed to characterize the non-linear mechanical behaviour of human dermis...
  19. ncbi request reprint Compression induced cell damage in engineered muscle tissue: an in vitro model to study pressure ulcer aetiology
    R G M Breuls
    Laboratory for Tissue Biomechanics and Engineering, Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513, 5600 MB Eindhoven, The Netherlands
    Ann Biomed Eng 31:1357-64. 2003
    ..Therefore, it is hypothetised that sustained cell deformation is an additional mechanism that plays a role in the development of pressure ulcers...
  20. pmc Numerical analysis of ischemia- and compression-induced injury in tissue-engineered skeletal muscle constructs
    Karlien K Ceelen
    Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513, Building W hoog 4 11, 5600 MB, Eindhoven, The Netherlands
    Ann Biomed Eng 38:570-82. 2010
    ..This study shows that a proper description of transport processes is essential for a correct interpretation of experiments in which indirect measurement methods are used...
  21. doi request reprint Ischemia-reperfusion injury in rat skeletal muscle assessed with T2-weighted and dynamic contrast-enhanced MRI
    S Loerakker
    Soft Tissue Biomechanics and Engineering, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Magn Reson Med 66:528-37. 2011
    ..These results show that reperfusion after prolonged ischemia may not be complete, thereby continuing the ischemic condition and aggravating tissue damage...
  22. ncbi request reprint The local matrix distribution and the functional development of tissue engineered cartilage, a finite element study
    B G Sengers
    Eindhoven University of Technology, Department of Biomedical Engineering, P O Box 513, 5600 MB Eindhoven, The Netherlands
    Ann Biomed Eng 32:1718-27. 2004
    ..This emphasizes the need for caution in the visual interpretation of tissue functionality from histology and underlines the importance of complementary measurements of the matrix's intrinsic molecular organization...
  23. ncbi request reprint Computational study of culture conditions and nutrient supply in cartilage tissue engineering
    B G Sengers
    Eindohoven University of Technology, Department of Biomedical Engineering, P O Box 513, 5600 MB Eindhoven, The Netherlands
    Biotechnol Prog 21:1252-61. 2005
    ....
  24. doi request reprint Which factors influence the ability of a computational model to predict the in vivo deformation behaviour of skeletal muscle?
    S Loerakker
    Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Comput Methods Biomech Biomed Engin 16:338-45. 2013
    ..With the improved model, the required sample size to detect significant differences between loading conditions can be diminished, which is clearly relevant in experiments involving animals...
  25. doi request reprint A novel method for visualising and quantifying through-plane skin layer deformations
    L C Gerhardt
    Soft Biomechanics and Tissue Engineering, Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands
    J Mech Behav Biomed Mater 14:199-207. 2012
    ....
  26. doi request reprint Multi-scale mechanical characterization of scaffolds for heart valve tissue engineering
    G Argento
    Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    J Biomech 45:2893-8. 2012
    ..It is shown that a pronounced degree of anisotropy is necessary to reproduce the deformation patterns observed in the native heart valve...
  27. doi request reprint Effects of valve geometry and tissue anisotropy on the radial stretch and coaptation area of tissue-engineered heart valves
    S Loerakker
    Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands
    J Biomech 46:1792-800. 2013
    ....
  28. doi request reprint How does muscle stiffness affect the internal deformations within the soft tissue layers of the buttocks under constant loading?
    S Loerakker
    Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Comput Methods Biomech Biomed Engin 16:520-9. 2013
    ..65 to 0.49. These results indicate the importance of restoring tissue properties after SCI, with the use of, for example, electrical stimulation, to prevent the development of DTI...
  29. ncbi request reprint Quantifying pressure sore-related muscle damage using high-resolution MRI
    E M H Bosboom
    Department of Materials Technology, Eindhoven Univ of Technology, 5600 MB Eindhoven, The Netherlands
    J Appl Physiol 95:2235-40. 2003
    ..Because MRI is nondestructive, it is a promising alternative for histology in research on pressure sore etiology, especially in follow-up studies to evaluate the development of muscle damage in time and in clinical studies...
  30. doi request reprint Pulsed heat shocks enhance procollagen type I and procollagen type III expression in human dermal fibroblasts
    S D Dams
    Eindhoven University of Technology, Eindhoven, The Netherlands
    Skin Res Technol 16:354-64. 2010
    ..The formation of wrinkles is associated with degeneration of the collagen matrix. For regeneration of the matrix, fibroblasts need to be stimulated in producing new collagen...
  31. doi request reprint A theoretical model to study the effects of cellular stiffening on the damage evolution in deep tissue injury
    T Nagel
    Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Comput Methods Biomech Biomed Engin 12:585-97. 2009
    ..65-fold and the rate of damage progression was up to 2.1 times higher in microstructural simulations when stiffening was included...
  32. doi request reprint Mechanical analysis of ovine and pediatric pulmonary artery for heart valve stent design
    M S Cabrera
    Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands Electronic address
    J Biomech 46:2075-81. 2013
    ..The material parameters derived from this study may be used to develop stent designs for both applications using computational models. ..
  33. ncbi request reprint Monitoring the biomechanical response of individual cells under compression: a new compression device
    E A G Peeters
    Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Med Biol Eng Comput 41:498-503. 2003
    ..Therefore it will contribute to the knowledge about strain-induced cell damage, as seen in pressure sores and other mechanically induced clinical conditions...
  34. ncbi request reprint A finite element model of the human buttocks for prediction of seat pressure distributions
    M M Verver
    TNO Automotive, PO Box 6033 2600 JA, Delft, The Netherlands
    Comput Methods Biomech Biomed Engin 7:193-203. 2004
    ..A parameter study shows that a pressure distribution at the interface between human and seat strongly depends on variations in human flesh and seat cushion properties...
  35. ncbi request reprint Estimation of spinal loading in vertical vibrations by numerical simulation
    M M Verver
    TNO Automotive, P O Box 6033, 2600 JA Delft, The Netherlands
    Clin Biomech (Bristol, Avon) 18:800-11. 2003
    ..This paper describes the prediction of spinal forces in car occupants during vertical vibrations using a numerical multi-body occupant model...
  36. ncbi request reprint Spatial and temporal heterogeneity of superficial muscle strain during in situ fixed-end contractions
    M R Drost
    Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, P O Box 616, 6200, Maastricht, The Netherlands
    J Biomech 36:1055-63. 2003
    ..Local muscle deformation is heterogeneous both temporally and spatially and may be related to proximity to the motor endplates...