Wilmar M Wiersinga

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint The philosophy of Graves' ophthalmopathy
    Wilmar M Wiersinga
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands
    Orbit 24:165-71. 2005
  2. ncbi request reprint Early versus late orbital decompression in Graves' orbitopathy: a retrospective study in 125 patients
    Lelio Baldeschi
    Orbital Centre, Department of Ophthalmology, University of Amsterdam, Amsterdam, The Netherlands
    Ophthalmology 113:874-8. 2006
  3. ncbi request reprint The effects of sex-steroid administration on the pituitary-thyroid axis in transsexuals
    Peter H Bisschop
    Department of Endocrinology and Metabolism, Laboratory of Endocrinology, Academic Medical, University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands
    Eur J Endocrinol 155:11-6. 2006
  4. doi request reprint A new and validated CT-based method for the calculation of orbital soft tissue volumes
    Noortje I Regensburg
    Orbital Centre, Department of Ophthalmology, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands
    Invest Ophthalmol Vis Sci 49:1758-62. 2008
  5. doi request reprint Smoking and thyroid
    Wilmar M Wiersinga
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Clin Endocrinol (Oxf) 79:145-51. 2013
  6. ncbi request reprint [Cardiovascular risks in patients with subclinical thyroid dysfunction]
    Wilmar M Wiersinga
    Academisch Medisch Centrum, afd Inwendige Geneeskunde Endocrinologie en Metabolisme, Amsterdam, The Netherlands
    Ned Tijdschr Geneeskd 156:A5477. 2012
  7. doi request reprint Quality of life in Graves' ophthalmopathy
    Wilmar M Wiersinga
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands
    Best Pract Res Clin Endocrinol Metab 26:359-70. 2012
  8. doi request reprint Autoimmunity in Graves' ophthalmopathy: the result of an unfortunate marriage between TSH receptors and IGF-1 receptors?
    Wilmar M Wiersinga
    Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam 1105 AZ, The Netherlands
    J Clin Endocrinol Metab 96:2386-94. 2011
  9. ncbi request reprint Increased oxidizability of low-density lipoproteins in hypothyroidism
    T Diekman
    Department of Endocrinology, University of Amsterdam, The Netherlands
    J Clin Endocrinol Metab 83:1752-5. 1998
  10. ncbi request reprint Management of Graves' ophthalmopathy
    Wilmar M Wiersinga
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands
    Nat Clin Pract Endocrinol Metab 3:396-404. 2007

Detail Information

Publications97

  1. ncbi request reprint The philosophy of Graves' ophthalmopathy
    Wilmar M Wiersinga
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands
    Orbit 24:165-71. 2005
    ....
  2. ncbi request reprint Early versus late orbital decompression in Graves' orbitopathy: a retrospective study in 125 patients
    Lelio Baldeschi
    Orbital Centre, Department of Ophthalmology, University of Amsterdam, Amsterdam, The Netherlands
    Ophthalmology 113:874-8. 2006
    ..To determine if early rehabilitative orbital decompression in Graves' orbitopathy (GO) leads to a more effective postoperative outcome than the same intervention performed at a later, more likely, fibrotic stage...
  3. ncbi request reprint The effects of sex-steroid administration on the pituitary-thyroid axis in transsexuals
    Peter H Bisschop
    Department of Endocrinology and Metabolism, Laboratory of Endocrinology, Academic Medical, University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands
    Eur J Endocrinol 155:11-6. 2006
    ....
  4. doi request reprint A new and validated CT-based method for the calculation of orbital soft tissue volumes
    Noortje I Regensburg
    Orbital Centre, Department of Ophthalmology, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands
    Invest Ophthalmol Vis Sci 49:1758-62. 2008
    ....
  5. doi request reprint Smoking and thyroid
    Wilmar M Wiersinga
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Clin Endocrinol (Oxf) 79:145-51. 2013
    ..The observed associations with smoking likely indicate causal relationships in view of consistent associations across studies, the presence of dose-response effects and disappearance of associations after cessation of smoking...
  6. ncbi request reprint [Cardiovascular risks in patients with subclinical thyroid dysfunction]
    Wilmar M Wiersinga
    Academisch Medisch Centrum, afd Inwendige Geneeskunde Endocrinologie en Metabolisme, Amsterdam, The Netherlands
    Ned Tijdschr Geneeskd 156:A5477. 2012
    ..1 or > 10 mU/l. Treatment of patients with TSH levels between 0.1-0.4 mU/l or 4-10 mU/l should depend on other risk factors and patient age, with no treatment for persons with a TSH level of 4-10 mU/l who are older than 65 years...
  7. doi request reprint Quality of life in Graves' ophthalmopathy
    Wilmar M Wiersinga
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands
    Best Pract Res Clin Endocrinol Metab 26:359-70. 2012
    ....
  8. doi request reprint Autoimmunity in Graves' ophthalmopathy: the result of an unfortunate marriage between TSH receptors and IGF-1 receptors?
