Huibert D Mansvelder

Summary

Affiliation: Center for Neurogenomics and Cognitive Research
Country: The Netherlands

Publications

  1. pmc Prelimbic and infralimbic prefrontal cortex interact during fast network oscillations
    Karlijn I van Aerde
    Center for Neurogenomics and Cognitive Research, Department of Integrative Neurophysiology, VU University Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 3:e2725. 2008
  2. pmc Human synapses show a wide temporal window for spike-timing-dependent plasticity
    Guilherme Testa-Silva
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, VU University Amsterdam, Netherlands
    Front Synaptic Neurosci 2:12. 2010
  3. pmc Layer-specific modulation of the prefrontal cortex by nicotinic acetylcholine receptors
    Rogier B Poorthuis
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, 1081HV Amsterdam, The Netherlands
    Cereb Cortex 23:148-61. 2013
  4. pmc GABAergic synapse properties may explain genetic variation in hippocampal network oscillations in mice
    Tim S Heistek
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam, Netherlands
    Front Cell Neurosci 4:18. 2010
  5. pmc Nicotine exposure during adolescence alters the rules for prefrontal cortical synaptic plasticity during adulthood
    Natalia A Goriounova
    Department of Integrative Neurophysiology, CNCR, Neuroscience Campus Amsterdam, VU University Amsterdam, Netherlands
    Front Synaptic Neurosci 4:3. 2012
  6. pmc Presynaptic ionotropic receptors controlling and modulating the rules for spike timing-dependent plasticity
    Matthijs B Verhoog
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam, Room C 440, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    Neural Plast 2011:870763. 2011
  7. pmc Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits
    Huibert D Mansvelder
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research CNCR, VU University Amsterdam, Amsterdam, The Netherlands
    Semin Cell Dev Biol 20:432-40. 2009
  8. doi request reprint Layer-specific interference with cholinergic signaling in the prefrontal cortex by smoking concentrations of nicotine
    Rogier B Poorthuis
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, Amsterdam, De Boelelaan 1085, 1081HV, The Netherlands
    J Neurosci 33:4843-53. 2013
  9. doi request reprint Nicotinic actions on neuronal networks for cognition: general principles and long-term consequences
    Rogier B Poorthuis
    Department of Integrative Neurophysiology, CNCR, Neuroscience Campus Amsterdam, VU University, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands
    Biochem Pharmacol 78:668-76. 2009
  10. doi request reprint Diacylglycerol lipase is not involved in depolarization-induced suppression of inhibition at unitary inhibitory connections in mouse hippocampus
    Rogier Min
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, 1081 HV Amsterdam, The Netherlands
    J Neurosci 30:2710-5. 2010

Collaborators

Detail Information

Publications54

  1. pmc Prelimbic and infralimbic prefrontal cortex interact during fast network oscillations
    Karlijn I van Aerde
    Center for Neurogenomics and Cognitive Research, Department of Integrative Neurophysiology, VU University Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 3:e2725. 2008
    ....
  2. pmc Human synapses show a wide temporal window for spike-timing-dependent plasticity
    Guilherme Testa-Silva
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, VU University Amsterdam, Netherlands
    Front Synaptic Neurosci 2:12. 2010
    ..The timing rules of STDP in human hippocampus, however, seem to differ from rodent hippocampus, and suggest a less strict interpretation of Hebb's predictions...
  3. pmc Layer-specific modulation of the prefrontal cortex by nicotinic acetylcholine receptors
    Rogier B Poorthuis
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, 1081HV Amsterdam, The Netherlands
    Cereb Cortex 23:148-61. 2013
    ..In LV and LVI, nAChR-induced activation of inhibitory and excitatory neurons results in a net augmentation of output neuron activity...
  4. pmc GABAergic synapse properties may explain genetic variation in hippocampal network oscillations in mice
    Tim S Heistek
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam, Netherlands
    Front Cell Neurosci 4:18. 2010
    ..These data indicate that differences in genetic background may result in different GABA(A)-receptor subunit expression, which affects the rhythm of pyramidal neuron firing and fast network activity through GABA synapse kinetics...
