Willem J Wiersinga

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint SWAB/NVALT (Dutch Working Party on Antibiotic Policy and Dutch Association of Chest Physicians) guidelines on the management of community-acquired pneumonia in adults
    W J Wiersinga
    Department of Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Neth J Med 70:90-101. 2012
  2. doi request reprint CD14 impairs host defense against gram-negative sepsis caused by Burkholderia pseudomallei in mice
    W Joost Wiersinga
    Centers for Infection and Immunity Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    J Infect Dis 198:1388-97. 2008
  3. pmc MyD88 dependent signaling contributes to protective host defense against Burkholderia pseudomallei
    W Joost Wiersinga
    Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, Amsterdam, The Netherlands
    PLoS ONE 3:e3494. 2008
  4. doi request reprint Immunosuppression associated with interleukin-1R-associated-kinase-M upregulation predicts mortality in Gram-negative sepsis (melioidosis)
    Willem Joost Wiersinga
    Center for Infection and Immunity Amsterdam, University of Amsterdam, Amsterdam, The Netherland
    Crit Care Med 37:569-76. 2009
  5. doi request reprint Immunity to Burkholderia pseudomallei
    Willem J Wiersinga
    Center for Infection and Immunity Amsterdam, Center for Experimental and Molecular Medicine and Department of Medicine, Academic Medical Center, Meibergdreef 9, Amsterdam, The Netherlands
    Curr Opin Infect Dis 22:102-8. 2009
  6. doi request reprint Urokinase receptor is necessary for bacterial defense against pneumonia-derived septic melioidosis by facilitating phagocytosis
    W Joost Wiersinga
    Center for Infection and Immunity Amsterdam, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 184:3079-86. 2010
  7. pmc Expression and function of macrophage migration inhibitory factor (MIF) in melioidosis
    W Joost Wiersinga
    Center for Infection and Immunity Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    PLoS Negl Trop Dis 4:e605. 2010
  8. ncbi request reprint [Sepsis: new insights into its pathogenesis and treatment]
    W Joost Wiersinga
    Academisch Medisch Centrum, afd Inwendige Geneeskunde, Center for Infection and Immunity Amsterdam, Center for Experimental Molecular Medicine, Amsterdam, The Netherlands
    Ned Tijdschr Geneeskd 154:A1130. 2010
  9. doi request reprint Current insights in sepsis: from pathogenesis to new treatment targets
    W Joost Wiersinga
    Center for Molecular Medicine and Division of Infectious Diseases, Academic Medical Centre, Amsterdam, The Netherlands
    Curr Opin Crit Care 17:480-6. 2011
  10. doi request reprint Gene-expression profiles in murine melioidosis
    W Joost Wiersinga
    Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, Amsterdam, The Netherlands
    Microbes Infect 10:868-77. 2008

Detail Information

Publications22

  1. ncbi request reprint SWAB/NVALT (Dutch Working Party on Antibiotic Policy and Dutch Association of Chest Physicians) guidelines on the management of community-acquired pneumonia in adults
    W J Wiersinga
    Department of Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Neth J Med 70:90-101. 2012
    ....
  2. doi request reprint CD14 impairs host defense against gram-negative sepsis caused by Burkholderia pseudomallei in mice
    W Joost Wiersinga
    Centers for Infection and Immunity Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    J Infect Dis 198:1388-97. 2008
    ..We have recently shown that during melioidosis, a severe infection caused by the gram-negative bacterium Burkholderia pseudomallei, TLR2 but not TLR4 impacts the immune response of the intact host in vivo...
  3. pmc MyD88 dependent signaling contributes to protective host defense against Burkholderia pseudomallei
    W Joost Wiersinga
    Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, Amsterdam, The Netherlands
    PLoS ONE 3:e3494. 2008
    ..Melioidosis, which is endemic in SE-Asia, is a severe infection caused by the gram-negative bacterium Burkholderia pseudomallei. We here aimed to characterize the role of MyD88 and TRIF in host defense against melioidosis...