    Wilmar M Wiersinga
    Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam 1105 AZ, The Netherlands
    J Clin Endocrinol Metab 96:2386-94. 2011
    ..This review on the pathophysiology of GO focused on orbital fibroblasts and the question whether autoimmunity against TSHR or IGF-1R is primarily involved...
  9. ncbi request reprint Increased oxidizability of low-density lipoproteins in hypothyroidism
    T Diekman
    Department of Endocrinology, University of Amsterdam, The Netherlands
    J Clin Endocrinol Metab 83:1752-5. 1998
    ..In conclusion, the hypothyroid state is not only associated with a quantitative increase of LDL particles, but it also changes their quality by increasing LDL oxidizability...
  10. ncbi request reprint Management of Graves' ophthalmopathy
    Wilmar M Wiersinga
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands
    Nat Clin Pract Endocrinol Metab 3:396-404. 2007
    ..Consequently, there is an urgent need for improved treatment modalities, and antibody therapy has shown promise in this respect...
  11. doi request reprint Is sleeping position related to asymmetry in bilateral Graves' ophthalmopathy?
    Wilmar M Wiersinga
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands
    Thyroid 18:541-4. 2008
    ....
  12. ncbi request reprint Effects of Graves' ophthalmopathy on quality of life
    W M Wiersinga
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands
    J Endocrinol Invest 27:259-64. 2004
    ..The GO-QOL is available in six languages, and can be used as a separate outcome measure in clinical studies...
  13. ncbi request reprint Combined thyroid eye clinic: the importance of a multidisciplinary health care in patients with Graves' orbitopathy
    Wilmar M Wiersinga
    Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands
    Pediatr Endocrinol Rev 7:250-3. 2010
    ..Joint clinics by ophthalmologists and endocrinologists are likely to improve the quality of care, and are also advantageous for education and clinical research...
  14. ncbi request reprint Thyroid associated ophthalmopathy: pediatric and endocrine aspects
    Wilmar M Wiersinga
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands
    Pediatr Endocrinol Rev 1:513-7. 2004
    ..The new compound SOM 230 might be much more effective in this respect...
  15. doi request reprint Should we treat mild subclinical/mild hyperthyroidism? Yes
    Wilmar M Wiersinga
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands
    Eur J Intern Med 22:324-9. 2011
    ..1 mU/l or lower. At TSH values>0.1-<0.4 mU/l treatment should be considered in the presence of risk factors (age>65 years, post menopause, osteoporosis, cardiac disease)...
  16. ncbi request reprint L-T4 and L-T3 combined treatment vs L-T4 alone
    W M Wiersinga
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands
    Ann Endocrinol (Paris) 68:216-9. 2007
  17. ncbi request reprint [The interpretation of the thyroid stimulating hormone (TSH) assay]
    W M Wiersinga
    Academisch Medisch Centrum Universiteit van Amsterdam, afd Endocrinologie en Metabolisme, Meibergdreef 9, 1105 AZ Amsterdam
    Ned Tijdschr Geneeskd 147:1156-8. 2003
    ..10 mU/l. A decreased TSH value in the course of treatment for Graves' hyperthyroidism does not necessarily indicate thyrotoxicosis, but may reflect persisting levels of TSH receptor stimulating antibodies...
  18. doi request reprint Do we need still more trials on T4 and T3 combination therapy in hypothyroidism?
    Wilmar M Wiersinga
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Eur J Endocrinol 161:955-9. 2009
    ..Future trials should target carriers of these polymorphisms to see whether they do better on T(4)/T(3) combination therapy than on T(4) monotherapy...
  19. ncbi request reprint A survey of iodine intake and thyroid volume in Dutch schoolchildren: reference values in an iodine-sufficient area and the effect of puberty
    W M Wiersinga
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands
    Eur J Endocrinol 144:595-603. 2001
    ..Iodine deficiency and endemic goiter have been reported in the past in The Netherlands, especially in the southeast...
  20. ncbi request reprint [From gene to disease; thyroid stimulating hormone receptor, hyperthyroidism and hypothyroidism]
    W M Wiersinga
    Academisch Medisch Centrum Universiteit van Amsterdam, afd Inwendige Ziekten, onderafd Endocrinologie en Metabolisme, Meibergdreef 9, 1105 AZ Amsterdam
    Ned Tijdschr Geneeskd 145:869-71. 2001
    ..Familial gestational hyperthyroidism is due to a mutant TSH-R which is hypersensitive to chorionic gonadotropin. Somatic gain-of-function mutations are a major cause of toxic thyroid adenomas...
  21. ncbi request reprint Thyroid hormone replacement therapy
    W M Wiersinga
    Department of Endocrinology and Metabolism, Academic Medical Centre, University of Amsterdam, NL 1105 AZ Amsterdam, The Netherlands
    Horm Res 56:74-81. 2001
    ..It could well be that a slow-release preparation containing both T(4) and T(3) might improve the quality of life, compared with T(4) replacement alone, in some hypothyroid patients...
