Rogier Versteeg

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi Inhibition of a new differentiation pathway in neuroblastoma by copy number defects of N-myc, Cdc42, and nm23 genes
    Linda J Valentijn
    Department of Human Genetics M1 134, Academic Medical Center, University of Amsterdam, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    Cancer Res 65:3136-45. 2005
  2. pmc Logic Learning Machine creates explicit and stable rules stratifying neuroblastoma patients
    Davide Cangelosi
    Laboratory of Molecular Biology, Gaslini Institute, Largo Gaslini 5, 16147 Genoa, Italy
    BMC Bioinformatics 14:S12. 2013
  3. pmc Design of a multi-signature ensemble classifier predicting neuroblastoma patients' outcome
    Andrea Cornero
    Laboratory of Molecular Biology, G Gaslini Institute, Genoa 16147, Italy
    BMC Bioinformatics 13:S13. 2012
  4. pmc A biology-driven approach identifies the hypoxia gene signature as a predictor of the outcome of neuroblastoma patients
    Paolo Fardin
    Laboratory of Molecular Biology, Gaslini Institute, Genoa, Italy
    Mol Cancer 9:185. 2010
  5. pmc The human transcriptome map reveals extremes in gene density, intron length, GC content, and repeat pattern for domains of highly and weakly expressed genes
    Rogier Versteeg
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, 1100DE Amsterdam, The Netherlands
    Genome Res 13:1998-2004. 2003
  6. ncbi Dickkopf-3 expression is a marker for neuroblastic tumor maturation and is down-regulated by MYCN
    Arjen Koppen
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Int J Cancer 122:1455-64. 2008
  7. pmc Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification
    Linda J Valentijn
    Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 109:19190-5. 2012
  8. doi Targeted BCL2 inhibition effectively inhibits neuroblastoma tumour growth
    Fieke Lamers
    Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO Box 22700, 1105 AZ Amsterdam, The Netherlands
    Eur J Cancer 48:3093-103. 2012
  9. doi MSX1 induces the Wnt pathway antagonist genes DKK1, DKK2, DKK3, and SFRP1 in neuroblastoma cells, but does not block Wnt3 and Wnt5A signalling to DVL3
    Ingrid Revet
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, AZ Amsterdam, The Netherlands
    Cancer Lett 289:195-207. 2010
  10. pmc Domain-wide regulation of gene expression in the human genome
    Hinco J Gierman
    Department of Human Genetics, Academic Medical Centre, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    Genome Res 17:1286-95. 2007

Collaborators

Detail Information

Publications60

  1. ncbi Inhibition of a new differentiation pathway in neuroblastoma by copy number defects of N-myc, Cdc42, and nm23 genes
    Linda J Valentijn
    Department of Human Genetics M1 134, Academic Medical Center, University of Amsterdam, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    Cancer Res 65:3136-45. 2005
    ..Three regions of chromosomal gain and loss thus affect genes functioning in one pathway in neuroblastoma. They converge to bring the pathway out of balance and prevent Cdc42 mediated differentiation...
  2. pmc Logic Learning Machine creates explicit and stable rules stratifying neuroblastoma patients
    Davide Cangelosi
    Laboratory of Molecular Biology, Gaslini Institute, Largo Gaslini 5, 16147 Genoa, Italy
    BMC Bioinformatics 14:S12. 2013
    ..Furthermore, we were interested in classifiers outputting explicit rules that could be easily translated into the clinical setting...
  3. pmc Design of a multi-signature ensemble classifier predicting neuroblastoma patients' outcome
    Andrea Cornero
    Laboratory of Molecular Biology, G Gaslini Institute, Genoa 16147, Italy
    BMC Bioinformatics 13:S13. 2012
    ..Here, we describe a new strategy to merge published neuroblastoma related gene signatures into a single, highly accurate, Multi-Signature Ensemble (MuSE)-classifier of neuroblastoma (NB) patients outcome...
  4. pmc A biology-driven approach identifies the hypoxia gene signature as a predictor of the outcome of neuroblastoma patients
    Paolo Fardin
    Laboratory of Molecular Biology, Gaslini Institute, Genoa, Italy
    Mol Cancer 9:185. 2010
    ..To examine the relationship between hypoxia and neuroblastoma, we generated and tested an in vitro derived hypoxia gene signature for its ability to predict patients' outcome...