  5. pmc Nicotine exposure during adolescence alters the rules for prefrontal cortical synaptic plasticity during adulthood
    Natalia A Goriounova
    Department of Integrative Neurophysiology, CNCR, Neuroscience Campus Amsterdam, VU University Amsterdam, Netherlands
    Front Synaptic Neurosci 4:3. 2012
    ..Here, we review and discuss these recent findings...
  6. pmc Presynaptic ionotropic receptors controlling and modulating the rules for spike timing-dependent plasticity
    Matthijs B Verhoog
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam, Room C 440, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    Neural Plast 2011:870763. 2011
    ..Furthermore, we will discuss how interaction between different types of ionotropic receptors may create "timing" windows during which particular timing rules lead to synaptic changes...
  7. pmc Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits
    Huibert D Mansvelder
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research CNCR, VU University Amsterdam, Amsterdam, The Netherlands
    Semin Cell Dev Biol 20:432-40. 2009
    ..Understanding how nicotine induces long-term changes in synapses and alters plasticity in the cortico-limbic circuits is essential to determining how these areas interact in decoding fundamental aspects of cognition and reward...
  8. doi request reprint Layer-specific interference with cholinergic signaling in the prefrontal cortex by smoking concentrations of nicotine
    Rogier B Poorthuis
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, Amsterdam, De Boelelaan 1085, 1081HV, The Netherlands
    J Neurosci 33:4843-53. 2013
    ..These mechanisms may be one of the first steps leading up to the pathophysiological changes associated with nicotine exposure during adolescence...
  9. doi request reprint Nicotinic actions on neuronal networks for cognition: general principles and long-term consequences
    Rogier B Poorthuis
    Department of Integrative Neurophysiology, CNCR, Neuroscience Campus Amsterdam, VU University, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands
    Biochem Pharmacol 78:668-76. 2009
    ..Understanding how nicotine induces long-term changes in neuronal circuits and alters plasticity in the prefrontal cortex is essential to determining how these mechanisms interact to alter cognition...
  10. doi request reprint Diacylglycerol lipase is not involved in depolarization-induced suppression of inhibition at unitary inhibitory connections in mouse hippocampus
    Rogier Min
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, 1081 HV Amsterdam, The Netherlands
    J Neurosci 30:2710-5. 2010
    ..We show that all DAGL inhibitors tested block slow self-inhibition in neocortical interneurons, which involves DAGL. We conclude that DAGL is not involved in DSI at unitary connections in hippocampus...
  11. pmc Extracellular matrix plasticity and GABAergic inhibition of prefrontal cortex pyramidal cells facilitates relapse to heroin seeking
    Michel C van den Oever
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, VU University Amsterdam, The Netherlands
    Neuropsychopharmacology 35:2120-33. 2010
    ....
  12. ncbi request reprint Nicotinic acetylcholine receptor β2 subunits in the medial prefrontal cortex control attention
    Karine Guillem
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research CNCR, Neuroscience Campus Amsterdam, VU University, 1081 HV Amsterdam, Netherlands
    Science 333:888-91. 2011
    ..Our findings show that β2-subunit expression in the PrL PFC is sufficient for endogenous nAChR-mediated cholinergic regulation of attentional performance...
  13. pmc NMDA receptors induce somatodendritic secretion in hypothalamic neurones of lactating female rats
    Christiaan P J de Kock
    Department of Experimental Neurophysiology, CNCR, Vrije Universiteit Amsterdam, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
    J Physiol 561:53-64. 2004
    ..Thus, in the hypothalamus, local signalling back and forth between pre- and postsynaptic compartments and between different synapses may occur independently of the firing activity of the postsynaptic neurone...
  14. ncbi request reprint Distributed network actions by nicotine increase the threshold for spike-timing-dependent plasticity in prefrontal cortex
    Jonathan J Couey
    Department of Experimental Neurophysiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV, Amsterdam, The Netherlands
    Neuron 54:73-87. 2007
    ..Thus, by activating nAChRs distributed throughout the PFC neuronal network, nicotine affects PFC information processing and storage by increasing the amount of postsynaptic activity necessary to induce STDP...
