J V Bovée

Summary

Country: The Netherlands

Publications

  1. ncbi EXT-mutation analysis and loss of heterozygosity in sporadic and hereditary osteochondromas and secondary chondrosarcomas
    J V Bovée
    Departments of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Hum Genet 65:689-98. 1999
  2. ncbi Molecular genetic characterization of both components of a dedifferentiated chondrosarcoma, with implications for its histogenesis
    J V Bovée
    Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands
    J Pathol 189:454-62. 1999
  3. ncbi Up-regulation of PTHrP and Bcl-2 expression characterizes the progression of osteochondroma towards peripheral chondrosarcoma and is a late event in central chondrosarcoma
    J V Bovée
    Department of Pathology, Leiden University Medical Center, The Netherlands
    Lab Invest 80:1925-34. 2000
  4. ncbi Chondrosarcoma is not characterized by detectable telomerase activity
    J V Bovée
    Department of Pathology, Leiden University Medical Center, P O Box 9600, L1 Q, 2300 RC Leiden, The Netherlands
    J Pathol 193:354-60. 2001
  5. ncbi Chromosome 9 alterations and trisomy 22 in central chondrosarcoma: a cytogenetic and DNA flow cytometric analysis of chondrosarcoma subtypes
    J V Bovée
    Department of Pathology, Leiden University Medical Center, The Netherlands
    Diagn Mol Pathol 10:228-35. 2001

Detail Information

Publications5

  1. ncbi EXT-mutation analysis and loss of heterozygosity in sporadic and hereditary osteochondromas and secondary chondrosarcomas
    J V Bovée
    Departments of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Hum Genet 65:689-98. 1999
    ..In contrast, no somatic EXT1 cDNA alterations were found in sporadic osteochondromas. No mutations were found in the EXT2 gene...
  2. ncbi Molecular genetic characterization of both components of a dedifferentiated chondrosarcoma, with implications for its histogenesis
    J V Bovée
    Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands
    J Pathol 189:454-62. 1999
    ....
  3. ncbi Up-regulation of PTHrP and Bcl-2 expression characterizes the progression of osteochondroma towards peripheral chondrosarcoma and is a late event in central chondrosarcoma
    J V Bovée
    Department of Pathology, Leiden University Medical Center, The Netherlands
    Lab Invest 80:1925-34. 2000
    ..In contrast, up-regulation of PTHrP and Bcl-2 seems to be a late event in central cartilaginous tumorigenesis because expression is mainly restricted to high-grade central tumors...
  4. ncbi Chondrosarcoma is not characterized by detectable telomerase activity
    J V Bovée
    Department of Pathology, Leiden University Medical Center, P O Box 9600, L1 Q, 2300 RC Leiden, The Netherlands
    J Pathol 193:354-60. 2001
    ..Either its true absence or inhibitory effects disabling telomerase detection exclude the telomerase TRAP assay as a diagnostic tool in the differential diagnosis of benign and low-grade malignant cartilaginous tumours...
  5. ncbi Chromosome 9 alterations and trisomy 22 in central chondrosarcoma: a cytogenetic and DNA flow cytometric analysis of chondrosarcoma subtypes
    J V Bovée
    Department of Pathology, Leiden University Medical Center, The Netherlands
    Diagn Mol Pathol 10:228-35. 2001
    ..Three central tumors showed involvement of the 9pl2-22 region, suggesting an important role for chromosome 9 in the oncogenesis of central chondrosarcoma. Moreover, trisomy 22 was found in four central chondrosarcomas only...