Wim van den Brink

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. pmc Investigating the efficacy of integrated cognitive behavioral therapy for adult treatment seeking substance use disorder patients with comorbid ADHD: study protocol of a randomized controlled trial
    Katelijne van Emmerik-van Oortmerssen
    Arkin Mental Health Care and Addiction Treatment Center, Amsterdam, The Netherlands
    BMC Psychiatry 13:132. 2013
  2. pmc Efficacy of as-needed nalmefene in alcohol-dependent patients with at least a high drinking risk level: results from a subgroup analysis of two randomized controlled 6-month studies
    Wim van den Brink
    Department of Psychiatry, Amsterdam Institute for Addiction Research, University of Amsterdam, Amsterdam, The Netherlands
    Alcohol Alcohol 48:570-8. 2013
  3. ncbi request reprint Evidence-based pharmacological treatment of substance use disorders and pathological gambling
    Wim van den Brink
    Academic Medical Center of the University of Amsterdam, Department of Psychiatry, Amsterdam Institute for Addiction Research AIAR, Meibergdreef 5, 1105 AZ Amsterdam, The Netherlands
    Curr Drug Abuse Rev 5:3-31. 2012
  4. pmc Cocaine Addiction Treatments to improve Control and reduce Harm (CATCH): new pharmacological treatment options for crack-cocaine dependence in the Netherlands
    Mascha Nuijten
    Parnassia Addiction Research Centre PARC, Brijder Addiction Treatment, PO Box 53002, 2505 AA The Hague, The Netherlands
    BMC Psychiatry 11:135. 2011
  5. ncbi request reprint ECNP consensus meeting March 2003 guidelines for the investigation of efficacy in substance use disorders
    W van den Brink
    Department of Psychiatry, Academic Medical Center University of Amsterdam, Tafelbergweg 25, 1105 BC Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 16:224-30. 2006
  6. ncbi request reprint Sensitivity of the Addiction Severity Index physical and sexual assault items: preliminary findings on gender differences
    W Langeland
    Amsterdam Institute for Addiction Research, Free University Amsterdam, The Netherlands
    Eur Addict Res 7:193-7. 2001
  7. ncbi request reprint Assessment of lifetime physical and sexual abuse in treated alcoholics. Validity of the Addiction Severity Index
    Willie Langeland
    Amsterdam Institute of Addiction Research, Amsterdam, The Netherlands
    Addict Behav 28:871-81. 2003
  8. doi request reprint Forum: Decriminalization of cannabis
    Wim van den Brink
    Amsterdam Institute for Addiction Research Academic Medical Center, University of Amsterdam Department of Psychiatry, Amsterdam, The Netherlands
    Curr Opin Psychiatry 21:122-6. 2008
  9. pmc Medical prescription of heroin to treatment resistant heroin addicts: two randomised controlled trials
    Wim van den Brink
    Central Committee on the Treatment of Heroin Addicts CCBH, Stratenum, Universiteitsweg 100, 3584 CG Utrecht, Netherlands
    BMJ 327:310. 2003
  10. ncbi request reprint Evidenced-based treatment of opioid-dependent patients
    Wim van den Brink
    Academic Medical Center, University of Amsterdam, Department of Psychiatry, The Netherlands
    Can J Psychiatry 51:635-46. 2006

Detail Information

Publications116 found, 100 shown here

  1. pmc Investigating the efficacy of integrated cognitive behavioral therapy for adult treatment seeking substance use disorder patients with comorbid ADHD: study protocol of a randomized controlled trial
    Katelijne van Emmerik-van Oortmerssen
    Arkin Mental Health Care and Addiction Treatment Center, Amsterdam, The Netherlands
    BMC Psychiatry 13:132. 2013
    ..Recent studies show positive effects of cognitive behavioral therapy (CBT) in ADHD patients without SUD, but CBT has not been studied in ADHD patients with comorbid SUD...
  2. pmc Efficacy of as-needed nalmefene in alcohol-dependent patients with at least a high drinking risk level: results from a subgroup analysis of two randomized controlled 6-month studies
    Wim van den Brink
    Department of Psychiatry, Amsterdam Institute for Addiction Research, University of Amsterdam, Amsterdam, The Netherlands
    Alcohol Alcohol 48:570-8. 2013
    ....
  3. ncbi request reprint Evidence-based pharmacological treatment of substance use disorders and pathological gambling
    Wim van den Brink
    Academic Medical Center of the University of Amsterdam, Department of Psychiatry, Amsterdam Institute for Addiction Research AIAR, Meibergdreef 5, 1105 AZ Amsterdam, The Netherlands
    Curr Drug Abuse Rev 5:3-31. 2012
    ....