  15. pmc Proteomics, ultrastructure, and physiology of hippocampal synapses in a fragile X syndrome mouse model reveal presynaptic phenotype
    Patricia Klemmer
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, 1081 HV Amsterdam, The Netherlands
    J Biol Chem 286:25495-504. 2011
    ....
  16. pmc Novel candidate genes associated with hippocampal oscillations
    Rick Jansen
    Department of Mathematics, VU University Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 6:e26586. 2011
    ..Furthermore, we showed that the amplitude of the hippocampal oscillations is genetically correlated with hippocampal volume and several measures of novel environment exploration...
  17. ncbi request reprint Increased threshold for spike-timing-dependent plasticity is caused by unreliable calcium signaling in mice lacking fragile X gene FMR1
    Rhiannon M Meredith
    Department of Experimental Neurophysiology, Center for Neurogenomics and Cognitive Research, VU University Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands
    Neuron 54:627-38. 2007
    ..Our results show that mechanisms for synaptic plasticity are in place in the FMR1-KO mouse PFC, but require stronger neuronal activity to be triggered...
  18. doi request reprint Prefrontal cortex AMPA receptor plasticity is crucial for cue-induced relapse to heroin-seeking
    Michel C van den Oever
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, VU University Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    Nat Neurosci 11:1053-8. 2008
    ..As reexposure to conditioned stimuli is a major cause for heroin relapse, inhibition of GluR2 endocytosis may provide a new target for the treatment of heroin addiction...
  19. pmc Nicotine exposure during adolescence leads to short- and long-term changes in spike timing-dependent plasticity in rat prefrontal cortex
    Natalia A Goriounova
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, Vrije Universiteit, 1081 HV Amsterdam, The Netherlands
    J Neurosci 32:10484-93. 2012
    ....
  20. doi request reprint Mechanisms underlying the rules for associative plasticity at adult human neocortical synapses
    Matthijs B Verhoog
    Department of Integrative Neurophysiology, VU University, 1081 HV, Amsterdam, The Netherlands, and Department of Neurosurgery, VU University Medical Center, Neuroscience Campus Amsterdam, 1081 HV, Amsterdam, The Netherlands
    J Neurosci 33:17197-208. 2013
    ..These findings provide a synaptic basis for the timing rules observed in human sensory and motor plasticity in vivo, and offer insights into the physiological role of L-type voltage-gated Ca2+ channels in the human brain...
  21. pmc Flexible spike timing of layer 5 neurons during dynamic beta oscillation shifts in rat prefrontal cortex
    Karlijn I van Aerde
    VU University Amsterdam, Center for Neurogenomics and Cognitive Research, Department of Integrative Neurophysiology, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands
    J Physiol 587:5177-96. 2009
    ..Thus, amplitude and frequency fluctuations within frequency bands may reflect activity in distinct cortical neuronal subnetworks that may process information in a parallel fashion...
  22. doi request reprint Fast network oscillations in vitro exhibit a slow decay of temporal auto-correlations
    Simon Shlomo Poil
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    Eur J Neurosci 34:394-403. 2011
    ....
  23. pmc Hyperconnectivity and slow synapses during early development of medial prefrontal cortex in a mouse model for mental retardation and autism
    Guilherme Testa-Silva
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, 1081 HV Amsterdam, The Netherlands
    Cereb Cortex 22:1333-42. 2012
    ..However, the slow synaptic time constants induce decreased responsiveness to low-frequency stimulation, which may explain deficits in integration and early information processing in attentional neuronal networks in NDDs...
  24. pmc External drive to inhibitory cells induces alternating episodes of high- and low-amplitude oscillations
    Oscar J Avella Gonzalez
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, VU University Amsterdam, Amsterdam, The Netherlands
    PLoS Comput Biol 8:e1002666. 2012
    ..Our results suggest that amplitude fluctuations are a general property of oscillatory neuronal networks that can arise through background input from areas external to the network...
