A F Cohen

Summary

Affiliation: Centre for Human Drug Research
Country: The Netherlands

Publications

  1. pmc Adherence to HAART therapy measured by electronic monitoring in newly diagnosed HIV patients in Botswana
    Reinout Vriesendorp
    Centre for Human Drug Research, Department of Clinical Pharmacology, Leiden University Medical Centre, Leiden, The Netherlands
    Eur J Clin Pharmacol 63:1115-21. 2007
  2. ncbi request reprint [Medical research and the pharmaceutical industry. Uneasy bedfellows or a prenuptial agreement?]
    A F Cohen
    Centre for Human Drug Research CHDR, Zernikedreef 10, 2333 CL Leiden
    Ned Tijdschr Geneeskd 145:1438-42. 2001
  3. ncbi request reprint [New drugs; palifermin]
    A F Cohen
    Centre for Human Drug Research, Zernikedreef 10, 2333 CL Leiden
    Ned Tijdschr Geneeskd 150:2753-4. 2006
  4. ncbi request reprint [European guideline for the quality of non-commercial clinical trials: elegant implementation in the Netherlands via the amended Dutch Medical Research Involving Human Subjects Act]
    A F Cohen
    Centre for Human Drug Research, Zernikedreef 10, 2333 CL Leiden
    Ned Tijdschr Geneeskd 147:1493-5. 2003
  5. ncbi request reprint [New drugs; ivabradine]
    A F Cohen
    Centre for Human Drug Research, Zernikedreef 10, 2333 CL Leiden
    Ned Tijdschr Geneeskd 150:2646-7. 2006
  6. doi request reprint Developing drug prototypes: pharmacology replaces safety and tolerability?
    Adam F Cohen
    Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Nat Rev Drug Discov 9:856-65. 2010
  7. ncbi request reprint [New medications; erlotinib]
    A F Cohen
    Centre for Human Drug Research, Zernikedreef 10, 2333 CL Leiden
    Ned Tijdschr Geneeskd 150:2703-4. 2006
  8. ncbi request reprint Pharmacokinetic and pharmacodynamic data to be derived from early-phase drug development: designing informative human pharmacology studies
    Adam Cohen
    Centre for Human Drug Research, Zernikedreef 10, Leiden, The Netherlands
    Clin Pharmacokinet 47:373-81. 2008
  9. ncbi request reprint [New drugs; nitisinone]
    A F Cohen
    Centre for Human Drug Research, Zernikedreef 10, 2333 CL Leiden
    Ned Tijdschr Geneeskd 150:2541-2. 2006
  10. ncbi request reprint [New medications; bevacizumab]
    A F Cohen
    Centre for Human Drug Research, Leiden
    Ned Tijdschr Geneeskd 150:2194-5. 2006

Collaborators

Detail Information

Publications82

  1. pmc Adherence to HAART therapy measured by electronic monitoring in newly diagnosed HIV patients in Botswana
    Reinout Vriesendorp
    Centre for Human Drug Research, Department of Clinical Pharmacology, Leiden University Medical Centre, Leiden, The Netherlands
    Eur J Clin Pharmacol 63:1115-21. 2007
    ....
  2. ncbi request reprint [Medical research and the pharmaceutical industry. Uneasy bedfellows or a prenuptial agreement?]
    A F Cohen
    Centre for Human Drug Research CHDR, Zernikedreef 10, 2333 CL Leiden
    Ned Tijdschr Geneeskd 145:1438-42. 2001
    ..All parties concerned should make transparent and clear agreements...
  3. ncbi request reprint [New drugs; palifermin]
    A F Cohen
    Centre for Human Drug Research, Zernikedreef 10, 2333 CL Leiden
    Ned Tijdschr Geneeskd 150:2753-4. 2006
    ..The safety of this product--being a growth factor --in the long term has not yet been shown. Adverse effects may occur in the skin and mucous membranes...
  4. ncbi request reprint [European guideline for the quality of non-commercial clinical trials: elegant implementation in the Netherlands via the amended Dutch Medical Research Involving Human Subjects Act]
    A F Cohen
    Centre for Human Drug Research, Zernikedreef 10, 2333 CL Leiden
    Ned Tijdschr Geneeskd 147:1493-5. 2003
    ..This is also an ideal opportunity for enhancing the national climate of clinical research and ensuring an improved translation of local research ideas into clinical trial protocols...
