J W Mouton

Summary

Affiliation: Canisius Wilhelmina Hospital
Country: The Netherlands

Publications

  1. pmc Concentration-effect relationship of ceftazidime explains why the time above the MIC is 40 percent for a static effect in vivo
    Johan W Mouton
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Ziekenhuis Nijmegen, Weg door Jonkerbos 100, 6532 SZ Nijmegen, The Netherlands
    Antimicrob Agents Chemother 51:3449-51. 2007
  2. ncbi Breakpoints: current practice and future perspectives
    Johan W Mouton
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Weg door Jonkerbos 100, 6532 SZ, Nijmegen, The Netherlands
    Int J Antimicrob Agents 19:323-31. 2002
  3. ncbi A retrospective analysis using Monte Carlo simulation to evaluate recommended ceftazidime dosing regimens in healthy volunteers, patients with cystic fibrosis, and patients in the intensive care unit
    Johan W Mouton
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Ziekenhuis, Nijmegen, The Netherlands
    Clin Ther 27:762-72. 2005
  4. ncbi Relationship between minimum inhibitory concentration and stationary concentration revisited: growth rates and minimum bactericidal concentrations
    Johan W Mouton
    Clin Pharmacokinet 44:767-8. 2005
  5. ncbi Pharmacodynamics of tobramycin in patients with cystic fibrosis
    Johan W Mouton
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Ziekenhuis Nijmegen, 6532 SZ Nijmegen, The Netherlands
    Diagn Microbiol Infect Dis 52:123-7. 2005
  6. pmc A multi-center blinded study on the efficiency of phenotypic screening methods to detect glycopeptide intermediately susceptible Staphylococcus aureus (GISA) and heterogeneous GISA (h-GISA)
    Andreas Voss
    Radboud University Nijmegen Medical Centre, Nijmegen University Centre of Infectious Diseases, The Netherlands
    Ann Clin Microbiol Antimicrob 6:9. 2007
  7. ncbi Comparative pharmacokinetics of the carbapenems: clinical implications
    J W Mouton
    Department of Medical Microbiology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    Clin Pharmacokinet 39:185-201. 2000
  8. pmc Pharmacokinetics of itraconazole and hydroxyitraconazole in healthy subjects after single and multiple doses of a novel formulation
    J W Mouton
    Canisius Wilhelmina Ziekenhuis Nijmegen, Nijmegen, The Netherlands
    Antimicrob Agents Chemother 50:4096-102. 2006
  9. ncbi Impact of pharmacodynamics on breakpoint selection for susceptibility testing
    Johan W Mouton
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Weg door Jonkerbos 100, 6532 SZ Nijmegen, The Netherlands
    Infect Dis Clin North Am 17:579-98. 2003
  10. ncbi The DUEL study: a multi-center in vitro evaluation of linezolid compared with other antibiotics in the Netherlands
    J W Mouton
    Department of Medical Microbiology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    Clin Microbiol Infect 7:486-91. 2001

Detail Information

Publications93

  1. pmc Concentration-effect relationship of ceftazidime explains why the time above the MIC is 40 percent for a static effect in vivo
    Johan W Mouton
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Ziekenhuis Nijmegen, Weg door Jonkerbos 100, 6532 SZ Nijmegen, The Netherlands
    Antimicrob Agents Chemother 51:3449-51. 2007
    ..The parameter estimates obtained in vitro predicted a time above the MIC of between 35 and 38% for a static effect in mice after 24 h of treatment...
  2. ncbi Breakpoints: current practice and future perspectives
    Johan W Mouton
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Weg door Jonkerbos 100, 6532 SZ, Nijmegen, The Netherlands
    Int J Antimicrob Agents 19:323-31. 2002
    ....
  3. ncbi A retrospective analysis using Monte Carlo simulation to evaluate recommended ceftazidime dosing regimens in healthy volunteers, patients with cystic fibrosis, and patients in the intensive care unit
    Johan W Mouton
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Ziekenhuis, Nijmegen, The Netherlands
    Clin Ther 27:762-72. 2005
    ..Most predictions to date have used data from healthy volunteers...
  4. ncbi Relationship between minimum inhibitory concentration and stationary concentration revisited: growth rates and minimum bactericidal concentrations
    Johan W Mouton
    Clin Pharmacokinet 44:767-8. 2005
  5. ncbi Pharmacodynamics of tobramycin in patients with cystic fibrosis
    Johan W Mouton
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Ziekenhuis Nijmegen, 6532 SZ Nijmegen, The Netherlands
    Diagn Microbiol Infect Dis 52:123-7. 2005
    ..This study demonstrates the applicability of pharmacodynamic relationships in determining efficacy of antimicrobial therapy, by demonstrating a strong PI-effect relationship in a group of only 13 patients...
  6. pmc A multi-center blinded study on the efficiency of phenotypic screening methods to detect glycopeptide intermediately susceptible Staphylococcus aureus (GISA) and heterogeneous GISA (h-GISA)
    Andreas Voss
    Radboud University Nijmegen Medical Centre, Nijmegen University Centre of Infectious Diseases, The Netherlands
    Ann Clin Microbiol Antimicrob 6:9. 2007
    ..To determine the true incidence of hGISA/GISA and its consequent clinical impact, methods must be defined that will reliably and reproducibly discriminate these resistant phenotypes from vancomycin susceptible S. aureus (VSSA)...