  4. pmc Cocaine Addiction Treatments to improve Control and reduce Harm (CATCH): new pharmacological treatment options for crack-cocaine dependence in the Netherlands
    Mascha Nuijten
    Parnassia Addiction Research Centre PARC, Brijder Addiction Treatment, PO Box 53002, 2505 AA The Hague, The Netherlands
    BMC Psychiatry 11:135. 2011
    ..The present study (Cocaine Addiction Treatments to improve Control and reduce Harm; CATCH) investigates the possibilities and problems associated with new pharmacological treatments for crack dependent patients...
  5. ncbi request reprint ECNP consensus meeting March 2003 guidelines for the investigation of efficacy in substance use disorders
    W van den Brink
    Department of Psychiatry, Academic Medical Center University of Amsterdam, Tafelbergweg 25, 1105 BC Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 16:224-30. 2006
  6. ncbi request reprint Sensitivity of the Addiction Severity Index physical and sexual assault items: preliminary findings on gender differences
    W Langeland
    Amsterdam Institute for Addiction Research, Free University Amsterdam, The Netherlands
    Eur Addict Res 7:193-7. 2001
    ..Evaluation of the Addiction Severity Index (ASI) as a screen for identifying sexual and physical assault histories...
  7. ncbi request reprint Assessment of lifetime physical and sexual abuse in treated alcoholics. Validity of the Addiction Severity Index
    Willie Langeland
    Amsterdam Institute of Addiction Research, Amsterdam, The Netherlands
    Addict Behav 28:871-81. 2003
    ....
  8. doi request reprint Forum: Decriminalization of cannabis
    Wim van den Brink
    Amsterdam Institute for Addiction Research Academic Medical Center, University of Amsterdam Department of Psychiatry, Amsterdam, The Netherlands
    Curr Opin Psychiatry 21:122-6. 2008
  9. pmc Medical prescription of heroin to treatment resistant heroin addicts: two randomised controlled trials
    Wim van den Brink
    Central Committee on the Treatment of Heroin Addicts CCBH, Stratenum, Universiteitsweg 100, 3584 CG Utrecht, Netherlands
    BMJ 327:310. 2003
    ..To determine whether supervised medical prescription of heroin can successfully treat addicts who do not sufficiently benefit from methadone maintenance treatment...
  10. ncbi request reprint Evidenced-based treatment of opioid-dependent patients
    Wim van den Brink
    Academic Medical Center, University of Amsterdam, Department of Psychiatry, The Netherlands
    Can J Psychiatry 51:635-46. 2006
    ..To provide an overview of treatment options for opioid-dependent patients...
  11. ncbi request reprint The effect of naltrexone and acamprosate on cue-induced craving, autonomic nervous system and neuroendocrine reactions to alcohol-related cues in alcoholics
    Wendy Ooteman
    Amsterdam Institute for Addiction Research, Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 17:558-66. 2007
    ..It is hypothesized that naltrexone exerts its effects primarily on cue-induced craving and neuroendocrine cue reactivity, whereas acamprosate exerts its effect primarily on autonomic nervous system reactions to alcohol-related cues...
  12. pmc Brain activation patterns associated with cue reactivity and craving in abstinent problem gamblers, heavy smokers and healthy controls: an fMRI study
    Anna E Goudriaan
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands
    Addict Biol 15:491-503. 2010
    ..Increased brain activation in related fronto-limbic brain areas was present in HSM with higher FTND scores compared with HSM with lower FTND scores...
  13. ncbi request reprint Cognition in novice ecstasy users with minimal exposure to other drugs: a prospective cohort study
    Thelma Schilt
    Amsterdam Institute for Addiction Research, The Netherlands
    Arch Gen Psychiatry 64:728-36. 2007
    ..However, owing to the cross-sectional and retrospective nature of currently available studies, questions remain regarding the causal direction and clinical relevance of these findings...
  14. ncbi request reprint Ecstasy use and self-reported depression, impulsivity, and sensation seeking: a prospective cohort study
    Maartje M L de Win
    Department of Radiology, University of Amsterdam, Academic Medical Center, The Netherlands
    J Psychopharmacol 20:226-35. 2006
    ..However, low level ecstasy use may increase (certain aspects of) sensation seeking...
  15. doi request reprint Predicting the effect of naltrexone and acamprosate in alcohol-dependent patients using genetic indicators
    Wendy Ooteman
    Amsterdam Institute for Addiction Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Addict Biol 14:328-37. 2009
    ..This provides evidence for the matching potential of genotypes. It is expected that more effective treatments can be offered when genetic information is used in patient-treatment-matching...
  16. doi request reprint Neurobiological substrates of cue-elicited craving and anhedonia in recently abstinent opioid-dependent males
    Fleur Zijlstra
    Department of Nuclear Medicine, Academic Medical Centre, 1105 AZ, Amsterdam, The Netherlands
    Drug Alcohol Depend 99:183-92. 2009
    ..The neural correlates of cue-induced craving and anhedonia in opioid-dependent patients are, however, not well understood. We studied brain activation patterns following visual presentation of neutral, pleasant and heroin-related cues...