  22. ncbi request reprint [The practice guideline 'Thyroid disorders' (first revision) from the Dutch College of General Practitioners; a response from the perspective of internal medicine]
    W M Wiersinga
    Academisch Medisch Centrum Universiteit van Amsterdam, afd Inwendige Geneeskunde, onderafd Endocrinologie en Metabolisme, Amsterdam
    Ned Tijdschr Geneeskd 151:2822-4. 2007
    ....
  23. ncbi request reprint Thyroid cancer in children and adolescents--consequences in later life
    W M Wiersinga
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands
    J Pediatr Endocrinol Metab 14:1289-96; discussion 1297-8. 2001
    ..Consequences in adult life relate to long-term complications of thyroid surgery, 131I treatment and TSH-suppressive doses of L-T4...
  24. ncbi request reprint Graves' ophthalmopathy: a rational approach to treatment
    Wilmar M Wiersinga
    Dept Endocrinology and Metabolism, Academic Medical Center F5 171, Meibergdreef 9, 1105 Amsterdam, The Netherlands
    Trends Endocrinol Metab 13:280-7. 2002
    ..The patient should be reassured that functional and cosmetic improvement of eye changes is feasible, but restoration can require one to two years. To a certain extent, refraining from smoking prevents the development or worsening of GO...
  25. ncbi request reprint Epidemiology and prevention of Graves' ophthalmopathy
    Wilmar M Wiersinga
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Thyroid 12:855-60. 2002
    ..Smoking withdrawal may increase the effectiveness of immunosuppressive treatment...
  26. pmc The role of thyroid hormone nuclear receptors in the heart: evidence from pharmacological approaches
    Wilmar M Wiersinga
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Heart Fail Rev 15:121-4. 2010
    ..Induction of a hypothyroid cardiac phenotype by amiodarone may be advantageous by decreasing energy demands and increasing energy availability...
  27. ncbi request reprint Thyrotropin, but not a polymorphism in type II deiodinase, predicts response to paroxetine in major depression
    Jantien P Brouwer
    Department of Endocrinology, Academic Medical Center, The Netherlands
    Eur J Endocrinol 154:819-25. 2006
    ....
  28. ncbi request reprint Glucocorticoids and relapse of major depression (dexamethasone/corticotropin-releasing hormone test in relation to relapse of major depression)
    Bente C Appelhof
    Department of Endocrinology and Metabolism, Academic Medical Center of the University of Amsterdam, The Netherlands
    Biol Psychiatry 59:696-701. 2006
    ..Knowledge of pathogenic mechanisms and predictors of relapse in major depressive disorder is still limited. Hypothalamic-pituitary-adrenocortical (HPA) axis dysregulation is thought to be related to the development and course of depression...
  29. doi request reprint Thyrotropin receptor-stimulating Graves' disease immunoglobulins induce hyaluronan synthesis by differentiated orbital fibroblasts from patients with Graves' ophthalmopathy not only via cyclic adenosine monophosphate signaling pathways
    Clementine J J van Zeijl
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Thyroid 21:169-76. 2011
    ....
  30. ncbi request reprint Thyroid and adrenal axis in major depression: a controlled study in outpatients
    Jantien P Brouwer
    Department of Endocrinology, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Endocrinol 152:185-91. 2005
    ..We therefore conducted a controlled study in unipolar depressed outpatients who had been free of antidepressants for at least 3 months...
  31. doi request reprint Natural history of the transition from euthyroidism to overt autoimmune hypo- or hyperthyroidism: a prospective study
    Grigoris Effraimidis
    Departments of Endocrinology and Metabolism Cardiology, Academic Medical Centre, University of Amsterdam, PO Box 22700, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Eur J Endocrinol 164:107-13. 2011
    ..To evaluate the progression in time from euthyroidism to overt autoimmune hypothyroidism or to overt autoimmune hyperthyroidism...
  32. ncbi request reprint Polymorphisms in type 2 deiodinase are not associated with well-being, neurocognitive functioning, and preference for combined thyroxine/3,5,3'-triiodothyronine therapy
    Bente C Appelhof
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, F5 171, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    J Clin Endocrinol Metab 90:6296-9. 2005
    ..Levothyroxine-treated patients can be assumed to derive T3 exclusively from deiodination of T4, which, in the central nervous system, is regulated by type II deiodinase (DII)...
  33. doi request reprint Prediction of progression to overt hypothyroidism or hyperthyroidism in female relatives of patients with autoimmune thyroid disease using the Thyroid Events Amsterdam (THEA) score
    Thea G A Strieder
    Department of Endocrinology and Metabolism, Academic Medical Center, Room F5 171, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands
    Arch Intern Med 168:1657-63. 2008
    ..Our goal was to develop a simple predictive score that has broad applicability and is easily calculated at presentation for progression to overt hypothyroidism or hyperthyroidism within 5 years in female relatives of patients with AITD...