  7. ncbi Comparative pharmacokinetics of the carbapenems: clinical implications
    J W Mouton
    Department of Medical Microbiology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    Clin Pharmacokinet 39:185-201. 2000
    ..The availability of oral carbapenems will have a profound effect on the use of carbapenems in the community...
  8. pmc Pharmacokinetics of itraconazole and hydroxyitraconazole in healthy subjects after single and multiple doses of a novel formulation
    J W Mouton
    Canisius Wilhelmina Ziekenhuis Nijmegen, Nijmegen, The Netherlands
    Antimicrob Agents Chemother 50:4096-102. 2006
    ..NCF may provide an alternative to the HPBCD solution for the further optimization of antifungal treatment with itraconazole...
  9. ncbi Impact of pharmacodynamics on breakpoint selection for susceptibility testing
    Johan W Mouton
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Weg door Jonkerbos 100, 6532 SZ Nijmegen, The Netherlands
    Infect Dis Clin North Am 17:579-98. 2003
    ..Because dose-effect relationships have now been reasonably well established for most drugs, these should now be used to reappraise current clinical breakpoints...
  10. ncbi The DUEL study: a multi-center in vitro evaluation of linezolid compared with other antibiotics in the Netherlands
    J W Mouton
    Department of Medical Microbiology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    Clin Microbiol Infect 7:486-91. 2001
    ..To evaluate bacterial susceptibility to linezolid in the Netherlands in comparison with other antibiotics...
  11. ncbi Tubal factor pathology caused by Chlamydia trachomatis: the role of serology
    J W Mouton
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    Int J STD AIDS 13:26-9. 2002
    ..trachomatis, and will contribute in simplifying the work-up in patients with infertility...
  12. ncbi Continuous infusion of beta-lactams
    Johan W Mouton
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    Curr Opin Crit Care 13:598-606. 2007
    ..Continuous infusion of beta-lactam antibiotics is becoming increasingly popular. The background and current clinical evidence are discussed. Tools to apply continuous infusion are analyzed...
  13. ncbi Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs
    Johan W Mouton
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Weg door Jonkerbos 100, 6532 SZ Nijmegen, The Netherlands
    Int J Antimicrob Agents 19:355-8. 2002
    ..The appropriate definition and use of these parameters is a matter of controversy. This paper contains a proposal to use PK/PD expressions for antimicrobial agents and their units in a uniform manner...
  14. doi Dose-response relationships of three amphotericin B formulations in a non-neutropenic murine model of invasive aspergillosis
    J W Mouton
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Ziekenhuis Nijmegen, Nijmegen, The Netherlands
    Med Mycol 47:802-7. 2009
    ..This study shows that AmBi and ABLC were significantly more efficacious than AmB in a non-neutropenic murine model of invasive aspergillosis, and that the effect observed was primarily dependent on the first dose administered...
  15. pmc Use of Monte Carlo simulations to select therapeutic doses and provisional breakpoints of BAL9141
    Johan W Mouton
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    Antimicrob Agents Chemother 48:1713-8. 2004
    ..The corresponding provisional breakpoint is S (susceptible) </= 4 mg/liter...
  16. ncbi Tissue concentrations: do we ever learn?
    Johan W Mouton
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Ziekenhuis, Nijmegen, The Netherlands
    J Antimicrob Chemother 61:235-7. 2008
    ..This way of presenting data with the derived conclusions is often misleading and may ultimately be harmful in patient care...
  17. ncbi Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs: an update
    Johan W Mouton
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Weg door Jonkerbos 100, 6532 SZ Nijmegen, The Netherlands
    J Antimicrob Chemother 55:601-7. 2005
    ..This paper describes in a uniform manner the use of PK/PD expressions for antimicrobial agents, and their units...
  18. ncbi Pharmacokinetic/pharmacodynamic modelling of antibacterials in vitro and in vivo using bacterial growth and kill kinetics: the minimum inhibitory concentration versus stationary concentration
    Johan W Mouton
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    Clin Pharmacokinet 44:201-10. 2005
    ..It does not represent the dynamic effect of the antimicrobial at any point in time, but rather the total antimicrobial effect over the incubation period at a fixed concentration...
  19. pmc Use of pharmacodynamic indices to predict efficacy of combination therapy in vivo
    J W Mouton
    Erasmus University Rotterdam, Rotterdam, The Netherlands
    Antimicrob Agents Chemother 43:2473-8. 1999
    ..When given in combination, there appears to be a degree of synergism independent of the dosing regimen applied...
  20. pmc In vitro interactions between amphotericin B, itraconazole, and flucytosine against 21 clinical Aspergillus isolates determined by two drug interaction models
    D T A Te Dorsthorst
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Weg door Jonkerbos 100, 6532 SZ Nijmegen, The Netherlands
    Antimicrob Agents Chemother 48:2007-13. 2004
    ..However, the correlation of these results with clinical outcome remains difficult and needs to be further investigated...
