A P Vlaar

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. pmc Mechanical ventilation and the titer of antibodies as risk factors for the development of transfusion-related lung injury
    A P J Vlaar
    Department of Intensive Care Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
    Crit Care Res Pract 2012:720950. 2012
  2. pmc Early intravenous unfractionated heparin and outcome in acute lung injury and acute respiratory distress syndrome: a retrospective propensity matched cohort study
    Jorrit J Hofstra
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, AZ, Amsterdam, The Netherlands
    BMC Pulm Med 12:43. 2012
  3. ncbi request reprint [Transfusion-related acute lung injury]
    Alexander P J Vlaar
    Academisch Medisch Centrum Universiteit van Amsterdam, afd Intensive Care Volwassenen, Amsterdam, The Netherlands
    Ned Tijdschr Geneeskd 157:A5524. 2013
  4. ncbi request reprint Transfusion-related acute lung injury in cardiac surgery patients is characterized by pulmonary inflammation and coagulopathy: a prospective nested case-control study
    Alexander P J Vlaar
    Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Crit Care Med 40:2813-20. 2012
  5. doi request reprint Transfusion-related acute lung injury: Current understanding and preventive strategies
    A P J Vlaar
    Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Transfus Clin Biol 19:117-24. 2012
  6. pmc Soluble urokinase-type plasminogen activator receptor levels in patients with burn injuries and inhalation trauma requiring mechanical ventilation: an observational cohort study
    Yara Backes
    Department of Intensive Care Medicine, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Crit Care 15:R270. 2011
  7. ncbi request reprint Prevention of immune-mediated transfusion-related acute lung injury; from bloodbank to patient
    Marcella C A Müller
    Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Curr Pharm Des 18:3241-8. 2012
  8. doi request reprint The effect of blood transfusion on pulmonary permeability in cardiac surgery patients: a prospective multicenter cohort study
    Alexander P J Vlaar
    Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Transfusion 52:82-90. 2012
  9. pmc Blood transfusion during cardiac surgery is associated with inflammation and coagulation in the lung: a case control study
    Pieter R Tuinman
    Department of Intensive Care Medicine and Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, Meibergdreef 9, Amsterdam NL 1105 AZ, The Netherlands
    Crit Care 15:R59. 2011
  10. pmc Mechanical ventilation using non-injurious ventilation settings causes lung injury in the absence of pre-existing lung injury in healthy mice
    Esther K Wolthuis
    Department of Intensive Care Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Crit Care 13:R1. 2009

Collaborators

Detail Information

Publications32

  1. pmc Mechanical ventilation and the titer of antibodies as risk factors for the development of transfusion-related lung injury
    A P J Vlaar
    Department of Intensive Care Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
    Crit Care Res Pract 2012:720950. 2012
    ..In contrast, mice ventilated with low tidal volumes did not develop lung injury, irrespective of the dose of antibody used. Conclusions. In the presence of injurious MV, onset of TRALI depends on the titer of antibodies infused...
  2. pmc Early intravenous unfractionated heparin and outcome in acute lung injury and acute respiratory distress syndrome: a retrospective propensity matched cohort study
    Jorrit J Hofstra
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, AZ, Amsterdam, The Netherlands
    BMC Pulm Med 12:43. 2012
    ..We hypothesized that an intravenous therapeutic dose of unfractionated heparin would favorably influence outcome of critically ill patients diagnosed with ALI...
  3. ncbi request reprint [Transfusion-related acute lung injury]
    Alexander P J Vlaar
    Academisch Medisch Centrum Universiteit van Amsterdam, afd Intensive Care Volwassenen, Amsterdam, The Netherlands
    Ned Tijdschr Geneeskd 157:A5524. 2013
    ..Anti-HLA and anti-HNA antibodies are highly prevalent in multiparous female donors. The exclusion of female donors for plasma and thrombocyte products has led to a 33-66% reduction in the incidence of TRALI...
