W I de Boer

Summary

Country: The Netherlands

Publications

  1. doi request reprint Altered expression of epithelial junctional proteins in atopic asthma: possible role in inflammation
    W I de Boer
    Department of Pulmonary Medicine, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands
    Can J Physiol Pharmacol 86:105-12. 2008
  2. pmc Effects of cigarette smoke condensate on proliferation and wound closure of bronchial epithelial cells in vitro: role of glutathione
    Fabrizio Luppi
    Department of Pulmonology, Leiden University Medical Center, PO Box 9600, 2300RC, Leiden, The Netherlands
    Respir Res 6:140. 2005
  3. ncbi request reprint Cytokines and therapy in COPD: a promising combination?
    W I de Boer
    Department of Pulmonary Medicine, Erasmus University, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Chest 121:209S-218S. 2002
  4. pmc Future therapeutic treatment of COPD: struggle between oxidants and cytokines
    Willem I de Boer
    Netherlands Asthma Foundation, Leusden, The Netherlands
    Int J Chron Obstruct Pulmon Dis 2:205-28. 2007
  5. ncbi request reprint Molecular mechanisms in chronic obstructive pulmonary disease: potential targets for therapy
    Willem I de Boer
    Netherlands Asthma Foundation, Leusden, The Netherlands
    Cell Biochem Biophys 47:131-48. 2007
  6. ncbi request reprint Potential new drugs for therapy of chronic obstructive pulmonary disease
    W I de Boer
    Netherlands Asthma Foundation, Leusden, The Netherlands
    Expert Opin Investig Drugs 12:1067-86. 2003
  7. pmc Enhanced bronchial expression of vascular endothelial growth factor and receptors (Flk-1 and Flt-1) in patients with chronic obstructive pulmonary disease
    A R Kranenburg
    Department of Pharmacology, Erasmus MC, University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Thorax 60:106-13. 2005
  8. ncbi request reprint Tobacco use in relation to COPD and asthma
    M N Hylkema
    Dept of Pathology and Laboratory Medicine, University Medical Center Groningen, University of Groningen, P O Box 30 001, 9700 RB, Groningen, The Netherlands
    Eur Respir J 29:438-45. 2007
  9. ncbi request reprint Human neutrophil defensins and secretory leukocyte proteinase inhibitor in squamous metaplastic epithelium of bronchial airways
    J Aarbiou
    Department of Pulmonology, C3 P, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
    Inflamm Res 53:230-8. 2004
  10. ncbi request reprint Interleukin-8 stimulates cell proliferation in non-small cell lung cancer through epidermal growth factor receptor transactivation
    F Luppi
    Department of Pulmonology, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands
    Lung Cancer 56:25-33. 2007

Collaborators

Detail Information

Publications10

  1. doi request reprint Altered expression of epithelial junctional proteins in atopic asthma: possible role in inflammation
    W I de Boer
    Department of Pulmonary Medicine, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands
    Can J Physiol Pharmacol 86:105-12. 2008
    ..Our results suggest that the lower epithelial alpha-catenin, E-cadherin and (or) ZO-1 expression in patients with atopic asthma contributes to a defective airway epithelial barrier and a higher influx of eosinophils in the epithelium...
  2. pmc Effects of cigarette smoke condensate on proliferation and wound closure of bronchial epithelial cells in vitro: role of glutathione
    Fabrizio Luppi
    Department of Pulmonology, Leiden University Medical Center, PO Box 9600, 2300RC, Leiden, The Netherlands
    Respir Res 6:140. 2005
    ..We also studied whether modulation of intracellular glutathione/thiol levels could attenuate CSC-induced cell proliferation...
  3. ncbi request reprint Cytokines and therapy in COPD: a promising combination?
    W I de Boer
    Department of Pulmonary Medicine, Erasmus University, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Chest 121:209S-218S. 2002
    ..As lung levels of these cytokines are higher in COPD compared to non-COPD patients, they may represent targets for novel therapies...
  4. pmc Future therapeutic treatment of COPD: struggle between oxidants and cytokines
    Willem I de Boer
    Netherlands Asthma Foundation, Leusden, The Netherlands
    Int J Chron Obstruct Pulmon Dis 2:205-28. 2007
    ....
  5. ncbi request reprint Molecular mechanisms in chronic obstructive pulmonary disease: potential targets for therapy
    Willem I de Boer
    Netherlands Asthma Foundation, Leusden, The Netherlands
    Cell Biochem Biophys 47:131-48. 2007
    ..Finally, other drugs such as retinoic acids may provide restoration of lung tissue structure. Such approaches, however, must await the first results of growth factor or cytokine antagonist therapy in chronic lung diseases...
  6. ncbi request reprint Potential new drugs for therapy of chronic obstructive pulmonary disease
    W I de Boer
    Netherlands Asthma Foundation, Leusden, The Netherlands
    Expert Opin Investig Drugs 12:1067-86. 2003
    ..Some of these drugs are shown to be effective in patients with other chronic inflammatory diseases but still have to prove their efficacy in the treatment of chronic obstructive pulmonary disease...
  7. pmc Enhanced bronchial expression of vascular endothelial growth factor and receptors (Flk-1 and Flt-1) in patients with chronic obstructive pulmonary disease
    A R Kranenburg
    Department of Pharmacology, Erasmus MC, University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Thorax 60:106-13. 2005
    ..Vascular endothelial growth factor (VEGF) and its receptors VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1) could play a role in tissue remodelling and angiogenesis in COPD...
  8. ncbi request reprint Tobacco use in relation to COPD and asthma
    M N Hylkema
    Dept of Pathology and Laboratory Medicine, University Medical Center Groningen, University of Groningen, P O Box 30 001, 9700 RB, Groningen, The Netherlands
    Eur Respir J 29:438-45. 2007
    ..In the present paper, new concepts are discussed with respect to pathology, treatment, smoking cessation and tobacco control. Recommendations for future directions are given...
  9. ncbi request reprint Human neutrophil defensins and secretory leukocyte proteinase inhibitor in squamous metaplastic epithelium of bronchial airways
    J Aarbiou
    Department of Pulmonology, C3 P, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
    Inflamm Res 53:230-8. 2004
    ..The aim of this study was to analyze a possible contribution of human neutrophil defensins and secretory leukocyte proteinase inhibitor (SLPI) to the induction of airway epithelial changes such as squamous cell metaplasia...
  10. ncbi request reprint Interleukin-8 stimulates cell proliferation in non-small cell lung cancer through epidermal growth factor receptor transactivation
    F Luppi
    Department of Pulmonology, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands
    Lung Cancer 56:25-33. 2007
    ..These results suggest that IL-8 increases cell proliferation in NSCLC cell lines via transactivation of the EGFR and that this mechanism involves metalloproteinase activity...