  21. ncbi Bioavailability of ciprofloxacin after multiple enteral and intravenous doses in ICU patients with severe gram-negative intra-abdominal infections
    S de Marie
    Erasmus University Medical Center, Rotterdam Dijkzigt Hospital, Department of Medical Microbiology and Infectious Diseases, Rotterdam, The Netherlands
    Intensive Care Med 24:343-6. 1998
    ..Few data are available on the pharmacokinetics of multiple enteral dosing of ciprofloxacin in critically ill intensive care patients and none for those with severe gram-negative intra-abdominal infections (GNIAI)...
  22. pmc Effect of pH on the in vitro activities of amphotericin B, itraconazole, and flucytosine against Aspergillus isolates
    D T A Te Dorsthorst
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    Antimicrob Agents Chemother 48:3147-50. 2004
    ..0 than at pH 7.0. The poor correlation between in vitro results and clinical outcome could be due to a difference in pH between the in vitro susceptibility test and at the site of infection...
  23. pmc Detection of Chlamydia trachomatis in male and female urine specimens by using the amplified Chlamydia trachomatis test
    J W Mouton
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Hospital Rotterdam, The Netherlands
    J Clin Microbiol 35:1369-72. 1997
    ..4, 99.0, 86.1, and 95.4%, respectively, for samples from males. We conclude that the AMP-CT test is a fast and reliable test for the detection of C. trachomatis in urine specimens from females and, in particular, males...
  24. ncbi Pharmacokinetics of sequential intravenous and enteral fluconazole in critically ill surgical patients with invasive mycoses and compromised gastro-intestinal function
    S L Buijk
    Department of Surgical Intensive Care, Erasmus University Medical Center, Rotterdam, The Netherlands
    Intensive Care Med 27:115-21. 2001
    ..3) To determine if enteral administration of fluconazole, which has an important pharmaco-economic advantage, is justified in this specific patient group...
  25. pmc Colorimetric assay for antifungal susceptibility testing of Aspergillus species
    J Meletiadis
    Department of Medical Microbiology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Clin Microbiol 39:3402-8. 2001
    ..Under these settings, the formazan production correlated linearly with the fungal biomass and less-variable concentration effect curves for amphotericin B and itraconazole were obtained...
  26. pmc Comparison of fractional inhibitory concentration index with response surface modeling for characterization of in vitro interaction of antifungals against itraconazole-susceptible and -resistant Aspergillus fumigatus isolates
    D T A Te Dorsthorst
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    Antimicrob Agents Chemother 46:702-7. 2002
    ..The use of response surface modeling to determine the interaction of drugs against filamentous fungi is promising, and more consistent results are obtained by this method than by using FIC indices...
  27. pmc Relationship between in vitro activities of amphotericin B and flucytosine and pH for clinical yeast and mold isolates
    D T A Te Dorsthorst
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Weg door Jonkerbos 100, 6532 SZ Nijmegen, The Netherlands
    Antimicrob Agents Chemother 49:3341-6. 2005
    ..125 to 1,024 microg/ml at pH 7.0 and from 0.02 to 4 microg/ml at pH 5.0. For Rhizopus spp. and S. prolificans, the relationship could not be determined, since the MIC was >1,024 microg/ml over a pH range of 4.0 to 7.9...
  28. pmc Comparison of NCCLS and 3-(4,5-dimethyl-2-Thiazyl)-2, 5-diphenyl-2H-tetrazolium bromide (MTT) methods of in vitro susceptibility testing of filamentous fungi and development of a new simplified method
    J Meletiadis
    Departments of Medical Microbiology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Clin Microbiol 38:2949-54. 2000
    ..Furthermore, the new assay was easier to perform and more sensitive than the MTT method...
  29. pmc In vitro interaction of flucytosine combined with amphotericin B or fluconazole against thirty-five yeast isolates determined by both the fractional inhibitory concentration index and the response surface approach
    D T A Te Dorsthorst
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    Antimicrob Agents Chemother 46:2982-9. 2002
    ..Response surface approach is an alternative method for determining the interaction between antifungal agents. By using this approach, some of the problems encountered with the FIC were overcome...
  30. pmc Efficacy and pharmacodynamics of flucytosine monotherapy in a nonneutropenic murine model of invasive aspergillosis
    D T A Te Dorsthorst
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    Antimicrob Agents Chemother 49:4220-6. 2005
    ..86). We conclude that 5FC monotherapy is efficacious in a murine Aspergillus fumigatus infection model...
  31. pmc In vivo efficacy of trovafloxacin against Bacteroides fragilis in mixed infection with either Escherichia coli or a vancomycin-resistant strain of Enterococcus faecium in an established-abscess murine model
    L E Stearne
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Antimicrob Agents Chemother 45:1394-401. 2001
    ..In addition, we have shown for the first time that a decrease in bacterial numbers also leads to a reduction in both abscess weight and inflammation...
  32. pmc Comparative in vitro activities of trovafloxacin (CP-99,219) against 445 gram-positive isolates from patients with endocarditis and those with other bloodstream infections
    H P Endtz
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands
    Antimicrob Agents Chemother 41:1146-9. 1997
    ..Further experimental and in vivo studies are warranted to evaluate the efficacy of trovafloxacin in the treatment of bacterial endocarditis and other infections caused by gram-positive organisms...