  17. doi request reprint Sustained effects of ecstasy on the human brain: a prospective neuroimaging study in novel users
    Maartje M L de Win
    Department of Radiology, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    Brain 131:2936-45. 2008
    ..Although we do not know yet whether these effects are reversible or not, we cannot exclude that ecstasy even in low doses is neurotoxic to the brain...
  18. pmc Cost utility analysis of co-prescribed heroin compared with methadone maintenance treatment in heroin addicts in two randomised trials
    Marcel G W Dijkgraaf
    Department of Clinical Epidemiology and Biostatistics J1B 216 Academic Medical Centre, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, Netherlands
    BMJ 330:1297. 2005
    ..To determine the cost utility of medical co-prescription of heroin compared with methadone maintenance treatment for chronic, treatment resistant heroin addicts...
  19. ncbi request reprint Pharmacokinetics and pharmacodynamics of high doses of pharmaceutically prepared heroin, by intravenous or by inhalation route in opioid-dependent patients
    Elisabeth J Rook
    Slotervaart Hospital, Department of Pharmacy and Pharmacology, Amsterdam, Netherlands
    Basic Clin Pharmacol Toxicol 98:86-96. 2006
    ..In both groups, in this blinded study heroin dose increments were more appreciated than dose reductions. Increments of 50% of the regular heroin dose did not cause any serious side effect...
  20. ncbi request reprint Development and validation of the Amsterdam Motives for Drinking Scale (AMDS): an attempt to distinguish relief and reward drinkers
    Wendy Ooteman
    Amsterdam Institute for Addiction Research, Overschiestraat 65, 1062 XD, Amsterdam, The Netherlands
    Alcohol Alcohol 41:284-92. 2006
    ..The aim of this study is to develop and validate a questionnaire on drinking motives that can distinguish relief and reward drinkers...
  21. doi request reprint Free-choice and no-choice high-fat diets affect striatal dopamine D2/3 receptor availability, caloric intake, and adiposity
    Elsmarieke van de Giessen
    Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Obesity (Silver Spring) 20:1738-40. 2012
    ..These results are relevant for future studies on DIO when considering choice of diet type...
  22. doi request reprint The nicotinic acetylcholine receptor partial agonist varenicline and the treatment of drug dependence: a review
    Cleo L Crunelle
    Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 20:69-79. 2010
    ..Based on a review of the available literature, we hypothesize a potential role for varenicline in the prevention of relapse in patients recovering from drug dependence other than nicotine dependence...
  23. ncbi request reprint The craving withdrawal model for alcoholism: towards the DSM-V. Improving the discriminant validity of alcohol use disorder diagnosis
    Carla de Bruijn
    Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands
    Alcohol Alcohol 40:314-22. 2005
    ..CWM requires craving and withdrawal for the diagnosis of alcohol dependence and raises the alcohol abuse threshold to two DSM-IV AUD criteria...
  24. ncbi request reprint The effectiveness of anxiety treatment on alcohol-dependent patients with a comorbid phobic disorder: a randomized controlled trial
    Annemiek Schadé
    Department of Psychiatry and Institute for Extramural Medicine, Amsterdam, The Netherlands
    Alcohol Clin Exp Res 29:794-800. 2005
    ..We attempted to answer this question by conducting a trial among patients with a double diagnosis of alcohol dependence and agoraphobia or social phobia...
  25. doi request reprint Neurotoxic effects of ecstasy on the thalamus
    Maartje M L de Win
    Department of Radiology, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    Br J Psychiatry 193:289-96. 2008
    ..Neurotoxic effects of ecstasy have been reported, although it remains unclear whether effects can be attributed to ecstasy, other recreational drugs or a combination of these...
  26. doi request reprint Heroin-assisted treatment in the Netherlands: History, findings, and international context
    Peter Blanken
    Central Committee on the Treatment of Heroin Addicts CCBH, Utrecht, The Netherlands
    Eur Neuropsychopharmacol 20:S105-58. 2010
    ..Together, these data show that HAT can now be considered a safe and proven-effective intervention for the treatment of chronic, treatment-resistant heroin dependent patients...
  27. ncbi request reprint Fluvoxamine reduces responsiveness of HPA axis in adult female BPD patients with a history of sustained childhood abuse
    Thomas Rinne
    Leiden University Medical Center, Department of Psychiatry, Netherlands
    Neuropsychopharmacology 28:126-32. 2003
    ..In conclusion, Fluvoxamine treatment reduces the hyperresponsiveness of the HPA axis in BPD patients with a history of sustained childhood abuse. This effect is likely to be obtained in the first 6 weeks of treatment...
