Research Topics
| Pascale Daran-LapujadeSummaryAffiliation: Delft University of Technology Country: The Netherlands Publications
| Collaborators
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Detail Information
Publications
Role of transcriptional regulation in controlling fluxes in central carbon metabolism of Saccharomyces cerevisiae. A chemostat culture studyPascale Daran-Lapujade
Kluyver Laboratory of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
J Biol Chem 279:9125-38. 2004..These results indicate that in vivo fluxes in the central carbon metabolism of S. cerevisiae grown in steadystate, carbon-limited chemostat cultures are controlled to a large extent via post-transcriptional mechanisms...- Comparative genotyping of the Saccharomyces cerevisiae laboratory strains S288C and CEN.PK113-7D using oligonucleotide microarraysPascale Daran-Lapujade
Kluyver Laboratory of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC, Delft, The Netherlands
FEMS Yeast Res 4:259-69. 2003..However, to obtain meaningful information at the individual gene level, this method should be backed up by additional techniques... 
Dynamics of glycolytic regulation during adaptation of Saccharomyces cerevisiae to fermentative metabolismJoost van den Brink
Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
Appl Environ Microbiol 74:5710-23. 2008..cerevisiae to fermentative conditions and provides a better understanding of the roles of different regulatory mechanisms that influence the dynamics of yeast glycolysis...- New insights into the Saccharomyces cerevisiae fermentation switch: dynamic transcriptional response to anaerobicity and glucose-excessJoost van den Brink
Kluyver Centre for Genomics of Industrial Fermentation and Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
BMC Genomics 9:100. 2008..This transition was studied by exposing aerobic glucose-limited chemostat cultures grown at a low specific growth rate to two simultaneous perturbations: oxygen depletion and relief of glucose limitation... - Control of the glycolytic flux in Saccharomyces cerevisiae grown at low temperature: a multi-level analysis in anaerobic chemostat culturesSiew Leng Tai
Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628BC Delft, The Netherlands
J Biol Chem 282:10243-51. 2007.... - The fluxes through glycolytic enzymes in Saccharomyces cerevisiae are predominantly regulated at posttranscriptional levelsPascale Daran-Lapujade
Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC, Delft, The Netherlands
Proc Natl Acad Sci U S A 104:15753-8. 2007..Within the 50-20% hierarchical regulation of fluxes, transcription played a minor role, whereas regulation of protein synthesis or degradation was the most important. These also contributed to 75-100% of the regulation of protein levels... - Cellular responses of Saccharomyces cerevisiae at near-zero growth rates: transcriptome analysis of anaerobic retentostat culturesLéonie G M Boender
Kluyver Centre for Genomics of Industrial Fermentation, Delft, The Netherlands
FEMS Yeast Res 11:603-20. 2011..We propose retentostat as a powerful cultivation tool to investigate chronological ageing-related processes... 
Extreme calorie restriction and energy source starvation in Saccharomyces cerevisiae represent distinct physiological statesLéonie G M Boender
Kluyver Centre for Genomics of Industrial Fermentation, Julianalaan 67, 2628 BC Delft, The Netherlands Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
Biochim Biophys Acta 1813:2133-44. 2011..These results demonstrate that extreme calorie restriction and carbon starvation represent different physiological states in S. cerevisiae...- Acclimation of Saccharomyces cerevisiae to low temperature: a chemostat-based transcriptome analysisSiew Leng Tai
Department of Biotechnology, Delft University of Technology, 2628 BC Delft, The Netherlands
Mol Biol Cell 18:5100-12. 2007.... - Identity of the growth-limiting nutrient strongly affects storage carbohydrate accumulation in anaerobic chemostat cultures of Saccharomyces cerevisiaeLucie A Hazelwood
Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
Appl Environ Microbiol 75:6876-85. 2009..Consistent with the high glycogen levels in ammonia-limited cultures, the ratio of glycogen synthase to glycogen phosphorylase in these cultures was up to eightfold higher than the ratio in the other glucose-excess cultures... - Prolonged selection in aerobic, glucose-limited chemostat cultures of Saccharomyces cerevisiae causes a partial loss of glycolytic capacityMickel L A Jansen
Kluyver Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
