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Genomes and Genes | A P VlaarSummaryAffiliation: Academic Medical Center Country: The Netherlands Publications
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Publications
[Transfusion-related acute lung injury]Alexander P J Vlaar
Academisch Medisch Centrum Universiteit van Amsterdam, afd Intensive Care Volwassenen, Amsterdam, The Netherlands
Ned Tijdschr Geneeskd 157:A5524. 2013..Anti-HLA and anti-HNA antibodies are highly prevalent in multiparous female donors. The exclusion of female donors for plasma and thrombocyte products has led to a 33-66% reduction in the incidence of TRALI...- Transfusion-related acute lung injury in cardiac surgery patients is characterized by pulmonary inflammation and coagulopathy: a prospective nested case-control studyAlexander P J Vlaar
Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
Crit Care Med 40:2813-20. 2012..The objective of the present study was to determine inflammation and coagulation pathways involved in the onset of transfusion-related acute lung injury... 
Transfusion-related acute lung injury: Current understanding and preventive strategiesA P J Vlaar
Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
Transfus Clin Biol 19:117-24. 2012..This review discusses the current understanding of TRALI and preventive strategies available...
Soluble urokinase-type plasminogen activator receptor levels in patients with burn injuries and inhalation trauma requiring mechanical ventilation: an observational cohort studyYara Backes
Department of Intensive Care Medicine, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Crit Care 15:R270. 2011..The aim of this study was to investigate the diagnostic and prognostic value of systemic and pulmonary levels of suPAR in burn patients with inhalation trauma who need mechanical ventilation...- Prevention of immune-mediated transfusion-related acute lung injury; from bloodbank to patientMarcella C A Müller
Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
Curr Pharm Des 18:3241-8. 2012..From a bedside view, the most important measure to prevent TRALI is to limit patients' exposure to allogenic bloodproducts. Furthermore recognition and awareness of the syndrome need to be heightened among clinicians... - The effect of blood transfusion on pulmonary permeability in cardiac surgery patients: a prospective multicenter cohort studyAlexander P J Vlaar
Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
Transfusion 52:82-90. 2012..Mediators of increased pulmonary vascular leakage after transfusion are unknown. We hypothesized that factors may include antibodies or bioactive lipids, which have been implicated in transfusion-related acute lung injury... - Blood transfusion during cardiac surgery is associated with inflammation and coagulation in the lung: a case control studyPieter R Tuinman
Department of Intensive Care Medicine and Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, Meibergdreef 9, Amsterdam NL 1105 AZ, The Netherlands
Crit Care 15:R59. 2011..We hypothesized that blood transfusion is associated with changes in pulmonary and systemic inflammation and coagulation occurring in patients who do not meet the clinical diagnosis of transfusion-related acute lung injury (TRALI)... - Mechanical ventilation using non-injurious ventilation settings causes lung injury in the absence of pre-existing lung injury in healthy miceEsther K Wolthuis
Department of Intensive Care Medicine, University of Amsterdam, Amsterdam, The Netherlands
Crit Care 13:R1. 2009..To study VILI in healthy mice, the authors used a MV model with clinically relevant ventilator settings, avoiding massive damage of lung structures and shock, and preventing metabolic acidosis... - Ventilation with lower tidal volumes as compared with conventional tidal volumes for patients without acute lung injury: a preventive randomized controlled trialRogier M Determann
Department of Intensive Care Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
Crit Care 14:R1. 2010..We compared the effect of conventional with lower tidal volumes on pulmonary inflammation and development of lung injury in critically ill patients without ALI at the onset of mechanical ventilation... - Nebulized antithrombin limits bacterial outgrowth and lung injury in Streptococcus pneumoniae pneumonia in ratsJorrit J Hofstra
Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands
Crit Care 13:R145. 2009..We evaluated the effect of nebulized anticoagulants on pulmonary coagulopathy and inflammation in a rat model of Streptococcus pneumoniae pneumonia... - Malignancies associated with chronic hepatitis C: case report and review of the literatureA P J Vlaar
Departments of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
Neth J Med 69:211-5. 2011..A case report of HCV-related HCC and B-cell lymphoma illustrates the increased risk for HCV-infected patients to develop other malignancies besides HCC... - Accumulation of bioactive lipids during storage of blood products is not cell but plasma derived and temperature dependentAlexander P J Vlaar
Department of Intensive Care Medicine, Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, Amsterdam, The Netherlands
Transfusion 51:2358-66. 2011..LysoPCs are thought to be derived from cell membrane degradation products such as phosphatidylcholines (PC) by partial hydrolysis of PC, a process that is catalyzed by phospholipase A(2) (PLA(2) )... - The relation between aged blood products and onset of transfusion-related acute lung injury. A review of pre-clinical dataA P Vlaar
Laboratory of Experimental Intensive Care and Anesthesiology L E I CA, Academic Medical Centre, Amsterdam, The Netherlands
Clin Lab 57:267-72. 2011..Further research is needed to elucidate possible mechanisms of onset of TRALI by aged blood products... - The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control studyAlexander P J Vlaar
Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
Blood 117:4218-25. 2011..In conclusion, the incidence of TRALI is high in cardiac surgery patients and associated with adverse outcome. Our results suggest that cardiac surgery patients may benefit from exclusion of blood products containing HLA/HNA antibodies... - The divergent clinical presentations of transfusion-related acute lung injury illustrated by two case reportsAlexander P J Vlaar
Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
