H L Zaaijer

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. pmc Hepatitis C virus infection among transmission-prone medical personnel
    H L Zaaijer
    Laboratory of Clinical Virology, Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, Postbus 22660, 1100 DD, Amsterdam, The Netherlands
    Eur J Clin Microbiol Infect Dis 31:1473-7. 2012
  2. pmc Human coronavirus 229E encodes a single ORF4 protein between the spike and the envelope genes
    Ronald Dijkman
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, The Netherlands
    Virol J 3:106. 2006
  3. pmc Occult hepatitis B infection: an evolutionary scenario
    Formijn J van Hemert
    Department of Medical Microbiology, Laboratory of Experimental Virology, Center for Infection and Immunity Amsterdam Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Virol J 5:146. 2008
  4. pmc Influenza infection and risk of acute pulmonary embolism
    Matthijs van Wissen
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Thromb J 5:16. 2007
  5. pmc Hepatitis B virus infected health care workers in The Netherlands, 2000-2008
    T J Daha
    Office of the Infection Prevention Working Party, Leiden University Medical Centre, Leiden, The Netherlands
    Eur J Clin Microbiol Infect Dis 28:1041-4. 2009
  6. doi request reprint Susceptibility of hepatitis B virus to lamivudine restored by resistance to adefovir
    H L Zaaijer
    Laboratory of Clinical Virology, Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Med Virol 81:413-6. 2009
  7. ncbi request reprint [Needlestick injuries and unprotected sex in the Netherlands]
    H L Zaaijer
    Academisch Medisch Centrum Universiteit van Amsterdam, afd Klinische Virologie, LI III, Amsterdam
    Ned Tijdschr Geneeskd 152:1959-60. 2008
  8. doi request reprint Multiple surface antigen mutations in five blood donors with occult hepatitis B virus infection
    H L Zaaijer
    Central Laboratory of the Red Cross Blood Transfusion Service CLB, Sanquin, Amsterdam, Netherlands
    J Med Virol 80:1344-9. 2008
  9. ncbi request reprint Substitution rate of the hepatitis B virus surface gene
    H L Zaaijer
    Academic Medical Center AMC CINIMA, Clinical Virology, University of Amsterdam, Amsterdam, The Netherlands
    J Viral Hepat 15:239-45. 2008
  10. doi request reprint HBsAg-negative mono-infection with hepatitis B virus genotype G
    H L Zaaijer
    Department of Blood borne Infections, Sanquin, Plesmanlaan 125, Amsterdam, The Netherlands
    J Viral Hepat 18:815-9. 2011