  33. pmc Analysis of growth characteristics of filamentous fungi in different nutrient media
    J Meletiadis
    Department of Medical Microbiology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Clin Microbiol 39:478-84. 2001
    ..In conclusion, the growth curves provide a useful tool to gain insight into the growth characteristics of filamentous fungi in different nutrient media and may help to optimize the methodology for antifungal susceptibility testing...
  34. pmc Comparison of three commercially available amplification assays, AMP CT, LCx, and COBAS AMPLICOR, for detection of Chlamydia trachomatis in first-void urine
    W H Goessens
    Department of Medical Microbiology and Infectious Diseases, University Hospital Rotterdam, The Netherlands
    J Clin Microbiol 35:2628-33. 1997
    ..By application of this new gold standard, existing differences between methods are highlighted; future evaluations of new techniques should be validated against two or more amplification assays...
  35. doi Concentration-dependency of beta-lactam-induced filament formation in Gram-negative bacteria
    J Buijs
    Department of Medical Microbiology and Infectious Diseases, Atrium Medical Centre, Heerlen, The Netherlands
    Clin Microbiol Infect 14:344-9. 2008
    ..Interestingly, ESBL-producing isolates were not protected against filament induction. The induction of filament production may lead to additional risks during empirical treatment of severe infections...
  36. ncbi Sensitivity and specificity of three new commercially available Chlamydia trachomatis tests
    R P Verkooyen
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands
    Int J STD AIDS 13:23-5. 2002
    ..We conclude that the new synthetic peptide-based EIA tests are able to detect species-specific Ct antibodies, which are strongly correlated to (active) infection...
  37. pmc Comparison of spectrophotometric and visual readings of NCCLS method and evaluation of a colorimetric method based on reduction of a soluble tetrazolium salt, 2,3-bis [2-methoxy-4-nitro-5-[(sulfenylamino) carbonyl]-2H-tetrazolium-hydroxide], for antifunga
    J Meletiadis
    Department of Medical Microbiology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Clin Microbiol 39:4256-63. 2001
    ..The XTT method and spectrophotometric readings can increase the sensitivity and the precision, respectively, of in vitro susceptibility testing of Aspergillus species...
  38. pmc Pharmacokinetic-pharmacodynamic modeling of activity of ceftazidime during continuous and intermittent infusion
    J W Mouton
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Hospital Rotterdam, The Netherlands
    Antimicrob Agents Chemother 41:733-8. 1997
    ..Application of these models will eventually provide us with parameters which can be used for further dosage optimization...
  39. doi Prevalence and molecular mechanism of macrolide resistance in beta-haemolytic streptococci in The Netherlands
    C C Van Leer Buter
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Antimicrob Agents 35:590-2. 2010
    ..4%). Eighty-eight percent of resistance was mediated by erm(A) and erm(B) genes. Macrolide resistance in beta-haemolytic streptococci in The Netherlands is low, but increasing macrolide resistance was observed in group B streptococci...
  40. pmc Comparison of pharmacodynamics of azithromycin and erythromycin in vitro and in vivo
    J G den Hollander
    Department of Medical Microbiology and Infectious Diseases, University Hospital, Rotterdam, The Netherlands
    Antimicrob Agents Chemother 42:377-82. 1998
    ..It is concluded that the results in terms of predictive pharmacodynamic parameters are comparable for the in vitro and in vivo models and that high initial concentrations of azithromycin favor a good outcome...
  41. ncbi Role of ceftazidime dose regimen on the selection of resistant Enterobacter cloacae in the intestinal flora of rats treated for an experimental pulmonary infection
    W H F Goessens
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Antimicrob Chemother 59:507-16. 2007
    ....
  42. ncbi Pathophysiology of in-vitro induced filaments, spheroplasts and rod-shaped bacteria in neutropenic mice
    J Buijs
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    Clin Microbiol Infect 12:1105-11. 2006
    ..There was a clear intra-individual relationship between local endotoxin, systemic endotoxin, TNF-alpha and IL-6 production, but these parameters did not differ among groups...
  43. doi Serum concentrations of cefotaxime and its metabolite desacetyl-cefotaxime in infants and children during continuous infusion
    R A Bertels
    Department of Pediatrics, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    Infection 36:415-20. 2008
    ..However, few data exist on pharmacokinetics of cefotaxime and its metabolite in infants and children. As part of a quality assessment program, concentrations of cefotaxime and its metabolite desacetyl-cefotaxime were examined...
  44. pmc Patient-to-patient spread of a single strain of Corynebacterium striatum causing infections in a surgical intensive care unit
    A H Brandenburg
    Department of Medical Microbiology, University Hospital Rotterdam, The Netherlands
    J Clin Microbiol 34:2089-94. 1996
    ..We conclude that C. striatum can cause serious nosocomial infections in surgical intensive care unit patients and may spread from patient to patient via the hands of attending personnel...
  45. ncbi Tobramycin population pharmacokinetics in neonates
    M de Hoog
    Department of Pediatrics, Erasmus University, Rotterdam, The Netherlands
    Clin Pharmacol Ther 62:392-9. 1997
    ..To establish a tobramycin dosing schedule for neonates of various gestational ages...