  34. ncbi request reprint Novel neuroanatomical pathways for thyroid hormone action in the human anterior pituitary
    Anneke Alkemade
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands
    Eur J Endocrinol 154:491-500. 2006
    ....
  35. ncbi request reprint Prediction of treatment response by HPA-axis and glucocorticoid receptor polymorphisms in major depression
    Jantien P Brouwer
    Department of Endocrinology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands
    Psychoneuroendocrinology 31:1154-63. 2006
    ..We investigated whether treatment response is predicted by hypothalamus-pituitary-adrenal (HPA) axis parameters, or by genetic polymorphisms in the glucocorticoid receptor (GR), that regulates its feedback...
  36. doi request reprint Action of specific thyroid hormone receptor α(1) and β(1) antagonists in the central and peripheral regulation of thyroid hormone metabolism in the rat
    Hermina C van Beeren
    Department of Endocrinology and Metabolism, Laboratory of Endocrinology, University of Amsterdam, Amsterdam, The Netherlands
    Thyroid 22:1275-82. 2012
    ..In the present study, Amio and Dron were used as tools to discriminate between TRα(1) or TRβ(1) regulated genes in central and peripheral thyroid hormone metabolism...
  37. doi request reprint Age and stress as determinants of the severity of hyperthyroidism caused by Graves' disease in newly diagnosed patients
    Xander G Vos
    Department of Endocrinology and Metabolism, F5 161, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Eur J Endocrinol 160:193-9. 2009
    ..We tested the hypothesis whether advancing age is associated with less exposure to stress, resulting in a lower immunological response, and less severe Graves' hyperthyroidism...
  38. ncbi request reprint Combined therapy with levothyroxine and liothyronine in two ratios, compared with levothyroxine monotherapy in primary hypothyroidism: a double-blind, randomized, controlled clinical trial
    Bente C Appelhof
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, F5 161, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    J Clin Endocrinol Metab 90:2666-74. 2005
    ..Decrease in body weight was associated with satisfaction with study medication...
  39. doi request reprint Thyroid hormone receptor {alpha} modulates lipopolysaccharide-induced changes in peripheral thyroid hormone metabolism
    Joan Kwakkel
    Ph D Student, Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, F5 165, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Endocrinology 151:1959-69. 2010
    ..We conclude that alterations in peripheral thyroid hormone metabolism induced by LPS administration are partly regulated via TRalpha...
  40. ncbi request reprint Cognitive functioning and well-being in euthyroid patients on thyroxine replacement therapy for primary hypothyroidism
    Ellie M Wekking
    Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Endocrinol 153:747-53. 2005
    ..We also investigated whether serum TSH and thyroid antibodies are determinants of neurocognitive functioning and well-being...
  41. doi request reprint Complete inhibition of rhTSH-, Graves' disease IgG-, and M22-induced cAMP production in differentiated orbital fibroblasts by a low-molecular-weight TSHR antagonist
    Clementine J J van Zeijl
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, 1105 AZ The Netherlands
    J Clin Endocrinol Metab 97:E781-5. 2012
    ..Our results suggest that GD-IgG- and M22-induced cAMP production in differentiated OF is exclusively mediated via the TSHR because it can be completely blocked by the LMW TSHR antagonist, Org 274179-0...
  42. ncbi request reprint Traumatic neuroma of the infraorbital nerve subsequent to inferomedial orbital decompression for Graves' orbitopathy
    Lelio Baldeschi
    Orbital Center, Department of Ophthalmology, University of Amsterdam, The Netherlands
    Eur J Ophthalmol 20:481-4. 2010
    ..To present and discuss the occurrence of a traumatic neuroma subsequent to inferomedial orbital decompression surgery in Graves' orbitopathy...
  43. ncbi request reprint A randomized controlled trial of orbital radiotherapy versus sham irradiation in patients with mild Graves' ophthalmopathy
    Mark F Prummel
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Clin Endocrinol Metab 89:15-20. 2004
    ..Radiotherapy is an effective treatment in mild ophthalmopathy. However, the improvement upon irradiation may not be associated with an increase in quality of life or a reduction in treatment costs...
  44. ncbi request reprint Reactivation of Graves' orbitopathy after rehabilitative orbital decompression
    Lelio Baldeschi
    Orbital Center, Department of Ophthalmology, University of Amsterdam, Amsterdam, The Netherlands
    Ophthalmology 114:1395-402. 2007
    ..To present and discuss three cases of apparent reactivation of Graves' orbitopathy (GO) after orbital decompression and to evaluate the incidence of this phenomenon...
  45. ncbi request reprint Neuroanatomical pathways for thyroid hormone feedback in the human hypothalamus
    Anneke Alkemade
    Department of Endocrinology and Metabolism, Academic Medical Center of the University of Amsterdam, P O Box 22700, 1100 DE, Amsterdam, The Netherlands
    J Clin Endocrinol Metab 90:4322-34. 2005
    ..Recent findings point to an increasing number of hypothalamic proteins involved in the central regulation of thyroid hormone feedback. The functional neuroanatomy of these proteins in the human hypothalamus is largely unknown at present...