  5. ncbi request reprint [New drugs; ivabradine]
    A F Cohen
    Centre for Human Drug Research, Zernikedreef 10, 2333 CL Leiden
    Ned Tijdschr Geneeskd 150:2646-7. 2006
    ..The agent can be used in patients with angina pectoris when beta-blockers are insufficiently effective, provided that the heart rate is at least 60 beats per minute at the beginning of the treatment...
  6. doi request reprint Developing drug prototypes: pharmacology replaces safety and tolerability?
    Adam F Cohen
    Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Nat Rev Drug Discov 9:856-65. 2010
    ..For these prototypical drugs development has to proceed in a much more adaptive manner, using tailor-made objectives, the development of special methodology and a cyclical rather than a linear type of project management...
  7. ncbi request reprint [New medications; erlotinib]
    A F Cohen
    Centre for Human Drug Research, Zernikedreef 10, 2333 CL Leiden
    Ned Tijdschr Geneeskd 150:2703-4. 2006
    ..The agent is indicated for the treatment of patients with advanced local or metastasised non-small-cell pulmonary carcinoma after other cytostatic therapy has failed...
  8. ncbi request reprint Pharmacokinetic and pharmacodynamic data to be derived from early-phase drug development: designing informative human pharmacology studies
    Adam Cohen
    Centre for Human Drug Research, Zernikedreef 10, Leiden, The Netherlands
    Clin Pharmacokinet 47:373-81. 2008
    ....
  9. ncbi request reprint [New drugs; nitisinone]
    A F Cohen
    Centre for Human Drug Research, Zernikedreef 10, 2333 CL Leiden
    Ned Tijdschr Geneeskd 150:2541-2. 2006
    ..The inhibition of 4HPPD, an enzyme that is active early in the catabolic cascade, prevents the accumulation of toxic metabolites of tyrosine...
  10. ncbi request reprint [New medications; bevacizumab]
    A F Cohen
    Centre for Human Drug Research, Leiden
    Ned Tijdschr Geneeskd 150:2194-5. 2006
    ..Mean disease-free survival is prolonged in patients with metastatic colorectal carcinoma who are treated with bevacizumab. Evaluation of bevacizumab in other indications is underway...
  11. ncbi request reprint [Clinical researchers and the pharmaceutic industry. The research contract is not an addendum]
    A F Cohen
    Afd Klinische Farmacologie, Universiteit Leiden
    Ned Tijdschr Geneeskd 143:1345-9. 1999
    ..Investigators should have their own standard contract ready, and they should invest time and energy in understanding the contracts of the research they are carrying out...
  12. ncbi request reprint [Class substitution of medicines--between cost reduction and the position of professionals in health care]
    A F Cohen
    Centre for Human Drug Research CHDR, Zernikedreef 10, 2333 CL Leiden
    Ned Tijdschr Geneeskd 146:551-3. 2002
    ..The provision of education in medical and pharmaceutical curricula is the most effective manner for limiting drug costs...
  13. ncbi request reprint [New drugs; omalizumab]
    A F Cohen
    Centre for Human Drug Research, Leiden
    Ned Tijdschr Geneeskd 150:2871-2. 2006
    ..Until recently, the most important side effects are skin reactions at the site of administration and headache. Prospective data on additional long-term side effects are still being collected...
  14. ncbi request reprint [New medications; ziconotide]
    A F Cohen
    Centre for Human Drug Research, Zernikedreef 10, 2333 CL Leiden
    Ned Tijdschr Geneeskd 150:2427-8. 2006
    ..Ziconotide blocks N-type calcium channels, which play an important role in the transmission of pain signals in the dorsal ganglia of the spinal cord. The drug is indicated for 'severe chronic pain' and is administered intrathecally...
  15. ncbi request reprint [New medications; zonisamide]
    A F Cohen
    Centre for Human Drug Research, Leiden
    Ned Tijdschr Geneeskd 150:2313. 2006
    ..It affects, among other things, the voltage-sensitive sodium and calcium channels, thus disrupting synchronised neuronal firing; as a result, it diminishes the spread of seizure discharges...
  16. doi request reprint Modelling of the concentration--effect relationship of THC on central nervous system parameters and heart rate -- insight into its mechanisms of action and a tool for clinical research and development of cannabinoids
    A Strougo
    Centre for Human Drug Research, Statistics, Leiden, The Netherlands
    J Psychopharmacol 22:717-26. 2008
    ..Third, many new cannabinoid agonists and antagonists are in development. PK-PD models for THC can be used as a reference for new agonists or as tools to quantitate the pharmacological properties of cannabinoid antagonists...
