Research Topics
| C W J OomensSummaryAffiliation: Eindhoven University of Technology Country: The Netherlands Publications
| Collaborators
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Detail Information
Publications
The importance of internal strain as opposed to interface pressure in the prevention of pressure related deep tissue injuryC W J Oomens
Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513 5600 MB Eindhoven, The Netherlands
J Tissue Viability 19:35-42. 2010..The paper reveals that it may be possible to identify a damage threshold for healthy skeletal muscle tissue based on local internal deformations...
Can loaded interface characteristics influence strain distributions in muscle adjacent to bony prominences?C W J Oomens
Eindhoven University of Technology, Eindhoven, The Netherlands
Comput Methods Biomech Biomed Engin 6:171-80. 2003....
Finite element modelling of contracting skeletal muscleC W J Oomens
Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands
Philos Trans R Soc Lond B Biol Sci 358:1453-60. 2003..The results have been compared with experimentally determined strains at the surface of the muscle. Qualitatively there is good agreement between measured and calculated strains, but the measured strains were higher...- The relative contributions of different skin layers to the mechanical behavior of human skin in vivo using suction experimentsF M Hendriks
Eindhoven University of Technology, Department of Biomedical Engineering, P.O. Box 513, 5600 MB Eindhoven, The Netherlands
Med Eng Phys 28:259-66. 2006..11 kPa for the top-layer and C(10,rd) = 0.16 MPa for the reticular dermis. This unexpected, extreme stiffness ratio of the material parameters let to convergence problems of the finite element software for most of the individuals... - Validation of a numerical model of skeletal muscle compression with MR tagging: a contribution to pressure ulcer researchK K Ceelen
Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513, 5600 MB Eindhoven, The Netherlands
J Biomech Eng 130:061015. 2008..It was concluded that the model was suitable for calculating strains in skeletal muscle tissues in which damage is measured due to compression... - Compression-induced damage and internal tissue strains are relatedK K Ceelen
Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513, Building W hoog 4 11, 5600 MB Eindhoven, The Netherlands
J Biomech 41:3399-404. 2008..Using dedicated finite element modeling, a considerable reduction in the inherent biological variation was obtained, leading to the proposal that muscle deformation can prove a generic predictive indicator of damage... - Mechanical and failure properties of single attached cells under compressionE A G Peeters
Department of Biomedical Engineering, Eindhoven University of Technology, Den Dolech 2, P O Box 513, 5600 MB Eindhoven, The Netherlands
J Biomech 38:1685-93. 2005..14+/-0.32 kpa... - Heat shocks enhance procollagen type I and III expression in fibroblasts in ex vivo human skinS D Dams
Philips Research Eindhoven, Eindhoven, The Netherlands
Skin Res Technol 17:167-80. 2011..Aged dermis, in fact, has a degenerated collagen matrix. To regenerate this matrix, fibroblasts need to be stimulated into synthesizing new collagen... - Influence of hydration and experimental length scale on the mechanical response of human skin in vivo, using optical coherence tomographyF M Hendriks
Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
Skin Res Technol 10:231-41. 2004..This indicates the need of a multi-layered material layer FEM, which can be used to identify mechanical behaviour of epidermis and dermis... - A reaction-diffusion model to predict the influence of neo-matrix on the subsequent development of tissue-engineered cartilageC C van Donkelaar
Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
Comput Methods Biomech Biomed Engin 14:425-32. 2011..In conclusion, non-constant diffusion renders significant effects on both the microscopic ECM development and the macroscopic mechanical properties of developing tissue-engineered cartilage... - The effects of deformation, ischemia, and reperfusion on the development of muscle damage during prolonged loadingS Loerakker
Soft Tissue Biomechanics and Engineering, Dept of Biomedical Engineering, Eindhoven Univ of Technology, P O Box 513, 5600 MB Eindhoven, The Netherlands
J Appl Physiol 111:1168-77. 2011..These variations are related to intrinsic factors, such as pathological state, which partly explain the individual susceptibility to the development of DTI and highlight the need for regular assessments of individual subjects... - Temporal effects of mechanical loading on deformation-induced damage in skeletal muscle tissueS Loerakker
Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513, Building W Hoog 4 108, 5600 MB, Eindhoven, The Netherlands
Ann Biomed Eng 38:2577-87. 2010..Temporary load reliefs were inefficient in reducing deformation-induced damage, but may still influence the development of ischemia-induced damage during longer loading periods... - Computational modeling to predict the temporal regulation of chondrocyte metabolism in response to various dynamic compression regimensB G Sengers
Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600, MB, Eindhoven, The Netherlands
Biomech Model Mechanobiol 5:111-22. 2006..The mechanisms behind this inhibitory effect and the computational implementation, however, require further investigation... - A new MR-compatible loading device to study in vivo muscle damage development in rats due to compressive loadingA Stekelenburg
Department of Materials Technology, Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513, 5600 MB Eindhoven, The Netherlands
Med Eng Phys 28:331-8. 2006..With this new set-up, the different factors that may play a role in the onset of muscle damage can be studied, what we believe will lead to a better understanding of the contributing factors to pressure ulcer development... - Microstructural analysis of deformation-induced hypoxic damage in skeletal muscleK K Ceelen
Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513, 5600 MB, Eindhoven, The Netherlands
Biomech Model Mechanobiol 7:277-84. 2008..The results show that weakening of dead cells indeed affects the damage accumulation in other cells. Further, the fact that cells stop consuming oxygen after they have died, delays cell death of other cells... - A numerical-experimental method to characterize the non-linear mechanical behaviour of human skinF M Hendriks
