J V Bovée

Summary

Country: The Netherlands

Publications

  1. pmc EXT-mutation analysis and loss of heterozygosity in sporadic and hereditary osteochondromas and secondary chondrosarcomas
    J V Bovée
    Departments of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Hum Genet 65:689-98. 1999
  2. ncbi request reprint Molecular genetic characterization of both components of a dedifferentiated chondrosarcoma, with implications for its histogenesis
    J V Bovée
    Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands
    J Pathol 189:454-62. 1999
  3. ncbi request reprint Up-regulation of PTHrP and Bcl-2 expression characterizes the progression of osteochondroma towards peripheral chondrosarcoma and is a late event in central chondrosarcoma
    J V Bovée
    Department of Pathology, Leiden University Medical Center, The Netherlands
    Lab Invest 80:1925-34. 2000
  4. ncbi request reprint Chondrosarcoma is not characterized by detectable telomerase activity
    J V Bovée
    Department of Pathology, Leiden University Medical Center, P O Box 9600, L1 Q, 2300 RC Leiden, The Netherlands
    J Pathol 193:354-60. 2001
  5. ncbi request reprint Chromosome 9 alterations and trisomy 22 in central chondrosarcoma: a cytogenetic and DNA flow cytometric analysis of chondrosarcoma subtypes
    J V Bovée
    Department of Pathology, Leiden University Medical Center, The Netherlands
    Diagn Mol Pathol 10:228-35. 2001

Detail Information

Publications5

  1. pmc EXT-mutation analysis and loss of heterozygosity in sporadic and hereditary osteochondromas and secondary chondrosarcomas
    J V Bovée
    Departments of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Hum Genet 65:689-98. 1999
    ..In contrast, no somatic EXT1 cDNA alterations were found in sporadic osteochondromas. No mutations were found in the EXT2 gene...
  2. ncbi request reprint Molecular genetic characterization of both components of a dedifferentiated chondrosarcoma, with implications for its histogenesis
    J V Bovée
    Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands
    J Pathol 189:454-62. 1999
    ....
  3. ncbi request reprint Up-regulation of PTHrP and Bcl-2 expression characterizes the progression of osteochondroma towards peripheral chondrosarcoma and is a late event in central chondrosarcoma
    J V Bovée
    Department of Pathology, Leiden University Medical Center, The Netherlands
    Lab Invest 80:1925-34. 2000
    ..In contrast, up-regulation of PTHrP and Bcl-2 seems to be a late event in central cartilaginous tumorigenesis because expression is mainly restricted to high-grade central tumors...
  4. ncbi request reprint Chondrosarcoma is not characterized by detectable telomerase activity
    J V Bovée
    Department of Pathology, Leiden University Medical Center, P O Box 9600, L1 Q, 2300 RC Leiden, The Netherlands
    J Pathol 193:354-60. 2001
    ..Either its true absence or inhibitory effects disabling telomerase detection exclude the telomerase TRAP assay as a diagnostic tool in the differential diagnosis of benign and low-grade malignant cartilaginous tumours...
  5. ncbi request reprint Chromosome 9 alterations and trisomy 22 in central chondrosarcoma: a cytogenetic and DNA flow cytometric analysis of chondrosarcoma subtypes
    J V Bovée
    Department of Pathology, Leiden University Medical Center, The Netherlands
    Diagn Mol Pathol 10:228-35. 2001
    ..Three central tumors showed involvement of the 9pl2-22 region, suggesting an important role for chromosome 9 in the oncogenesis of central chondrosarcoma. Moreover, trisomy 22 was found in four central chondrosarcomas only...