  17. doi request reprint The effects of the glycine reuptake inhibitor R213129 on the central nervous system and on scopolamine-induced impairments in psychomotor and cognitive function in healthy subjects
    M Liem-Moolenaar
    Centre for Human Drug Research, Leiden, The Netherlands
    J Psychopharmacol 24:1671-9. 2010
    ..The effects of higher doses in healthy volunteers and the clinical efficacy in patients remain to be established...
  18. ncbi request reprint The influence of reduced liver blood flow on the pharmacokinetics and pharmacodynamics of recombinant tissue factor pathway inhibitor
    M J Kemme
    Centre for Human Drug Research, Department of Clinical Chemistry, Leiden University Medical Center, The Netherlands
    Clin Pharmacol Ther 67:504-11. 2000
    ..The aim of this study was to examine the effect of exercise-induced reduction in liver blood flow on the pharmacokinetics and pharmacodynamics of rTFPI...
  19. doi request reprint Psychomotor and cognitive effects of a single oral dose of talnetant (SB223412) in healthy volunteers compared with placebo or haloperidol
    M Liem-Moolenaar
    Centre for Human Drug Research, Leiden, The Netherlands
    J Psychopharmacol 24:73-82. 2010
    ..The results suggest that talnetant penetrates the brain, but it remains to be established whether this dose is sufficient and whether the observed effect profile is class-specific for NK3-antagonists...
  20. ncbi request reprint The effect of warfarin on the pharmacokinetics and pharmacodynamics of napsagatran in healthy male volunteers
    R A Faaij
    Centre for Human Drug Research CHDR, Zernikedreef 10, 2333 CL Leiden, The Netherlands
    Eur J Clin Pharmacol 57:25-9. 2001
    ..The effect of oral warfarin on the pharmacokinetics and pharmacodynamics of the synthetic direct thrombin inhibitor napsagatran was investigated...
  21. doi request reprint Inhibition of THC-induced effects on the central nervous system and heart rate by a novel CB1 receptor antagonist AVE1625
    L Zuurman
    Centre for Human Drug Research, Leiden, The Netherlands
    J Psychopharmacol 24:363-71. 2010
    ..This study shows a useful method for studying the effects of CB1 antagonists. AVE1625 penetrates the brain and antagonises THC-induced effects with doses at or above 20 mg...
  22. doi request reprint The effects of TPA023, a GABAAα2,3 subtype-selective partial agonist, on essential tremor in comparison to alcohol
    S L de Haas
    Centre for Human Drug Research, Leiden, The Netherlands
    J Psychopharmacol 26:282-91. 2012
    ..These results provide no support for a therapeutic role of TPA023 in the suppression of ET symptoms...
  23. doi request reprint The effects of a glycine reuptake inhibitor R231857 on the central nervous system and on scopolamine-induced impairments in cognitive and psychomotor function in healthy subjects
    M Liem-Moolenaar
    Centre for Human Drug Research, Leiden, The Netherlands
    J Psychopharmacol 24:1681-7. 2010
    ..The effects of higher doses in healthy volunteers and the clinical efficacy in patients remain to be established...
  24. ncbi request reprint No evidence for functional involvement of 5-HT2B receptors in serotonin-induced vasodilatation in the human forearm
    M J Kemme
    Centre for Human Drug Research, Leiden, The Netherlands
    J Cardiovasc Pharmacol 36:699-703. 2000
    ..5-HT-induced vasodilatation did not differ between treatments and time points. It appears that there is no functional involvement of 5-HT2B receptors in 5-HT-mediated vasodilatation in the human forearm...
  25. doi request reprint Effect of intrapulmonary tetrahydrocannabinol administration in humans
    L Zuurman
    Centre for Human Drug Research, Pharmacology CNS, Leiden, The Netherlands
    J Psychopharmacol 22:707-16. 2008
    ..These results may be applicable in the development of novel cannabinoid agonists and antagonists, and in studies of the pharmacology and physiology of cannabinoid systems in humans...
  26. ncbi request reprint The oral bioavailability of pentosan polysulphate sodium in healthy volunteers
    R A Faaij
    Centre for Human Drug Research, Leiden, The Netherlands
    Eur J Clin Pharmacol 54:929-35. 1999
    ..The objective of the present study was to assess the oral bioavailability of PPS. However, since specific assays for PPS do not exist, this was done by using primary and secondary effect parameters...
  27. pmc Concentration-effect relationships of two infusion rates of the imidazoline antihypertensive agent rilmenidine for blood pressure and development of side-effects in healthy subjects
    S J de Visser
    Centre for Human Drug Research, Zernikedreef 10, 2333 CL Leiden, The Netherlands
    Br J Clin Pharmacol 51:423-8. 2001
    ..The aim of this study was to compare the effect profiles of i.v. administered rilmenidine aimed at the same target plasma concentration, but attained with different rates...
