Edmond J Remarque

Summary

Affiliation: Biomedical Primate Research Centre
Country: The Netherlands

Publications

  1. pmc Generation of humoral immune responses to multi-allele PfAMA1 vaccines; effect of adjuvant and number of component alleles on the breadth of response
    Kwadwo A Kusi
    Department of Parasitology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    PLoS ONE 5:e15391. 2010
  2. pmc Vaccination with Plasmodium knowlesi AMA1 formulated in the novel adjuvant co-vaccine HT™ protects against blood-stage challenge in rhesus macaques
    Muzamil Mahdi Abdel Hamid
    Department of Parasitology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    PLoS ONE 6:e20547. 2011
  3. pmc The impact of hotspot-targeted interventions on malaria transmission: study protocol for a cluster-randomized controlled trial
    Teun Bousema
    Department of Immunology and Infection Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Trials 14:36. 2013
  4. pmc Humoral immune responses to a single allele PfAMA1 vaccine in healthy malaria-naïve adults
    Edmond J Remarque
    Biomedical Primate Research Centre, Rijswijk, The Netherlands
    PLoS ONE 7:e38898. 2012
  5. pmc Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein
    Martha Sedegah
    USMMVP, Malaria Department, NMRC, Silver Spring, MD 20910, USA
    Malar J 9:241. 2010
  6. pmc Cohort study of the association of antibody levels to AMA1, MSP119, MSP3 and GLURP with protection from clinical malaria in Ghanaian children
    Daniel Dodoo
    Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
    Malar J 7:142. 2008
  7. pmc A diversity-covering approach to immunization with Plasmodium falciparum apical membrane antigen 1 induces broader allelic recognition and growth inhibition responses in rabbits
    Edmond J Remarque
    Department of Parasitology, Biomedical Primate Research Centre, Lange Kleiweg 139, 2288 GJ Rijswijk, The Netherlands
    Infect Immun 76:2660-70. 2008
  8. pmc Diversity covering AMA1-MSP119 fusion proteins as malaria vaccines
    Bart W Faber
    Biomedical Primate Research Centre, Department of Parasitology, Rijswijk, The Netherlands
    Infect Immun 81:1479-90. 2013
  9. pmc Safety and immunogenicity of multi-antigen AMA1-based vaccines formulated with CoVaccine HT™ and Montanide ISA 51 in rhesus macaques
    Kwadwo A Kusi
    Department of Parasitology, Biomedical Primate Research Centre, Postbox 3306, 2280 GH, Rijswijk, The Netherlands
    Malar J 10:182. 2011
  10. pmc Humoral immune response to mixed PfAMA1 alleles; multivalent PfAMA1 vaccines induce broad specificity
    Kwadwo A Kusi
    Department of Parasitology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    PLoS ONE 4:e8110. 2009