  25. doi request reprint Retrieval-specific endocytosis of GluA2-AMPARs underlies adaptive reconsolidation of contextual fear
    Priyanka Rao-Ruiz
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Vrije Universiteit, Amsterdam, The Netherlands
    Nat Neurosci 14:1302-8. 2011
    ....
  26. ncbi request reprint Long-lasting nicotinic modulation of GABAergic synaptic transmission in the rat nucleus accumbens associated with behavioural sensitization to amphetamine
    Mischa De Rover
    Department of Experimental Neurophysiology, Institute for Neurosciences INW, Centre for Neurogenomics and Cognitive Research, Vrije Universiteit, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    Eur J Neurosci 19:2859-70. 2004
    ..This is a new mechanism by which drugs of abuse may induce alterations in the processing and integration of NAc inputs involved in psychomotor sensitization...
  27. ncbi request reprint Nicotinic modulation of neuronal networks: from receptors to cognition
    Huibert D Mansvelder
    Department of Experimental Neurophysiology, Center for Neurogenomics and Cognitive Research CNCR, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    Psychopharmacology (Berl) 184:292-305. 2006
    ....
  28. doi request reprint GABAergic inhibition shapes frequency adaptation of cortical activity in a frequency-dependent manner
    Tim S Heistek
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research CNCR, Neuroscience Campus Amsterdam, VU University, The Netherlands
    Brain Res 1321:31-9. 2010
    ..These findings suggest that GABAergic inhibition affects cortical excitation at different frequencies differentially, favoring facilitation at higher frequencies of excitation...
  29. pmc Short- and long-term consequences of nicotine exposure during adolescence for prefrontal cortex neuronal network function
    Natalia A Goriounova
    Department of Integrative Neurophysiology, CNCR, Neuroscience Campus Amsterdam, VU University, Amsterdam, The Netherlands
    Cold Spring Harb Perspect Med 2:a012120. 2012
    ..Here we provide an overview of these recent findings...
  30. doi request reprint Lasting synaptic changes underlie attention deficits caused by nicotine exposure during adolescence
    Danielle S Counotte
    Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, VU University, Amsterdam, The Netherlands
    Nat Neurosci 14:417-9. 2011
    ..Restoring mGluR2 activity in vivo by local infusion of a group II mGluR agonist in adult rats that received nicotine as adolescents rescued attentional disturbances...
  31. doi request reprint Inbred mouse strains differ in multiple hippocampal activity traits
    R Jansen
    Department of Mathematics, VU University Amsterdam, Amsterdam, The Netherlands
    Eur J Neurosci 30:1092-100. 2009
    ..Our findings show that several traits of hippocampal gamma oscillations and spontaneous activity are heritable and could thus be potentially useful in gene-finding strategies based on endophenotypes...
  32. ncbi request reprint Somatodendritic secretion in oxytocin neurons is upregulated during the female reproductive cycle
    Christiaan P J de Kock
    Department of Experimental Neurophysiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, The Netherlands
    J Neurosci 23:2726-34. 2003
    ..These results demonstrate that somatodendritic release is augmented during lactation, which is a novel form of plasticity to change the strength of synaptic transmission...
  33. pmc Adolescent nicotine exposure transiently increases high-affinity nicotinic receptors and modulates inhibitory synaptic transmission in rat medial prefrontal cortex
    Danielle S Counotte
    Department of Molecular and Cellular Neurobiology, Vrije Universiteit Medical Center, Neuroscience Campus, 1081 HV Amsterdam, The Netherlands
    FASEB J 26:1810-20. 2012
    ..Together, this suggests that these receptors play a role in mediating the acute rewarding effects of nicotine and may underlie the increased sensitivity of adolescents to nicotine...