  28. ncbi request reprint Pharmacodynamics and pharmacokinetics of a single oral dose of nitrazepam in healthy volunteers: an interethnic comparative study between Japanese and European volunteers
    J M van Gerven
    Centre for Human Drug Research, Zernikedreef 10, 2333 CL Leiden, The Netherlands
    J Clin Pharmacol 38:1129-36. 1998
    ..Interethnic comparative studies are feasible, and provide meaningful information about potential racial differences in disposition and action of drugs. Such studies can form a rational basis for comparative clinical trials...
  29. pmc Cardiovascular side effects of inhaled salbutamol in hypoxic asthmatic patients
    J Burggraaf
    Centre for Human Drug Research, Zernikedreef 10, 2333 CL Leiden, The Netherlands
    Thorax 56:567-9. 2001
    ..A study was undertaken to investigate the effect of hypoxia on the systemic vascular effects of salbutamol in patients with asthma who are hypoxic by assessing forearm blood flow (FBF) as a measure of peripheral vasodilatation...
  30. ncbi request reprint Sorbitol as a marker for drug-induced decreases of variable duration in liver blood flow in healthy volunteers
    J Burggraaf
    Centre for Human Drug Research and Department of Clinical Chemistry, Leiden University Medical Centre, Leiden, The Netherlands
    Eur J Pharm Sci 12:133-9. 2000
    ..We therefore used sorbitol to evaluate drug-induced decreases in LBF of variable duration with i.v. infusions of somatostatin and its synthetic analogue octreotide...
  31. ncbi request reprint The sugar absorption test in the evaluation of the gastrointestinal intolerance to bisphosphonates: studies with oral pamidronate
    I M Twiss
    Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Pharmacol Ther 69:431-7. 2001
    ..Increases in the lactulose/mannitol ratio and sucrose excretion indicate increased small intestinal permeability and gastroduodenal disease, respectively...
  32. pmc Absence of an interaction between the synthetic pentasaccharide fondaparinux and oral warfarin
    R A Faaij
    Centre for Human Drug Research, Leiden, The Netherlands, and NV Organon, Oss, The Netherlands
    Br J Clin Pharmacol 54:304-8. 2002
    ..To investigate the pharmacokinetic and pharmacodynamic interaction of the antithrombotic pentasaccharide fondaparinux (Org31540/SR90107A), given subcutaneously, and oral warfarin in healthy subjects...
  33. ncbi request reprint Pharmacodynamic and pharmacokinetic effects of the intravenously administered CB1 receptor agonist Org 28611 in healthy male volunteers
    L Zuurman
    Centre for Human Drug Research, Leiden, The Netherlands
    J Psychopharmacol 23:633-44. 2009
    ....
  34. ncbi request reprint Cognitive performance and serotonergic function in users of ecstasy
    R J Verkes
    Centre for Human Drug Research, Leiden, The Netherlands
    Psychopharmacology (Berl) 153:196-202. 2001
    ..The neurotoxic effects in humans are less clear and little is known about the functional consequences, although some studies suggest memory impairment. Given the widespread use of MDMA, our lack of knowledge raises concerns...
  35. ncbi request reprint Sympathovagal imbalance in hyperthyroidism
    J Burggraaf
    Centre for Human Drug Research, Leiden University Medical Centre, 2333 CL Leiden, The Netherlands
    Am J Physiol Endocrinol Metab 281:E190-5. 2001
    ..Thus thyrotoxicosis is characterized by profound sympathovagal imbalance, brought about by increased sympathetic activity in the presence of diminished vagal tone...
  36. doi request reprint Pharmacokinetics, pharmacodynamics and the pharmacokinetic/ pharmacodynamic relationship of zolpidem in healthy subjects
    S L de Haas
    Centre for Human Drug Research, Leiden, The Netherlands
    J Psychopharmacol 24:1619-29. 2010
    ..A transit tolerance model (in which a hypothetical factor builds up with time that antagonises the effects of the parent compound) is compatible with a rapid reversible desensitisation of GABAergic subunits...
  37. doi request reprint Hypothalamic glutamate levels following serotonergic stimulation: a pilot study using 7-Tesla magnetic resonance spectroscopy in healthy volunteers
    G E Jacobs
    Centre for Human Drug Research, Leiden, The Netherlands
    Prog Neuropsychopharmacol Biol Psychiatry 34:486-91. 2010
    ....