Collaborators

Detail Information

Publications24

  1. pmc Generation of humoral immune responses to multi-allele PfAMA1 vaccines; effect of adjuvant and number of component alleles on the breadth of response
    Kwadwo A Kusi
    Department of Parasitology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    PLoS ONE 5:e15391. 2010
    ..Our data confirms the feasibility and potential of multi-allele PfAMA1 formulations, and highlights the need for adjuvants with improved antibody potentiation properties for AMA1-based vaccines...
  2. pmc Vaccination with Plasmodium knowlesi AMA1 formulated in the novel adjuvant co-vaccine HT™ protects against blood-stage challenge in rhesus macaques
    Muzamil Mahdi Abdel Hamid
    Department of Parasitology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    PLoS ONE 6:e20547. 2011
    ....
  3. pmc The impact of hotspot-targeted interventions on malaria transmission: study protocol for a cluster-randomized controlled trial
    Teun Bousema
    Department of Immunology and Infection Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Trials 14:36. 2013
    ..Targeting these hotspots might represent a highly efficacious way of controlling or eliminating malaria if the hotspots fuel malaria transmission to the wider community...
  4. pmc Humoral immune responses to a single allele PfAMA1 vaccine in healthy malaria-naïve adults
    Edmond J Remarque
    Biomedical Primate Research Centre, Rijswijk, The Netherlands
    PLoS ONE 7:e38898. 2012
    ..Trial registration: ClinicalTrials.gov NCT00730782...
  5. pmc Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein
    Martha Sedegah
    USMMVP, Malaria Department, NMRC, Silver Spring, MD 20910, USA
    Malar J 9:241. 2010
    ..Since CD8+ T cell responses have been implicated in protection against pre-erythrocytic stage malaria, this study was designed to identify MHC class I-restricted epitopes within AMA1...
  6. pmc Cohort study of the association of antibody levels to AMA1, MSP119, MSP3 and GLURP with protection from clinical malaria in Ghanaian children
    Daniel Dodoo
    Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
    Malar J 7:142. 2008
    ..This study was aimed at assessing in a standardized manner the relationship between the antibody responses to four malaria vaccine candidate antigens and protection from clinical malaria, in a cohort of Ghanaian children...
  7. pmc A diversity-covering approach to immunization with Plasmodium falciparum apical membrane antigen 1 induces broader allelic recognition and growth inhibition responses in rabbits
    Edmond J Remarque
    Department of Parasitology, Biomedical Primate Research Centre, Lange Kleiweg 139, 2288 GJ Rijswijk, The Netherlands
    Infect Immun 76:2660-70. 2008
    ..This suggests that vaccines based upon the DiCo mix approach provide a broader functional immunity than immunization with a single allele...
  8. pmc Diversity covering AMA1-MSP119 fusion proteins as malaria vaccines
    Bart W Faber
    Biomedical Primate Research Centre, Department of Parasitology, Rijswijk, The Netherlands
    Infect Immun 81:1479-90. 2013
    ..This study shows that combination of multiple vaccine candidates in fusion proteins may lead to improved characteristics of the vaccine...
  9. pmc Safety and immunogenicity of multi-antigen AMA1-based vaccines formulated with CoVaccine HT™ and Montanide ISA 51 in rhesus macaques
    Kwadwo A Kusi
    Department of Parasitology, Biomedical Primate Research Centre, Postbox 3306, 2280 GH, Rijswijk, The Netherlands
    Malar J 10:182. 2011
    ....
  10. pmc Humoral immune response to mixed PfAMA1 alleles; multivalent PfAMA1 vaccines induce broad specificity
    Kwadwo A Kusi
    Department of Parasitology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    PLoS ONE 4:e8110. 2009
    ..This explains the broadened cross inhibition of diverse malaria parasites, and suggests multi-allele approaches warrant further clinical investigation...
  11. pmc Immunization with different PfAMA1 alleles in sequence induces clonal imprint humoral responses that are similar to responses induced by the same alleles as a vaccine cocktail in rabbits
    Kwadwo A Kusi
    Department of Parasitology, Biomedical Primate Research Centre, Postbox 3306, 2280 GH Rijswijk, The Netherlands
    Malar J 10:40. 2011
    ..Cross-strain antibodies are most likely elicited against epitopes that are shared by the allelic antigens in the vaccine cocktail...
  12. doi request reprint Production, quality control, stability and pharmacotoxicity of cGMP-produced Plasmodium falciparum AMA1 FVO strain ectodomain expressed in Pichia pastoris
    Bart W Faber
    Department of Parasitology, Biomedical Primate Research Center, Lange Kleiweg 139, 2288 GJ Rijswijk, The Netherlands
    Vaccine 26:6143-50. 2008
    ..These formulations also showed no pharmacotoxicity in rabbits. The final product conformed to preset criteria and was judged suitable for use in human clinical trials...
  13. pmc Suppression of Plasmodium cynomolgi in rhesus macaques by coinfection with Babesia microti
    Leonie M van Duivenvoorde
    Department of Parasitology, Biomedical Primate Research Centre, 2288 GJ Rijswijk, The Netherlands
    Infect Immun 78:1032-9. 2010