  46. ncbi [An outbreak of psittacosis at a bird-fanciers fair in the Netherlands]
    Y Berk
    Canisius Wilhelmina Ziekenhuis, Nijmegen
    Ned Tijdschr Geneeskd 152:1889-92. 2008
    ..The clinical picture ranges from asymptomatic or mild, flue-like symptoms to severe illness. A timely diagnosis is necessary for successful outbreak management. The realtime PCR is an adequate test in that respect...
  47. ncbi Pharmacokinetics of ceftazidime in serum and peritoneal exudate during continuous versus intermittent administration to patients with severe intra-abdominal infections
    S L C E Buijk
    Department of Surgical Intensive Care, Erasmus University Medical Centre, Rotterdam, The Netherlands
    J Antimicrob Chemother 49:121-8. 2002
    ..60% of the concomitant serum AUCs. In critically ill surgical patients with severe IAIs, CI of ceftazidime resulted in more favourable concentrations in serum and peritoneal exudate than 8-hourly bolus infusion...
  48. pmc Ciprofloxacin in polyethylene glycol-coated liposomes: efficacy in rat models of acute or chronic Pseudomonas aeruginosa infection
    Irma A J M Bakker-Woudenberg
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Antimicrob Agents Chemother 46:2575-81. 2002
    ..Complete bacterial eradication is never observed...
  49. pmc Molecular detection of the macrolide efflux gene: to discriminate or not to discriminate between mef(A) and mef(E)
    Corne H W Klaassen
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen 6532 SZ, The Netherlands
    Antimicrob Agents Chemother 49:1271-8. 2005
  50. ncbi Vancomycin: pharmacokinetics and administration regimens in neonates
    Matthijs de Hoog
    Department of Pediatrics, Erasmus Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
    Clin Pharmacokinet 43:417-40. 2004
    ..Patients with renal failure and other special subpopulations, such as patients exposed to ECMO or indomethacin, need to be monitored more closely...
  51. doi Decreased ciprofloxacin susceptibility in Salmonella Typhi and Paratyphi infections in ill-returned travellers: the impact on clinical outcome and future treatment options
    R J Hassing
    Department of Internal Medicine and Infectious Diseases, Erasmus Medical Centre, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Clin Microbiol Infect Dis 32:1295-301. 2013
    ..We demonstrated that, in some cases, an adequate ƒAUC(0-24)/MIC ratio could be achieved by increasing the dose of ciprofloxacin or by the use of alternative fluoroquinolones...
  52. pmc Improved efficacy of ciprofloxacin administered in polyethylene glycol-coated liposomes for treatment of Klebsiella pneumoniae pneumonia in rats
    I A Bakker-Woudenberg
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, 3000 DR Rotterdam, The Netherlands
    Antimicrob Agents Chemother 45:1487-92. 2001
    ..PEG-coated liposomal ciprofloxacin was well tolerated in relatively high doses, permitting once daily administration with relatively low ciprofloxacin clearance and without compromising therapeutic efficacy...
  53. pmc Effect of dosing and dosing frequency on the efficacy of ceftizoxime and the emergence of ceftizoxime resistance during the early development of murine abscesses caused by Bacteroides fragilis and Enterobacter cloacae mixed infection
    Lorna E T Stearne
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, 6500 GS, Nijmegen, The Netherlands
    Antimicrob Agents Chemother 51:3605-11. 2007
    ..cloacae mutants. An fAUC-to-MIC ratio of 1,000 was needed to prevent the emergence of this resistance...
  54. ncbi Continuous administration of PBP-2- and PBP-3-specific beta-lactams causes higher cytokine responses in murine Pseudomonas aeruginosa and Escherichia coli sepsis
    Jacqueline Buijs
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    J Antimicrob Chemother 59:926-33. 2007
    ..PBP-2-specific antibiotics induce spheroplasts, again associated with low endotoxin release. We hypothesized that antibiotic type, concentration and regimen influence bacterial morphology, endotoxin levels and inflammatory response...
  55. pmc Effect of treatment duration on pharmacokinetic/pharmacodynamic indices correlating with therapeutic efficacy of ceftazidime in experimental Klebsiella pneumoniae lung infection
    Irma A J M Bakker-Woudenberg
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Antimicrob Agents Chemother 50:2919-25. 2006
    ..The effect of long-term treatment should be studied more extensively in other models of infection...
  56. ncbi Antifungal susceptibility patterns of opportunistic fungi in the genera verruconis and ochroconis
    S Seyedmousavi
    Department of Medical Microbiology, Radboudumc, Nijmegen, The Netherlands Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Sari, Iran
    Antimicrob Agents Chemother 58:3285-92. 2014
    ..Echinocandins and POS showed the greatest in vitro activity, providing possible treatment options for Ochroconis and Verruconis infections. ..
  57. ncbi In-vitro susceptibility and molecular characterisation of macrolide resistance mechanisms among Streptococcus pneumonia isolates in The Netherlands: the DUEL 2 study
    C Neeleman
    Department of Intensive Care, University Hospital St Radboud, Nijmegen, The Netherlands
    Clin Microbiol Infect 11:312-8. 2005
    ..Among the 19 mef-positive isolates, 14 (73.7%) carried the mef(A) gene, and only five (26.3%) carried the mef(E) gene. No linezolid cross-resistance or multiresistance (resistance to more than two classes of antibiotics) was observed...
