Jeffrey J Bajramovic

Summary

Affiliation: Biomedical Primate Research Centre
Country: The Netherlands

Publications

  1. ncbi request reprint Regulation of innate immune responses in the central nervous system
    Jeffrey J Bajramovic
    Alternatives Unit, Biomedical Primate Research Centre, Lange Kleiweg 161, 2288 GJ Rijswijk, The Netherlands
    CNS Neurol Disord Drug Targets 10:4-24. 2011
  2. doi request reprint Oligodendrocyte-specific protein is encephalitogenic in rhesus macaques and induces specific demyelination of the optic nerve
    Jeffrey J Bajramovic
    Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    Eur J Immunol 38:1452-64. 2008
  3. doi request reprint Induction of progressive demyelinating autoimmune encephalomyelitis in common marmoset monkeys using MOG34-56 peptide in incomplete freund adjuvant
    S Anwar Jagessar
    Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    J Neuropathol Exp Neurol 69:372-85. 2010
  4. doi request reprint Statins amplify TLR-induced responses in microglia via inhibition of cholesterol biosynthesis
    Céline van der Putten
    Alternatives Unit, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    Glia 60:43-52. 2012
  5. doi request reprint Differential expression of adenosine A3 receptors controls adenosine A2A receptor-mediated inhibition of TLR responses in microglia
    Céline van der Putten
    Alternatives Unit, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    J Immunol 182:7603-12. 2009
  6. pmc Induction of experimental autoimmune encephalomyelitis with recombinant human myelin oligodendrocyte glycoprotein in incomplete Freund's adjuvant in three non-human primate species
    Krista G Haanstra
    Department of Immunobiology, Biomedical Primate Research Centre, P O Box 3306, 2280 GH, Rijswijk, The Netherlands
    J Neuroimmune Pharmacol 8:1251-64. 2013
  7. ncbi request reprint Differentiation of primary adult microglia alters their response to TLR8-mediated activation but not their capacity as APC
    Ella A Zuiderwijk-Sick
    Alternatives Unit, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    Glia 55:1589-600. 2007
  8. pmc Phagocytes containing a disease-promoting Toll-like receptor/Nod ligand are present in the brain during demyelinating disease in primates
    Lizette Visser
    Department of Immunology, Erasmus Medical Center, University Medical Center Rotterdam, PO Box 2040, 3000 DR Rotterdam, The Netherlands
    Am J Pathol 169:1671-85. 2006
  9. ncbi request reprint Identification of soluble CD14 as an endogenous agonist for Toll-like receptor 2 on human astrocytes by genome-scale functional screening of glial cell derived proteins
    Malika Bsibsi
    Department of Biosciences, TNO Quality of Life, Leiden, The Netherlands
    Glia 55:473-82. 2007
  10. ncbi request reprint Modulation of the cytokine network in human adult astrocytes by human herpesvirus-6A
    Sonja Meeuwsen
    Division Biomedical Research, TNO Prevention and Health, P O Box 2215, 2301 CE Leiden, The Netherlands
    J Neuroimmunol 164:37-47. 2005