  4. ncbi request reprint Transfusion-related acute lung injury in cardiac surgery patients is characterized by pulmonary inflammation and coagulopathy: a prospective nested case-control study
    Alexander P J Vlaar
    Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Crit Care Med 40:2813-20. 2012
    ..The objective of the present study was to determine inflammation and coagulation pathways involved in the onset of transfusion-related acute lung injury...
  5. doi request reprint Transfusion-related acute lung injury: Current understanding and preventive strategies
    A P J Vlaar
    Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Transfus Clin Biol 19:117-24. 2012
    ..This review discusses the current understanding of TRALI and preventive strategies available...
  6. pmc Soluble urokinase-type plasminogen activator receptor levels in patients with burn injuries and inhalation trauma requiring mechanical ventilation: an observational cohort study
    Yara Backes
    Department of Intensive Care Medicine, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Crit Care 15:R270. 2011
    ..The aim of this study was to investigate the diagnostic and prognostic value of systemic and pulmonary levels of suPAR in burn patients with inhalation trauma who need mechanical ventilation...
  7. ncbi request reprint Prevention of immune-mediated transfusion-related acute lung injury; from bloodbank to patient
    Marcella C A Müller
    Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Curr Pharm Des 18:3241-8. 2012
    ..From a bedside view, the most important measure to prevent TRALI is to limit patients' exposure to allogenic bloodproducts. Furthermore recognition and awareness of the syndrome need to be heightened among clinicians...
  8. doi request reprint The effect of blood transfusion on pulmonary permeability in cardiac surgery patients: a prospective multicenter cohort study
    Alexander P J Vlaar
    Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Transfusion 52:82-90. 2012
    ..Mediators of increased pulmonary vascular leakage after transfusion are unknown. We hypothesized that factors may include antibodies or bioactive lipids, which have been implicated in transfusion-related acute lung injury...
  9. pmc Blood transfusion during cardiac surgery is associated with inflammation and coagulation in the lung: a case control study
    Pieter R Tuinman
    Department of Intensive Care Medicine and Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, Meibergdreef 9, Amsterdam NL 1105 AZ, The Netherlands
    Crit Care 15:R59. 2011
    ..We hypothesized that blood transfusion is associated with changes in pulmonary and systemic inflammation and coagulation occurring in patients who do not meet the clinical diagnosis of transfusion-related acute lung injury (TRALI)...
  10. pmc Mechanical ventilation using non-injurious ventilation settings causes lung injury in the absence of pre-existing lung injury in healthy mice
    Esther K Wolthuis
    Department of Intensive Care Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Crit Care 13:R1. 2009
    ..To study VILI in healthy mice, the authors used a MV model with clinically relevant ventilator settings, avoiding massive damage of lung structures and shock, and preventing metabolic acidosis...
  11. pmc Ventilation with lower tidal volumes as compared with conventional tidal volumes for patients without acute lung injury: a preventive randomized controlled trial
    Rogier M Determann
    Department of Intensive Care Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Crit Care 14:R1. 2010
    ..We compared the effect of conventional with lower tidal volumes on pulmonary inflammation and development of lung injury in critically ill patients without ALI at the onset of mechanical ventilation...
  12. pmc Nebulized antithrombin limits bacterial outgrowth and lung injury in Streptococcus pneumoniae pneumonia in rats
    Jorrit J Hofstra
    Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands
    Crit Care 13:R145. 2009
    ..We evaluated the effect of nebulized anticoagulants on pulmonary coagulopathy and inflammation in a rat model of Streptococcus pneumoniae pneumonia...
  13. ncbi request reprint Developing specific therapeutic strategies for transfusion-related acute lung injury. An overview of potentially useful animal models
    Alexander P J Vlaar
    Department of Intensive Care Medicine, Laboratory of Experimental Intensive Care and Anesthesiology L E I C A, Academic Medical Center, room M0 228, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Cardiovasc Hematol Agents Med Chem 5:319-26. 2007
    ..We discuss the present TRALI animal models and their shortcomings and propose future animal models, in which clinically relevant "first hits" can be applied, thereby imitating the complex clinical situation...