Med Sci Monit 16:CS129-34. 2010..Patients who exhibit another risk factor for the onset of ALI may be neglected as having TRALI, which contributes to underreporting... - Developing specific therapeutic strategies for transfusion-related acute lung injury. An overview of potentially useful animal modelsAlexander P J Vlaar
Department of Intensive Care Medicine, Laboratory of Experimental Intensive Care and Anesthesiology L E I C A, Academic Medical Center, room M0 228, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
Cardiovasc Hematol Agents Med Chem 5:319-26. 2007..We discuss the present TRALI animal models and their shortcomings and propose future animal models, in which clinically relevant "first hits" can be applied, thereby imitating the complex clinical situation... - Determinants of transfusion decisions in a mixed medical-surgical intensive care unit: a prospective cohort studyAlexander P J Vlaar
Department of Intensive Care Medicine, Laboratory of Experimental Intensive Care and Anesthesiology, M0 228, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands
Blood Transfus 7:106-10. 2009..Insight into physicians' transfusion decisions may aid efforts to restrict transfusion practice... - A survey of physicians' reasons to transfuse plasma and platelets in the critically ill: a prospective single-centre cohort studyA P J Vlaar
Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Transfus Med 19:207-12. 2009..Transfusion of platelets was restrictive in non-bleeding patients and liberal in bleeding patients. Education on indications of FFP transfusion and improved identification of bleeding may reduce transfusion rates... - Diagnosing acute lung injury in the critically ill: a national survey among critical care physiciansA P J Vlaar
Department of Intensive Care Medicine, Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Centre, Meibergdreef 9, Amsterdam, The Netherlands
Acta Anaesthesiol Scand 53:1293-9. 2009..Incidence reports on acute lung injury (ALI) vary widely. An insight into the diagnostic preferences of critical care physicians when diagnosing ALI may improve identification of the ALI patient population... - The practice of reporting transfusion-related acute lung injury: a national survey among clinical and preclinical disciplinesAlexander P J Vlaar
Department of Intensive Care Medicine and Department of Hematology, Academic Medical Center, Amsterdam, The Netherlands
Transfusion 50:443-51. 2010..g., sepsis) predisposes to TRALI. TRALI is a clinical diagnosis. Disciplines involved in managing TRALI may differ in decision-making on the reporting of TRALI... - Transfusion-related acute lung injury: a change of perspectiveA P Vlaar
Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Centre, Amsterdam, The Netherlands
Neth J Med 67:320-6. 2009..Studies are also needed to identify at-risk patients. In these studies, we advocate the use of the consensus definition to improve comparability of risk factors and outcome of TRALI across patient populations... - Mechanical ventilation aggravates transfusion-related acute lung injury induced by MHC-I class antibodiesA P J Vlaar
Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
Intensive Care Med 36:879-87. 2010..We examined the influence of mechanical ventilation (MV) on the development of TRALI, combining a murine MV model causing ventilator-induced lung injury with a model of antibody-induced TRALl... - Supernatant of stored platelets causes lung inflammation and coagulopathy in a novel in vivo transfusion modelAlexander P J Vlaar
Department of Intensive Care Medicine, Academic Medical Center, Amsterdam
Blood 116:1360-8. 2010..In a "2-hit" model, aged PLTs contribute to pulmonary and systemic coagulopathy, which may be mediated by LysoPCs, which accumulate in the supernatant of PLTs during storage... - Supernatant of aged erythrocytes causes lung inflammation and coagulopathy in a "two-hit" in vivo syngeneic transfusion modelAlexander P J Vlaar
Department of Intensive Care Medicine, Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, Amsterdam, The Netherlands
Anesthesiology 113:92-103. 2010..Using a syngeneic in vivo transfusion model, we investigated whether transfusion of stored rat erythrocytes causes lung injury in healthy and in lipopolysaccharide-primed rats in a "two-hit" model of lung injury... - The effect of aspirin in transfusion-related acute lung injury in critically ill patientsP R Tuinman
Department of Intensive Care Medicine and Laboratory of Experimental Intensive Care and Anesthesiology L E I C A, Academic Medical Center, Amsterdam, The Netherlands
Anaesthesia 67:594-9. 2012..66). In conclusion, aspirin did not protect against transfusion-related lung injury in this cohort of critically ill patients... - Lack of evidence of CD40 ligand involvement in transfusion-related acute lung injuryP R Tuinman
Department of Intensive Care Medicine and Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, Amsterdam, The Netherlands
Clin Exp Immunol 165:278-84. 2011..In conclusion, these results do not support the idea that the CD40-CD40L interaction is involved in mediating TRALI... - Risk factors and outcome of transfusion-related acute lung injury in the critically ill: a nested case-control studyAlexander P J Vlaar
Intensive Care Department, Academic Medical Center, Amsterdam, The Netherlands
Crit Care Med 38:771-8. 2010..To determine the incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of critically ill patients... - Recombinant human soluble tumor necrosis factor-alpha receptor fusion protein partly attenuates ventilator-induced lung injuryEsther K Wolthuis
Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, C3 423, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Shock 31:262-6. 2009..The number of caspase 3-positive cells was significantly higher in etanercept-treated animals. Inhibition of TNF by etanercept attenuates, in part, MV-induced changes... - Transfusion-related risk of secondary bacterial infections in sepsis patients: a retrospective cohort studyNicole P Juffermans
Department of Intensive Care Medicine, University of Amsterdam, Amsterdam, The Netherlands
Shock 35:355-9. 2011..Storage time of RBCs influences this increased risk. These findings suggest that immunomodulatory effects of blood transfusion contribute to adverse outcome in the convalescent phase of sepsis...