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Regulation of innate immune responses in the central nervous system
    Jeffrey J Bajramovic
    Alternatives Unit, Biomedical Primate Research Centre, Lange Kleiweg 161, 2288 GJ Rijswijk, The Netherlands
    CNS Neurol Disord Drug Targets 10:4-24. 2011
    ..In addition, intracellular activating and inhibitory signaling cascades are summarized in detail and their therapeutic potential is analyzed...
  2. doi request reprint Oligodendrocyte-specific protein is encephalitogenic in rhesus macaques and induces specific demyelination of the optic nerve
    Jeffrey J Bajramovic
    Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    Eur J Immunol 38:1452-64. 2008
    ..Our data demonstrate that in rhesus monkeys immune responses directed at OSP are encephalitogenic, leading to inflammatory responses throughout the central nervous system and to selective demyelination of the optic nerve...
  3. doi request reprint Induction of progressive demyelinating autoimmune encephalomyelitis in common marmoset monkeys using MOG34-56 peptide in incomplete freund adjuvant
    S Anwar Jagessar
    Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    J Neuropathol Exp Neurol 69:372-85. 2010
    ....
  4. doi request reprint Statins amplify TLR-induced responses in microglia via inhibition of cholesterol biosynthesis
    Céline van der Putten
    Alternatives Unit, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    Glia 60:43-52. 2012
    ..Amplification of TLR-induced responses in microglia by statin exposure might contribute to the generation of a more pro-inflammatory CNS microenvironment which can be of relevance for the pathogenesis of neuroinflammatory disorders...
  5. doi request reprint Differential expression of adenosine A3 receptors controls adenosine A2A receptor-mediated inhibition of TLR responses in microglia
    Céline van der Putten
    Alternatives Unit, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    J Immunol 182:7603-12. 2009
    ..This would suggest exploration of combinations of A(2A)R agonists and A(3)R antagonists to dampen microglial activation during chronic neuroinflammatory conditions...
  6. pmc Induction of experimental autoimmune encephalomyelitis with recombinant human myelin oligodendrocyte glycoprotein in incomplete Freund's adjuvant in three non-human primate species
    Krista G Haanstra
    Department of Immunobiology, Biomedical Primate Research Centre, P O Box 3306, 2280 GH, Rijswijk, The Netherlands
    J Neuroimmune Pharmacol 8:1251-64. 2013
    ..Animals without an early high IgM response either did not develop disease (rhesus monkeys) or developed only mild signs of neurological deficit (marmoset and cynomolgus monkeys). ..
  7. ncbi request reprint Differentiation of primary adult microglia alters their response to TLR8-mediated activation but not their capacity as APC
    Ella A Zuiderwijk-Sick
    Alternatives Unit, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    Glia 55:1589-600. 2007
    ..Resident primate microglia may thereby help shape rather than initiate adaptive immune responses...
  8. pmc Phagocytes containing a disease-promoting Toll-like receptor/Nod ligand are present in the brain during demyelinating disease in primates
    Lizette Visser
    Department of Immunology, Erasmus Medical Center, University Medical Center Rotterdam, PO Box 2040, 3000 DR Rotterdam, The Netherlands
    Am J Pathol 169:1671-85. 2006
    ..The presence of PGN in the inflamed brain may have major implications because TLR2/Nod ligation potentially promotes inflammation and disease progression...
  9. ncbi request reprint Identification of soluble CD14 as an endogenous agonist for Toll-like receptor 2 on human astrocytes by genome-scale functional screening of glial cell derived proteins
    Malika Bsibsi
    Department of Biosciences, TNO Quality of Life, Leiden, The Netherlands
    Glia 55:473-82. 2007
    ..In conclusion, our data indicate that apart from its well-known ability to act as a co-receptor for TLR-dependent signaling by peptidoglycans or LPS, soluble CD14 can also act as a direct agonist for TLR2...
  10. ncbi request reprint Modulation of the cytokine network in human adult astrocytes by human herpesvirus-6A
    Sonja Meeuwsen
    Division Biomedical Research, TNO Prevention and Health, P O Box 2215, 2301 CE Leiden, The Netherlands
    J Neuroimmunol 164:37-47. 2005
    ..Our data suggest that HHV-6 itself does not evoke a pro-inflammatory response in astrocytes but rather triggers immune modulatory factors in the face of inflammation...
  11. ncbi request reprint Persistent, noncytolytic infection of neurons by Borna disease virus interferes with ERK 1/2 signaling and abrogates BDNF-induced synaptogenesis
    Aymeric Hans
    Unite des Virus Lents, CNRS URA 1930, Institut Pasteur, Paris, France
    FASEB J 18:863-5. 2004
    ..These results may help to understand the behavioral disorders associated with BDV infection...