  46. ncbi request reprint Risk factors for and prevalence of thyroid disorders in a cross-sectional study among healthy female relatives of patients with autoimmune thyroid disease
    Thea G A Strieder
    Departments of Endocrinology and Metabolism and Cardiology, Academical Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Clin Endocrinol (Oxf) 59:396-401. 2003
    ..Therefore, we started a large prospective cohort study in subjects at risk of developing AITD, for example healthy female relatives of AITD patients. Here we report on their baseline characteristics...
  47. ncbi request reprint Thyrotropin receptor autoantibodies are associated with continued thyrotropin suppression in treated euthyroid Graves' disease patients
    Leon J S Brokken
    Department of Endocrinology and Metabolism, University of Amsterdam, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
    J Clin Endocrinol Metab 88:4135-8. 2003
    ..424; P = 0.004), and not with free T(4) or T(3) values. Our findings suggest that TBII suppress TSH secretion independently of thyroid hormone levels, most likely by binding to the pituitary TSH receptor...
  48. doi request reprint Age and gender-specific reference values of orbital fat and muscle volumes in Caucasians
    Noortje I Regensburg
    Orbital Centre, Department of Ophthalmology, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Br J Ophthalmol 95:1660-3. 2011
    ..To provide age and gender-specific reference values for orbital fat and muscle volumes (MV) in Caucasian adults...
  49. ncbi request reprint Thyroid autoimmunity and miscarriage
    Mark F Prummel
    Department of Endocrinology and Metabolism, F5 171 Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Eur J Endocrinol 150:751-5. 2004
    ..Randomized clinical trials with l-thyroxine (aiming at TSH values between 0.4 and 2.0 mU/l) and with selenium (to decrease antibodies against thyroid peroxidase) are clearly needed to elucidate further the nature of this association...
  50. doi request reprint Treatment of amiodarone-induced thyrotoxicosis type 2: a randomized clinical trial
    Silvia A Eskes
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam 1105AZ, The Netherlands
    J Clin Endocrinol Metab 97:499-506. 2012
    ..When prednisone fails to restore euthyroidism, possibly due to mixed cases of AIT type 1 and 2, perchlorate (ClO(4)) might be useful because ClO(4) reduces the cytotoxic effect of amiodarone on thyrocytes...
  51. doi request reprint Variation in phenotypic appearance of Graves' disease: effect of genetic anticipation and duration of complaints
    Xander G Vos
    Department of Endocrinology and Metabolism Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Eur J Endocrinol 161:113-8. 2009
    ..In this study, we evaluated whether the duration of symptoms or a positive family history of autoimmune thyroid disease (AITD) are related to specific phenotypes in patients with a first episode of Graves' hyperthyroidism (GH)...
  52. doi request reprint Densities of orbital fat and extraocular muscles in graves orbitopathy patients and controls
    Noortje I Regensburg
    Orbital Centre, Department of Ophthalmology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Ophthal Plast Reconstr Surg 27:236-40. 2011
    ..To investigate CT densities of orbital soft tissue volumes in patients with Graves orbitopathy (GO) and to compare these with the densities of controls...
  53. ncbi request reprint Thyroid peroxidase autoantibodies in euthyroid subjects
    Mark F Prummel
    Department of Endocrinology and Metabolism, F5 169 Academic Medical Center, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands
    Best Pract Res Clin Endocrinol Metab 19:1-15. 2005
    ....
  54. ncbi request reprint Stress is not associated with thyroid peroxidase autoantibodies in euthyroid women
    Thea G A Strieder
    Department of Endocrinology and Metabolism, Academical Medical Center, University of Amsterdam, 1105 AZ Amsterdam Zuidoost, The Netherlands
    Brain Behav Immun 19:203-6. 2005
    ..We used validated questionnaires to evaluate an association between TPO antibodies, an early marker for AITD, and self-reported stress...
  55. doi request reprint Discontinuation of smoking increases the risk for developing thyroid peroxidase antibodies and/or thyroglobulin antibodies: a prospective study
    Grigoris Effraimidis
    Department of Endocrinology, Academic Medical Center, Amsterdam, The Netherlands
    J Clin Endocrinol Metab 94:1324-8. 2009
    ..Autoimmune thyroid disease develops in genetic susceptible subjects, provoked by environmental factors. Little is known of the environment in the early stages of autoimmunity...
  56. doi request reprint Transient hypothyroxinemia in juvenile glycoprotein hormone subunit B5 knock-out mice
    Clementine J J van Zeijl
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Mol Cell Endocrinol 321:231-8. 2010
    ..Thus, lacking GPB5 results in moderate deviations of the HPT-axis. The more pronounced differences observed in juvenile mice compared to adult mice are in agreement with the notion that GPB5 has a role during development...
