W Westerhof

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Hypermelanocytic guttate and macular segmental hypomelanosis
    W Westerhof
    Netherlands Institute for Pigmentary Disorders, Amsterdam, The Netherlands
    Br J Dermatol 151:701-5. 2004
  2. ncbi request reprint Generalized mottled pigmentation with postnatal skin blistering in three generations
    Wiete Westerhof
    Netherlands Institute for Pigment Disorders, IWO Building, Academic Medical Center, Meibergdreef 35, 1105 AZ Amsterdam Zuidoost, The Netherlands
    J Am Acad Dermatol 50:S65-9. 2004
  3. ncbi request reprint Propionibacterium acnes and the pathogenesis of progressive macular hypomelanosis
    Wiete Westerhof
    Netherlands Institute for Pigment Disorders, and the Department of Dermatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Arch Dermatol 140:210-4. 2004
  4. ncbi request reprint The discovery of the human melanocyte
    Wiete Westerhof
    Netherlands Institute for Pigment Disorders, and Department of Dermatology Academic Medical Center, University of Amsterdam
    Pigment Cell Res 19:183-93. 2006
  5. ncbi request reprint Treatment of acquired junctional melanocytic naevi by Q-switched and normal mode ruby laser
    W Westerhof
    Netherlands Institute for Pigment Disorders and Department of Dermatology, IWO Building Academic Medical Centre, University of Amsterdam, Meibergdreef 35, The Netherlands
    Br J Dermatol 148:80-5. 2003
  6. ncbi request reprint Mucopolysaccharides from psyllium involved in wound healing
    W Westerhof
    Department of Dermatology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1005AZ Amsterdam, The Netherlands
    Drugs Exp Clin Res 27:165-75. 2001
  7. ncbi request reprint Evolutionary, biologic, and social aspects of skin color
    Wiete Westerhof
    Color Foundation, Landsmeer, The Netherlands
    Dermatol Clin 25:293-302, vii. 2007
  8. ncbi request reprint Vitiligo puzzle: the pieces fall in place
    Wiete Westerhof
    Color Foundation, Landsmeer, The Netherlands
    Pigment Cell Res 20:345-59. 2007
  9. doi request reprint Ultrastructural findings in progressive macular hypomelanosis indicate decreased melanin production
    G N Relyveld
    Netherlands Institute for Pigment Disorders, and Department of Dermatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Eur Acad Dermatol Venereol 22:568-74. 2008
  10. ncbi request reprint Association of the Köbner phenomenon with disease activity and therapeutic responsiveness in vitiligo vulgaris
    M D Njoo
    Netherlands Institute for Pigmentary Disorders, Academic Medical Centre, Amsterdam
    Arch Dermatol 135:407-13. 1999

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Hypermelanocytic guttate and macular segmental hypomelanosis
    W Westerhof
    Netherlands Institute for Pigmentary Disorders, Amsterdam, The Netherlands
    Br J Dermatol 151:701-5. 2004
    ..It is paradoxical that a hypomelanotic macule shows a histological picture of an increase in normal functioning melanocytes. In all probability a deficient melanosome transfer is responsible for this unexpected phenomenon...
  2. ncbi request reprint Generalized mottled pigmentation with postnatal skin blistering in three generations
    Wiete Westerhof
    Netherlands Institute for Pigment Disorders, IWO Building, Academic Medical Center, Meibergdreef 35, 1105 AZ Amsterdam Zuidoost, The Netherlands
    J Am Acad Dermatol 50:S65-9. 2004
    ..Molecular biological investigation would be required to characterize the phenotype of this entity, which apparently was a mutation occurring in one family for three generations...
  3. ncbi request reprint Propionibacterium acnes and the pathogenesis of progressive macular hypomelanosis
    Wiete Westerhof
    Netherlands Institute for Pigment Disorders, and the Department of Dermatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Arch Dermatol 140:210-4. 2004
    ..Healthy follicular skin did not show bacteria in histological sections, and cultures did not yield anaerobic bacteria...
  4. ncbi request reprint The discovery of the human melanocyte
    Wiete Westerhof
    Netherlands Institute for Pigment Disorders, and Department of Dermatology Academic Medical Center, University of Amsterdam
    Pigment Cell Res 19:183-93. 2006
    ..The foundation established over the past 4000 yr is the basis for all current research into this fascinating cell type...
  5. ncbi request reprint Treatment of acquired junctional melanocytic naevi by Q-switched and normal mode ruby laser
    W Westerhof
    Netherlands Institute for Pigment Disorders and Department of Dermatology, IWO Building Academic Medical Centre, University of Amsterdam, Meibergdreef 35, The Netherlands
    Br J Dermatol 148:80-5. 2003
    ..Pigment laser treatment of benign pigmented lesions has shown a low potential for scarring by selectively targeting melanosomes in melanocytes and keratinocytes...