Eindhoven University of Technology, Department of Biomedical Engineering, Eindhoven, The Netherlands
Skin Res Technol 9:274-83. 2003..A numerical-experimental method was developed to characterize the non-linear mechanical behaviour of human dermis... - Compression induced cell damage in engineered muscle tissue: an in vitro model to study pressure ulcer aetiologyR G M Breuls
Laboratory for Tissue Biomechanics and Engineering, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands
Ann Biomed Eng 31:1357-64. 2003..Therefore, it is hypothetised that sustained cell deformation is an additional mechanism that plays a role in the development of pressure ulcers... - Compression-induced deep tissue injury examined with magnetic resonance imaging and histologyA Stekelenburg
Eindhoven University of Technology, Department of Materials Technology, PO Box 513, Den Dolech 2, 5600 MB Eindhoven, The Netherlands
J Appl Physiol 100:1946-54. 2006..Differences in damage development distal and proximal to the indenter position suggested a contribution of perfusion status in the measured tissue changes that, however, appeared be to reversible... - Numerical analysis of ischemia- and compression-induced injury in tissue-engineered skeletal muscle constructsKarlien K Ceelen
Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513, Building W hoog 4 11, 5600 MB, Eindhoven, The Netherlands
Ann Biomed Eng 38:570-82. 2010..This study shows that a proper description of transport processes is essential for a correct interpretation of experiments in which indirect measurement methods are used... - Computational study of culture conditions and nutrient supply in cartilage tissue engineeringB G Sengers
Eindohoven University of Technology, Department of Biomedical Engineering, P.O. Box 513, 5600 MB Eindhoven, The Netherlands
Biotechnol Prog 21:1252-61. 2005.... - Ischemia-reperfusion injury in rat skeletal muscle assessed with T2-weighted and dynamic contrast-enhanced MRIS Loerakker
Soft Tissue Biomechanics and Engineering, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
Magn Reson Med 66:528-37. 2011..These results show that reperfusion after prolonged ischemia may not be complete, thereby continuing the ischemic condition and aggravating tissue damage... - The local matrix distribution and the functional development of tissue engineered cartilage, a finite element studyB G Sengers
Eindhoven University of Technology, Department of Biomedical Engineering, P O Box 513, 5600 MB Eindhoven, The Netherlands
Ann Biomed Eng 32:1718-27. 2004..This emphasizes the need for caution in the visual interpretation of tissue functionality from histology and underlines the importance of complementary measurements of the matrix's intrinsic molecular organization... - A novel method for visualising and quantifying through-plane skin layer deformationsL C Gerhardt
Soft Biomechanics and Tissue Engineering, Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands
J Mech Behav Biomed Mater 14:199-207. 2012.... - Multi-scale mechanical characterization of scaffolds for heart valve tissue engineeringG Argento
Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
J Biomech 45:2893-8. 2012..It is shown that a pronounced degree of anisotropy is necessary to reproduce the deformation patterns observed in the native heart valve... - Which factors influence the ability of a computational model to predict the in vivo deformation behaviour of skeletal muscle?S Loerakker
Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
Comput Methods Biomech Biomed Engin 16:338-45. 2013..With the improved model, the required sample size to detect significant differences between loading conditions can be diminished, which is clearly relevant in experiments involving animals... - A theoretical model to study the effects of cellular stiffening on the damage evolution in deep tissue injuryT Nagel
Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
Comput Methods Biomech Biomed Engin 12:585-97. 2009..65-fold and the rate of damage progression was up to 2.1 times higher in microstructural simulations when stiffening was included... - Pulsed heat shocks enhance procollagen type I and procollagen type III expression in human dermal fibroblastsS D Dams
Eindhoven University of Technology, Eindhoven, The Netherlands
Skin Res Technol 16:354-64. 2010..The formation of wrinkles is associated with degeneration of the collagen matrix. For regeneration of the matrix, fibroblasts need to be stimulated in producing new collagen... - Quantifying pressure sore-related muscle damage using high-resolution MRIE M H Bosboom
Department of Materials Technology, Eindhoven Univ of Technology, 5600 MB Eindhoven, The Netherlands
J Appl Physiol 95:2235-40. 2003..Because MRI is nondestructive, it is a promising alternative for histology in research on pressure sore etiology, especially in follow-up studies to evaluate the development of muscle damage in time and in clinical studies... - Monitoring the biomechanical response of individual cells under compression: a new compression deviceE A G Peeters
Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
Med Biol Eng Comput 41:498-503. 2003..Therefore it will contribute to the knowledge about strain-induced cell damage, as seen in pressure sores and other mechanically induced clinical conditions... - Estimation of spinal loading in vertical vibrations by numerical simulationM M Verver
TNO Automotive, P.O. Box 6033, 2600 JA Delft, The Netherlands
Clin Biomech (Bristol, Avon) 18:800-11. 2003..This paper describes the application of a numerical human model for prediction of spinal forces, that could be used as a basis for derivation of hypotheses regarding low back pain disorders... - A finite element model of the human buttocks for prediction of seat pressure distributionsM M Verver
TNO Automotive, PO Box 6033 2600 JA, Delft, The Netherlands
Comput Methods Biomech Biomed Engin 7:193-203. 2004..A parameter study shows that a pressure distribution at the interface between human and seat strongly depends on variations in human flesh and seat cushion properties... - Spatial and temporal heterogeneity of superficial muscle strain during in situ fixed-end contractionsM R Drost
Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, P O Box 616, 6200, Maastricht, The Netherlands
J Biomech 36:1055-63. 2003..Local muscle deformation is heterogeneous both temporally and spatially and may be related to proximity to the motor endplates...