    ..cynomolgi infection and with higher C-reactive protein (CRP) serum levels 1 week after malaria infection. Therefore, we conclude that ongoing infection with B. microti parasites leads to suppression of malaria infection...
  14. doi request reprint Apical membrane antigen 1: a malaria vaccine candidate in review
    Edmond J Remarque
    Department of Parasitology, Biomedical Primate Research Centre, 2280 GH Rijswijk, The Netherlands
    Trends Parasitol 24:74-84. 2008
    ..The current understanding of AMA1 will be presented, particularly in relation to the vaccine potential of AMA1 and the approaches being taken towards clinical development...
  15. pmc Malaria infection by sporozoite challenge induces high functional antibody titres against blood stage antigens after a DNA prime, poxvirus boost vaccination strategy in Rhesus macaques
    Muzamil Mahdi Abdel Hamid
    Department of Parasitology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    Malar J 10:29. 2011
    ..knowlesi. In the present study, the role of the blood stage antigens in protection was studied in depth, focusing on antibody formation against the blood stage antigens and the functionality thereof...
  16. pmc Malaria vaccine-related benefits of a single protein comprising Plasmodium falciparum apical membrane antigen 1 domains I and II fused to a modified form of the 19-kilodalton C-terminal fragment of merozoite surface protein 1
    Bart W Faber
    Department of Parasitology, Biomedical Primate Research Centre, Lange Kleiweg 157, 2288 GJ Rijswijk, The Netherlands
    Infect Immun 75:5947-55. 2007
    ....
  17. pmc Measurement of the plasma levels of antibodies against the polymorphic vaccine candidate apical membrane antigen 1 in a malaria-exposed population
    Kwadwo A Kusi
    Department of Parasitology, Biomedical Primate Research Centre, Postbox 3306, 2280, GH Rijswijk, The Netherlands
    BMC Infect Dis 12:32. 2012
    ..For polymorphic antigens such as apical membrane antigen 1 (AMA1), this may be confounded by the occurrence of a large number of allelic variants in nature...
  18. pmc Haplotype diversity generated by ancient recombination-like events in the MHC of Indian rhesus macaques
    Gaby G M Doxiadis
    Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Lange Kleiweg 161, 2288 GJ Rijswijk, The Netherlands
    Immunogenetics 65:569-84. 2013
    ..Thus, recombination-like processes appear to be a way to expand a diminished genetic repertoire in an isolated and relatively small founder population. ..
  19. doi request reprint A novel method to clean protein G agarose for affinity column matrix with renewed binding capacity and high IgG selectivity
    Boaz O Owuor
    Department of Parasitology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    J Immunol Methods 352:192-4. 2010
    ..We report here a novel and simple cleaning method involving the use of polyethylene glycol (PEG8000) that renews matrix-binding capacity comparable to a new resin while retaining high selectivity for IgG...
  20. doi request reprint Pinpointing a selective sweep to the chimpanzee MHC class I region by comparative genomics
    Natasja G de Groot
    Biomedical Primate Research Centre, Department of Comparative Genetics and Refinement, Lange Kleiweg 139, 2288 GJ Rijswijk, The Netherlands
    Mol Ecol 17:2074-88. 2008
    ..However, recombination did not have sufficient time to erase the signal of the selective sweep...
  21. pmc Statistical model to evaluate in vivo activities of antimalarial drugs in a Plasmodium cynomolgi-macaque model for Plasmodium vivax malaria
    Clemens H M Kocken
    Biomedical Primate Research Centre, Department of Parasitology, GH Rijswijk, The Netherlands
    Antimicrob Agents Chemother 53:421-7. 2009
    ..By applying NLME modeling treatment effects are readily quantified. Such drug development studies are more informative and contribute to reduction and refinement in animal experimentation...
  22. pmc AIDS-protective HLA-B*27/B*57 and chimpanzee MHC class I molecules target analogous conserved areas of HIV-1/SIVcpz
    Natasja G de Groot
    Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, 2288 GJ Rijswijk, The Netherlands
    Proc Natl Acad Sci U S A 107:15175-80. 2010
    ..The functional characteristics of the contemporary chimpanzee MHC repertoire suggest that the selective sweep was caused by a lentiviral pandemic...
  23. doi request reprint KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro
    Anne Marie Zeeman
    Biomedical Primate Research Centre, Department of Parasitology, Rijswijk, The Netherlands
    Antimicrob Agents Chemother 58:1586-95. 2014
    ..From these results, we conclude that KAI407 may represent a new compound class for P. vivax malaria prophylaxis and potentially a radical cure. ..
  24. pmc MVA.85A boosting of BCG and an attenuated, phoP deficient M. tuberculosis vaccine both show protective efficacy against tuberculosis in rhesus macaques
    Frank A W Verreck
    Department of Parasitology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    PLoS ONE 4:e5264. 2009
    ..Relevant models are required to downselect the most promising vaccines entering clinical efficacy testing and to identify correlates of protection...