  6. ncbi request reprint Mucopolysaccharides from psyllium involved in wound healing
    W Westerhof
    Department of Dermatology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1005AZ Amsterdam, The Netherlands
    Drugs Exp Clin Res 27:165-75. 2001
    ....
  7. ncbi request reprint Evolutionary, biologic, and social aspects of skin color
    Wiete Westerhof
    Color Foundation, Landsmeer, The Netherlands
    Dermatol Clin 25:293-302, vii. 2007
    ..Owing to its undeniable visibility, skin color has always had a sociologic connotation, which has up to the present time caused division between people...
  8. ncbi request reprint Vitiligo puzzle: the pieces fall in place
    Wiete Westerhof
    Color Foundation, Landsmeer, The Netherlands
    Pigment Cell Res 20:345-59. 2007
    ..A similar complex mechanism may also lead to some other autoimmune diseases...
  9. doi request reprint Ultrastructural findings in progressive macular hypomelanosis indicate decreased melanin production
    G N Relyveld
    Netherlands Institute for Pigment Disorders, and Department of Dermatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Eur Acad Dermatol Venereol 22:568-74. 2008
    ..The purpose of the study is to gain an insight into the pathogenesis of PMH...
  10. ncbi request reprint Association of the Köbner phenomenon with disease activity and therapeutic responsiveness in vitiligo vulgaris
    M D Njoo
    Netherlands Institute for Pigmentary Disorders, Academic Medical Centre, Amsterdam
    Arch Dermatol 135:407-13. 1999
    ..To investigate the association between the experimentally induced Kobner phenomenon (KP-e) and the Kobner phenomenon by history (KP-h), disease activity, and therapeutic responsiveness in vitiligo vulgaris...
  11. ncbi request reprint The development of guidelines for the treatment of vitiligo. Clinical Epidemiology Unit of the Istituto Dermopatico dell'Immacolata-Istituto di Recovero e Cura a Carattere Scientifico (IDI-IRCCS) and the Archives of Dermatology
    M D Njoo
    Netherlands Institute for Pigmentary Disorders, Academic Medical Center, University of Amsterdam
    Arch Dermatol 135:1514-21. 1999
    ..To develop and introduce evidence-based guidelines for the treatment of vitiligo in children and in adults...
  12. ncbi request reprint Vitiligo. Pathogenesis and treatment
    M D Njoo
    Department of Dermatology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Am J Clin Dermatol 2:167-81. 2001
    ..In widespread vitiligo, residual pigment can be removed by depigmentation agents. Sunscreens, camouflage products, and good guidance may help the patient cope better with the disease...
  13. ncbi request reprint A systematic review of autologous transplantation methods in vitiligo
    M D Njoo
    Netherlands Institute for Pigmentary Disorders, University of Amsterdam, The Netherlands
    Arch Dermatol 134:1543-9. 1998
    ..A systematic review of the effectiveness, safety, and applicability of autologous transplantation methods in vitiligo...
  14. ncbi request reprint Treatment of vitiligo with UV-B radiation vs topical psoralen plus UV-A
    W Westerhof
    The Netherlands Institute for Pigmentary Disorders, Amsterdam, The Netherlands
    Arch Dermatol 133:1525-8. 1997
    ..To compare the efficacy and safety of 2 treatment modalities, topical psoralen plus UV-A (PUVA) with unsubstituted psoralen and 311-nm UV-B radiation, in patients with vitiligo...
  15. ncbi request reprint Repigmentation of leucodermic defects in piebaldism by dermabrasion and thin split-thickness skin grafting in combination with minigrafting
    M D Njoo
    Netherlands Institute for Pigmentary Disorders, Academic Medical Centre, Amsterdam
    Br J Dermatol 139:829-33. 1998
    ..Complications were minor and easy to correct. Dermabrasion and split-skin grafting followed by minigrafting should be considered as the first choice of therapy in piebaldism...
  16. ncbi request reprint Nonsurgical repigmentation therapies in vitiligo. Meta-analysis of the literature
    M D Njoo
    Netherlands Institute for Pigmentary Disorders, University of Amsterdam, The Netherlands
    Arch Dermatol 134:1532-40. 1998
    ..To assess the effectiveness and safety of nonsurgical repigmentation therapies in localized and generalized vitiligo by means of a meta-analysis...
  17. ncbi request reprint UVB 311 nm tolerance of vitiligo skin increases with skin photo type
    Anne Lou D B Caron-Schreinemachers
    Netherlands Institute for Pigment Disorders, Amsterdam, The Netherlands
    Acta Derm Venereol 85:24-6. 2005
    ..We suggest that there must be a protection mechanism, other than that offered by melanin pigmentation. The antioxidant status may play a role in this phenomenon...
  18. ncbi request reprint Immunopolarization of CD4+ and CD8+ T cells to Type-1-like is associated with melanocyte loss in human vitiligo
    Anna Wankowicz-Kalinska
    Department of Pathology, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    Lab Invest 83:683-95. 2003
    ..Altogether our data support the role of cellular mechanisms playing a significant part in the destruction of melanocytes in human autoimmune vitiligo...
