A O Verkerk
Affiliation: Academic Medical Center
Country: The Netherlands
Végh A, den Haan A, Cócera Ortega L, Verkerk A, Sluijter J, Bakker D, et al
. Cardiomyocyte Progenitor Cells as a Functional Gene Delivery Vehicle for Long-Term Biological Pacing. Molecules. 2019;24: pubmed publisher
..05). In sum, CMPCs expressing HCN4-GFP functionally couple to NRVMs and induce physiologically controlled pacemaker activity and may therefore provide an attractive delivery platform for sustained pacemaker function. ..
Verkerk A, den Ruijter H, Bourier J, Boukens B, Brouwer I, Wilders R, et al
. Dietary fish oil reduces pacemaker current and heart rate in rabbit. Heart Rhythm. 2009;6:1485-92 pubmed publisher
..An FO diet prolongs the sinus cycle length because of, at least in part, a reduction in I(f) density. Our results explain FO-induced heart rate reduction and suggest FO as an alternative or adjunct to I(f)-lowering drugs. ..
Verkerk A, Wilders R. Pacemaker activity of the human sinoatrial node: an update on the effects of mutations in HCN4 on the hyperpolarization-activated current. Int J Mol Sci. 2015;16:3071-94 pubmed publisher
..Future research may solve apparent inconsistencies between data from clinical studies and data from in vitro and in silico experiments. ..
Verkerk A, Veerman C, Zegers J, Mengarelli I, Bezzina C, Wilders R. Patch-Clamp Recording from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Improving Action Potential Characteristics through Dynamic Clamp. Int J Mol Sci. 2017;18: pubmed publisher
..In conclusion, the dynamic clamp-based approach of IK1 injection has broad applicability for detailed AP measurements in hiPSC-CMs. ..