Arthur A M Wilde

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. doi request reprint Long QT syndrome: beyond the causal mutation
    Ahmad S Amin
    A A M Wilde Department of Cardiology, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    J Physiol 591:4125-39. 2013
  2. pmc Founder mutations in the Netherlands: familial idiopathic ventricular fibrillation and DPP6
    P G Postema
    Department of Cardiology and Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neth Heart J 19:290-6. 2011
  3. pmc Vasovagal syncope or ventricular fibrillation. Your diagnosis better be accurate
    Arthur A M Wilde
    Clin Auton Res 17:203-5. 2007
  4. doi request reprint Left cardiac sympathetic denervation for catecholaminergic polymorphic ventricular tachycardia
    Arthur A M Wilde
    University of Amsterdam, Amsterdam
    N Engl J Med 358:2024-9. 2008
  5. doi request reprint Channelopathies in children and adults
    Arthur A M Wilde
    Heart Failure Research Centre, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Pacing Clin Electrophysiol 31:S41-5. 2008
  6. ncbi request reprint Proposed diagnostic criteria for the Brugada syndrome: consensus report
    Arthur A M Wilde
    Experimental and Molecular Cardiology Group, Academic Medical Center, Amsterdam, and the Interuniversity Cardiology Institute, The Netherlands
    Circulation 106:2514-9. 2002
  7. ncbi request reprint Inherited arrhythmia syndromes
    Arthur Am Wilde
    Experimental and Molecular Cardiology Group, Academic Medical Center, Amsterdam, The Netherlands
    Circ J 71:A12-9. 2007
  8. ncbi request reprint Genotype-specific onset of arrhythmias in congenital long-QT syndrome: possible therapy implications
    Hanno L Tan
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circulation 114:2096-103. 2006
  9. ncbi request reprint Ten years of genes in inherited arrhythmia syndromes: an example of what we have learned from patients, electrocardiograms, and computers
    Arthur A M Wilde
    Department of Clinical and Experimental Cardiology, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
    J Electrocardiol 38:145-9. 2005
  10. ncbi request reprint Is there a genetic basis for malignant ventricular arrhythmias?
    Arthur A M Wilde
    Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Heart Rhythm 2:1145-7. 2005

Detail Information

Publications131 found, 100 shown here

  1. doi request reprint Long QT syndrome: beyond the causal mutation
    Ahmad S Amin
    A A M Wilde Department of Cardiology, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    J Physiol 591:4125-39. 2013
    ....
  2. pmc Founder mutations in the Netherlands: familial idiopathic ventricular fibrillation and DPP6
    P G Postema
    Department of Cardiology and Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neth Heart J 19:290-6. 2011
    ..In addition, when closely coupled extrasystoles initiate ventricular fibrillation in the absence of other identifiable causes, a link to the DPP6 gene should be suspected...
  3. pmc Vasovagal syncope or ventricular fibrillation. Your diagnosis better be accurate
    Arthur A M Wilde
    Clin Auton Res 17:203-5. 2007
  4. doi request reprint Left cardiac sympathetic denervation for catecholaminergic polymorphic ventricular tachycardia
    Arthur A M Wilde
    University of Amsterdam, Amsterdam
    N Engl J Med 358:2024-9. 2008
    ....
  5. doi request reprint Channelopathies in children and adults
    Arthur A M Wilde
    Heart Failure Research Centre, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Pacing Clin Electrophysiol 31:S41-5. 2008
    ..At the same time and of equal importance, unaffected family members (noncarriers) can be reassured...
  6. ncbi request reprint Proposed diagnostic criteria for the Brugada syndrome: consensus report
    Arthur A M Wilde
    Experimental and Molecular Cardiology Group, Academic Medical Center, Amsterdam, and the Interuniversity Cardiology Institute, The Netherlands
    Circulation 106:2514-9. 2002
  7. ncbi request reprint Inherited arrhythmia syndromes
    Arthur Am Wilde
    Experimental and Molecular Cardiology Group, Academic Medical Center, Amsterdam, The Netherlands
    Circ J 71:A12-9. 2007
    ..It is likely that this development will further increase the knowledge of the (patho-) physiology of these disease entities, but also of more common arrhythmia syndromes...
  8. ncbi request reprint Genotype-specific onset of arrhythmias in congenital long-QT syndrome: possible therapy implications
    Hanno L Tan
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circulation 114:2096-103. 2006
    ..This disparity may point to different arrhythmia mechanisms and may affect therapy strategies. We studied whether the proportion of pause-dependent TdP onset varies among LQTS genotypes...
  9. ncbi request reprint Ten years of genes in inherited arrhythmia syndromes: an example of what we have learned from patients, electrocardiograms, and computers
    Arthur A M Wilde
    Department of Clinical and Experimental Cardiology, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
    J Electrocardiol 38:145-9. 2005
    ..As such these studies serve as a good example of what can be reached in a multidisciplinary approach with clinical and basic scientists...
  10. ncbi request reprint Is there a genetic basis for malignant ventricular arrhythmias?