  58. pmc Efficacy of posaconazole against three clinical Aspergillus fumigatus isolates with mutations in the cyp51A gene
    Eleftheria Mavridou
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, and Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Antimicrob Agents Chemother 54:860-5. 2010
    ..fumigatus strains for which MICs are 0.5 mg/liter requires doses exceeding the present licensed doses. Increasing the standard dosing regimen may have some effect and may be clinically useful if no alternatives are available...
  59. pmc The influence of labour on the pharmacokinetics of intravenously administered amoxicillin in pregnant women
    Anouk E Muller
    Erasmus MC, University Medical Centre Rotterdam, Department of Medical Microbiology and Infectious Diseases, Rotterdam, The Netherlands
    Br J Clin Pharmacol 66:866-74. 2008
    ..These might change the pharmacokinetics of amoxicillin, necessitating adjustment of the dose for prevention of neonatal infections. We investigated the influence of labour on the pharmacokinetics of amoxicillin...
  60. ncbi Rapid and reliable real-time PCR assay for detection of the macrolide efflux gene and subsequent discrimination between its distinct subclasses mef(A) and mef(E)
    Debby M Klomberg
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Weg door Jonkerbos 100, 6532 SZ Nijmegen, The Netherlands
    J Microbiol Methods 60:269-73. 2005
    ..Furthermore, the real-time format offers semiquantitative results allowing identification of contaminated cultures and/or DNA preparations...
  61. pmc Effect of a single percutaneous abscess drainage puncture and imipenem therapy, alone or in combination, in treatment of mixed-infection abscesses in mice
    Lorna E T Stearne
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, The Netherlands
    Antimicrob Agents Chemother 46:3712-8. 2002
    ..Possible reasons for the reduced activity of imipenem in vivo are discussed, and we conclude that standard susceptibility tests overestimate the efficacy of this antibiotic against the organisms present in these abscesses...
  62. doi The role of pharmacokinetics/pharmacodynamics in setting clinical MIC breakpoints: the EUCAST approach
    J W Mouton
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Microbiol Infect 18:E37-45. 2012
    ..These are the breakpoints that in the EUCAST breakpoint tables are referred to as 'non-species-related breakpoints'...
  63. pmc Non-adherence to antimicrobial treatment guidelines results in more broad-spectrum but not more appropriate therapy
    L B J van der Velden
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Geert Grooteplein zuid 10, 6525 GA, Nijmegen, The Netherlands
    Eur J Clin Microbiol Infect Dis 31:1561-8. 2012
    ..This did not result in a higher rate of susceptibility of the isolated pathogens to the prescribed empirical therapy...
  64. ncbi Oral immunization with a polyvalent bacterial lysate can reduce mortality by infection with S. pneumoniae or influenza A in mice
    G J van Daal
    Dept. of Anesthesia, Erasmus University Rotterdam, The Netherlands
    Pneumologie 44:1180-2. 1990
    ..pneumoniae or influenza A. The results suggest that oral immunization reduces the mortality rate. We believe that this effect is partially due to nonspecific defense mechanisms...
  65. ncbi Colonization and infection by Serratia species in a paediatric surgical intensive care unit
    M J Albers
    Department of Pediatric Surgery, Sophia Children s Hospital University Hospital Rotterdam, Rotterdam, The Netherlands
    J Hosp Infect 48:7-12. 2001
    ..Both the respiratory and digestive tracts were frequently colonized. Our findings do not support the contention that the digestive tract is more important as reservoir than the respiratory tract in neonates...
  66. pmc In vitro activities of pentamidine, pyrimethamine, trimethoprim, and sulfonamides against Aspergillus species
    Javier Afeltra
    Department of Medical Microbiology, University Medical Center Nijmegen, The Netherlands
    Antimicrob Agents Chemother 46:2029-31. 2002
    ..Sulfamethoxazole, sulfadiazine, and pentamidine were active in vitro. The MICs obtained with RPMI 1640 were significantly higher than those with yeast nitrogen base. More studies are needed to further elucidate the action of these drugs...
  67. pmc Potent synergistic in vitro interaction between nonantimicrobial membrane-active compounds and itraconazole against clinical isolates of Aspergillus fumigatus resistant to itraconazole
    Javier Afeltra
    Department of Medical Microbiology, University Medical Center and Department of Medical Microbiology and Infectious Diseases, Canisius Wilhemina Hospital, Nijmegen, The Netherlands
    Antimicrob Agents Chemother 48:1335-43. 2004
    ..In general, the combination of ITZ with calcium pump blockers displayed in vitro synergistic activity, primarily against ITZ-R strains, and warrants further investigation...
  68. pmc Efficacy of antifungal therapy in a nonneutropenic murine model of zygomycosis
    Eric Dannaoui
    Department of Medical Microbiology, University Medical Center St Radboud, 6500 HB Nijmegen, The Netherlands
    Antimicrob Agents Chemother 46:1953-9. 2002
    ..The efficacy of itraconazole in these models of zygomycosis suggests that this drug, as well as the new azole compounds presently under development, warrants close evaluation...
