Pascale Daran-Lapujade

Summary

Affiliation: Delft University of Technology
Country: The Netherlands

Publications

  1. ncbi request reprint Role of transcriptional regulation in controlling fluxes in central carbon metabolism of Saccharomyces cerevisiae. A chemostat culture study
    Pascale Daran-Lapujade
    Kluyver Laboratory of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
    J Biol Chem 279:9125-38. 2004
  2. ncbi request reprint Comparative genotyping of the Saccharomyces cerevisiae laboratory strains S288C and CEN.PK113-7D using oligonucleotide microarrays
    Pascale Daran-Lapujade
    Kluyver Laboratory of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC, Delft, The Netherlands
    FEMS Yeast Res 4:259-69. 2003
  3. ncbi request reprint Control of the glycolytic flux in Saccharomyces cerevisiae grown at low temperature: a multi-level analysis in anaerobic chemostat cultures
    Siew Leng Tai
    Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628BC Delft, The Netherlands
    J Biol Chem 282:10243-51. 2007
  4. pmc Dynamics of glycolytic regulation during adaptation of Saccharomyces cerevisiae to fermentative metabolism
    Joost van den Brink
    Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
    Appl Environ Microbiol 74:5710-23. 2008
  5. pmc The fluxes through glycolytic enzymes in Saccharomyces cerevisiae are predominantly regulated at posttranscriptional levels
    Pascale Daran-Lapujade
    Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC, Delft, The Netherlands
    Proc Natl Acad Sci U S A 104:15753-8. 2007
  6. pmc New insights into the Saccharomyces cerevisiae fermentation switch: dynamic transcriptional response to anaerobicity and glucose-excess
    Joost van den Brink
    Kluyver Centre for Genomics of Industrial Fermentation and Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
    BMC Genomics 9:100. 2008
  7. pmc Cellular responses of Saccharomyces cerevisiae at near-zero growth rates: transcriptome analysis of anaerobic retentostat cultures
    Léonie G M Boender
    Kluyver Centre for Genomics of Industrial Fermentation, Delft, The Netherlands
    FEMS Yeast Res 11:603-20. 2011
  8. doi request reprint Extreme calorie restriction and energy source starvation in Saccharomyces cerevisiae represent distinct physiological states
    Léonie G M Boender
    Kluyver Centre for Genomics of Industrial Fermentation, Julianalaan 67, 2628 BC Delft, The Netherlands Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
    Biochim Biophys Acta 1813:2133-44. 2011
  9. ncbi request reprint Prolonged selection in aerobic, glucose-limited chemostat cultures of Saccharomyces cerevisiae causes a partial loss of glycolytic capacity
    Mickel L A Jansen
    Kluyver Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
    Microbiology 151:1657-69. 2005
  10. pmc Identity of the growth-limiting nutrient strongly affects storage carbohydrate accumulation in anaerobic chemostat cultures of Saccharomyces cerevisiae
    Lucie A Hazelwood
    Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
    Appl Environ Microbiol 75:6876-85. 2009