  14. doi request reprint A survey of physicians' reasons to transfuse plasma and platelets in the critically ill: a prospective single-centre cohort study
    A P J Vlaar
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Transfus Med 19:207-12. 2009
    ..Transfusion of platelets was restrictive in non-bleeding patients and liberal in bleeding patients. Education on indications of FFP transfusion and improved identification of bleeding may reduce transfusion rates...
  15. ncbi request reprint Diagnosing acute lung injury in the critically ill: a national survey among critical care physicians
    A P J Vlaar
    Department of Intensive Care Medicine, Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Centre, Meibergdreef 9, Amsterdam, The Netherlands
    Acta Anaesthesiol Scand 53:1293-9. 2009
    ..Incidence reports on acute lung injury (ALI) vary widely. An insight into the diagnostic preferences of critical care physicians when diagnosing ALI may improve identification of the ALI patient population...
  16. doi request reprint The practice of reporting transfusion-related acute lung injury: a national survey among clinical and preclinical disciplines
    Alexander P J Vlaar
    Department of Intensive Care Medicine and Department of Hematology, Academic Medical Center, Amsterdam, The Netherlands
    Transfusion 50:443-51. 2010
    ..g., sepsis) predisposes to TRALI. TRALI is a clinical diagnosis. Disciplines involved in managing TRALI may differ in decision-making on the reporting of TRALI...
  17. ncbi request reprint Malignancies associated with chronic hepatitis C: case report and review of the literature
    A P J Vlaar
    Departments of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Neth J Med 69:211-5. 2011
    ..A case report of HCV-related HCC and B-cell lymphoma illustrates the increased risk for HCV-infected patients to develop other malignancies besides HCC...
  18. doi request reprint Accumulation of bioactive lipids during storage of blood products is not cell but plasma derived and temperature dependent
    Alexander P J Vlaar
    Department of Intensive Care Medicine, Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, Amsterdam, The Netherlands
    Transfusion 51:2358-66. 2011
    ..LysoPCs are thought to be derived from cell membrane degradation products such as phosphatidylcholines (PC) by partial hydrolysis of PC, a process that is catalyzed by phospholipase A(2) (PLA(2) )...
  19. ncbi request reprint The relation between aged blood products and onset of transfusion-related acute lung injury. A review of pre-clinical data
    A P Vlaar
    Laboratory of Experimental Intensive Care and Anesthesiology L E I CA, Academic Medical Centre, Amsterdam, The Netherlands
    Clin Lab 57:267-72. 2011
    ..Further research is needed to elucidate possible mechanisms of onset of TRALI by aged blood products...
  20. doi request reprint The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study
    Alexander P J Vlaar
    Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Blood 117:4218-25. 2011
    ..In conclusion, the incidence of TRALI is high in cardiac surgery patients and associated with adverse outcome. Our results suggest that cardiac surgery patients may benefit from exclusion of blood products containing HLA/HNA antibodies...
  21. ncbi request reprint Transfusion-related acute lung injury: a change of perspective
    A P Vlaar
    Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Centre, Amsterdam, The Netherlands
    Neth J Med 67:320-6. 2009
    ..Studies are also needed to identify at-risk patients. In these studies, we advocate the use of the consensus definition to improve comparability of risk factors and outcome of TRALI across patient populations...
  22. ncbi request reprint The divergent clinical presentations of transfusion-related acute lung injury illustrated by two case reports
    Alexander P J Vlaar
    Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Med Sci Monit 16:CS129-34. 2010
    ..Patients who exhibit another risk factor for the onset of ALI may be neglected as having TRALI, which contributes to underreporting...