  69. pmc Method for measuring postantifungal effect in Aspergillus species
    Roxana G Vitale
    Department of Medical Microbiology, University Medical Center Nijmegen, The Netherlands
    Antimicrob Agents Chemother 46:1960-5. 2002
    ..Further studies are warranted to investigate the implications of PAFE in relation to clinical efficacy and dosing frequency...
  70. pmc Comparison of the Etest and the sensititre colorimetric methods with the NCCLS proposed standard for antifungal susceptibility testing of Aspergillus species
    Joseph Meletiadis
    Department of Medical Microbiology, University Medical Center Nijmegen, The Netherlands
    J Clin Microbiol 40:2876-85. 2002
    ....
  71. ncbi Rapid and reliable identification of Streptococcus anginosus group isolates to the species level by real-time PCR and melting curve analysis
    Ingrid M E Desar
    Department of Internal Medicine, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    J Microbiol Methods 75:372-4. 2008
    ..Based on melting curve analysis, the S. anginosus species isolates could be further subdivided into two subgroups, each associated with different clinically relevant ribotypes of S. anginosus...
  72. pmc In vitro activities at pH 5.0 and pH 7.0 and in vivo efficacy of flucytosine against Aspergillus fumigatus
    Paul E Verweij
    Department of Medical Microbiology, Radboud University Nijmegen Medical Center, P O Box 9101, Nijmegen 6500 HB, The Netherlands
    Antimicrob Agents Chemother 52:4483-5. 2008
    ..0 instead of pH 7.0. The in vitro MIC at pH 5.0 corresponded to the in vivo efficacy of flucytosine monotherapy in a murine model of invasive aspergillosis...
  73. pmc In vitro drug interaction modeling of combinations of azoles with terbinafine against clinical Scedosporium prolificans isolates
    Joseph Meletiadis
    Department of Medical Microbiology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Antimicrob Agents Chemother 47:106-17. 2003
    ..Fully parametric approaches in combination with the modified colorimetric method might prove useful for testing the in vitro interaction of antifungal drugs against filamentous fungi...
  74. ncbi In vitro susceptibilities of Zygomycota to polyenes
    Eric Dannaoui
    Department of Medical Microbiology, University Medical Center St Radboud, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Antimicrob Chemother 49:741-4. 2002
    ..001). The one C. bertholletiae and one A. elegans isolates were less susceptible to amphotericin B (MICs 2 mg/L) and were also less susceptible to nystatin...
  75. ncbi Evaluation of the post-antifungal effect (PAFE) of amphotericin B and nystatin against 30 zygomycetes using two different media
    Roxana G Vitale
    Department of Medical Microbiology, University Medical Center Nijmegen, and Nijmegen University Center for Infectious Diseases, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Antimicrob Chemother 52:65-70. 2003
    ..5.8 h) > R. oryzae (3.3 h) > A. corymbifera (2.9 h) > R. microsporus (1.7 h). PAFE was not induced in Rhizomucor spp. PAFE was dependent on drug concentration...
  76. pmc In vitro activities of new and conventional antifungal agents against clinical Scedosporium isolates
    Joseph Meletiadis
    Departments of Medical Microbiology, University Medical Center, Nijmegen, The Netherlands
    Antimicrob Agents Chemother 46:62-8. 2002
    ..These cutoffs were in many cases reproducible between 48 and 72 h...
  77. pmc Pneumolysin is a key factor in misidentification of macrolide-resistant Streptococcus pneumoniae and is a putative virulence factor of S. mitis and other streptococci
    Chris Neeleman
    Department of Intensive Care Medicine, University Hospital St Radboud, Nijmegen, The Netherlands
    J Clin Microbiol 42:4355-7. 2004
    ..In contrast to the lytA gene, the ply gene proved to be not specific for S. pneumoniae. The presence of the ply gene in other streptococci, in particular Streptococcus mitis, suggests that pneumolysin plays a pathogenic role...
  78. pmc Comparative study of the effects of ceftizoxime, piperacillin, and piperacillin-tazobactam concentrations on antibacterial activity and selection of antibiotic-resistant mutants of Enterobacter cloacae and Bacteroides fragilis in vitro and in vivo in mixe
    Lorna E T Stearne
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Antimicrob Agents Chemother 48:1688-98. 2004
    ..cloacae and B. fragilis. Results demonstrate the adverse microbiological outcome of choosing an expanded-spectrum cephalosporin like CZX for empirical treatment of mixed infections involving a susceptible Enterobacter strain...
  79. ncbi Assessing in vitro combinations of antifungal drugs against yeasts and filamentous fungi: comparison of different drug interaction models
    Joseph Meletiadis
    Department of Medical Microbiology, Nijmegen University Center for Infectious Diseases, Nijmegen, The Netherlands
    Med Mycol 43:133-52. 2005
    ..Semi-parametric approaches need particular care as experimental errors are not eliminated from the entire response surface...