Microbiology 151:1657-69. 2005..Although extensive physiological analysis offered insight into the underlying cellular processes, the evolutionary 'driving force' for several of the observed changes remains to be elucidated... - Exploiting combinatorial cultivation conditions to infer transcriptional regulationTheo A Knijnenburg
Information and Communication Theory Group, Faculty of Electrical Engineering, Mathematics and Computer Science, Delft University of Technology, Mekelweg 4, 2628 CD Delft, The Netherlands
BMC Genomics 8:25. 2007.... - Two-dimensional transcriptome analysis in chemostat cultures. Combinatorial effects of oxygen availability and macronutrient limitation in Saccharomyces cerevisiaeSiew Leng Tai
Kluyver Laboratory of Biotechnology, Delft University of Technology, Julianalaan 67, 2628BC Delft, The Netherlands
J Biol Chem 280:437-47. 2005..Furthermore, the two-dimensional approach to transcriptome analysis is a valuable new tool to study the interaction of different transcriptional regulation systems... - An atypical PMR2 locus is responsible for hypersensitivity to sodium and lithium cations in the laboratory strain Saccharomyces cerevisiae CEN.PK113-7DPascale Daran-Lapujade
Department of Biotechnology, Kluyver Centre for Genomics of Industrial Fermentation, Delft University of Technology, Julianalaan 67, Delft, The Netherlands
FEMS Yeast Res 9:789-92. 2009..cerevisiae strains. The sodium and lithium hypersensitivity of CEN.PK strains, which is potentially detrimental during cultivation in sodium-rich media, could, however, be suppressed by overexpression of ENA6... - Chemostat-based micro-array analysis in baker's yeastPascale Daran-Lapujade
Department of Biotechnology, Delft University of Technology and Kluyver Centre for Genomics of Industrial Fermentation, Delft, The Netherlands
Adv Microb Physiol 54:257-311. 2009..Therefore, chemostat cultivation and derived methods for controlled cultivation of micro-organisms are anticipated to become increasingly important in microbial physiology and systems biology... - Reproducibility of oligonucleotide microarray transcriptome analyses. An interlaboratory comparison using chemostat cultures of Saccharomyces cerevisiaeMatthew D W Piper
Kluyver Laboratory of Biotechnology, Technical University of Delft, Julianalaan 26, Delft 2628BC, The Netherlands
J Biol Chem 277:37001-8. 2002.... - Prolonged maltose-limited cultivation of Saccharomyces cerevisiae selects for cells with improved maltose affinity and hypersensitivityMickel L A Jansen
Department of Biotechnology, Delft University of Technology, 2628 BC Delft, The Netherlands
Appl Environ Microbiol 70:1956-63. 2004..The observed trade-off between substrate affinity and substrate tolerance may be relevant for metabolic engineering and strain selection for utilization of substrates that are taken up by proton symport... - Similar temperature dependencies of glycolytic enzymes: an evolutionary adaptation to temperature dynamics?Luisa Ana B Cruz
Department of Biotechnology, Delft University of Technology and Kluyver Centre for Genomics of Industrial Fermentation, Julianalaan 67, Delft, The Netherlands
BMC Syst Biol 6:151. 2012..To understand regulation strategies that underlie microbial temperature responses and adaptation, we studied glycolytic pathway kinetics in Saccharomyces cerevisiae during temperature changes... - amdSYM, a new dominant recyclable marker cassette for Saccharomyces cerevisiaeDaniel Solis-Escalante
Department of Biotechnology, Delft University of Technology, Delft, The Netherlands Kluyver Centre for Genomics of Industrial Fermentation, Delft, The Netherlands
FEMS Yeast Res 13:126-39. 2013..The present work therefore demonstrates that amdSYM is a useful addition to the genetic engineering toolbox for Saccharomyces laboratory, wild, and industrial strains... - Integrated multilaboratory systems biology reveals differences in protein metabolism between two reference yeast strainsAndré B Canelas
Department of Biotechnology, Kluyver Centre for Genomics of Industrial Fermentation, Delft University of Technology, Julianalaan 67, Delft 2628 BC, The Netherlands
Nat Commun 1:145. 2010..On the basis of the integrated analysis of the high-throughput data, we hypothesize that differences in phenotype are due to differences in protein metabolism... - De novo sequencing, assembly and analysis of the genome of the laboratory strain Saccharomyces cerevisiae CEN.PK113-7D, a model for modern industrial biotechnologyJurgen F Nijkamp
The Delft Bioinformatics Lab, Department of Intelligent Systems, Delft University of Technology, Mekelweg 4, 2628 CD Delft, The Netherlands
Microb Cell Fact 11:36. 2012..The assembled sequence reveals that CEN.PK113-7D has a mosaic genome that combines characteristics of laboratory strains and wild-industrial strains...