    Arthur A M Wilde
    Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Heart Rhythm 2:1145-7. 2005
  11. pmc Genetics of cardiac arrhythmias
    Arthur A M Wilde
    Experimental and Molecular Cardiology Group, Academic Medical Center, Amsterdam, The Netherlands
    Heart 91:1352-8. 2005
  12. ncbi request reprint Is there a role for implantable cardioverter defibrillators in long QT syndrome?
    Arthur A M Welde
    Academic Medical Center, and Interuniversity Cardiology Institute of The Netherlands, Amsterdam
    J Cardiovasc Electrophysiol 13:S110-3. 2002
    ..Some genetic subtypes, such as LQTS3, may not respond as well (or even adversely) to antiadrenergic therapy and, thus, benefit more from implantable cardioverter defibrillator therapy...
  13. doi request reprint Phenotypical manifestations of mutations in the genes encoding subunits of the cardiac sodium channel
    Arthur A M Wilde
    Department of Clinical and Experimental Cardiology, Academic Medical Center, University Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circ Res 108:884-97. 2011
    ....
  14. ncbi request reprint [Presymptomatic screening after a sudden cardiac death in the family]
    A A Wilde
    Academisch Medisch Centrum, Amsterdam
    Ned Tijdschr Geneeskd 143:1643-8. 1999
    ..g. in asymptomatic persons with the Brugada syndrome, a form of right bundle branch block). Presymptomatic investigation must be performed multidisciplinary...
  15. ncbi request reprint A mutation in the human cardiac sodium channel (E161K) contributes to sick sinus syndrome, conduction disease and Brugada syndrome in two families
    Jeroen P P Smits
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, The Netherlands
    J Mol Cell Cardiol 38:969-81. 2005
    ....
  16. doi request reprint The ICD for primary prevention in patients with inherited cardiac diseases: indications, use, and outcome: a comparison with secondary prevention
    Louise R A Olde Nordkamp
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Circ Arrhythm Electrophysiol 6:91-100. 2013
    ..This study evaluates the efficacy and harm rate of ICD implantations for primary prevention compared with secondary prevention in inherited cardiac diseases...
  17. doi request reprint Familial evaluation in catecholaminergic polymorphic ventricular tachycardia: disease penetrance and expression in cardiac ryanodine receptor mutation-carrying relatives
    Christian van der Werf
    Department of Cardiology, Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands
    Circ Arrhythm Electrophysiol 5:748-56. 2012
    ..Previous studies of CPVT patients mainly involved probands, so current insight into disease penetrance, expression, genotype-phenotype correlations, and arrhythmic event rates in relatives carrying the Ryr2 mutation is limited...
  18. doi request reprint Exercise-induced ECG changes in Brugada syndrome
    Ahmad S Amin
    Heart Failure Research Center and Department of Cardiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Circ Arrhythm Electrophysiol 2:531-9. 2009
    ..Yet, the effects of exercise on the BrS ECG phenotype have not been studied. We aimed to assess ECG responses to exercise in BrS and determine whether these responses are affected by the presence of an SCN5A mutation...
  19. ncbi request reprint Expanding spectrum of human RYR2-related disease: new electrocardiographic, structural, and genetic features
    Zahurul A Bhuiyan
    Department of Clinical Genetics, Academic Medical Centre, University of Amsterdam, The Netherlands
    Circulation 116:1569-76. 2007
    ..Additional features include baseline bradycardia and, in some patients, right ventricular fatty displacement. The clinical spectrum is expanded by the 2 families described here...
  20. doi request reprint A complex double deletion in LMNA underlies progressive cardiac conduction disease, atrial arrhythmias, and sudden death
    Roos F Marsman
    Heart Failure Research Center, Department of Experimental Cardiology, Amsterdam, The Netherlands
    Circ Cardiovasc Genet 4:280-7. 2011
    ..Cardiac conduction disease is a clinically and genetically heterogeneous disorder characterized by defects in electrical impulse generation and conduction and is associated with sudden cardiac death...
  21. ncbi request reprint Role of sequence variations in the human ether-a-go-go-related gene (HERG, KCNH2) in the Brugada syndrome
    Arie O Verkerk
    Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Cardiovasc Res 68:441-53. 2005
    ..Other causally related genes still await identification. We evaluated the role of HERG (KCNH2), which encodes the alpha-subunit of the rapid delayed rectifier K(+) channel (I(Kr)), in BrS...
  22. doi request reprint Gender-specific differences in major cardiac events and mortality in lamin A/C mutation carriers
    Ingrid A W van Rijsingen
    Department of Cardiology Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands
    Eur J Heart Fail 15:376-84. 2013
    ..There are few data on the impact of age and gender on cardiac disease penetrance and mortality...
  23. ncbi request reprint A common polymorphism in KCNH2 (HERG) hastens cardiac repolarization
    Connie R Bezzina
    Experimental and Molecular Cardiology Group, Room M0 052, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Cardiovasc Res 59:27-36. 2003
    ....