  4. doi request reprint Immunosuppression associated with interleukin-1R-associated-kinase-M upregulation predicts mortality in Gram-negative sepsis (melioidosis)
    Willem Joost Wiersinga
    Center for Infection and Immunity Amsterdam, University of Amsterdam, Amsterdam, The Netherland
    Crit Care Med 37:569-76. 2009
    ..pseudomallei.Design: Ex vivo study...
  5. doi request reprint Immunity to Burkholderia pseudomallei
    Willem J Wiersinga
    Center for Infection and Immunity Amsterdam, Center for Experimental and Molecular Medicine and Department of Medicine, Academic Medical Center, Meibergdreef 9, Amsterdam, The Netherlands
    Curr Opin Infect Dis 22:102-8. 2009
    ..This review summarizes current understanding on the molecular characterization of B. pseudomallei and the immunology of melioidosis...
  6. doi request reprint Urokinase receptor is necessary for bacterial defense against pneumonia-derived septic melioidosis by facilitating phagocytosis
    W Joost Wiersinga
    Center for Infection and Immunity Amsterdam, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 184:3079-86. 2010
    ..pseudomallei by facilitating the migration of neutrophils toward the primary site of infection and subsequently facilitating the phagocytosis of B. pseudomallei...
  7. pmc Expression and function of macrophage migration inhibitory factor (MIF) in melioidosis
    W Joost Wiersinga
    Center for Infection and Immunity Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    PLoS Negl Trop Dis 4:e605. 2010
    ..Melioidosis, caused by Burkholderia pseudomallei, is an important cause of community-acquired sepsis in Southeast-Asia. We aimed to characterize the expression and function of MIF in melioidosis...
  8. ncbi request reprint [Sepsis: new insights into its pathogenesis and treatment]
    W Joost Wiersinga
    Academisch Medisch Centrum, afd Inwendige Geneeskunde, Center for Infection and Immunity Amsterdam, Center for Experimental Molecular Medicine, Amsterdam, The Netherlands
    Ned Tijdschr Geneeskd 154:A1130. 2010
    ..The increasing insights into the pathogenesis of sepsis have identified a whole new range of potential drugs which are currently being tested in clinical trials...
  9. doi request reprint Current insights in sepsis: from pathogenesis to new treatment targets
    W Joost Wiersinga
    Center for Molecular Medicine and Division of Infectious Diseases, Academic Medical Centre, Amsterdam, The Netherlands
    Curr Opin Crit Care 17:480-6. 2011
    ..Sepsis continues to be a leading cause of ICU death. This review summarizes current knowledge on sepsis pathogenesis and new therapeutical strategies...
  10. doi request reprint Gene-expression profiles in murine melioidosis
    W Joost Wiersinga
    Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, Amsterdam, The Netherlands
    Microbes Infect 10:868-77. 2008
    ..pseudomallei, increasing our insights into the extent of inflammation activation in the pulmonary and systemic compartment during melioidosis...
  11. ncbi request reprint [Giant diverticulum of the sigmoid]
    W J Wiersinga
    afd Interne Geneeskunde, Academisch Medisch Centrum Universiteit van Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam
    Ned Tijdschr Geneeskd 148:143-7. 2004
    ..In view of the severity of these complications, resection of that part of the intestine in which the giant diverticulum arises is the treatment of choice...
  12. ncbi request reprint [Toll-like receptors and the significance for clinical medicine]
    W J Wiersinga
    Academisch Medisch Centrum Universiteit van Amsterdam, Laboratorium voor Experimentele Interne Geneeskunde, Meibergdreef 9, 1105 AZ Amsterdam
    Ned Tijdschr Geneeskd 149:1150-5. 2005
    ..The first drug that works by modulating the TLR response has already been registered...
  13. ncbi request reprint Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei
    W Joost Wiersinga
    Academic Medical Centre, Centre for Infection and Immunity Amsterdam CINIMA, Amsterdam, The Netherlands
    Nat Rev Microbiol 4:272-82. 2006
    ..Studying how the disease is acquired and the host-pathogen interactions involved will underpin these efforts; this review presents an overview of current knowledge in these areas, highlighting key topics for evaluation...