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Role of transcriptional regulation in controlling fluxes in central carbon metabolism of Saccharomyces cerevisiae. A chemostat culture study
    Pascale Daran-Lapujade
    Kluyver Laboratory of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
    J Biol Chem 279:9125-38. 2004
    ..These results indicate that in vivo fluxes in the central carbon metabolism of S. cerevisiae grown in steadystate, carbon-limited chemostat cultures are controlled to a large extent via post-transcriptional mechanisms...
  2. ncbi request reprint Comparative genotyping of the Saccharomyces cerevisiae laboratory strains S288C and CEN.PK113-7D using oligonucleotide microarrays
    Pascale Daran-Lapujade
    Kluyver Laboratory of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC, Delft, The Netherlands
    FEMS Yeast Res 4:259-69. 2003
    ..However, to obtain meaningful information at the individual gene level, this method should be backed up by additional techniques...
  3. ncbi request reprint Control of the glycolytic flux in Saccharomyces cerevisiae grown at low temperature: a multi-level analysis in anaerobic chemostat cultures
    Siew Leng Tai
    Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628BC Delft, The Netherlands
    J Biol Chem 282:10243-51. 2007
    ....
  4. pmc Dynamics of glycolytic regulation during adaptation of Saccharomyces cerevisiae to fermentative metabolism
    Joost van den Brink
    Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
    Appl Environ Microbiol 74:5710-23. 2008
    ..cerevisiae to fermentative conditions and provides a better understanding of the roles of different regulatory mechanisms that influence the dynamics of yeast glycolysis...
  5. pmc The fluxes through glycolytic enzymes in Saccharomyces cerevisiae are predominantly regulated at posttranscriptional levels
    Pascale Daran-Lapujade
    Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC, Delft, The Netherlands
    Proc Natl Acad Sci U S A 104:15753-8. 2007
    ..Within the 50-20% hierarchical regulation of fluxes, transcription played a minor role, whereas regulation of protein synthesis or degradation was the most important. These also contributed to 75-100% of the regulation of protein levels...
  6. pmc New insights into the Saccharomyces cerevisiae fermentation switch: dynamic transcriptional response to anaerobicity and glucose-excess
    Joost van den Brink
    Kluyver Centre for Genomics of Industrial Fermentation and Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
    BMC Genomics 9:100. 2008
    ..This transition was studied by exposing aerobic glucose-limited chemostat cultures grown at a low specific growth rate to two simultaneous perturbations: oxygen depletion and relief of glucose limitation...
  7. pmc Cellular responses of Saccharomyces cerevisiae at near-zero growth rates: transcriptome analysis of anaerobic retentostat cultures
    Léonie G M Boender
    Kluyver Centre for Genomics of Industrial Fermentation, Delft, The Netherlands
    FEMS Yeast Res 11:603-20. 2011
    ..We propose retentostat as a powerful cultivation tool to investigate chronological ageing-related processes...
  8. doi request reprint Extreme calorie restriction and energy source starvation in Saccharomyces cerevisiae represent distinct physiological states
    Léonie G M Boender
    Kluyver Centre for Genomics of Industrial Fermentation, Julianalaan 67, 2628 BC Delft, The Netherlands Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
    Biochim Biophys Acta 1813:2133-44. 2011
    ..These results demonstrate that extreme calorie restriction and carbon starvation represent different physiological states in S. cerevisiae...
  9. ncbi request reprint Prolonged selection in aerobic, glucose-limited chemostat cultures of Saccharomyces cerevisiae causes a partial loss of glycolytic capacity
    Mickel L A Jansen
    Kluyver Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
    Microbiology 151:1657-69. 2005
    ..Although extensive physiological analysis offered insight into the underlying cellular processes, the evolutionary 'driving force' for several of the observed changes remains to be elucidated...
  10. pmc Identity of the growth-limiting nutrient strongly affects storage carbohydrate accumulation in anaerobic chemostat cultures of Saccharomyces cerevisiae
    Lucie A Hazelwood
    Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
    Appl Environ Microbiol 75:6876-85. 2009
    ..Consistent with the high glycogen levels in ammonia-limited cultures, the ratio of glycogen synthase to glycogen phosphorylase in these cultures was up to eightfold higher than the ratio in the other glucose-excess cultures...
  11. ncbi request reprint One-step assembly and targeted integration of multigene constructs assisted by the I-SceI meganuclease in Saccharomyces cerevisiae
    Niels G A Kuijpers
    Department of Biotechnology, Delft University of Technology, Delft, The Netherlands Kluyver Centre for Genomics of Industrial Fermentation, Delft, The Netherlands
    FEMS Yeast Res 13:769-81. 2013
    ..This study paves the way for the fast, efficient, and stable integration of large DNA constructs in S. cerevisiae chromosomes...
  12. pmc Exploiting combinatorial cultivation conditions to infer transcriptional regulation
    Theo A Knijnenburg
    Information and Communication Theory Group, Faculty of Electrical Engineering, Mathematics and Computer Science, Delft University of Technology, Mekelweg 4, 2628 CD Delft, The Netherlands
    BMC Genomics 8:25. 2007
    ....
  13. pmc Acclimation of Saccharomyces cerevisiae to low temperature: a chemostat-based transcriptome analysis
    Siew Leng Tai
    Department of Biotechnology, Delft University of Technology, 2628 BC Delft, The Netherlands
    Mol Biol Cell 18:5100-12. 2007
    ....
  14. ncbi request reprint Two-dimensional transcriptome analysis in chemostat cultures. Combinatorial effects of oxygen availability and macronutrient limitation in Saccharomyces cerevisiae
    Siew Leng Tai