  24. ncbi request reprint Characterization of a novel SCN5A mutation associated with Brugada syndrome reveals involvement of DIIIS4-S5 linker in slow inactivation
    Simona Casini
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Cardiovasc Res 76:418-29. 2007
    ..The G1319V mutation is located in the loop connecting transmembrane segments 4 and 5 in domain III (DIIIS4-S5), a region so far considered to be exclusively involved in fast inactivation...
  25. ncbi request reprint Compound heterozygosity for mutations (W156X and R225W) in SCN5A associated with severe cardiac conduction disturbances and degenerative changes in the conduction system
    Connie R Bezzina
    Experimental and Molecular Cardiology Group, Academic Medical Center, Amsterdam, The Netherlands
    Circ Res 92:159-68. 2003
    ..The morphological changes within the heart of the deceased sibling may have occurred secondary to the Na+ channel abnormality and contributed to the severity of the disorder in this individual...
  26. doi request reprint Arrhythmogenic right ventricular dysplasia/cardiomyopathy: pathogenic desmosome mutations in index-patients predict outcome of family screening: Dutch arrhythmogenic right ventricular dysplasia/cardiomyopathy genotype-phenotype follow-up study
    Moniek G P J Cox
    Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Circulation 123:2690-700. 2011
    ..Previous genotype-phenotype relation studies involved mainly overt ARVD/C index patients, so follow-up data on relatives are scarce...
  27. pmc Haplotype-sharing analysis implicates chromosome 7q36 harboring DPP6 in familial idiopathic ventricular fibrillation
    Marielle Alders
    Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands
    Am J Hum Genet 84:468-76. 2009
    ..Penetrance of IVF was high; 50% of risk-haplotype carriers experienced (aborted) sudden cardiac death before the age of 58 years. We propose DPP6 as a gene for IVF and increased DPP6 expression as the likely pathogenetic mechanism...
  28. pmc The role of the epinephrine test in the diagnosis and management of children suspected of having congenital long QT syndrome
    Sally Ann B Clur
    Department of Pediatric Cardiology, Emma Children s Hospital, Academic Medical Centre, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands
    Pediatr Cardiol 31:462-8. 2010
    ..Due to the discordance with genotyping, the epinephrine test cannot be used to diagnose genotype-positive LQTS but when used in combination with phenotype assessment and genetic screening, it could enable better management decisions...
  29. doi request reprint Active cascade screening in primary inherited arrhythmia syndromes: does it lead to prophylactic treatment?
    Nynke Hofman
    Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands
    J Am Coll Cardiol 55:2570-6. 2010
    ..The purpose of this study was to investigate the follow-up and treatment of the mutation-carrying relatives of a proband with an inherited arrhythmia syndrome...
  30. doi request reprint Mechanism of right precordial ST-segment elevation in structural heart disease: excitation failure by current-to-load mismatch
    Mark G Hoogendijk
    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Heart Rhythm 7:238-48. 2010
    ..The Brugada sign has been associated with mutations in SCN5A and with right ventricular structural abnormalities. Their role in the Brugada sign and the associated ventricular arrhythmias is unknown...
  31. pmc Fever-induced QTc prolongation and ventricular arrhythmias in individuals with type 2 congenital long QT syndrome
    Ahmad S Amin
    Heart Failure Research Center, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    J Clin Invest 118:2552-61. 2008
    ....
  32. doi request reprint Yield of molecular and clinical testing for arrhythmia syndromes: report of 15 years' experience
    Nynke Hofman
    Department of Clinical Genetics N H, M A, S D H, M M A M M, M P L, R H L d D, I v L, Department of Cardiology H L T, A A M W, and Department of Epidemiology, Biostatistics, and Bioinformatics I K, Academic Medical Center, Amsterdam, The Netherlands
    Circulation 128:1513-21. 2013
    ..We studied the yield of DNA testing for these syndromes using a candidate-gene approach over our 15 years of experience...
  33. pmc SNPs identified as modulators of ECG traits in the general population do not markedly affect ECG traits during acute myocardial infarction nor ventricular fibrillation risk in this condition
    Raha Pazoki
    Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, The Netherlands
    PLoS ONE 8:e57216. 2013
    ....
  34. doi request reprint Slow and discontinuous conduction conspire in Brugada syndrome: a right ventricular mapping and stimulation study
    Pieter G Postema
    Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circ Arrhythm Electrophysiol 1:379-86. 2008
    ..The pathophysiological basis of the arrhythmias and type-1 BrS-ECG is unresolved. We studied the electrophysiological characteristics of the RV endocardium in BrS...
  35. ncbi request reprint Overlap syndrome of cardiac sodium channel disease in mice carrying the equivalent mutation of human SCN5A-1795insD
    Carol Ann Remme
    Department of Cardiology, Academic Medical Center, Room K2 110, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Circulation 114:2584-94. 2006
    ..We investigated the electrophysiological characteristics of a transgenic model of the murine equivalent mutation 1798insD...