  14. pmc High-throughput mRNA profiling characterizes the expression of inflammatory molecules in sepsis caused by Burkholderia pseudomallei
    W Joost Wiersinga
    Academic Medical Center, Meibergdreef 9, Room G2 132, 1105 AZ Amsterdam, The Netherlands
    Infect Immun 75:3074-9. 2007
    ..Gene profiling such as was done here provides an excellent tool to obtain insight into the extent of inflammation activation in patients with severe infection...
  15. pmc Endogenous interleukin-18 improves the early antimicrobial host response in severe melioidosis
    W Joost Wiersinga
    Academic Medical Center, Meibergdreef 9, Room G2 132, 1105 AZ Amsterdam, The Netherlands
    Infect Immun 75:3739-46. 2007
    ..Together, these data indicate that the enhanced production of IL-18 in melioidosis is an essential part of a protective immune response to this severe infection...
  16. ncbi request reprint Inflammation patterns induced by different Burkholderia species in mice
    W Joost Wiersinga
    Center for Infection and Immunity Amsterdam CINIMA, Amsterdam, The Netherlands
    Cell Microbiol 10:81-7. 2008
    ..pseudomallei 1026b or AJ1D8. These data show that B. pseudomallei AJ1D8 is just as lethal as wild-type B. pseudomallei in an in vivo mouse model, and B. thailandensis is perhaps more virulent than is often recognized...
  17. pmc Toll-like receptor 2 impairs host defense in gram-negative sepsis caused by Burkholderia pseudomallei (Melioidosis)
    W Joost Wiersinga
    Center for Infection and Immunity Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    PLoS Med 4:e248. 2007
    ..Melioidosis is a severe infection caused by the gram-negative bacterium, Burkholderia pseudomallei, that is endemic in Southeast Asia. We aimed to characterize the expression and function of TLRs in septic melioidosis...
  18. ncbi request reprint Activation of coagulation with concurrent impairment of anticoagulant mechanisms correlates with a poor outcome in severe melioidosis
    W J Wiersinga
    Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Thromb Haemost 6:32-9. 2008
    ..Knowledge of the involvement of coagulation and fibrinolysis in the pathogenesis of melioidosis is highly limited...
  19. ncbi request reprint Expression profile and function of triggering receptor expressed on myeloid cells-1 during melioidosis
    W Joost Wiersinga
    Center for Infection and Immunity Amsterdam, Amsterdam, 1105 AZ, The Netherlands
    J Infect Dis 196:1707-16. 2007
    ..We aimed to characterize TREM-1 expression and function during sepsis caused by Burkholderia pseudomallei (melioidosis)...
  20. doi request reprint Diabetes does not influence activation of coagulation, fibrinolysis or anticoagulant pathways in Gram-negative sepsis (melioidosis)
    Gavin C K W Koh
    Center for Experimental and Molecular Medicine, Department of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, Amsterdam, The Netherlands
    Thromb Haemost 106:1139-48. 2011
    ..pseudomallei sepsis...
  21. pmc Osteopontin is not crucial to protective immunity during murine tuberculosis
    Gerritje J W van der Windt
    Center of Infection and Immunity Amsterdam CINIMA, Amsterdam, The Netherlands
    Immunology 128:e766-76. 2009
    ..These data suggest that OPN is not crucial for protective immunity upon M. tuberculosis infection and during the late phase of tuberculosis may even be detrimental for the host...
  22. ncbi request reprint TLR2-dependent MyD88 signaling contributes to early host defense in murine Enterococcus faecium peritonitis
    Masja Leendertse
    Center for Infection and Immunity Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    J Immunol 180:4865-74. 2008
    ..faecium in vitro or in vivo. These data suggest that MyD88 contributes to the effective clearance of E. faecium during peritonitis at least in part via TLR2 and by facilitating neutrophil recruitment to the site of the infection...