  5. pmc The human transcriptome map reveals extremes in gene density, intron length, GC content, and repeat pattern for domains of highly and weakly expressed genes
    Rogier Versteeg
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, 1100DE Amsterdam, The Netherlands
    Genome Res 13:1998-2004. 2003
    ..Ridges are therefore an integral part of a higher order structure in the genome related to transcriptional regulation...
  6. ncbi Dickkopf-3 expression is a marker for neuroblastic tumor maturation and is down-regulated by MYCN
    Arjen Koppen
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Int J Cancer 122:1455-64. 2008
    ..High DKK3 expression in the benign ganglioneuromas and down-regulation of DKK3 by MYCN in neuroblastoma might contribute to the strongly different clinical behavior of both neuroblastic tumor types...
  7. pmc Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification
    Linda J Valentijn
    Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 109:19190-5. 2012
    ..The functional MYCN-157 signature recognizes classical neuroblastoma with MYCN amplification, as well as a newly identified group marked by MYCN protein stabilization...
  8. doi Targeted BCL2 inhibition effectively inhibits neuroblastoma tumour growth
    Fieke Lamers
    Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO Box 22700, 1105 AZ Amsterdam, The Netherlands
    Eur J Cancer 48:3093-103. 2012
    ..These findings establish BCL2 as a promising drug target in neuroblastoma and warrant further evaluation of ABT263 and other BCL2 inhibiting drugs...
  9. doi MSX1 induces the Wnt pathway antagonist genes DKK1, DKK2, DKK3, and SFRP1 in neuroblastoma cells, but does not block Wnt3 and Wnt5A signalling to DVL3
    Ingrid Revet
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, AZ Amsterdam, The Netherlands
    Cancer Lett 289:195-207. 2010
    ..These results suggest involvement of MSX1 in Wnt signalling and demonstrate activity of the more upstream Wnt pathway in neuroblastic cells...
  10. pmc Domain-wide regulation of gene expression in the human genome
    Hinco J Gierman
    Department of Human Genetics, Academic Medical Centre, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    Genome Res 17:1286-95. 2007
    ..These results reveal a novel domain-wide regulatory mechanism that, together with transcription factors, exerts a dual control over gene transcription...
  11. pmc Identification of BIRC6 as a novel intervention target for neuroblastoma therapy
    Fieke Lamers
    Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO Box 22700, Amsterdam, AZ 1105, The Netherlands
    BMC Cancer 12:285. 2012
    ..Neuroblastoma are pediatric tumors of the sympathetic nervous system with a poor prognosis. Apoptosis is often deregulated in cancer cells, but only a few defects in apoptotic routes have been identified in neuroblastoma...
  12. doi OTX2 directly activates cell cycle genes and inhibits differentiation in medulloblastoma cells
    Jens Bunt
    Department of Oncogenomics, Academic Medical Center, Amsterdam, The Netherlands
    Int J Cancer 131:E21-32. 2012
    ..These analyses provide more insight in the molecular network of OTX2, demonstrating that OTX2 is essential in medulloblastoma and directly drives proliferation by regulation of cell cycle genes...
  13. doi LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression
    Jan J Molenaar
    Department of Oncogenomics, Academic Medical Center, Amsterdam, The Netherlands
    Nat Genet 44:1199-206. 2012
    ..Interference with this pathway might offer therapeutic perspectives...
  14. doi The MSX1 homeobox transcription factor is a downstream target of PHOX2B and activates the Delta-Notch pathway in neuroblastoma
    Ingrid Revet
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Exp Cell Res 314:707-19. 2008
    ..This suggests a block in differentiation of these tumours at distinct developmental stages or lineages...
  15. pmc Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells
    Jan J Molenaar
    Department of Human Genetics, Academic Medical Center, Department of Pediatric Oncology, Emma Kinderziekenhuis, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO Box 22700, 1105 AZ Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 106:12968-73. 2009
    ..The synthetically lethal relationship between CDK2 and MYCN indicates CDK2 inhibitors as potential MYCN-selective cancer therapeutics...
  16. doi Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes
    Jan J Molenaar
    Department of Oncogenomics, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Nature 483:589-93. 2012
    ..The genomic landscape of neuroblastoma therefore reveals two novel molecular defects, chromothripsis and neuritogenesis gene alterations, which frequently occur in high-risk tumours...
