Gerben A Koning

Summary

Affiliation: Delft University of Technology
Country: The Netherlands

Publications

  1. ncbi request reprint Targeting liposomes to tumor endothelial cells for neutron capture therapy
    Gerben A Koning
    Department of Radiochemistry, Interfaculty Reactor Institute, Delft University of Technology, Mekelweg 15, NL 2629JB Delft, The Netherlands
    Appl Radiat Isot 61:963-7. 2004
  2. ncbi request reprint Phenylboronate 160Tb complexes for molecular recognition of glycoproteins expressed on tumor cells
    Kristina Djanashvili
    Biocatalysis and Organic Chemistry, Delft University of Technology, Julianalaan 136, 2628 BL Delft, The Netherlands
    Contrast Media Mol Imaging 2:35-41. 2007
  3. ncbi request reprint Anti-tumor efficacy of tumor vasculature-targeted liposomal doxorubicin
    Raymond M Schiffelers
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, P O Box 80 082, 3508 TB, Utrecht, The Netherlands
    J Control Release 91:115-22. 2003
  4. ncbi request reprint MR molecular imaging and fluorescence microscopy for identification of activated tumor endothelium using a bimodal lipidic nanoparticle
    Willem J M Mulder
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, MB Eindhoven, The Netherlands
    FASEB J 19:2008-10. 2005
  5. ncbi request reprint Ligand-targeted liposomes directed against pathological vasculature
    Raymond M Schiffelers
    Dept of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, TB Utrecht, 3508, The Netherlands
    J Liposome Res 12:129-35. 2002
  6. ncbi request reprint Targeting of angiogenic endothelial cells at sites of inflammation by dexamethasone phosphate-containing RGD peptide liposomes inhibits experimental arthritis
    Gerben A Koning
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Arthritis Rheum 54:1198-208. 2006
  7. ncbi request reprint Early in vivo assessment of angiostatic therapy efficacy by molecular MRI
    Willem J M Mulder
    Biomedical NMR, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands
    FASEB J 21:378-83. 2007
  8. ncbi request reprint Targeting of liposomes to angiogenic endothelial cells
    Raymond M Schiffelers
    Dept of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, PO Box 80082 3508 TB Utrecht, The Netherlands
    Cell Mol Biol Lett 7:255. 2002
  9. ncbi request reprint Coformulated N-octanoyl-glucosylceramide improves cellular delivery and cytotoxicity of liposomal doxorubicin
    Robert Jan Veldman
    Division of Cellular Biochemistry, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam
    J Pharmacol Exp Ther 315:704-10. 2005
  10. ncbi request reprint Selective intracellular delivery of dexamethasone into activated endothelial cells using an E-selectin-directed immunoconjugate
    Maaike Everts
    Department of Pharmacokinetics, Groningen University Institute for Drug Exploration, Groningen, The Netherlands
    J Immunol 168:883-9. 2002