  38. pmc The central nervous system effects, pharmacokinetics and safety of the NAALADase-inhibitor GPI 5693
    J P van der Post
    Centre for Human Drug Research, Leiden, The Netherlands
    Br J Clin Pharmacol 60:128-36. 2005
    ..The aim was to assess the central nervous system (CNS) effects, pharmacokinetics and safety of GPI 5693, an inhibitor of a novel CNS-drug target, NAALADase which is being evaluated for the treatment of neuropathic pain...
  39. ncbi request reprint Gallbladder volume as a biomarker for the motilin effect in healthy volunteers and patients with functional dyspepsia
    I M C Kamerling
    Centre for Human Drug Research, Leiden, The Netherlands
    Aliment Pharmacol Ther 19:797-804. 2004
    ..To investigate a motilin effect on gallbladder volume in healthy volunteers and patients with functional dyspepsia...
  40. ncbi request reprint No Influence of acute hypertriglyceridemia on plasma t-PA in healthy male volunteers
    M J Kemme
    Centre for Human Drug Research, Zernikedreef 10, 2333 CL, Leiden, Netherlands
    Thromb Res 103:9-16. 2001
    ..26 U/ml, CI: -3.7, 4.3). Mean t-PA clearance and liver blood flow were unaffected by the Intralipid infusion. These results indicate that acute hypertriglyceridemia does not alter plasma fibrinolytic parameters in healthy male volunteers...
  41. ncbi request reprint A comparison of the effects of propofol and midazolam on memory during two levels of sedation by using target-controlled infusion
    A de Roode
    Department of Anesthesiology and Centre for Human Drug Research, Leiden University Medical Centre, Leiden, The Netherlands
    Anesth Analg 91:1056-61. 2000
    ..To compare the effects of both drugs, they were titrated using a computer-controlled infusion system to produce similar high and low levels of sedation...
  42. ncbi request reprint Estimating potency for the Emax-model without attaining maximal effects
    R C Schoemaker
    Centre for Human Drug Research, Leiden, The Netherlands
    J Pharmacokinet Biopharm 26:581-93. 1998
    ..Simulations are presented to investigate the nature of the new parameter and published examples are used as illustration...
  43. ncbi request reprint Pharmacodynamics and pharmacokinetics of the novel thrombopoietin mimetic peptide RWJ-800088 in humans
    M Liem-Moolenaar
    Centre for Human Drug Research, Leiden, The Netherlands
    Clin Pharmacol Ther 84:481-7. 2008
    ..RWJ-800088 was well tolerated, with no evidence of antibody formation in this single-dose study. Additional patient studies are warranted to investigate the therapeutic use of this novel peptide...
  44. pmc Evaluation of biomarkers for cardiotoxicity of anthracyclin-based chemotherapy
    F J F Broeyer
    Centre for Human Drug Research, Leiden, The Netherlands
    J Cancer Res Clin Oncol 134:961-8. 2008
    ..Therefore a study was performed to evaluate non-invasive markers of anthracyclin-induced cardiac effects, with emphasis on course-to-course variation...
  45. ncbi request reprint [New drugs; natalizumab]
    H van Bronswijk
    Leids Universitair Medisch Centrum, Albinusdreef 2, 2333 ZA Leiden
    Ned Tijdschr Geneeskd 152:499-500. 2008
    ..Therefore, further research is required to determine the role of natalizumab in clinical practice...
  46. ncbi request reprint Onset of action during on-demand treatment with maalox suspension or low-dose ranitidine for heartburn
    R A Faaij
    Centre for Human Drug Research CHDR, Leiden, The Netherlands
    Aliment Pharmacol Ther 13:1605-10. 1999
    ....
  47. pmc Biomarkers for the effects of antipsychotic drugs in healthy volunteers
    S J de Visser
    Centre for Human Drug Research, Zernikedreef 10, 2333 CL Leiden, The Netherlands
    Br J Clin Pharmacol 51:119-32. 2001
    ..The number of tests used in human psychopharmacology appears to be excessive. Future studies should look for the most specific and sensitive test within each of the domains that are most susceptible to neuroleptics...
  48. ncbi request reprint Pharmacodynamic and pharmacokinetic effects of TPA023, a GABA(A) alpha(2,3) subtype-selective agonist, compared to lorazepam and placebo in healthy volunteers
    S L de Haas
    Centre for Human Drug Research, Leiden, The Netherlands
    J Psychopharmacol 21:374-83. 2007
    ..Contrary to lorazepam, TPA023 caused no detectable memory impairment or postural imbalance. These differences reflect the selectivity of TPA023 for different GABA(A) receptor subtypes...