  17. pmc Joint binding of OTX2 and MYC in promotor regions is associated with high gene expression in medulloblastoma
    Jens Bunt
    Department of Oncogenomics, Academic Medical Center, Amsterdam, The Netherlands
    PLoS ONE 6:e26058. 2011
    ..Genes within this class of promoter regions were enriched for medulloblastoma and stem cell specific genes. Our data suggest an important functional interaction between OTX2 and MYC in regulating gene expression in medulloblastoma...
  18. doi OTX2 sustains a bivalent-like state of OTX2-bound promoters in medulloblastoma by maintaining their H3K27me3 levels
    Jens Bunt
    Department of Oncogenomics, Academic Medical Center, Amsterdam, The Netherlands
    Acta Neuropathol 125:385-94. 2013
    ....
  19. doi Copy number defects of G1-cell cycle genes in neuroblastoma are frequent and correlate with high expression of E2F target genes and a poor prognosis
    Jan J Molenaar
    Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, The Netherlands
    Genes Chromosomes Cancer 51:10-9. 2012
    ..These tumors have a poor prognosis. Our findings suggest that pharmacological inhibition of cell cycle genes might bear therapeutic promises for patients with high risk neuroblastoma...
  20. doi Stability of PCR targets for monitoring minimal residual disease in neuroblastoma
    Janine Stutterheim
    Department of Pediatric Oncology, Emma Children s Hospital, Academic Medical Center, Amsterdam, The Netherlands
    J Mol Diagn 14:168-75. 2012
    ..If the median value of relative expression of a panel of PCR targets is used, most variations due to treatment and outgrowth of subclones level out, allowing for reliable application and quantification of MRD-PCR targets in NB patients...
  21. doi Knockdown of survivin (BIRC5) causes apoptosis in neuroblastoma via mitotic catastrophe
    Fieke Lamers
    Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO Box 22700, 1105 AZ Amsterdam, The Netherlands
    Endocr Relat Cancer 18:657-68. 2011
    ..We conclude that BIRC5 stabilizes the microtubules in the chromosomal passenger complex in neuroblastoma and that the apoptotic response results from mitotic catastrophe, which makes BIRC5 an interesting target for therapy...
  22. doi Regulation of cell cycle genes and induction of senescence by overexpression of OTX2 in medulloblastoma cell lines
    Jens Bunt
    Department of Human Genetics, Academic Medical Center, Amsterdam, The Netherlands
    Mol Cancer Res 8:1344-57. 2010
    ..Our data indicate that OTX2 directly induces a series of cell cycle genes but requires cooperating genes for an oncogenic acceleration of the cell cycle...
  23. ncbi Direct regulation of the minichromosome maintenance complex by MYCN in neuroblastoma
    Arjen Koppen
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    Eur J Cancer 43:2413-22. 2007
    ..These data suggest that MYCN stimulates the expression of not only MCM7, which is a well defined MYCN target gene, but also of the complete minichromosome maintenance complex...
  24. pmc The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification
    Dirk Geerts
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Int J Cancer 126:2012-24. 2010
    ....
  25. doi Mutations in the Ras-Raf Axis underlie the prognostic value of CD133 in colorectal cancer
    Kristel Kemper
    Laboratory for Experimental Oncology and Radiobiology, Center for Experimental Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Clin Cancer Res 18:3132-41. 2012
    ..We therefore set out to delineate the relation between CD133 expression and prognosis...
  26. pmc Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features
    Marcel Kool
    Department of Human Genetics, Academic Medical Center, Amsterdam, The Netherlands
    PLoS ONE 3:e3088. 2008
    ..This illustrates the potential benefits of a robust classification of medulloblastoma patients and a detailed knowledge of associated biological mechanisms...
  27. doi Cyclin D1 and CDK4 activity contribute to the undifferentiated phenotype in neuroblastoma
    Jan J Molenaar
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Cancer Res 68:2599-609. 2008
    ..Several new potential downstream players are identified. We conclude that neuroblastoma functionally depend on overexpression of G(1)-regulating genes to maintain their undifferentiated phenotype...