  57. doi request reprint Prevalence of growth hormone deficiency in Hashimoto's thyroiditis
    Silvia A Eskes
    Academic Medical Center Amsterdam, Department of Endocrinology and Metabolism, Meibergdreef 9, 1100 DD Amsterdam, The Netherlands
    J Clin Endocrinol Metab 95:2266-70. 2010
    ..Autoimmune hypophysitis can result in GH deficiency (GHD) and is associated with other autoimmune endocrine diseases like Hashimoto's thyroiditis. Recent studies suggest a high prevalence (5%) of GHD in Hashimoto's thyroiditis...
  58. doi request reprint Effects of thyrotropin and thyrotropin-receptor-stimulating Graves' disease immunoglobulin G on cyclic adenosine monophosphate and hyaluronan production in nondifferentiated orbital fibroblasts of Graves' ophthalmopathy patients
    Clementine J J van Zeijl
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Thyroid 20:535-44. 2010
    ..We hypothesize that TSHR activation, via cAMP signaling, results in induction of HAS1-3 mRNA expression and HA production by nondifferentiated GO orbital fibroblasts...
  59. doi request reprint Effect of smoking on orbital fat and muscle volume in Graves' orbitopathy
    Noortje I Regensburg
    Department of Ophthalmology, University of Amsterdam, Amsterdam, The Netherlands
    Thyroid 21:177-81. 2011
    ..Cigarette smoke enhances adipogenesis in cultured human orbital fibroblasts. The present study tested our hypothesis that smoking is associated with increased orbital fat in GO patients...
  60. doi request reprint Genotypes in relation to phenotypic appearance and exposure to environmental factors in Graves' hyperthyroidism
    Xander G Vos
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Eur J Endocrinol 167:783-92. 2012
    ..Genetic polymorphisms and environmental factors are both involved in the pathogenesis of Graves' disease, but their interaction and effect on Graves' phenotypes have scarcely been investigated...
  61. doi request reprint Vitamin D deficiency is not associated with early stages of thyroid autoimmunity
    Grigoris Effraimidis
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Eur J Endocrinol 167:43-8. 2012
    ..Vitamin D deficiency has been identified as a risk factor for a number of autoimmune diseases including type 1 diabetes and multiple sclerosis...
  62. doi request reprint Type 3 deiodinase is highly expressed in infiltrating neutrophilic granulocytes in response to acute bacterial infection
    Anita Boelen
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Thyroid 18:1095-103. 2008
    ..Our earlier studies showed that granulocytes express type 3 deiodinase (D3) when activated during a turpentine-induced abscess. We hypothesized that D3 expression by granulocytes may also occur during bacterial infection...
  63. ncbi request reprint Thyroid hormone receptor isoform expression in livers of critically ill patients
    Daphne C Thijssen-Timmer
    Department of Endocrinology and Metabolism, F5 171, Academic Medical Centre, Amsterdam, The Netherlands
    Thyroid 17:105-12. 2007
    ..The THRA gene encodes two isoforms of the thyroid hormone receptor (TR), TRalpha1 and TRalpha2. The ratio of these splice variants could have a marked influence on T3-regulated gene expression, especially during illness...
  64. doi request reprint Involvement of stress in the pathogenesis of autoimmune thyroid disease: a prospective study
    Grigoris Effraimidis
    Departments of Endocrinology and Metabolism, Academical Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Psychoneuroendocrinology 37:1191-8. 2012
    ..An association between stress and autoimmune thyroid disease (AITD) (especially Graves' hyperthyroidism) has been reported, but all studies so far on this topic have been retrospective...
  65. doi request reprint Amiodarone and thyroid
    Silvia A Eskes
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands
    Best Pract Res Clin Endocrinol Metab 23:735-51. 2009
    ....
  66. doi request reprint Frequency and characteristics of TBII-seronegative patients in a population with untreated Graves' hyperthyroidism: a prospective study
    Xander G Vos
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdamn, Amsterdam, The Netherlands
    Clin Endocrinol (Oxf) 69:311-7. 2008
    ..The aim of the present study, therefore, was to prospectively evaluate the frequency and characteristics of TBII-seronegative patients in a population of untreated GH diagnosed independent of serum TBII...
  67. ncbi request reprint Facial disfigurement: is it in the eye of the beholder? A study in patients with Graves' ophthalmopathy
    Caroline B Terwee
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Institute for Research in Extramural Medicine, Amsterdam, The Netherlands
    Clin Endocrinol (Oxf) 58:192-8. 2003
    ....
  68. ncbi request reprint Hypothalamic thyroid hormone feedback in health and disease
    Eric Fliers
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Prog Brain Res 153:189-207. 2006
    ..This model for thyroid hormone action in the human hypothalamus awaits confirmation in future experimental studies...
  69. ncbi request reprint Orbital irradiation for Graves' ophthalmopathy: Is it safe? A long-term follow-up study
    Iris M M J Wakelkamp
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands
    Ophthalmology 111:1557-62. 2004
    ..We evaluated the frequency of long-term complications of orbital irradiation (radiation-induced tumors, cataract, and retinopathy) in comparison with glucocorticoids...