  36. doi request reprint Quantitative trait loci for electrocardiographic parameters and arrhythmia in the mouse
    Brendon P Scicluna
    Heart Failure Research Center, Department of Experimental Cardiology, University of Amsterdam, Amsterdam, The Netherlands
    J Mol Cell Cardiol 50:380-9. 2011
    ..The detection of QTL influencing ECG indices and arrhythmia is an essential step towards identifying genetic networks for sudden, arrhythmic, cardiac death...
  37. doi request reprint Quality of life and psychological distress in hypertrophic cardiomyopathy mutation carriers: a cross-sectional cohort study
    Imke Christiaans
    Academic Medical Center, Department of Clinical Genetics, Amsterdam, The Netherlands
    Am J Med Genet A 149:602-12. 2009
    ..Because these variables can be addressed and adjusted during pre- and post-test counseling, genetic counseling should focus on these determinants...
  38. doi request reprint Type of SCN5A mutation determines clinical severity and degree of conduction slowing in loss-of-function sodium channelopathies
    Paola G Meregalli
    Department of Cardiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Heart Rhythm 6:341-8. 2009
    ..The penetrance and expressivity of the disease are highly variable, and new tools for risk stratification are needed...
  39. ncbi request reprint Substitution of a conserved alanine in the domain IIIS4-S5 linker of the cardiac sodium channel causes long QT syndrome
    Jeroen P P Smits
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Cardiovasc Res 67:459-66. 2005
    ..Here we present the electrophysiological properties of the A1330T sodium channel mutation (DIIIS4-S5 linker). Like the A1330P, LQT3 mutation, A1330T, causes LQT3 in the absence of a persistent current...
  40. doi request reprint A novel alpha-tropomyosin mutation associates with dilated and non-compaction cardiomyopathy and diminishes actin binding
    Judith B A van de Meerakker
    Department of Anatomy, Embryology and Physiology, Academic Medical Center, Amsterdam, The Netherlands
    Biochim Biophys Acta 1833:833-9. 2013
    ..Mutations in alpha-tropomyosin (TPM1), a thin filament protein involved in structural and regulatory roles in muscle cells, are associated with hypertrophic cardiomyopathy (HCM) and very rarely with DCM...
  41. doi request reprint An intronic mutation leading to incomplete skipping of exon-2 in KCNQ1 rescues hearing in Jervell and Lange-Nielsen syndrome
    Zahurul A Bhuiyan
    Department of Clinical Genetics, Academic Medical Centre, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Prog Biophys Mol Biol 98:319-27. 2008
    ..The novel KCNQ1 mutation found in this study is very likely a founder mutation in the southern province of Saudi Arabia emphasizing its screening in the LQT population in this region...
  42. doi request reprint New ECG criteria in arrhythmogenic right ventricular dysplasia/cardiomyopathy
    Moniek G P J Cox
    Department of Cardiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    Circ Arrhythm Electrophysiol 2:524-30. 2009
    ..Current task force criteria (TFC) for diagnosis have limited sensitivity. The aim of this study was to assess the diagnostic value of additional criteria on activation delay and VT to improve identification of affected individuals...
  43. doi request reprint Arrhythmogenic right ventricular dysplasia/cardiomyopathy diagnostic task force criteria: impact of new task force criteria
    Moniek G P J Cox
    Department of Cardiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    Circ Arrhythm Electrophysiol 3:126-33. 2010
    ..A new international task force modified criteria to improve diagnostic yield. A comparison of diagnosis by 1994 TFC versus newly proposed criteria in 3 patient groups was conducted...
  44. ncbi request reprint Exclusion of multiple candidate genes and large genomic rearrangements in SCN5A in a Dutch Brugada syndrome cohort
    Tamara T Koopmann
    Center for Heart Failure Research, Experimental and Molecular Cardiology Group, University of Amsterdam, Amsterdam, The Netherlands
    Heart Rhythm 4:752-5. 2007
    ..Genetic heterogeneity and/or undetected SCN5A mutations, such as exon duplications and deletions, could be involved in the remaining 80% mutation-negative patients...
  45. ncbi request reprint Common sodium channel promoter haplotype in asian subjects underlies variability in cardiac conduction
    Connie R Bezzina
    Experimental and Molecular Cardiology Group, Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circulation 113:338-44. 2006
    ..In this study, we tested the hypothesis that an SCN5A promoter polymorphism common in Asians modulates variability in cardiac conduction...
  46. doi request reprint A mutation in CALM1 encoding calmodulin in familial idiopathic ventricular fibrillation in childhood and adolescence
    Roos F Marsman
    Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    J Am Coll Cardiol 63:259-66. 2014
    ..This study aimed to identify the genetic defect in a family with idiopathic ventricular fibrillation (IVF) manifesting in childhood and adolescence...
  47. doi request reprint Carriers of the hypertrophic cardiomyopathy MYBPC3 mutation are characterized by reduced myocardial efficiency in the absence of hypertrophy and microvascular dysfunction
    Stefan A J Timmer
    Department of Cardiology, VU University Medical Center, De Boelelaan 1117, Amsterdam, The Netherlands
    Eur J Heart Fail 13:1283-9. 2011
    ..Therefore, the aim was to investigate myocardial perfusion and energetics in genotype-positive, phenotype-negative HCM subjects (carriers)...