  28. doi Targeted BIRC5 silencing using YM155 causes cell death in neuroblastoma cells with low ABCB1 expression
    Fieke Lamers
    Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO Box 22700, 1105 AZ Amsterdam, The Netherlands
    Eur J Cancer 48:763-71. 2012
    ..Therefore YM155 is a promising novel compound for treatment of neuroblastoma with low ABCB1 expression...
  29. doi The construction of genome-based transcriptional units
    Sander R van Hooff
    Bioinformatics Laboratory, Academic Medical Center, Meibergdreef 9, Amsterdam, The Netherlands
    OMICS 13:105-14. 2009
    ..We believe that ongoing research efforts are necessary to further improve current methods. This should include detailed documentation, comparison, and evaluation of current methods...
  30. doi Silencing of SPRY1 triggers complete regression of rhabdomyosarcoma tumors carrying a mutated RAS gene
    Gerben Schaaf
    Department of Human Genetics, Academic Medical Centre, University of Amsterdam, Amsterdam 1105 AZ, The Netherlands
    Cancer Res 70:762-71. 2010
    ..Our findings argue that SPRY1 inhibition can offer a therapeutic strategy to treat childhood RMS and possibly other tumors carrying oncogenic RAS mutations...
  31. ncbi Rearrangements and increased expression of cyclin D1 (CCND1) in neuroblastoma
    Jan J Molenaar
    Department of Human Genetics, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Genes Chromosomes Cancer 36:242-9. 2003
    ..Analysis of the 3'-UTR of CCND1 showed a rearrangement in 1 of 96 tumors. These clonal aberrations of CCND1 together with the high expression suggest a role for deregulated CCND1 activity in neuroblastoma tumorigenesis...
  32. ncbi Dickkopf-1 is down-regulated by MYCN and inhibits neuroblastoma cell proliferation
    Arjen Koppen
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    Cancer Lett 256:218-28. 2007
    ..These results suggest that MYCN might stimulate cell proliferation by inhibiting the expression of DKK1. DKK1 might exert part of its growth suppressive effect by induction of SYNPO2 expression...
  33. ncbi The N-myc and c-myc downstream pathways include the chromosome 17q genes nm23-H1 and nm23-H2
    Marc B Godfried
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Oncogene 21:2097-101. 2002
    ..These observations suggest a major role for nm23-H1 and nm23-H2 in tumorigenesis of unfavorable neuroblastomas...
  34. doi A NOTCH3 transcriptional module induces cell motility in neuroblastoma
    Johan van Nes
    Department of Oncogenomics, Academic Medical Center, Amsterdam, The Netherlands
    Clin Cancer Res 19:3485-94. 2013
    ..Migration and epithelial-mesenchymal transitions have been implicated in metastasis but they are hardly investigated in neuroblastoma...
  35. doi FOXO3a is a major target of inactivation by PI3K/AKT signaling in aggressive neuroblastoma
    Evan E Santo
    Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Cancer Res 73:2189-98. 2013
    ..Our work indicates that expression of FOXO3a and its targets offer useful prognostic markers as well as biomarkers for PI3K/AKT inhibitor efficacy in neuroblastoma...
  36. pmc The three-dimensional structure of human interphase chromosomes is related to the transcriptome map
    Sandra Goetze
    Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 318, Amsterdam, The Netherlands
    Mol Cell Biol 27:4475-87. 2007
    ..Together, our results reveal novel general aspects of 3D chromosome architecture that are related to genome structure and function...
  37. ncbi The role of the MEIS homeobox genes in neuroblastoma
    Dirk Geerts
    Department of Human Genetics M1 159, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Cancer Lett 197:87-92. 2003
    ..These include genes involved in developmental signalling pathways, chromatin binding, cell cycle control, proliferation, and apoptosis. The results presented provide important clues for the oncogenic function of MEIS1 in neuroblastoma...
  38. pmc Prevalence of congenital heart defects in neuroblastoma patients: a cohort study and systematic review of literature
    Klaartje van Engelen
    Department of Cardiology, Academic Medical Centre, Amsterdam, The Netherlands
    Eur J Pediatr 168:1081-90. 2009
    ..Prevalence was less than 3.6% in the majority of studies. Most studies lacked information on validity. We conclude that current evidence does not support standard cardiac screening in all patients with neuroblastoma...