    Kluyver Laboratory of Biotechnology, Delft University of Technology, Julianalaan 67, 2628BC Delft, The Netherlands
    J Biol Chem 280:437-47. 2005
    ..Furthermore, the two-dimensional approach to transcriptome analysis is a valuable new tool to study the interaction of different transcriptional regulation systems...
  15. pmc A versatile, efficient strategy for assembly of multi-fragment expression vectors in Saccharomyces cerevisiae using 60 bp synthetic recombination sequences
    Niels G A Kuijpers
    Department of Biotechnology, Delft University of Technology, Julianalaan 67, Delft 2628 BC, The Netherlands
    Microb Cell Fact 12:47. 2013
    ..Here, we present and evaluate an optimized and robust method for in vivo assembly of plasmids from overlapping DNA fragments in S. cerevisiae...
  16. pmc Similar temperature dependencies of glycolytic enzymes: an evolutionary adaptation to temperature dynamics?
    Luisa Ana B Cruz
    Department of Biotechnology, Delft University of Technology and Kluyver Centre for Genomics of Industrial Fermentation, Julianalaan 67, Delft, The Netherlands
    BMC Syst Biol 6:151. 2012
    ..To understand regulation strategies that underlie microbial temperature responses and adaptation, we studied glycolytic pathway kinetics in Saccharomyces cerevisiae during temperature changes...
  17. doi request reprint Chemostat-based micro-array analysis in baker's yeast
    Pascale Daran-Lapujade
    Department of Biotechnology, Delft University of Technology and Kluyver Centre for Genomics of Industrial Fermentation, Delft, The Netherlands
    Adv Microb Physiol 54:257-311. 2009
    ..Therefore, chemostat cultivation and derived methods for controlled cultivation of micro-organisms are anticipated to become increasingly important in microbial physiology and systems biology...
  18. pmc Prolonged maltose-limited cultivation of Saccharomyces cerevisiae selects for cells with improved maltose affinity and hypersensitivity
    Mickel L A Jansen
    Department of Biotechnology, Delft University of Technology, 2628 BC Delft, The Netherlands
    Appl Environ Microbiol 70:1956-63. 2004
    ..The observed trade-off between substrate affinity and substrate tolerance may be relevant for metabolic engineering and strain selection for utilization of substrates that are taken up by proton symport...
  19. ncbi request reprint Reproducibility of oligonucleotide microarray transcriptome analyses. An interlaboratory comparison using chemostat cultures of Saccharomyces cerevisiae
    Matthew D W Piper
    Kluyver Laboratory of Biotechnology, Technical University of Delft, Julianalaan 26, Delft 2628BC, The Netherlands
    J Biol Chem 277:37001-8. 2002
    ....
  20. pmc Transcriptome-based characterization of interactions between Saccharomyces cerevisiae and Lactobacillus delbrueckii subsp. bulgaricus in lactose-grown chemostat cocultures
    Filipa Mendes
    Kluyver Centre for Genomics of Industrial Fermentation, Delft, The Netherlands
    Appl Environ Microbiol 79:5949-61. 2013
    ..cerevisiae. This study demonstrates that chemostat-based transcriptome analysis is a powerful tool to investigate microbial interactions in mixed populations. ..
  21. doi request reprint An atypical PMR2 locus is responsible for hypersensitivity to sodium and lithium cations in the laboratory strain Saccharomyces cerevisiae CEN.PK113-7D
    Pascale Daran-Lapujade
    Department of Biotechnology, Kluyver Centre for Genomics of Industrial Fermentation, Delft University of Technology, Julianalaan 67, Delft, The Netherlands
    FEMS Yeast Res 9:789-92. 2009
    ..cerevisiae strains. The sodium and lithium hypersensitivity of CEN.PK strains, which is potentially detrimental during cultivation in sodium-rich media, could, however, be suppressed by overexpression of ENA6...
  22. ncbi request reprint To divide or not to divide: a key role of Rim15 in calorie-restricted yeast cultures
    Markus M M Bisschops
    Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands Kluyver Centre for Genomics of Industrial Fermentation, PO Box 5057, 2600 GA Delft, The Netherlands
    Biochim Biophys Acta 1843:1020-30. 2014
    ....
  23. pmc De novo sequencing, assembly and analysis of the genome of the laboratory strain Saccharomyces cerevisiae CEN.PK113-7D, a model for modern industrial biotechnology
    Jurgen F Nijkamp
    The Delft Bioinformatics Lab, Department of Intelligent Systems, Delft University of Technology, Mekelweg 4, 2628 CD Delft, The Netherlands
    Microb Cell Fact 11:36. 2012
    ..The assembled sequence reveals that CEN.PK113-7D has a mosaic genome that combines characteristics of laboratory strains and wild-industrial strains...
  24. ncbi request reprint Physiological and Transcriptional Responses of Anaerobic Chemostat Cultures of Saccharomyces cerevisiae Subjected to Diurnal Temperature Cycles
    Marit Hebly
    Industrial Microbiology Section, Department of Biotechnology, Delft University of Technology, Delft, The Netherlands Kluyver Centre for Genomics of Industrial Fermentation, Delft, The Netherlands Netherlands Consortium for Systems Biology, Amsterdam, The Netherlands
    Appl Environ Microbiol 80:4433-49. 2014
    ....
  25. pmc amdSYM, a new dominant recyclable marker cassette for Saccharomyces cerevisiae
    Daniel Solis-Escalante
    Department of Biotechnology, Delft University of Technology, Delft, The Netherlands
    FEMS Yeast Res 13:126-39. 2013
    ..The present work therefore demonstrates that amdSYM is a useful addition to the genetic engineering toolbox for Saccharomyces laboratory, wild, and industrial strains...
  26. doi request reprint Integrated multilaboratory systems biology reveals differences in protein metabolism between two reference yeast strains
    André B Canelas
    Department of Biotechnology, Kluyver Centre for Genomics of Industrial Fermentation, Delft University of Technology, Julianalaan 67, Delft 2628 BC, The Netherlands
    Nat Commun 1:145. 2010
    ..On the basis of the integrated analysis of the high-throughput data, we hypothesize that differences in phenotype are due to differences in protein metabolism...