  70. doi request reprint The influence of previous orbital irradiation on the outcome of rehabilitative decompression surgery in graves orbitopathy
    Lelio Baldeschi
    Orbital Center, Department of Ophthalmology, University of Amsterdam, Amsterdam, The Netherlands
    Am J Ophthalmol 145:534-540. 2008
    ..To investigate whether orbital irradiation influences the outcome of decompression surgery in Graves orbitopathy...
  71. ncbi request reprint Ultra short-loop feedback control of thyrotropin secretion
    Mark F Prummel
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Thyroid 14:825-9. 2004
    ....
  72. ncbi request reprint Triiodothyronine addition to paroxetine in the treatment of major depressive disorder
    Bente C Appelhof
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    J Clin Endocrinol Metab 89:6271-6. 2004
    ..On the contrary, more adverse reactions occurred in T3-treated patients...
  73. ncbi request reprint The removal of the deep lateral wall in orbital decompression: its contribution to exophthalmos reduction and influence on consecutive diplopia
    Lelio Baldeschi
    Orbital Center, Department of Ophthalmology, University of Amsterdam, Amsterdam, The Netherlands
    Am J Ophthalmol 140:642-7. 2005
    ..To evaluate the contribution of maximal removal of the deep lateral wall of the orbit to exophthalmos reduction in Graves' orbitopathy and its influence on the onset of consecutive diplopia...
  74. ncbi request reprint Multi-center study on the characteristics and treatment strategies of patients with Graves' orbitopathy: the first European Group on Graves' Orbitopathy experience
    Mark F Prummel
    Department of Endocrinology and Metabolism, F5 171 Academic Medical Center, University of Amsterdam, Meibergdreef 5, 1105 AZ Amsterdam, The Netherlands
    Eur J Endocrinol 148:491-5. 2003
    ..The European Group on Graves' Orbitopathy aims to overcome this and has designed a preliminary case record form (CRF) to assess Graves' orbitopathy patients. This form was used in this first multi-center study...
  75. ncbi request reprint Thyroid dysfunction during pregnancy and in the first postpartum year in women with diabetes mellitus type 1
    P Robert J Gallas
    Department of Endocrinology and Metabolism, Academic Medical Centre, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands
    Eur J Endocrinol 147:443-51. 2002
    ..To assess prevalence, incidence and risk factors in The Netherlands we performed a prospective cohort study...
  76. doi request reprint Comparison of cyclodeviation and duction measurement in Graves' orbitopathy patients using different devices
    Hinke Marijke Jellema
    Department of Ophthalmology, Orthoptic unit, Academic Medical Center, Amsterdam, The Netherlands
    Strabismus 19:43-51. 2011
    ..To compare measurement outcomes of different devices measuring cyclodeviation and ductions in Graves' orbitopathy (GO) patients...
  77. ncbi request reprint Interleukin-18, a proinflammatory cytokine, contributes to the pathogenesis of non-thyroidal illness mainly via the central part of the hypothalamus-pituitary-thyroid axis
    Anita Boelen
    Department of Endocrinology, Academic Medical Center, University of Amsterdam, The Netherlands
    Eur J Endocrinol 151:497-502. 2004
    ..IL-18 is a proinflammatory cytokine which shares important biological properties with IL-12, such as interferon (IFN)-gamma-inducing activity...
  78. ncbi request reprint The environment and autoimmune thyroid diseases
    Mark F Prummel
    Department of Endocrinology and Metabolism, F5 171, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Eur J Endocrinol 150:605-18. 2004
    ..Further research is warranted into the importance of fetal microchimerism and of viral infections capable of mounting an endogenous interferon-alpha response...
  79. ncbi request reprint TR(beta)1 protein is preferentially expressed in the pericentral zone of rat liver and exhibits marked diurnal variation
    Behrouz Zandieh Doulabi
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Endocrinology 143:979-84. 2002
    ..This finding together with the observed diurnal rhythm has major implications for interpreting and timing experiments concerning the TR and its downstream actions in liver...
  80. ncbi request reprint Myxedema coma
    Eric Fliers
    Department of Endocrinology and Metabolism, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Rev Endocr Metab Disord 4:137-41. 2003
  81. ncbi request reprint The large eyes of Wolfgang Amadeus Mozart. (On the occasion of the 250th Mozart anniversary year)
    Richard H C Zegers
    Department of Ophthalmology, Academic Medical Center, Meibergdreef 9, Amsterdam, 1100 AZ, The Netherlands
    Int Ophthalmol 26:201-6. 2005
    ..However, these diseases are unlikely causes given their topical and systemic features...