Collaborators

Detail Information

Publications31

  1. pmc Hepatitis C virus infection among transmission-prone medical personnel
    H L Zaaijer
    Laboratory of Clinical Virology, Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, Postbus 22660, 1100 DD, Amsterdam, The Netherlands
    Eur J Clin Microbiol Infect Dis 31:1473-7. 2012
    ..If a zero-risk approach is desirable and costs are less relevant, the recurrent screening of EPP-performing personnel for HCV is superior to the follow-up of reported occupational exposures...
  2. pmc Human coronavirus 229E encodes a single ORF4 protein between the spike and the envelope genes
    Ronald Dijkman
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, The Netherlands
    Virol J 3:106. 2006
    ....
  3. pmc Occult hepatitis B infection: an evolutionary scenario
    Formijn J van Hemert
    Department of Medical Microbiology, Laboratory of Experimental Virology, Center for Infection and Immunity Amsterdam Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Virol J 5:146. 2008
    ..To gain insight into the mechanism of the development of occult infection, we compared the full-length HBV genome from a blood donor carrying an occult infection (d4) with global genotype D genomes...
  4. pmc Influenza infection and risk of acute pulmonary embolism
    Matthijs van Wissen
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Thromb J 5:16. 2007
    ..Influenza infections have been associated with procoagulant changes. Whether influenza infections lead to an increased risk of pulmonary embolism remains to be established...
  5. pmc Hepatitis B virus infected health care workers in The Netherlands, 2000-2008
    T J Daha
    Office of the Infection Prevention Working Party, Leiden University Medical Centre, Leiden, The Netherlands
    Eur J Clin Microbiol Infect Dis 28:1041-4. 2009
    ..It remains unknown how this affects the safety of patients. Application in the Netherlands of a European or a British guideline would have, respectively, doubled or tripled the number of restricted health care workers...
  6. doi request reprint Susceptibility of hepatitis B virus to lamivudine restored by resistance to adefovir
    H L Zaaijer
    Laboratory of Clinical Virology, Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Med Virol 81:413-6. 2009
    ..Although clinically insufficient, this effect indicates that HBV polymerase resistance mutations may be antagonistic, which is relevant if chronic HBV infection is to be treated by a combination of polymerase inhibitors...
  7. ncbi request reprint [Needlestick injuries and unprotected sex in the Netherlands]
    H L Zaaijer
    Academisch Medisch Centrum Universiteit van Amsterdam, afd Klinische Virologie, LI III, Amsterdam
    Ned Tijdschr Geneeskd 152:1959-60. 2008
    ..It is questionable whether prophylaxis after unprotected sex (voluntary and involuntary) should be managed using current needle-stick protocols. These accidents require a separate protocol...
  8. doi request reprint Multiple surface antigen mutations in five blood donors with occult hepatitis B virus infection
    H L Zaaijer
    Central Laboratory of the Red Cross Blood Transfusion Service CLB, Sanquin, Amsterdam, Netherlands
    J Med Virol 80:1344-9. 2008
    ....
  9. ncbi request reprint Substitution rate of the hepatitis B virus surface gene
    H L Zaaijer
    Academic Medical Center AMC CINIMA, Clinical Virology, University of Amsterdam, Amsterdam, The Netherlands
    J Viral Hepat 15:239-45. 2008
    ....
  10. doi request reprint HBsAg-negative mono-infection with hepatitis B virus genotype G
    H L Zaaijer
    Department of Blood borne Infections, Sanquin, Plesmanlaan 125, Amsterdam, The Netherlands
    J Viral Hepat 18:815-9. 2011
    ..Our findings demonstrate that HBV genotype G mono-infection occurs and that routine serology is unsuitable for its detection...
  11. pmc Parvovirus B19 viraemia in Dutch blood donors
    H L Zaaijer
    Sanquin, Central Laboratory of the Netherlands Blood Transfusion Service, Amsterdam, The Netherlands
    Epidemiol Infect 132:1161-6. 2004
    ..We inferred that the course of viraemia in asymptomatic donors shows a short peak (> 10(9) copies parvovirus DNA/ml), followed by viraemia below 10(6) copies/ml for about 2 weeks...
  12. ncbi request reprint Occult hepatitis B virus infection before and 1 year after start of HAART in HIV type 1-positive patients
    K Pogany
    Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine, and AIDS, National AIDS Trial and Evaluation Center NATEC, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
    AIDS Res Hum Retroviruses 21:922-6. 2005
    ..Our results illustrate that occult HBV infection is more a diagnostic than a clinical problem. It may be caused by very low levels of HBV replication, concurrent presence of HBsAg and anti-HBs, or mutations in the HBsAg a determinant...
  13. doi request reprint Validation of a sensitive and specific real-time PCR for detection and quantitation of hepatitis B virus covalently closed circular DNA in plasma of chronic hepatitis B patients
    R B Takkenberg
    AMC Liver Center, Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Med Virol 81:988-95. 2009
    ..ALT levels and HAI-score were not correlated with plasma cccDNA levels. These findings suggest that cccDNA levels in plasma are not the result of increased hepatocyte degeneration, but indicate that other mechanisms might be responsible...
  14. doi request reprint Genetic variation in IL28B and treatment outcome in HBeAg-positive and -negative chronic hepatitis B patients treated with Peg interferon alfa-2a and adefovir
    A de Niet
    Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Scand J Gastroenterol 47:475-81. 2012
    ..Additional studies are needed to enlarge sample size and to refine our understanding of IL28B biology in the context of chronic hepatitis B response to immunomodulatory and direct antiviral therapy...
  15. ncbi request reprint Diversity and origin of hepatitis B virus in Dutch blood donors
    M H G M Koppelman
    Department of Virology, Sanquin Central Laboratory of the Blood Transfusion Service, Amsterdam, The Netherlands
    J Med Virol 73:29-32. 2004
    ..On the other hand, it must be realised that, after 20 years of vaccination of at-risk groups, HBV still circulates in the at-risk groups and Dutch blood donors acquire the HBV strains involved...
  16. ncbi request reprint Needlestick injuries and infectious patients in a major academic medical centre from 2003 to 2010
    G Frijstein
    Occupational Health and Safety Department, Academic Medical Centre, Amsterdam, The Netherlands