  39. ncbi MEIS homeobox genes in neuroblastoma
    Dirk Geerts
    Department of Human Genetics M1 131, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Cancer Lett 228:43-50. 2005
    ..To date however, the connotation of these genes in neuroblastoma pathogenesis is scant. This review recapitulates data on the MEIS homeobox control genes in cancer and focuses on neuroblastoma...
  40. doi Detecting minimal residual disease in neuroblastoma: the superiority of a panel of real-time quantitative PCR markers
    Janine Stutterheim
    Department of Pediatric Oncology, Emma Children s Hospital, Academic Medical Center, Amsterdam, The Netherlands
    Clin Chem 55:1316-26. 2009
    ..PHOX2B has been identified as a sensitive and specific MRD marker; however, its expression varies between tumors. Therefore, a panel of markers could increase sensitivity...
  41. ncbi The N-myc paradox: N-myc overexpression in neuroblastomas is associated with sensitivity as well as resistance to apoptosis
    Max M van Noesel
    Department of Human Genetics, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Cancer Lett 197:165-72. 2003
    ..Analysis of the CASP9 mediated route in a series of neuroblastoma cell lines, we found normal expression and no aberrant methylation of four apoptotic intermediates, including CASP9 itself...
  42. ncbi High delta-like 1 expression in a subset of neuroblastoma cell lines corresponds to a differentiated chromaffin cell type
    Vera A E Van Limpt
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Int J Cancer 105:61-9. 2003
    ....
  43. ncbi Clustering of hypermethylated genes in neuroblastoma
    Max M van Noesel
    Department of Human Genetics, Academic Medical Center, Amsterdam, The Netherlands
    Genes Chromosomes Cancer 38:226-33. 2003
    ..The methylation pattern therefore supports a model in which CpG islands are not randomly targeted by methylation in cancer. Specific transcriptional silencing probably marks genes that can become methylated...
  44. ncbi The Phox2B homeobox gene is mutated in sporadic neuroblastomas
    Vera van Limpt
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Oncogene 23:9280-8. 2004
    ..However, TrkA and Phox2B showed a positive correlation in a panel of 66 neuroblastoma tumours. Although Phox2B mutations are infrequent (2.3%), they implicate a role for the Phox2B pathway in oncogenesis...
  45. pmc CD44 Expression in Intestinal Epithelium and Colorectal Cancer Is Independent of p53 Status
    Jurrit Zeilstra
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 8:e72849. 2013
    ..Our data demonstrate that CD44 expression in normal and malignant intestinal epithelial cells is not regulated by p53, implying that regulation of this potentially important therapeutic target is tissue and cancer-type specific. ..
  46. doi Molecular risk stratification of medulloblastoma patients based on immunohistochemical analysis of MYC, LDHB, and CCNB1 expression
    Talitha de Haas
    Department of Human Genetics, Neuropathology, and Neurogenetics, Academic Medical Center, Amsterdam, The Netherlands
    Clin Cancer Res 14:4154-60. 2008
    ..The aim of this study is to improve the risk stratification of medulloblastoma patients by using the expression of multiple prognostic markers in combination with current clinical parameters...
  47. ncbi Read-through transcript from NM23-H1 into the neighboring NM23-H2 gene encodes a novel protein, NM23-LV
    Linda J Valentijn
    Department of Human Genetics, M1 134, Academic Medical Center, University of Amsterdam, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    Genomics 87:483-9. 2006
    ..Neuroblastoma tumors show high-level expression of NM23-H1 and-H2 as well as NM23-LV mRNA. In neuroblastoma cells, the NM23-LV protein has mainly a cytoplasmic localization, but some nuclear staining was observed as well...
  48. doi Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients
    Felipe De Sousa E Melo
    Laboratory of Experimental Oncology and Radiobiology, Center for Experimental Molecular Medicine, Academic Medical Center, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands
    Cell Stem Cell 9:476-85. 2011
    ....
  49. ncbi Phox2B mutations and the Delta-Notch pathway in neuroblastoma
    Vera van Limpt
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    Cancer Lett 228:59-63. 2005
    ..Phox2B is also related to the TrkA differentiation pathway in neuroblastoma. Here we will review the role of Phox2B in differentiation programs of the SNS and in neuroblastoma pathogenesis...