  48. doi request reprint Mortality risk of untreated myosin-binding protein C-related hypertrophic cardiomyopathy: insight into the natural history
    Eline A Nannenberg
    Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands
    J Am Coll Cardiol 58:2406-14. 2011
    ..The goal of this study was to assess the mortality of hypertrophic cardiomyopathy (HCM), partly in times when the disease was not elucidated and patients were untreated...
  49. pmc How do hypertrophic cardiomyopathy mutations affect myocardial function in carriers with normal wall thickness? Assessment with cardiovascular magnetic resonance
    Tjeerd Germans
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    J Cardiovasc Magn Reson 12:13. 2010
    ..We aimed to confirm the presence of functional abnormalities using cardiovascular magnetic resonance (CMR), and to investigate if sensitive functional assessment could be employed to identify carriers...
  50. doi request reprint Value of history-taking in syncope patients: in whom to suspect long QT syndrome?
    Nancy Colman
    Department of Cardiology B2, Academic Medical Centre, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    Europace 11:937-43. 2009
    ..Long QT syndrome (LQTS), a potentially fatal disorder, has to be distinguished from non-fatal conditions. Our aim was to investigate whether history-taking can be used in identifying patients likely to have LQTS...
  51. doi request reprint Manifest disease, risk factors for sudden cardiac death, and cardiac events in a large nationwide cohort of predictively tested hypertrophic cardiomyopathy mutation carriers: determining the best cardiological screening strategy
    Imke Christiaans
    Department of Clinical Genetics, Academic Medical Centre, Amsterdam, The Netherlands
    Eur Heart J 32:1161-70. 2011
    ....
  52. pmc The role of renin-angiotensin-aldosterone system polymorphisms in phenotypic expression of MYBPC3-related hypertrophic cardiomyopathy
    Iris C R M Kolder
    Heart Failure Research Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Eur J Hum Genet 20:1071-7. 2012
    ....
  53. ncbi request reprint Contribution of inherited heart disease to sudden cardiac death in childhood
    Nynke Hofman
    Department of Clinical Genetics, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Pediatrics 120:e967-73. 2007
    ..We aimed to establish the cause of sudden cardiac death in the children of whom the family was referred to our cardiogenetics department and the diagnostic yield of these investigations...
  54. doi request reprint Cardiac sodium channel overlap syndromes: different faces of SCN5A mutations
    Carol Ann Remme
    Department of Experimental Cardiology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Trends Cardiovasc Med 18:78-87. 2008
    ..Here, we provide an overview of current knowledge on SCN5A mutations associated with sodium channel overlap syndromes and discuss a possible role for modifiers in determining disease expressivity in the individual patient...
  55. pmc Obtaining insurance after DNA diagnostics: a survey among hypertrophic cardiomyopathy mutation carriers
    Imke Christiaans
    Department of Cardiology, Academic Medical Centre, Amsterdam, The Netherlands
    Eur J Hum Genet 18:251-3. 2010
    ....
  56. ncbi request reprint A cardiac sodium channel mutation cosegregates with a rare connexin40 genotype in familial atrial standstill
    W Antoinette Groenewegen
    Department of Medical Physiology, University Medical Center, Utrecht, The Netherlands
    Circ Res 92:14-22. 2003
    ..We propose that, although the functional effect of each genetic change is relatively benign, the combined effect of genetic changes eventually progresses to total AS...
  57. doi request reprint Incidence, causes, and outcomes of out-of-hospital cardiac arrest in children. A comprehensive, prospective, population-based study in the Netherlands
    Abdennasser Bardai
    Heart Failure Research Center, Department of Cardiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands
    J Am Coll Cardiol 57:1822-8. 2011
    ....
  58. ncbi request reprint Pathophysiological mechanisms of Brugada syndrome: depolarization disorder, repolarization disorder, or more?
    Paola G Meregalli
    Department of Cardiology, Room M0 105, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Cardiovasc Res 67:367-78. 2005
    ....
  59. ncbi request reprint Sudden unexplained death: heritability and diagnostic yield of cardiological and genetic examination in surviving relatives
    Hanno L Tan
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circulation 112:207-13. 2005
    ..We aimed to establish the diagnostic yield of such assessments...
  60. doi request reprint Electrocardiographic P wave changes after thoracoscopic pulmonary vein isolation for atrial fibrillation
    Martina Nassif
    Heart Center, Department of Cardiology and Experimental Cardiology, Academic Medical Center, Meibergdreef 9, 1105, AZ, Amsterdam, The Netherlands
    J Interv Card Electrophysiol 37:275-82. 2013
    ....
  61. pmc SCN5A mutations in Brugada syndrome are associated with increased cardiac dimensions and reduced contractility
    Frans van Hoorn
    Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e42037. 2012
    ..We aimed to determine whether clinical evidence may be obtained that Na(v)1.5 is involved in maintaining cardiac structural integrity...