    Neth J Med 69:465-8. 2011
    ..The number and nature of the occupational exposures indicate that preventive measures must focus on the replacement of needles by safety devices and on awareness training of experienced nurses and of persons in training...
  17. ncbi request reprint Hepatitis B virus (HBV) DNA levels and the management of HBV-infected health care workers
    A A van der Eijk
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    J Viral Hepat 13:2-4. 2006
    ..The issue of standardization has to be addressed, before a universal, maximum level of viraemia for EPP performing HCWs can be introduced...
  18. doi request reprint Infectivity of pre-seroconversion donations: an analysis of lookback exercises in The Netherlands, 2000-2006
    R W Lieshout-Krikke
    Sanquin Blood Supply Foundation, Blood Bank North West, Amsterdam, The Netherlands
    Vox Sang 102:193-7. 2012
    ..Lookback exercises may detect infection in recipients of pre-seroconversion donations. This study provides an analysis of the Dutch lookback exercises in the years 2000 through 2006...
  19. doi request reprint Comparison of the hepatitis B virus core, surface and polymerase gene substitution rates in chronically infected patients
    M A A van de Klundert
    Sanquin, Blood borne Infections, Amsterdam, The Netherlands
    J Viral Hepat 19:e34-40. 2012
    ..Because the HBV core gene reflects the duration of infection more accurately, it is more suitable for the analysis of short-term viral evolution and of hepatitis B transmission chains...
  20. ncbi request reprint Human parechovirus infections in Dutch children and the association between serotype and disease severity
    K S M Benschop
    Department of Clinical Virology, Academic Medical Center, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
    Clin Infect Dis 42:204-10. 2006
    ..HPeV3 infection has been associated with transient paralysis and neonatal infection and has until now only been reported in Japan and Canada...
  21. doi request reprint New developments in antiviral therapy for chronic hepatitis B
    R B Takkenberg
    AMC Liver Center, Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Vox Sang 98:481-94. 2010
    ..This review summarizes the current treatment options with their response rates and discusses future strategies for chronic hepatitis B treatment...
  22. doi request reprint Epidemiology of high-level parvovirus B19 viraemia among Dutch blood donors, 2003-2009
    K Kooistra
    Sanquin, Department of Blood borne Infections, Amsterdam, The Netherlands
    Vox Sang 100:261-6. 2011
    ..We studied the incidence of high-level B19 viraemia (B19 DNA>10(6) IU/ml) in 6.5 million Dutch blood donations...
  23. doi request reprint The yield of temporary exclusion of blood donors, exposed to emerging infections abroad
    R W Lieshout-Krikke
    Sanquin Blood Supply Foundation, Department of Blood borne Infections, Amsterdam, The Netherlands
    Vox Sang 104:12-8. 2013
    ..In this study, the yield of donor deferral after travelling was evaluated, by comparing the estimated numbers of infected donors returning from various affected areas...
  24. ncbi request reprint Chronic hepatitis E after solid organ transplantation
    A de Niet
    Departments of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neth J Med 70:261-6. 2012
    ..Studies are required to determine the optimal duration of ribavirin therapy and to assess outcome for solid organ transplant recipients with chronic HEV infection...
  25. doi request reprint The outcome of donor screening for human T-cell lymphotropic virus infection in The Netherlands
    F J Prinsze
    Sanquin Blood Supply Foundation, Department of Blood borne Infections, Amsterdam, The Netherlands
    Vox Sang 102:198-203. 2012
    ..In 1993, the screening of all blood donations for Human T-Cell Lymphotropic virus (HTLV) was introduced in The Netherlands. We analysed the outcome and costs of HTLV donor screening...
  26. ncbi request reprint Hepatitis G virus RNA and hepatitis G virus-E2 antibodies in Dutch hemophilia patients in relation to transfusion history
    E P Mauser-Bunschoten
    Van Creveldkliniek, University Hospital Utrecht, Utrecht, The Netherlands Viral Diagnostic Laboratory, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands
    Blood 92:2164-8. 1998
    ..HGV infection is frequently seen in patients with hemophilia. In older age groups a lower rate of HGV-RNA positivity is seen coinciding with a higher rate of antienvelope antibodies...
  27. doi request reprint Transmission networks of HIV-1 among men having sex with men in the Netherlands
    Daniela Bezemer
    HIV Monitoring Foundation, Academic Medical Centre, Amsterdam, The Netherlands
    AIDS 24:271-82. 2010
    ..To obtain insight in the HIV-1 transmission networks among men having sex with men (MSM) in the Netherlands...
  28. ncbi request reprint Bilateral pleural effusion and a subsegmental infiltrate due to Chlamydia pneumoniae in a mechanically ventilated patient
    A W Toorians
    Intensive Care Adults, Vrije Universiteit Medisch Centrum, Amsterdam, The Netherlands
    Neth J Med 59:62-5. 2001
    ..Diagnosis was made by polymerase chain reaction on both pleural effusions...
  29. ncbi request reprint Treatment of chronic hepatitis C virus infection - Dutch national guidelines
    J de Bruijne
    Department of Gastroenterology and Hepatology, Academic Medical Centre Amsterdam, The Netherlands
    Neth J Med 66:311-22. 2008
    ..It is expected that new anti-HCV-medication (STAT-C, specifically targeted antiviral therapy for HCV) will become available in the near future. Therefore treatment of chronic HCV infection will probably be more effective in the future...
  30. ncbi request reprint Treatment of chronic hepatitis B virus infection - Dutch national guidelines
    E H C J Buster
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Centre Rotterdam, The Netherlands
    Neth J Med 66:292-306. 2008
    ..However, the complexity of HBV therapy has also increased. Nowadays, virtually all chronic HBV-infected patients can be effectively managed, either by inducing sustained off-treatment response or by maintaining an on-treatment response...
  31. ncbi request reprint [ 'Severe acute respiratory syndrome' (SARS) in perspective]
    H L Zaaijer
    VU Medisch Centrum, afd Medische Microbiologie en Infectiepreventie, Postbus 7057, 1007 MB Amsterdam
    Ned Tijdschr Geneeskd 147:846-8. 2003
    ..The possibility that the bioindustry constitutes a risky microbiological 'experiment' makes a discussion as to its future in the Netherlands urgent...