  50. ncbi Tumor-specific down-regulation of the tumor necrosis factor-related apoptosis-inducing ligand decoy receptors DcR1 and DcR2 is associated with dense promoter hypermethylation
    Max M van Noesel
    Department of Human Genetics, Academic Medical Center, 1105 AZ, Amsterdam, The Netherlands
    Cancer Res 62:2157-61. 2002
    ..These data suggest that hypermethylation of the promoters of DcR1 and DcR2 is important in the down-regulation of expression in neuroblastoma and other tumor types...
  51. ncbi OTX1 and OTX2 expression correlates with the clinicopathologic classification of medulloblastomas
    Talitha de Haas
    Department of Human Genetics, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Neuropathol Exp Neurol 65:176-86. 2006
    ..Combined with data from rodents, our results therefore suggest that both nodular/desmoplastic and at least part of the classic medulloblastomas originate from cells of the EGL, albeit from different regions...
  52. ncbi ArrayCGH-based classification of neuroblastoma into genomic subgroups
    Evi Michels
    Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
    Genes Chromosomes Cancer 46:1098-108. 2007
    ..Further multicentric studies on large tumor series are warranted in order to improve therapeutic stratification in conjunction with other features such as age at diagnosis, tumor stage, and gene expression signatures...
  53. pmc Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells
    Pantelis Hatzis
    Hubrecht Institute, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Mol Cell Biol 28:2732-44. 2008
    ..The TCF4-binding regions significantly correlate with Wnt-responsive gene expression profiles derived from primary human adenomas and often behave as beta-catenin/TCF4-dependent enhancers in transient reporter assays...
  54. ncbi Expression of prenylated Rab acceptor 1 domain family, member 2 (PRAF2) in neuroblastoma: correlation with clinical features, cellular localization, and cerulenin-mediated apoptosis regulation
    Dirk Geerts
    Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu, HI 96813, USA
    Clin Cancer Res 13:6312-9. 2007
    ..In addition, we determined the localization of PRAF2 protein in neuroblastoma cells and studied its regulation in apoptosis...
  55. ncbi Biochemistry meets nuclear architecture: multicolor immuno-FISH for co-localization analysis of chromosome segments and differentially expressed gene loci with various histone methylations
    Roman Zinner
    Anthropology and Human Genetics, Department of Biology II, Ludwig Maximilians University, Grosshadernerstrasse 2, D 82152 Martinsried, Germany
    Adv Enzyme Regul 47:223-41. 2007
  56. ncbi Regulation of type III iodothyronine deiodinase expression in human cell lines
    Monique H A Kester
    Department of Internal Medicine, Erasmus Medical Center, Room Ee 502, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Endocrinology 147:5845-54. 2006
    ....
  57. ncbi Biological effects of TrkA and TrkB receptor signaling in neuroblastoma
    Alexander Schramm
    Division of Hematology Oncology and Endocrinology, University Children s Hospital of Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Cancer Lett 228:143-53. 2005
    ..This short review discusses recent data on the biological roles of TrkA and TrkB signaling in neuroblastoma...
  58. ncbi Pediatric neuroblastomas: genetic and epigenetic 'danse macabre'
    Max M van Noesel
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, 3015 GJ Rotterdam, The Netherlands
    Gene 325:1-15. 2004
    ..Finally, we will try to relate these pathways to the embryonal origin of neuroblastomas and discuss possible new avenues in the therapeutic approach of future neuroblastoma patients...
  59. ncbi Localization of the 17q breakpoint of a constitutional 1;17 translocation in a patient with neuroblastoma within a 25-kb segment located between the ACCN1 and TLK2 genes and near the distal breakpoints of two microdeletions in neurofibromatosis type 1 pat
    Nadine Van Roy
    Department of Medical Genetics, Ghent University Hospital, Ghent, Belgium
    Genes Chromosomes Cancer 35:113-20. 2002
    ....
  60. pmc Comparison of RNAi efficiency mediated by tetracycline-responsive H1 and U6 promoter variants in mammalian cell lines
    Jørn R Henriksen
    Department of Pediatrics, University Hospital of North Norway, Tromsø, Norway
    Nucleic Acids Res 35:e67. 2007
    ..This inducible system for RNAi-based gene silencing is a good candidate for use both in basic research on gene function and for potential therapeutic applications...