  62. doi request reprint Risk factors for malignant ventricular arrhythmias in lamin a/c mutation carriers a European cohort study
    Ingrid A W van Rijsingen
    Department of Cardiology, Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands
    J Am Coll Cardiol 59:493-500. 2012
    ..The purpose of this study was to determine risk factors that predict malignant ventricular arrhythmias (MVA) in Lamin A/C (LMNA) mutation carriers...
  63. pmc Variants in the 3' untranslated region of the KCNQ1-encoded Kv7.1 potassium channel modify disease severity in patients with type 1 long QT syndrome in an allele-specific manner
    Ahmad S Amin
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur Heart J 33:714-23. 2012
    ..We aimed to study whether this can be explained by single nucleotide polymorphisms (SNPs) in KCNQ1's 3' untranslated region (3'UTR)...
  64. doi request reprint Facilitatory and inhibitory effects of SCN5A mutations on atrial fibrillation in Brugada syndrome
    Ahmad S Amin
    Heart Failure Research Center, Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Europace 13:968-75. 2011
    ..Here, we examined the relation between SCN5A mutations, atrial conduction velocity, atrial structural changes, and atrial ectopic activity in BrS...
  65. doi request reprint A gain-of-function TBX5 mutation is associated with atypical Holt-Oram syndrome and paroxysmal atrial fibrillation
    Alex V Postma
    Heart Failure Research Center, L2 108 1, Academic Medical Center, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    Circ Res 102:1433-42. 2008
    ....
  66. ncbi request reprint [Premature sudden death--consider serious familial heart rhythm disturbances]
    Pieter G Postema
    Academisch Medisch Centrum, afd Cardiologie, Hartfaal Centrum, Amsterdam, The Netherlands
    Ned Tijdschr Geneeskd 155:A3391. 2011
    ..Timely recognition of persons affected allows appropriate treatment and may implicate an implantable cardioverter defibrillator...
  67. doi request reprint Sodium channelopathies: do we really understand what's going on?
    Pieter G Postema
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Cardiovasc Electrophysiol 22:590-3. 2011
    ..One son who carried the ΔKPQ mutation but not the I1660V mutation did not show the expected Long-QT phenotype but, unexpectedly, showed a conduction disease/Brugada phenotype...
  68. doi request reprint Cardiac sodium channels and inherited electrophysiologic disorders: a pharmacogenetic overview
    Jeroen P P Smits
    University of Amsterdam, Academic Medical Center, Department of Cardiology, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Expert Opin Pharmacother 9:537-49. 2008
    ..An overview is given of the known risks of development of the previously mentioned complications of commonly prescribed drugs in patients affected with Na channel-related diseases and the underlying mechanisms...
  69. doi request reprint The yield of risk stratification for sudden cardiac death in hypertrophic cardiomyopathy myosin-binding protein C gene mutation carriers: focus on predictive screening
    Imke Christiaans
    Department of Clinical Genetics, Academic Medical Centre, Amsterdam, The Netherlands
    Eur Heart J 31:842-8. 2010
    ....
  70. doi request reprint Predictive genetic testing for cardiovascular diseases: impact on carrier children
    Tineke M Meulenkamp
    Medical Psychology, Academic Medical Center University of Amsterdam, and Pediatric Lipid Clinic, Emma s Children Hospital, Amsterdam, The Netherlands
    Am J Med Genet A 146:3136-46. 2008
    ..Nevertheless, dealing with the daily implications of their condition remains difficult in some situations, warranting continued availability of psychosocial support...
  71. doi request reprint Cardiac ion channels in health and disease
    Ahmad S Amin
    Heart Failure Research Center, University of Amsterdam, Amsterdam, The Netherlands
    Heart Rhythm 7:117-26. 2010
    ..This review discusses ion channels that contribute to action potential formation in healthy hearts and their role in inherited and acquired diseases...
  72. doi request reprint Genome-wide association study identifies a susceptibility locus at 21q21 for ventricular fibrillation in acute myocardial infarction
    Connie R Bezzina
    Department of Experimental Cardiology, University of Amsterdam, Amsterdam, The Netherlands
    Nat Genet 42:688-91. 2010
    ..This locus has not previously been implicated in arrhythmia susceptibility...
  73. doi request reprint Genetically determined differences in sodium current characteristics modulate conduction disease severity in mice with cardiac sodium channelopathy
    Carol Ann Remme
    Heart Failure Research Center, Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Room K2 110, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Circ Res 104:1283-92. 2009
    ..In particular, the sodium channel subunit beta4 (SCN4B) may constitute a potential genetic modifier of conduction and cardiac sodium channel disease...
  74. ncbi request reprint Right ventricular fibrosis and conduction delay in a patient with clinical signs of Brugada syndrome: a combined electrophysiological, genetic, histopathologic, and computational study
    Ruben Coronel
    Experimental and Molecular Cardiology Group, Academic Medical Center, Amsterdam, The Netherlands
    Circulation 112:2769-77. 2005
    ..The mechanism of ECG changes and arrhythmogenesis in Brugada syndrome (BS) patients is unknown...