  49. ncbi request reprint No evidence of the usefulness of eye blinking as a marker for central dopaminergic activity
    J van der Post
    Centre for Human Drug Research, Leiden, The Netherlands
    J Psychopharmacol 18:109-14. 2004
    ..1%) (CI -7.3 to -0.9) and visual analogue scales for mood (-2.1 mm) (CI -3.7 to -0.4). Spontaneous eye blink rate was not affected by sulpiride and lisuride, which makes eye blinking not suitable as a marker for central D2 activity...
  50. doi request reprint MK-0873, a PDE4 inhibitor, does not influence the pharmacokinetics of theophylline in healthy male volunteers
    J D Boot
    Centre for Human Drug Research, Zernikedreef 10, 2333 CL Leiden, The Netherlands
    Pulm Pharmacol Ther 21:573-7. 2008
    ..In view of this, it is important to investigate whether MK-0873 could affect the pharmacokinetics, safety and tolerability of theophylline, when both drugs are given concomitantly...
  51. ncbi request reprint Pharmacokinetic differences between Caucasian and Japanese subjects after single and multiple doses of a potential combined oral contraceptive (Org 30659 and EE)
    S J de Visser
    Centre for Human Drug Research, Zernikedreef 10, 2333 CL Leiden, The Netherlands
    Contraception 68:195-202. 2003
    ....
  52. ncbi request reprint The psychomotor effects of carbamazepine in epileptic patients and healthy volunteers
    M S M Pieters
    Centre for Human Drug Research, Leiden, The Netherlands
    J Psychopharmacol 17:269-72. 2003
    ..Of the used tests, DSST is most clearly related to cognitive function. It is concluded that the difference in DSST performance appears to reflect a long-term small neurocognitive difference between subjects with and without epilepsy...
  53. pmc The effect of motilin on the rectum in healthy volunteers
    I M C Kamerling
    Centre for Human Drug Research, Leiden University Medical Centre, The Netherlands
    Br J Clin Pharmacol 55:538-43. 2003
    ..However, little is known about the effects on the distal GI tract. To investigate the effect of exogenous motilin on rectal function, barostat measurements in the rectum were performed and lower abdominal symptoms were scored...
  54. pmc Biomarkers for the effects of benzodiazepines in healthy volunteers
    S J de Visser
    Centre for Human Drug Research, Zernikedreef 10, 2333 CL Leiden, The Netherlands
    Br J Clin Pharmacol 55:39-50. 2003
    ..The number of tests used in human psychopharmacology appears to be excessive and their sensitivity and reproducibility low...
  55. ncbi request reprint Evaluation of tests of central nervous system performance after hypoxemia for a model for cognitive impairment
    J van der Post
    Centre for Human Drug Research, Leiden University Medical Center, Leiden, The Netherlands
    J Psychopharmacol 16:337-43. 2002
    ..Sensitive effect measurements can be identified for these interventions. The applicability as a model for cognitive impairment should be investigated further...
  56. ncbi request reprint CNS effects of sumatriptan and rizatriptan in healthy female volunteers
    J van der Post
    Centre for Human Drug Research, Leiden, The Netherlands
    Cephalalgia 22:271-81. 2002
    ..477 (0.02, 0.935). Therapeutic doses of sumatriptan and rizatriptan caused CNS effects indicative of mild sedation. For EEG and recognition reaction times the effects were opposite to temazepam, indicating central stimulation...
  57. ncbi request reprint Dose-related effects of motilin on proximal gastrointestinal motility
    I M C Kamerling
    Centre for Human Drug Research, Leiden, The Netherlands
    Aliment Pharmacol Ther 16:129-35. 2002
    ..To assess non-invasively the dose-response relations for the effects of exogenous motilin on antrum contraction frequency, gall-bladder volume and gastric myoelectrical activity...
  58. ncbi request reprint Endothelial function in patients with hyperthyroidism before and after treatment with propranolol and thiamazol
    J Burggraaf
    Centre for Human Drug Research, Geneve, Switzerland
    Thyroid 11:153-60. 2001
    ..von Willebrand factor II (vWF:Ag-II) levels may be suitable markers to evaluate acute changes in endothelial function because this parameter responds more rapidly to changes in endothelial function than other factors...
  59. doi request reprint Pharmacodynamic and pharmacokinetic effects of MK-0343, a GABA(A) alpha2,3 subtype selective agonist, compared to lorazepam and placebo in healthy male volunteers
    S L de Haas
    Centre for Human Drug Research, Leiden, The Netherlands
    J Psychopharmacol 22:24-32. 2008
    ..Clinical studies in anxiety patients should show whether this dose of MK-0343 is therapeutically effective with a different side-effect profile...