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Targeting liposomes to tumor endothelial cells for neutron capture therapy
    Gerben A Koning
    Department of Radiochemistry, Interfaculty Reactor Institute, Delft University of Technology, Mekelweg 15, NL 2629JB Delft, The Netherlands
    Appl Radiat Isot 61:963-7. 2004
    ..Irradiation of RGD-(10)B-liposome incubated HUVEC with neutrons strongly inhibited endothelial cell viability. These results suggest that efficient NCT can be achieved by targeting (10)B-liposomes to angiogenic endothelium in tumors...
  2. ncbi request reprint Phenylboronate 160Tb complexes for molecular recognition of glycoproteins expressed on tumor cells
    Kristina Djanashvili
    Biocatalysis and Organic Chemistry, Delft University of Technology, Julianalaan 136, 2628 BL Delft, The Netherlands
    Contrast Media Mol Imaging 2:35-41. 2007
    ..Most likely, most of the free Tb remains adsorbed on the surface of the cells, although internalization of a small amount cannot be excluded...
  3. ncbi request reprint Anti-tumor efficacy of tumor vasculature-targeted liposomal doxorubicin
    Raymond M Schiffelers
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, P O Box 80 082, 3508 TB, Utrecht, The Netherlands
    J Control Release 91:115-22. 2003
    ..Likely, these RGD-LCL-doxorubicin antitumor effects are brought about through direct effects on tumor endothelial cells...
  4. ncbi request reprint MR molecular imaging and fluorescence microscopy for identification of activated tumor endothelium using a bimodal lipidic nanoparticle
    Willem J M Mulder
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, MB Eindhoven, The Netherlands
    FASEB J 19:2008-10. 2005
    ....
  5. ncbi request reprint Ligand-targeted liposomes directed against pathological vasculature
    Raymond M Schiffelers
    Dept of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, TB Utrecht, 3508, The Netherlands
    J Liposome Res 12:129-35. 2002
    ..In this contribution particular attention is given to the design of targeted long-circulating liposomes directed against the alpha v beta 3-integrin protein...
  6. ncbi request reprint Targeting of angiogenic endothelial cells at sites of inflammation by dexamethasone phosphate-containing RGD peptide liposomes inhibits experimental arthritis
    Gerben A Koning
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Arthritis Rheum 54:1198-208. 2006
    ....
  7. ncbi request reprint Early in vivo assessment of angiostatic therapy efficacy by molecular MRI
    Willem J M Mulder
    Biomedical NMR, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands
    FASEB J 21:378-83. 2007
    ..In conclusion, this study provides evidence that molecular MRI can be used to noninvasively measure the efficacy of angiogenesis inhibitors during the course of therapy...
  8. ncbi request reprint Targeting of liposomes to angiogenic endothelial cells
    Raymond M Schiffelers
    Dept of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, PO Box 80082 3508 TB Utrecht, The Netherlands
    Cell Mol Biol Lett 7:255. 2002
  9. ncbi request reprint Coformulated N-octanoyl-glucosylceramide improves cellular delivery and cytotoxicity of liposomal doxorubicin
    Robert Jan Veldman
    Division of Cellular Biochemistry, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam
    J Pharmacol Exp Ther 315:704-10. 2005
    ..N-Octanoyl-glucosylceramide enrichment might thus represent a major improvement of conventional liposomal doxorubicin formulations...
  10. ncbi request reprint Selective intracellular delivery of dexamethasone into activated endothelial cells using an E-selectin-directed immunoconjugate
    Maaike Everts
    Department of Pharmacokinetics, Groningen University Institute for Drug Exploration, Groningen, The Netherlands
    J Immunol 168:883-9. 2002
    ..In conclusion, this study demonstrates the possibility to selectively deliver the anti-inflammatory drug dexamethasone into activated endothelial cells, using an anti-E-selectin Ab as a carrier molecule...
  11. ncbi request reprint Liposome-enhanced MRI of neointimal lesions in the ApoE-KO mouse
    Willem J M Mulder
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Magn Reson Med 55:1170-4. 2006
    ..This study demonstrates that intimal thickening in ApoE-KO mice can be effectively detected by contrast-enhanced (CE)-MRI upon injection of paramagnetic liposomes...
  12. ncbi request reprint Radioprotective effect of transferrin targeted citicoline liposomes
    Jannapally Suresh Reddy
    NDDS Laboratory, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, AP, 506 009, India
    J Drug Target 14:13-9. 2006
    ..In conclusion, our results suggest that low concentrations of citicoline encapsulated in transferrin-coupled liposomes could offer therapeutic benefit in treating stroke compared to free citicoline...
  13. ncbi request reprint Lanthanide-loaded liposomes for multimodality imaging and therapy
    Sander W Zielhuis
    Department of Nuclear Medicine, University Medical Center, Utrecht, The Netherlands
    Cancer Biother Radiopharm 21:520-7. 2006
    ....
  14. ncbi request reprint Cytosolic delivery of liposomally targeted proteins induced by photochemical internalization
    Marjan M Fretz