  80. ncbi Extended-interval dosing of tobramycin in neonates: implications for therapeutic drug monitoring
    Matthijs de Hoog
    Department of Pediatrics, Pediatric Intensive Care Unit, Erasmus University and University Hospital Rotterdam Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    Clin Pharmacol Ther 71:349-58. 2002
    ..Our objective was to individualize tobramycin dosing regimens in neonates of various gestational ages with use of early therapeutic drug monitoring...
  81. ncbi Continuous versus intermittent infusion of temocillin, a directed spectrum penicillin for intensive care patients with nosocomial pneumonia: stability, compatibility, population pharmacokinetic studies and breakpoint selection
    Raf De Jongh
    Dienst Voor Intensieve Zorgen, Ziekenhuis Oost Limburg, B 3600 Genk, Belgium
    J Antimicrob Chemother 61:382-8. 2008
    ..We aimed at documenting its potential clinical usefulness in intensive care (IC) patients using pharmacokinetic/pharmacodynamic approaches applied to conventional (twice daily) and continuous infusion (CI) modes of administration...
  82. ncbi Why the AUC/MIC ratio should not be used to predict the effects of beta-lactams
    Johan W Mouton
    Clin Infect Dis 35:209-10. 2002
  83. ncbi Duration of antibiotic treatment: are even numbers odd?
    Emine Alp
    J Antimicrob Chemother 56:441-2. 2005
  84. ncbi European harmonization of MIC breakpoints for antimicrobial susceptibility testing of bacteria
    Gunnar Kahlmeter
    Klinisk mikrobiologi, Centrallasarettet, 351 85 Växjö, Sweden
    J Antimicrob Chemother 52:145-8. 2003
  85. ncbi Thoughts on "Population pharmacokinetics and relationship between demographic and clinical variables and pharmacokinetics of gentamicin in neonates"
    Matthijs de Hoog
    Ther Drug Monit 25:256-7; author reply 257. 2003
  86. pmc Population pharmacokinetic analysis of nonlinear behavior of piperacillin during intermittent or continuous infusion in patients with cystic fibrosis
    Alexander A Vinks
    Division of Pharmacology Research, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Antimicrob Agents Chemother 47:541-7. 2003
    ..6 mg/liters, respectively. The developed nonlinear pharmacokinetic models can be used to optimize piperacillin therapy administered via continuous infusion in patients with CF and have distinct advantages over conventional linear models...
  87. pmc Pharmacokinetics of penicillin G in infants with a gestational age of less than 32 weeks
    Anouk E Muller
    Medical Centre Haaglanden MCH, Department of Obstetrics and Gynecology, Lijnbaan 32, 2512 VA, The Hague, The Netherlands
    Antimicrob Agents Chemother 51:3720-5. 2007
    ..This regimen is therefore adequate for the treatment of common infections in neonates on the third day of life...
  88. pmc Correlation of the MIC and dose/MIC ratio of fluconazole to the therapeutic response of patients with mucosal candidiasis and candidemia
    Juan L Rodriguez-Tudela
    Servicio de Micologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Ctra Majadahonda Pozuelo km 2, 28220 Majadahonda, Spain
    Antimicrob Agents Chemother 51:3599-604. 2007
    ....
  89. pmc Pharmacokinetics of aztreonam in healthy subjects and patients with cystic fibrosis and evaluation of dose-exposure relationships using monte carlo simulation
    Alexander A Vinks
    Pediatric Pharmacology Research Unit, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MLC 6018, Cincinnati, OH 45229 3039, USA
    Antimicrob Agents Chemother 51:3049-55. 2007
    ..Patients suspected of having high clearance rates, such as CF patients, should be monitored closely, with dosing regimens adjusted accordingly...
  90. ncbi In vitro susceptibilities of zygomycetes to conventional and new antifungals
    Eric Dannaoui
    Department of Medical Microbiology, University Medical Center, St Radboud, PO Box 9101, 6500 HB Nijmegen
    J Antimicrob Chemother 51:45-52. 2003
    ..The spectrophotometric method appears to be a valuable alternative to the visual method for MIC determination for zygomycetes...
  91. ncbi New dosing strategies for antibacterial agents in the neonate
    Matthijs de Hoog
    Department of Pediatrics, Erasmus MC Sophia, Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    Semin Fetal Neonatal Med 10:185-94. 2005
    ..Empiric treatment should be based on efficacy, concerns about resistance as well as information from institutional microbiological surveillance...
  92. ncbi Amoxicillin pharmacokinetics in pregnant women with preterm premature rupture of the membranes
    Anouk E Muller
    Department of Obstetrics and Gynecology, Medical Centre Haaglanden, Lijnbaan, The Hague, The Netherlands
    Am J Obstet Gynecol 198:108.e1-6. 2008
    ..This study was undertaken to study the pharmacokinetics of intravenously administered amoxicillin in pregnant women with preterm premature rupture of the membranes (PPROM)...
  93. ncbi The epidemiology of vaginal colonisation with group B streptococci in a sexually transmitted disease clinic
    Erik Honig
    Department of Dermatology and Venerology, Erasmus University Medical Centre Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Eur J Obstet Gynecol Reprod Biol 105:177-80. 2002
    ..To determine whether Group B streptococcus (GBS) infection is sexually transmitted and whether colonisation with GBS could be related to vaginal symptoms or signs...