  60. ncbi request reprint Pharmacokinetic/pharmacodynamic assessment of tolerance to central nervous system effects of a 3 mg sustained release tablet of rilmenidine in hypertensive patients
    J P van der Post
    Centre for Human Drug Research, Leiden, The Netherlands
    J Psychopharmacol 18:221-7. 2004
    ..The reasons for these adaptations cannot be determined but may include drug tolerance and habituations to study procedures. Blood pressure control remained stable and adequate throughout the study...
  61. pmc Evaluation of proinflammatory cytokines and inflammation markers as biomarkers for the action of thiazolidinediones in Type 2 diabetes mellitus patients and healthy volunteers
    Martijn van Doorn
    Department of Molecular Biology, Leiden University, Leiden, The Netherlands
    Br J Clin Pharmacol 62:391-402. 2006
    ....
  62. pmc Exploratory polysomnographic evaluation of pregabalin on sleep disturbance in patients with epilepsy
    Sanne de Haas
    Centre for Human Drug Research CHDR, Leiden, The Netherlands
    J Clin Sleep Med 3:473-8. 2007
    ..To evaluate the effects of adjunctive pregabalin 300 mg/day versus placebo on polysomnographic (PSG) variables in patients with well controlled partial seizures and subjectively reported sleep disturbance...
  63. pmc Evaluation of metabolite profiles as biomarkers for the pharmacological effects of thiazolidinediones in Type 2 diabetes mellitus patients and healthy volunteers
    Martijn van Doorn
    Centre for Human Drug Research, Leiden, The Netherlands
    Br J Clin Pharmacol 63:562-74. 2007
    ....
  64. ncbi request reprint Disagreement between bedside and laboratory activated partial thromboplastin time and international normalized ratio for various novel anticoagulants
    M J Kemme
    Centre for Human Drug Research, Leiden, The Netherlands
    Blood Coagul Fibrinolysis 12:583-91. 2001
    ..The amount of disagreement depended on the anticoagulant given...
  65. ncbi request reprint Continuous intravenous furosemide in haemodynamically unstable children after cardiac surgery
    M M van der Vorst
    Department of Paediatrics, Leiden University Medical Centre, PO Box 9600, 2300 Leiden, The Netherlands
    Intensive Care Med 27:711-5. 2001
    ..A study was performed to obtain an impression regarding which clinically applicable measures may be used to design a rational scheme for continuous i.v. furosemide therapy in children after cardiac surgery...
  66. ncbi request reprint [New drugs; sunitinib and sorafenib]
    H van Bronswijk
    Leids Universitair Medisch Centrum, Albinusdreef 2, 2333 ZA, Leiden
    Ned Tijdschr Geneeskd 151:2888-90. 2007
    ....
  67. ncbi request reprint The pharmacokinetic and pharmacodynamic effects of SL65.1498, a GABA-A alpha2,3 selective agonist, in comparison with lorazepam in healthy volunteers
    S L de Haas
    Centre for Human Drug Research, Leiden, The Netherlands
    J Psychopharmacol 23:625-32. 2009
    ..This study showed that the three doses of SL65.1498 were well tolerated and induced no impairments on memory, sedation, psychomotor, and cognitive functions...
  68. pmc The pharmacokinetics and effects of a long-acting preparation of superoxide dismutase (PC-SOD) in man
    F J F Broeyer
    Centre for Human Drug Research, Leiden, The Netherlands
    Br J Clin Pharmacol 65:22-9. 2008
    ..To study the pharmacokinetics (PK), safety and tolerability of single rising doses up to 80 mg of superoxide dismutase covalently linked to lecithin (PC-SOD) in healthy White volunteers...
  69. ncbi request reprint REM sleep effects as a biomarker for the effects of antidepressants in healthy volunteers
    B Rijnbeek
    Centre for Human Drug Research, Leiden, The Netherlands
    J Psychopharmacol 17:196-203. 2003
    ..Models that take these complex relationships into account may provide more comprehensive and quantifiable results...
  70. ncbi request reprint Characterization of a standardized glucagon challenge test as a pharmacodynamic tool in pharmacological research
    M G J van Dongen
    Centre for Human Drug Research, Leiden, The Netherlands
    Horm Metab Res 46:269-73. 2014
    ....
  71. doi request reprint The effects of a novel histamine-3 receptor inverse agonist on essential tremor in comparison to stable levels of alcohol
    R W M Zoethout
    Centre for Human Drug Research, Leiden, The Netherlands
    J Psychopharmacol 26:292-302. 2012
    ....