  34. pmc Ventromedial prefrontal cortex pyramidal cells have a temporal dynamic role in recall and extinction of cocaine-associated memory
    Michel C van den Oever
    Departments of Molecular and Cellular Neurobiology and Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam, 1081 HV, The Netherlands, Department Bioengineering, Stanford University School of Medicine, Stanford, California 94305, Departments of Psychiatry and Cell Biology and Physiology, UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599
    J Neurosci 33:18225-33. 2013
    ....
  35. pmc Critical-state dynamics of avalanches and oscillations jointly emerge from balanced excitation/inhibition in neuronal networks
    Simon Shlomo Poil
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, 1081 HV Amsterdam, The Netherlands
    J Neurosci 32:9817-23. 2012
    ..Based on our network model, we introduce a concept of multi-level criticality in which power-law scaling can emerge on multiple time scales in oscillating networks...
  36. pmc High speed two-photon imaging of calcium dynamics in dendritic spines: consequences for spine calcium kinetics and buffer capacity
    L Niels Cornelisse
    Department of Experimental Neurophysiology, Centre for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 2:e1073. 2007
    ..Simulations at zero calcium-dye conditions show that calmodulin is more efficiently activated in spines, which indicates that spine morphology and buffering conditions in neocortical spines favor synaptic plasticity...
  37. pmc α2-containing GABAA receptors expressed in hippocampal region CA3 control fast network oscillations
    Tim S Heistek
    Department of Integrative Neurophysiology, CNCR, Neuroscience Campus Amsterdam, VU University, Amsterdam, The Netherlands
    J Physiol 591:845-58. 2013
    ..These findings suggest that α2-containing GABA(A) receptors expressed in the CA3 region provide the inhibition that controls hippocampal rhythm during cholinergically induced oscillations...
  38. doi request reprint Functional rescue of excitatory synaptic transmission in the developing hippocampus in Fmr1-KO mouse
    Rhiannon M Meredith
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, The Netherlands
    Neurobiol Dis 41:104-10. 2011
    ..These data support the role of mGluR antagonist treatment for functional synaptic correction at an early developmental stage in a model for fragile X syndrome...
  39. ncbi request reprint Cholinergic modulation of dopaminergic reward areas: upstream and downstream targets of nicotine addiction
    Huibert D Mansvelder
    Department of Experimental Neurophysiology, Institute for Neurosciences and Centre for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, De Boelelaan 1087, 1081 HV, Amsterdam, The Netherlands
    Eur J Pharmacol 480:117-23. 2003
    ..Thus, synaptic mechanisms both upstream and downstream of dopamine release are potentially important factors contributing to the etiology of nicotine addiction...
  40. ncbi request reprint Inter-Network Interactions: Impact of Connections between Oscillatory Neuronal Networks on Oscillation Frequency and Pattern
    Oscar J Avella Gonzalez
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, VU University Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 9:e100899. 2014
    ..Together, our results suggest that input from other oscillating networks may markedly alter a network's frequency spectrum and may partly be responsible for the rich repertoire of temporal oscillation patterns observed in the brain. ..
  41. doi request reprint Nicotinic acetylcholine receptors controlling attention: behavior, circuits and sensitivity to disruption by nicotine
    Rogier B Poorthuis
    Department of Integrative Neurophysiology, CNCR, Neuroscience Campus Amsterdam, VU University, Amsterdam, The Netherlands
    Biochem Pharmacol 86:1089-98. 2013
    ..In the long-term exposure to nicotine during adolescence leads to maladaptive adaptations of the PFC circuitry, which ultimately leads to a decrement in attention performance, again emphasizing the importance of nAChRs in attention. ..
  42. pmc Short term depression unmasks the ghost frequency
    Tjeerd V Olde Scheper
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e50189. 2012
    ..Our model of STP gives important insights into the potential roles of STP in self-regulation of cortical activity and long-range afferent input in neuronal microcircuits...
  43. pmc Detrended fluctuation analysis: a scale-free view on neuronal oscillations
    Richard Hardstone
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam Amsterdam, Netherlands
    Front Physiol 3:450. 2012
    ....