  19. ncbi request reprint Treatment of vitiligo vulgaris with narrow-band UVB and oral Polypodium leucotomos extract: a randomized double-blind placebo-controlled study
    M A Middelkamp-Hup
    Netherlands Institute for Pigment Disorders, Department of Dermatology, Academic Medical Center, 1100 DD Amsterdam, The Netherlands
    J Eur Acad Dermatol Venereol 21:942-50. 2007
    ..The first choice treatment for vitiligo vulgaris is narrow-band UVB (NB-UVB), but no satisfactory treatment exists...
  20. ncbi request reprint A new psoralen-containing gel for topical PUVA therapy: development, and treatment results in patients with palmoplantar and plaque-type psoriasis, and hyperkeratotic eczema
    M A De Rie
    Academic Medical Center, University of Amsterdam, Department of Dermatology, The Netherlands
    Br J Dermatol 132:964-9. 1995
    ....
  21. ncbi request reprint Aberrant expression of complement regulatory proteins, membrane cofactor protein and decay accelerating factor, in the involved epidermis of patients with vitiligo
    R M J G J van den Wijngaard
    Department of Pathology Room L 2 258, Academic Medical Centre, Amsterdam University, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Br J Dermatol 146:80-7. 2002
    ....
  22. ncbi request reprint Progressive macular hypomelanosis: an overview
    Germaine N Relyveld
    The Netherlands Institute for Pigment Disorders, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Am J Clin Dermatol 8:13-9. 2007
    ..There is insufficient information available as yet to comment on the recurrence rate after therapy...
  23. ncbi request reprint Quantitative and objective evaluation of wound debriding properties of collagenase and fibrinolysin/desoxyribonuclease in a necrotic ulcer animal model
    J R Mekkes
    Department of Dermatology, Academic Medical Center, University of Amsterdam, The Netherlands
    Arch Dermatol Res 290:152-7. 1998
    ..We conclude that collagenase is a suitable enzyme for wound debridement, but we were not able to detect clinical efficacy of fibrinolysin/DNAse in this model...
  24. ncbi request reprint Benzoyl peroxide/clindamycin/UVA is more effective than fluticasone/UVA in progressive macular hypomelanosis: a randomized study
    Germaine N Relyveld
    Netherlands Institute for Pigment Disorders, Amsterdam, The Netherlands
    J Am Acad Dermatol 55:836-43. 2006
    ..There is no effective treatment for progressive macular hypomelanosis. Recent findings indicate that Propionibacterium acnes may play a role in the pathogenesis...
  25. ncbi request reprint Difference in pathogenesis between vitiligo vulgaris and halo nevi associated with vitiligo is supported by an HLA association study
    Hannah C de Vijlder
    Netherlands Institute for Pigment Disorders, Department of Dermatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Pigment Cell Res 17:270-4. 2004
    ..083, P(u) = 0.0067). In conclusion, the differences in HLA association within clinical subtypes of vitiligo support our suggestion that vitiligo vulgaris and halo nevi associated with vitiligo have distinct pathogenic mechanisms...
  26. ncbi request reprint Gene expression patterns in melanocytic cells: candidate markers for early stage and malignant transformation
    Clifton B Meije
    Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Pathol 196:51-8. 2002
    ..The Ras-related protein Rab5b showed lower levels of expression in highly metastatic than in other melanoma cells. These three cDNAs may therefore be involved in the early stage and malignant transformation of melanocytes...
  27. ncbi request reprint Noninvasive techniques for the evaluation of skin color
    Susan Taylor
    Department of Dermatology, Columbia University, St Luke s Roosevelt Hospital Center, New York, NY, USA
    J Am Acad Dermatol 54:S282-90. 2006
    ..Dermoscopy is also useful for the differential diagnosis of benign melanocytic lesions and melanoma, and its use has been shown to significantly improve diagnostic accuracy...
  28. ncbi request reprint Safety and efficacy of combined use of 4-hydroxyanisole (mequinol) 2%/tretinoin 0.01% solution and sunscreen in solar lentigines
    Jean Paul Ortonne
    Hopital de l Archet, Service de Dermatologie, Rte Saint Antoine de Ginestière 151, 06002 Nice Cedex 03, France
    Cutis 74:261-4. 2004
    ..Our study shows that the mequinol 2%/tretinoin 0.01% solution is effective, convenient, and safe in the treatment of solar lentigines...
  29. ncbi request reprint Increased epidermal functioning wild-type p53 expression in vitiligo
    Karin U Schallreuter
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, West Yorkshire, UK
    Exp Dermatol 12:268-77. 2003
    ..Based on our results we hypothesize that the low incidence for actinic damage, basal cell and squamous cell carcinoma as documented in vitiligo could well reside in a protective function of up-regulated wild-type p53...