  72. ncbi request reprint [New drugs; exenatide and sitagliptin]
    H van Bronswijk
    Leids Universitair Medisch Centrum, Albinusdreef 2, 2333 ZA Leiden
    Ned Tijdschr Geneeskd 152:876-9. 2008
    ..Both drugs increase the GLP-I concentration, thereby improving insulin secretion from pancreatic p cells, restoring glycaemic control, preventing beta cell destruction, delaying gastric emptying, and reducing food intake...
  73. ncbi request reprint [New drugs; varenicline]
    H van Bronswijk
    Leids Universitair Medisch Centrum, Albinusdreef 2, 2333 ZA Leiden
    Ned Tijdschr Geneeskd 151:2503-4. 2007
    ..The most important side effects of varenicline are nausea, vomiting and headache. After one year, 22% of the treated group continued to abstain from smoking...
  74. ncbi request reprint [New drugs; daptomycin]
    H van Bronswijk
    Leids Universitair Medisch Centrum, Albinusdreef 2, 2333 ZA Leiden
    Ned Tijdschr Geneeskd 151:2777-8. 2007
    ..There is limited experience with treatment of Staphylococcus aureus bacteraemia. Its main adverse effects include gastrointestinal symptoms, skin reactions at the site of infusion, and raised serum creatine kinase...
  75. pmc Estimating impossible curves using NONMEM
    R C Schoemaker
    Centre for Human Drug Research, Leiden, The Netherlands
    Br J Clin Pharmacol 42:283-90. 1996
    ....
  76. ncbi request reprint Exogenous motilin affects postprandial proximal gastric motor function and visceral sensation
    I M C Kamerling
    Centre for Human Drug Research, Leiden, The Netherlands
    Dig Dis Sci 47:1732-6. 2002
    ..In conclusion, after normal postprandial gastric relaxation, motilin accelerated the return of gastric volume to baseline. In addition, motilin increased postprandial feelings of nausea...
  77. pmc Pharmacokinetics and systemic endocrine effects of the phyto-oestrogen 8-prenylnaringenin after single oral doses to postmenopausal women
    M Rad
    Centre for Human Drug Research, Leiden, The Netherlands
    Br J Clin Pharmacol 62:288-96. 2006
    ..The aim of this study was to investigate the pharmacokinetics, endocrine effects and tolerability of chemically synthesized 8-PN in postmenopausal women...
  78. ncbi request reprint Reversal of the late asthmatic response increases exhaled nitric oxide
    J D Boot
    Centre for Human Drug Research, Zernikedreef 10, 2333 CL Leiden, The Netherlands
    Respir Med 99:1591-4. 2005
  79. ncbi request reprint Subjective sleep disturbance in patients with partial epilepsy: a questionnaire-based study on prevalence and impact on quality of life
    Al de Weerd
    Centre for Sleep and Wake Disorders, Medical Centre Haaglanden, Westeinde Hospital, The Hague, The Netherlands
    Epilepsia 45:1397-404. 2004
    ..This study was designed to assess whether sleep disturbance is more frequent among patients with partial seizures and what impact on quality of life (QoL) sleep disturbance may have on patients with partial seizures...
  80. ncbi request reprint Doxorubicin and dexamethasone followed by thalidomide and dexamethasone is an effective well tolerated initial therapy for multiple myeloma
    Hani Hassoun
    Division of Hematologic Oncology, Department of Medicine, Hematology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Br J Haematol 132:155-61. 2006
    ..AD-TD administered with low dose aspirin for deep vein thrombosis prophylaxis was well tolerated and yielded a high response rate with minimal treatment-related morbidity...
  81. ncbi request reprint Pharmacokinetics of PC-SOD, a lecithinized recombinant superoxide dismutase, after single- and multiple-dose administration to healthy Japanese and Caucasian volunteers
    Jun Suzuki
    R and D Division, LTT Bio Pharma Co, Ltd, Tokyo 105 6201, Japan
    J Clin Pharmacol 48:184-92. 2008
    ..The relatively long half-life of PC-SOD (>24 hours) suggests that it is worthwhile to study the compound as a protective agent in clinical conditions with free radical overload...
  82. ncbi request reprint The impact of pre-clinical pharmacology and pharmacotherapy training on students' abilities and perceptions during clinical rotations
    Eline Dubois
    Leiden University Medical Center, Leiden, The Netherlands
    Med Teach 29:981-3. 2007
    ..This study compares the cohorts by performance in and perception of pharmacotherapeutic abilities during the internal medicine rotation...