Rhiannon M Meredith

Summary

Affiliation: Center for Neurogenomics and Cognitive Research
Country: The Netherlands

Publications

  1. doi request reprint Functional rescue of excitatory synaptic transmission in the developing hippocampus in Fmr1-KO mouse
    Rhiannon M Meredith
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, The Netherlands
    Neurobiol Dis 41:104-10. 2011
  2. doi request reprint Mechanisms underlying the rules for associative plasticity at adult human neocortical synapses
    Matthijs B Verhoog
    Department of Integrative Neurophysiology, VU University, 1081 HV, Amsterdam, The Netherlands, and Department of Neurosurgery, VU University Medical Center, Neuroscience Campus Amsterdam, 1081 HV, Amsterdam, The Netherlands
    J Neurosci 33:17197-208. 2013
  3. pmc Proteomics, ultrastructure, and physiology of hippocampal synapses in a fragile X syndrome mouse model reveal presynaptic phenotype
    Patricia Klemmer
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, 1081 HV Amsterdam, The Netherlands
    J Biol Chem 286:25495-504. 2011
  4. pmc Hyperconnectivity and slow synapses during early development of medial prefrontal cortex in a mouse model for mental retardation and autism
    Guilherme Testa-Silva
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, 1081 HV Amsterdam, The Netherlands
    Cereb Cortex 22:1333-42. 2012
  5. pmc High speed two-photon imaging of calcium dynamics in dendritic spines: consequences for spine calcium kinetics and buffer capacity
    L Niels Cornelisse
    Department of Experimental Neurophysiology, Centre for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 2:e1073. 2007
  6. pmc Layer-specific high-frequency action potential spiking in the prefrontal cortex of awake rats
    Zimbo S R M Boudewijns
    Department of Integrative Neurophysiology, Centre for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, Vrije Universiteit Amsterdam Amsterdam, Netherlands
    Front Cell Neurosci 7:99. 2013
  7. ncbi request reprint Distributed network actions by nicotine increase the threshold for spike-timing-dependent plasticity in prefrontal cortex
    Jonathan J Couey
    Department of Experimental Neurophysiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV, Amsterdam, The Netherlands
    Neuron 54:73-87. 2007
  8. ncbi request reprint Increased threshold for spike-timing-dependent plasticity is caused by unreliable calcium signaling in mice lacking fragile X gene FMR1
    Rhiannon M Meredith
    Department of Experimental Neurophysiology, Center for Neurogenomics and Cognitive Research, VU University Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands
    Neuron 54:627-38. 2007
  9. pmc STDP and Mental Retardation: Dysregulation of Dendritic Excitability in Fragile X Syndrome
    Rhiannon M Meredith
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam, Netherlands
    Front Synaptic Neurosci 2:10. 2010

Collaborators

Detail Information

Publications9

  1. doi request reprint Functional rescue of excitatory synaptic transmission in the developing hippocampus in Fmr1-KO mouse
    Rhiannon M Meredith
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, The Netherlands
    Neurobiol Dis 41:104-10. 2011
    ..These data support the role of mGluR antagonist treatment for functional synaptic correction at an early developmental stage in a model for fragile X syndrome...
  2. doi request reprint Mechanisms underlying the rules for associative plasticity at adult human neocortical synapses
    Matthijs B Verhoog
    Department of Integrative Neurophysiology, VU University, 1081 HV, Amsterdam, The Netherlands, and Department of Neurosurgery, VU University Medical Center, Neuroscience Campus Amsterdam, 1081 HV, Amsterdam, The Netherlands
    J Neurosci 33:17197-208. 2013
    ..These findings provide a synaptic basis for the timing rules observed in human sensory and motor plasticity in vivo, and offer insights into the physiological role of L-type voltage-gated Ca2+ channels in the human brain...
  3. pmc Proteomics, ultrastructure, and physiology of hippocampal synapses in a fragile X syndrome mouse model reveal presynaptic phenotype
    Patricia Klemmer
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, 1081 HV Amsterdam, The Netherlands
    J Biol Chem 286:25495-504. 2011
    ....
  4. pmc Hyperconnectivity and slow synapses during early development of medial prefrontal cortex in a mouse model for mental retardation and autism
    Guilherme Testa-Silva
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, 1081 HV Amsterdam, The Netherlands
    Cereb Cortex 22:1333-42. 2012
    ..However, the slow synaptic time constants induce decreased responsiveness to low-frequency stimulation, which may explain deficits in integration and early information processing in attentional neuronal networks in NDDs...
  5. pmc High speed two-photon imaging of calcium dynamics in dendritic spines: consequences for spine calcium kinetics and buffer capacity
    L Niels Cornelisse
    Department of Experimental Neurophysiology, Centre for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 2:e1073. 2007
    ..Simulations at zero calcium-dye conditions show that calmodulin is more efficiently activated in spines, which indicates that spine morphology and buffering conditions in neocortical spines favor synaptic plasticity...
  6. pmc Layer-specific high-frequency action potential spiking in the prefrontal cortex of awake rats
    Zimbo S R M Boudewijns
    Department of Integrative Neurophysiology, Centre for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, Vrije Universiteit Amsterdam Amsterdam, Netherlands
    Front Cell Neurosci 7:99. 2013
    ....
  7. ncbi request reprint Distributed network actions by nicotine increase the threshold for spike-timing-dependent plasticity in prefrontal cortex
    Jonathan J Couey
    Department of Experimental Neurophysiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV, Amsterdam, The Netherlands
    Neuron 54:73-87. 2007
    ..Thus, by activating nAChRs distributed throughout the PFC neuronal network, nicotine affects PFC information processing and storage by increasing the amount of postsynaptic activity necessary to induce STDP...
  8. ncbi request reprint Increased threshold for spike-timing-dependent plasticity is caused by unreliable calcium signaling in mice lacking fragile X gene FMR1
    Rhiannon M Meredith
    Department of Experimental Neurophysiology, Center for Neurogenomics and Cognitive Research, VU University Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands
    Neuron 54:627-38. 2007
    ..Our results show that mechanisms for synaptic plasticity are in place in the FMR1-KO mouse PFC, but require stronger neuronal activity to be triggered...
  9. pmc STDP and Mental Retardation: Dysregulation of Dendritic Excitability in Fragile X Syndrome
    Rhiannon M Meredith
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam, Netherlands
    Front Synaptic Neurosci 2:10. 2010
    ....