  75. doi request reprint ECG quantification of myocardial scar does not differ between primary and secondary prevention ICD recipients with ischemic heart disease
    Karin Kraaier
    Department of Cardiology, Medisch Spectrum Twente, Haaksbergerstraat 55, Enschede, The Netherlands
    Pacing Clin Electrophysiol 33:192-7. 2010
    ..In this study, we tested the hypothesis that QRS scores among ICD recipients for secondary prevention are higher than QRS scores in primary prevention patients...
  76. doi request reprint Do patients with long QT syndrome remain at risk for sudden cardiac death after 40 years of age?
    Pieter G Postema
    Department of Clinical and Experimental Cardiology at the Academic Medical Centre, Amsterdam, The Netherlands
    Nat Clin Pract Cardiovasc Med 5:602-3. 2008
    ..65-9.92). Clearly, patients with LQTS remain at increased risk of lethal events after 40 years of age, indicating that continuous, age-independent awareness for QT prolongation is essential...
  77. ncbi request reprint Genotype-phenotype relationship in Brugada syndrome: electrocardiographic features differentiate SCN5A-related patients from non-SCN5A-related patients
    Jeroen P P Smits
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    J Am Coll Cardiol 40:350-6. 2002
    ....
  78. doi request reprint Electrocardiographic factors playing a role in ischemic ventricular fibrillation in ST elevation myocardial infarction are related to the culprit artery
    Miguel E Lemmert
    Department of Cardiology, University Hospital Maastricht, Maastricht, The Netherlands
    Heart Rhythm 5:71-8. 2008
    ..Sudden cardiac death caused by ischemic ventricular fibrillation (VF) associated with ST elevation myocardial infarction (STEMI) is one of the most frequent causes of death...
  79. ncbi request reprint Diagnostic performance of various QTc interval formulas in a large family with long QT syndrome type 3: Bazett's formula not so bad after all
    Jan Brouwer
    Department of Cardiology, Thorax Center, University Hospital Groningen, Groningen, The Netherlands
    Ann Noninvasive Electrocardiol 8:269-74. 2003
    ..The aim of this study was to assess whether the various proposed corrections of the QT interval to heart rate help to improve the identification of carriers of the mutant gene...
  80. ncbi request reprint Gender differences in the long QT syndrome: effects of beta-adrenoceptor blockade
    Chantal E Conrath
    Department of Cardiology, University Medical Center, Utrecht, The Netherlands
    Cardiovasc Res 53:770-6. 2002
    ..Gender differences have been reported in patients with the congenital long QT syndrome (LQTS). We analyzed whether electrocardiographic differences existed in females, males, girls and boys in response to beta-adrenoceptor blockade...
  81. ncbi request reprint Delay in right ventricular activation contributes to Brugada syndrome
    Raymond Tukkie
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circulation 109:1272-7. 2004
    ..We aimed to establish the electrophysiological mechanism of Brugada syndrome by studying the timing and force of RV contraction...
  82. ncbi request reprint A family with Andersen-Tawil syndrome and dilated cardiomyopathy
    Bas A Schoonderwoerd
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Heart Rhythm 3:1346-50. 2006
  83. doi request reprint Nodoventricular accessory pathways in PRKAG2-dependent familial preexcitation syndrome reveal a disorder in cardiac development
    Hanno L Tan
    Heart Failure Research Center, Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circ Arrhythm Electrophysiol 1:276-81. 2008
    ..Yet, histopathologic proof is still lacking. We aimed to provide such proof...
  84. ncbi request reprint Cardiac involvement in carriers of Duchenne and Becker muscular dystrophy
    E M Hoogerwaard
    Department of Neurology, Academic Medical Centre, University of Amsterdam, The Netherlands
    Neuromuscul Disord 9:347-51. 1999
    ..If left ventricle dilatation or dilated cardiomyopathy is present a yearly follow up is needed, in order to start timely therapy...
  85. ncbi request reprint Premature ventricular contractions during triggered imaging with ultrasound contrast
    P A van der Wouw
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    J Am Soc Echocardiogr 13:288-94. 2000
    ..Further investigation into the relation of this phenomenon to both ultrasound energy and the contrast agent was carried out during a subsequent bolus-versus-infusion study...
  86. ncbi request reprint K(ATP) channel opening during ischemia: effects on myocardial noradrenaline release and ventricular arrhythmias
    C A Remme
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, The Netherlands
    J Cardiovasc Pharmacol 38:406-16. 2001
    ....
  87. ncbi request reprint [The heartache of muscular dystrophy]
    E M Hoogerwaard
    afd Neurologie, Academisch Medisch Centrum Universiteit van Amsterdam
    Ned Tijdschr Geneeskd 144:2181-4. 2000
    ..Patients with dilated cardiomyopathy and with a positive family history for dilated cardiomyopathy, muscle weakness or high serum creatine kinase activity should be screened for a mutation in the dystrophin gene...