  82. doi request reprint Initial thyroid status and cardiovascular risk factors: the EPIC-Norfolk prospective population study
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Clin Endocrinol (Oxf) 72:404-10. 2010
    ..Thyroid status affects several aspects of cardiovascular risk profile, including lipid levels and blood pressure. Whether thyroid status affects the risk of coronary heart disease (CHD) and all-cause mortality remains controversial...
  83. ncbi request reprint Increased uptake of technetium-99m HDP in the subcortical area of both femurs in a patient with Graves' disease
    Peter H Bisschop
    Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands
    Thyroid 17:689-90. 2007
  84. ncbi request reprint Supernumerary extraocular muscle in Graves' orbitopathy
    Lelio Baldeschi
    Orbital Center, Department of Ophthalmology, University of Amsterdam, Amsterdam, The Netherlands
    Thyroid 17:479-80. 2007
  85. ncbi request reprint Perspective--Part III: retrobulbar irradiation in Graves orbitopathy: the Dutch experience
    Wilmar M Wiersinga
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands
    Ophthal Plast Reconstr Surg 18:175-6. 2002
  86. ncbi request reprint Management of thyroid nodules in children and adolescents
    Wilmar M Wiersinga
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands
    Hormones (Athens) 6:194-9. 2007
    ..Levothyroxine treatment has a low efficacy. Experience with other treatment options like ethanol injection or laser therapy is still limited...
  87. ncbi request reprint Thyroid hormone receptor expression in the human hypothalamus and anterior pituitary
    Anneke Alkemade
    Department of Endocrinology, Academic Medical Center of the University of Amsterdam, The Netherlands
    J Clin Endocrinol Metab 90:904-12. 2005
    ....
  88. ncbi request reprint Author's response: medical or surgical decompression of optic neuropathy in Graves' ophthalmopathy: the choice remains unclear
    Iris M M J Wakelkamp
    Clin Endocrinol (Oxf) 65:408. 2006
  89. ncbi request reprint Diagnosis and management of amiodarone-induced thyrotoxicosis in Europe: results of an international survey among members of the European Thyroid Association
    Luigi Bartalena
    Division of Endocrinology, University of Insubria, Varese, Italy
    Clin Endocrinol (Oxf) 61:494-502. 2004
    ..To determine how expert European thyroidologists assess and treat amiodarone-induced thyrotoxicosis (AIT)...
  90. ncbi request reprint Management of amiodarone-induced thyrotoxicosis in Latin America: an electronic survey
    Leandro Arthur Diehl
    Londrina State University, Brazil
    Clin Endocrinol (Oxf) 65:433-8. 2006
    ..To assess diagnostic and therapeutic approaches to amiodarone-induced thyrotoxicosis (AIT) among members of the Latin American Thyroid Society (LATS)...
  91. ncbi request reprint Association of the TSHR gene with Graves' disease: the first disease specific locus
    Bryan M Dechairo
    Target Discovery, Oxagen Ltd, Abingdon OX14 4RY, UK
    Eur J Hum Genet 13:1223-30. 2005
    ..3; AIH, P=NS). These results in two independent Caucasian data sets suggest that the TSHR is the first replicated GD-specific locus meriting further fine mapping and functional analysis to identify the aetiological variants...
  92. ncbi request reprint Graves' quality of life
    Caroline B Terwee
    Ophthalmology 114:1416-7; author reply 1417-8. 2007
  93. ncbi request reprint Follow-up and management of differentiated thyroid carcinoma: a European perspective in clinical practice
    Martin Schlumberger
    service de Medicine Nucleaire, Institut Gustave Roussy, 94805 Villejuif, France
    Eur J Endocrinol 151:539-48. 2004
    ..We also offer expanded and additional comments on various issues in the management of DTC...
  94. ncbi request reprint Connective tissue growth factor is increased in plasma of type 1 diabetic patients with nephropathy
    Peggy Roestenberg
    Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
    Diabetes Care 27:1164-70. 2004
    ..The aim of the present study was to investigate the possible association of plasma CTGF levels in type 1 diabetic patients with markers relevant to development of diabetes complications...
  95. ncbi request reprint Determinants of liver damage associated with intravenous methylprednisolone pulse therapy in Graves' ophthalmopathy
    Rosario Le Moli
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands
    Thyroid 17:357-62. 2007
    ..However, acute and severe liver damage has been reported in sporadic cases during IVMP, resulting in fatal acute liver failure in four patients so far. The mechanism causing the liver damage is incompletely understood...
  96. ncbi request reprint Re: "thyroid eye disease presenting after cosmetic botulinum toxin injections"
    Lelio Baldeschi
    Ophthal Plast Reconstr Surg 23:498-9; author reply 499. 2007
  97. pmc Clinical features of dysthyroid optic neuropathy: a European Group on Graves' Orbitopathy (EUGOGO) survey
    David McKeag
    Centre for Endocrine and Diabetes Sciences, University Hospital of Wales, Cardiff CF 4 4XN, UK
    Br J Ophthalmol 91:455-8. 2007
    ..This study was performed to determine clinical features of dysthyroid optic neuropathy (DON) across Europe...