  23. doi request reprint Supernatant of aged erythrocytes causes lung inflammation and coagulopathy in a "two-hit" in vivo syngeneic transfusion model
    Alexander P J Vlaar
    Department of Intensive Care Medicine, Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, Amsterdam, The Netherlands
    Anesthesiology 113:92-103. 2010
    ..Using a syngeneic in vivo transfusion model, we investigated whether transfusion of stored rat erythrocytes causes lung injury in healthy and in lipopolysaccharide-primed rats in a "two-hit" model of lung injury...
  24. doi request reprint Supernatant of stored platelets causes lung inflammation and coagulopathy in a novel in vivo transfusion model
    Alexander P J Vlaar
    Department of Intensive Care Medicine, Academic Medical Center, Amsterdam
    Blood 116:1360-8. 2010
    ..In a "2-hit" model, aged PLTs contribute to pulmonary and systemic coagulopathy, which may be mediated by LysoPCs, which accumulate in the supernatant of PLTs during storage...
  25. doi request reprint Mechanical ventilation aggravates transfusion-related acute lung injury induced by MHC-I class antibodies
    A P J Vlaar
    Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Intensive Care Med 36:879-87. 2010
    ..We examined the influence of mechanical ventilation (MV) on the development of TRALI, combining a murine MV model causing ventilator-induced lung injury with a model of antibody-induced TRALl...
  26. pmc Determinants of transfusion decisions in a mixed medical-surgical intensive care unit: a prospective cohort study
    Alexander P J Vlaar
    Department of Intensive Care Medicine, Laboratory of Experimental Intensive Care and Anesthesiology, M0 228, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands
    Blood Transfus 7:106-10. 2009
    ..Insight into physicians' transfusion decisions may aid efforts to restrict transfusion practice...
  27. doi request reprint The effect of aspirin in transfusion-related acute lung injury in critically ill patients
    P R Tuinman
    Department of Intensive Care Medicine and Laboratory of Experimental Intensive Care and Anesthesiology L E I C A, Academic Medical Center, Amsterdam, The Netherlands
    Anaesthesia 67:594-9. 2012
    ..66). In conclusion, aspirin did not protect against transfusion-related lung injury in this cohort of critically ill patients...
  28. doi request reprint Activated protein C attenuates pulmonary coagulopathy in patients with acute respiratory distress syndrome
    A D Cornet
    Department of Intensive Care Medicine, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
    J Thromb Haemost 11:894-901. 2013
    ..We hypothesized that an infusion of recombinant human activated protein C (rh-APC), a natural anticoagulant, would attenuate pulmonary coagulopathy and injury...
  29. pmc Lack of evidence of CD40 ligand involvement in transfusion-related acute lung injury
    P R Tuinman
    Department of Intensive Care Medicine and Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, Amsterdam, The Netherlands
    Clin Exp Immunol 165:278-84. 2011
    ..In conclusion, these results do not support the idea that the CD40-CD40L interaction is involved in mediating TRALI...
  30. doi request reprint Risk factors and outcome of transfusion-related acute lung injury in the critically ill: a nested case-control study
    Alexander P J Vlaar
    Intensive Care Department, Academic Medical Center, Amsterdam, The Netherlands
    Crit Care Med 38:771-8. 2010
    ..To determine the incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of critically ill patients...
  31. doi request reprint Recombinant human soluble tumor necrosis factor-alpha receptor fusion protein partly attenuates ventilator-induced lung injury
    Esther K Wolthuis
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, C3 423, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Shock 31:262-6. 2009
    ..The number of caspase 3-positive cells was significantly higher in etanercept-treated animals. Inhibition of TNF by etanercept attenuates, in part, MV-induced changes...
  32. doi request reprint Transfusion-related risk of secondary bacterial infections in sepsis patients: a retrospective cohort study
    Nicole P Juffermans
    Department of Intensive Care Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Shock 35:355-9. 2011
    ..Storage time of RBCs influences this increased risk. These findings suggest that immunomodulatory effects of blood transfusion contribute to adverse outcome in the convalescent phase of sepsis...