  88. ncbi request reprint High diagnostic yield and accuracy of history, physical examination, and ECG in patients with transient loss of consciousness in FAST: the Fainting Assessment study
    Nynke van Dijk
    Departments of Internal Medicine, Academic Medical Center, University of Amsterdam AMC UvA, Amsterdam, The Netherlands
    J Cardiovasc Electrophysiol 19:48-55. 2008
    ..Transient loss of consciousness (TLOC) is a common clinical problem...
  89. ncbi request reprint Con: Newborn screening to prevent sudden cardiac death?
    Irene M van Langen
    Department of Clinical Genetics, Academic Medical Centre, Amsterdam, The Netherlands
    Heart Rhythm 3:1356-9. 2006
  90. pmc Recurrent intrauterine fetal loss due to near absence of HERG: clinical and functional characterization of a homozygous nonsense HERG Q1070X mutation
    Zahurul A Bhuiyan
    Department of Clinical Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Heart Rhythm 5:553-61. 2008
    ..Resolving the molecular genetic nature of these rare cases provides significant insight into the role of the affected proteins in arrhythmogenesis and (extra-) cardiac development...
  91. doi request reprint Prevalence and characterization of ECG abnormalities after intracerebral hemorrhage
    Maurits D R van Bree
    Department of Neurology, Academic Medical Centre Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Neurocrit Care 12:50-5. 2010
    ..The purpose of this study is to investigate the prevalence and type of ECG abnormalities in a consecutive series of ICH patients, and their possible association with pre-defined neurological and radiological parameters...
  92. doi request reprint Clinical and genetic analysis of long QT syndrome in children from six families in Saudi Arabia: are they different?
    Zahurul A Bhuiyan
    Department of Clinical Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Pediatr Cardiol 30:490-501. 2009
    ..3208 C > T in the KCNH2 gene, are presumably founder mutations in the Assir province of Saudi Arabia. Further, all LQTS causing mutations detected in this study are novel and have not been reported in other populations...
  93. pmc Drugs and Brugada syndrome patients: review of the literature, recommendations, and an up-to-date website (www.brugadadrugs.org)
    Pieter G Postema
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Heart Rhythm 6:1335-41. 2009
    ..Importantly, many drugs have been reported to induce the characteristic Brugada syndrome-linked ECG abnormalities and/or (fatal) ventricular tachyarrhythmias...
  94. ncbi request reprint Voltage-gated sodium channels: action players with many faces
    Tamara T Koopmann
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Ann Med 38:472-82. 2006
    ..In this review article, mutations in these genes leading to various inherited disorders are discussed...
  95. ncbi request reprint Contribution of sodium channel mutations to bradycardia and sinus node dysfunction in LQT3 families
    Marieke W Veldkamp
    Experimental and Molecular Cardiology Group, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, The Netherlands
    Circ Res 92:976-83. 2003
    ....
  96. ncbi request reprint Genetic control of sodium channel function
    Hanno L Tan
    Experimental and Molecular Cardiology Group, Department of Cardiology, Academic Medical Center, Room M0 052, P O Box 22700, 1100 DE, Amsterdam, The Netherlands
    Cardiovasc Res 57:961-73. 2003
    ....
  97. doi request reprint Health-related quality of life of children with a positive carrier status for inherited cardiovascular diseases
    Ellen M A Smets
    Department of Medical Psychology, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    Am J Med Genet A 146:700-7. 2008
    ..Yet, attention to possible problems in these children remains warranted...
  98. doi request reprint Symptoms and signs of syncope: a review of the link between physiology and clinical clues
    Wouter Wieling
    Department of Internal Medicine, Academic Medical Centre University of Amsterdam, Amsterdam, The Netherlands
    Brain 132:2630-42. 2009
    ..Complete loss of consciousness occurs with the 'turning up' of the eyeballs. Profound cerebral hypoperfusion may be accompanied by myoclonic jerks...
  99. ncbi request reprint Familial sudden death is an important risk factor for primary ventricular fibrillation: a case-control study in acute myocardial infarction patients
    Lukas R C Dekker
    Department of Cardiology, B2 116, Academic Medical Center, PO Box 22660, 1100 DD, Amsterdam, The Netherlands
    Circulation 114:1140-5. 2006
    ..Primary ventricular fibrillation (VF) accounts for the majority of deaths during the acute phase of myocardial infarction. Identification of patients at risk for primary VF remains very poor...
  100. ncbi request reprint Mechanisms of inherited cardiac conduction disease
    Jeroen P P Smits
    Department of Clinical and Experimental Cardiology, Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Room M 0 107, Meibergdreef 9, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Europace 7:122-37. 2005
    ..In this review we aim to find evidence for the idea that functional and structural ICCD are fundamentally different diseases and, if so, whether this has diagnostic and clinical consequences...
  101. doi request reprint Desmoglein-2 and desmocollin-2 mutations in dutch arrhythmogenic right ventricular dysplasia/cardiomypathy patients: results from a multicenter study
    Zahurul A Bhuiyan
    Department of Clinical Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circ Cardiovasc Genet 2:418-27. 2009
    ..We also aimed to distinguish relevant clinical and ECG parameters...