  44. doi request reprint Megalencephalic leucoencephalopathy with cysts: defect in chloride currents and cell volume regulation
    Margreet C Ridder
    Department of Child Neurology, VU University Medical Center, 1081 HV Amsterdam, The Netherlands
    Brain 134:3342-54. 2011
    ....
  45. pmc C-terminal interactors of the AMPA receptor auxiliary subunit Shisa9
    Anna R Karataeva
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, Vrije Universiteit University, Amsterdam, The Netherlands
    PLoS ONE 9:e87360. 2014
    ..Taken together, our data identifies novel interaction partners of Shisa9, and shows that the C-terminal interactions of Shisa9 through its PDZ domain interaction motif are important for AMPA receptor synaptic and network functions. ..
  46. pmc Competitive dynamics during resource-driven neurite outgrowth
    J J Johannes Hjorth
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, VU University Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 9:e86741. 2014
    ..Our findings point to the need to test the model predictions and to determine, by monitoring tubulin concentrations in outgrowing neurons, whether tubulin is the resource for which neurites compete. ..
  47. pmc Independently outgrowing neurons and geometry-based synapse formation produce networks with realistic synaptic connectivity
    Arjen Van Ooyen
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, VU University Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 9:e85858. 2014
    ..Together, our results suggest that baseline synaptic connectivity in local cortical circuits may largely result from accidentally overlapping axonal and dendritic branches of independently outgrowing neurons. ..
  48. doi request reprint Scale-free modulation of resting-state neuronal oscillations reflects prolonged brain maturation in humans
    Dirk J A Smit
    Department of Biological Psychology, VU University Amsterdam, 1081 BT Amsterdam, The Netherlands
    J Neurosci 31:13128-36. 2011
    ....
  49. pmc Label-free live brain imaging and targeted patching with third-harmonic generation microscopy
    Stefan Witte
    Biophysics Group, Institute for Lasers, Life, and Biophotonics Amsterdam, VU University, De Boelelaan 1081, 1081 HV, Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 108:5970-5. 2011
    ..This work is a major step towards label-free microscopic live brain imaging, and opens up possibilities for the development of laser-guided microsurgery techniques in the living brain...
  50. pmc Cholinergic modulation of the medial prefrontal cortex: the role of nicotinic receptors in attention and regulation of neuronal activity
    Bernard Bloem
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, Vrije Universiteit Amsterdam, Netherlands McGovern Institute for Brain Research, Massachusetts Institute of Technology Cambridge, MA, USA
    Front Neural Circuits 8:17. 2014
    ..Finally, we will review limitations of the existing studies and address how innovative technologies might push the field forward in order to gain understanding into the relation between ACh, neuronal activity and behavior. ..
  51. pmc Layer-specific high-frequency action potential spiking in the prefrontal cortex of awake rats
    Zimbo S R M Boudewijns
    Department of Integrative Neurophysiology, Centre for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, Vrije Universiteit Amsterdam Amsterdam, Netherlands
    Front Cell Neurosci 7:99. 2013
    ....
  52. pmc Short-coherence off-axis holographic phase microscopy of live cell dynamics
    Stefan Witte
    These authors contributed equally to this work LaserLaB, VU University Amsterdam, De Boelelaan 1081, 1081 HV Amsterdam, The Netherlands
    Biomed Opt Express 3:2184-9. 2012
    ..We perform phase imaging of HEK293 cells, to study the dynamics of cell volume regulation in response to an osmotic shock...
  53. ncbi request reprint Cellular and synaptic mechanisms of nicotine addiction
    Huibert D Mansvelder
    Vrije Universiteit Amsterdam, Faculty of Earth and Life Sciences, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands
    J Neurobiol 53:606-17. 2002
    ..Assessing the relative importance of these molecular phenomena in the behavioral effects of nicotine presents an exciting challenge for future research efforts...
  54. pmc STDP and Mental Retardation: Dysregulation of Dendritic Excitability in Fragile X Syndrome
    Rhiannon M Meredith
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam, Netherlands
    Front Synaptic Neurosci 2:10. 2010
    ....