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, P O BOX 80082, 3508 TB, Utrecht, The Netherlands
    Pharm Res 24:2040-7. 2007
    ..PCI makes use of photosensitising agents which localize in endocytic vesicles, inducing endosomal release upon light exposure...
  15. ncbi request reprint Strategies for cytosolic delivery of liposomal macromolecules
    Marjan M Fretz
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, P O BOX 80082, 3508 TB Utrecht, The Netherlands
    Int J Pharm 298:305-9. 2005
    ....
  16. pmc CD134 as target for specific drug delivery to auto-aggressive CD4+ T cells in adjuvant arthritis
    Elmieke P J Boot
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Arthritis Res Ther 7:R604-15. 2005
    ..Thus, CD134 can be used as a marker for auto-aggressive CD4+ T cells early in arthritis, and specific liposomal targeting of drugs to these cells via CD134 can be employed to downregulate disease development...
  17. ncbi request reprint Functional characterization of an endosome-disruptive peptide and its application in cytosolic delivery of immunoliposome-entrapped proteins
    Enrico Mastrobattista
    Department of Pharmaceutics, Utrecht University, P O Box 80 082, Utrecht 3508 TB, The Netherlands
    J Biol Chem 277:27135-43. 2002
    ..Thus, diINF-7 peptides entrapped inside liposomes can greatly enhance cytosolic delivery of liposomal macromolecules by pH-dependent destabilization of endosomal membranes after cellular uptake of liposomes...
  18. ncbi request reprint Endothelial cells at inflammatory sites as target for therapeutic intervention
    Gerben A Koning
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Utrecht University, The Netherlands
    Endothelium 9:161-71. 2002
    ....
  19. ncbi request reprint Efficient intracellular delivery of 5-fluorodeoxyuridine into colon cancer cells by targeted immunoliposomes
    Gerben A Koning
    Laboratory of Immunohematology, Catholic University of Sacro Cuore, Rome, Italy
    Cancer Detect Prev 26:299-307. 2002
    ..This approach may be attractive for other lipophilic anti-cancer (pro)drugs. In this sense our system also serves as a model for the development of new lipid-based drug delivery systems for anti-cancer therapy...
  20. ncbi request reprint Interference of macrophages with immunotargeting of liposomes
    Gerben A Koning
    Department of Cell Biology, Section Liposome Research, Groningen University Institute for Drug Exploration, The Netherlands
    J Liposome Res 12:107-19. 2002
    ..The rate of intracellular degradation of (immuno)liposomes internalized by liver macrophages is barely influenced by the presence of either PEG or immunoglobulins on the liposomal surface...
  21. ncbi request reprint In vitro cellular handling and in vivo targeting of E-selectin-directed immunoconjugates and immunoliposomes used for drug delivery to inflamed endothelium
    Maaike Everts
    Department of Pharmacokinetics and Drug Delivery, Groningen University Institute for Drug Exploration, Groningen, The Netherlands
    Pharm Res 20:64-72. 2003
    ....
  22. pmc Liposomal meningococcal B vaccination: role of dendritic cell targeting in the development of a protective immune response
    Carmen Arigita
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands
    Infect Immun 71:5210-8. 2003
    ..In conclusion, the use of targeted PorA liposomes results in an improved uptake by and activation of DC and an increased localization in draining lymph nodes. These effects correlate with an enhanced immune response toward the vaccine...
  23. ncbi request reprint Interaction of differently designed immunoliposomes with colon cancer cells and Kupffer cells. An in vitro comparison
    Gerben A Koning
    Department of Cell Biology, Section Liposome Research, Groningen University Institute for Drug Exploration, Faculty of Medical Sciences, University of Groningen, A Deusinglaan 1, 9713 AV, Groningen, The Netherlands
    Pharm Res 20:1249-57. 2003
    ..Evaluate the effectiveness of distal-end coupling of a tumor-specific antibody to liposomal polyethylene glycol (PEG) chains to improve target binding and reduce interference by macrophage uptake...
  24. ncbi request reprint A liposomal system for contrast-enhanced magnetic resonance imaging of molecular targets
    Willem J M Mulder
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513, 5600 MB, The Netherlands
    Bioconjug Chem 15:799-806. 2004
    ..This study suggests that this newly developed system may serve as a useful diagnostic tool to investigate pathological processes in vivo with MRI...
  25. ncbi request reprint OVCAR-3 cells internalize TAT-peptide modified liposomes by endocytosis
    Marjan M Fretz
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
    Biochim Biophys Acta 1665:48-56. 2004
    ..In conclusion, coupling TAT-peptide to the outer surface of liposomes leads to enhanced endocytosis of the liposomes by ovarian carcinoma cells, rather than direct cytosolic delivery by plasma membrane translocation...
  26. ncbi request reprint Targeted multifunctional lipid-based nanocarriers for image-guided drug delivery
    Gerben A Koning
    Laboratory Experimental Surgical Oncology, Department of Surgical Oncology, Erasmus MC, Rotterdam, The Netherlands
    Anticancer Agents Med Chem 7:425-40. 2007
    ....