  28. ncbi request reprint Population pharmacokinetics of heroin and its major metabolites
    Elisabeth J Rook
    Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands
    Clin Pharmacokinet 45:401-17. 2006
    ....
  29. doi request reprint Heavy alcohol use, rather than alcohol dependence, is associated with dysregulation of the hypothalamic-pituitary-adrenal axis and the autonomic nervous system
    Lynn Boschloo
    Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    Drug Alcohol Depend 116:170-6. 2011
    ..However, the relative contribution of alcohol use and AD is unclear...
  30. doi request reprint Impulsivity in adult ADHD patients with and without cocaine dependence
    Cleo L Crunelle
    Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Drug Alcohol Depend 129:18-24. 2013
    ..However, very little is known about differences in impulse control and other cognitive functions between ADHD patients with and without SUD...
  31. pmc Approach-bias predicts development of cannabis problem severity in heavy cannabis users: results from a prospective FMRI study
    Janna Cousijn
    Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e42394. 2012
    ..Moreover, the balance between cannabis approach and avoidance responses in the DLPFC and ACC may help identify individuals at-risk for cannabis use disorders and may be new targets for prevention and treatment...
  32. doi request reprint Predictors of the 2-year recurrence and persistence of alcohol dependence
    Lynn Boschloo
    Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    Addiction 107:1639-40. 2012
    ..To identify independent risk factors of the recurrence of alcohol dependence (AD) in people with a remitted disorder at baseline and persistence of AD in people with a current disorder at baseline...
  33. ncbi request reprint Screening for illicit heroin use in patients in a heroin-assisted treatment program
    Elisabeth J Rook
    Slotervaart Hospital, Department of Pharmacy and Pharmacology, Amsterdam, The Netherlands
    J Anal Toxicol 30:390-4. 2006
    ..Illicit heroin use was observed in a limited percentage of patients. Overall agreement between self-report and markers of illicit heroin use was good...
  34. ncbi request reprint Effects of frequent cannabis use on hippocampal activity during an associative memory task
    Gerry Jager
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, A 01 126, University Medical Center, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Eur Neuropsychopharmacol 17:289-97. 2007
    ..Therefore, lower brain activation may not signify neurocognitive impairment, but could be the expression of a non-cognitive variable related to frequent cannabis use, for example changes in cerebral perfusion or differences in vigilance...
  35. ncbi request reprint Origin of the comorbidity of anxiety disorders and alcohol dependence: findings of a general population study
    Loes A Marquenie
    Department of Psychiatry and Institute for Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Eur Addict Res 13:39-49. 2007
    ..The data are inconsistent with regard to comorbidity as a distinct psychopathological entity. These findings are of great importance for treatment planning in patients with alcohol dependence and comorbid anxiety disorders...
  36. ncbi request reprint Anxiety disorders: treatable regardless of the severity of comorbid alcohol dependence
    Annemiek Schadé
    Department of Psychiatry and Institute for Extramural Medicine, VU University Medical Centre, GGZ Buitenamstel, Amsterdam, The Netherlands
    Eur Addict Res 13:109-15. 2007
    ..The purpose of the present study was to find predictors of treatment success for comorbid anxiety disorders in alcohol-dependent patients...
  37. pmc Brain imaging studies in pathological gambling
    Ruth J van Holst
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Curr Psychiatry Rep 12:418-25. 2010
    ..This review concludes with a discussion regarding the challenges and new developments in the field of neurobiological gambling research and comments on their implications for the treatment of PG...
  38. ncbi request reprint Low dopamine transporter occupancy by methylphenidate as a possible reason for reduced treatment effectiveness in ADHD patients with cocaine dependence
    Cleo L Crunelle
    Amsterdam Institute for Addiction Research, Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Collaborative Antwerp Psychiatric Research Institute CAPRI, University of Antwerp, Antwerp, Belgium Electronic address
    Eur Neuropsychopharmacol 23:1714-23. 2013
    ..This trial is registered at the Dutch Trial Register, www.trialregister.nl, under Trial ID number NTR3127. ..
  39. ncbi request reprint A prospective cohort study on sustained effects of low-dose ecstasy use on the brain in new ecstasy users
    Maartje M L de Win
    Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neuropsychopharmacology 32:458-70. 2007
    ..Additional studies are needed to replicate these findings...
  40. doi request reprint Predictive validity of treatment allocation guidelines on drinking outcome in alcohol-dependent patients
    Maarten J M Merkx
    Amsterdam Institute for Addiction Research, Academic Medical Center, University of Amsterdam, The Netherlands
    Addict Behav 38:1691-8. 2013
    ..9% vs. 38.3% success). Based on these results, we suggest ways to improve the algorithm for allocating patients to treatment...
  41. ncbi request reprint Investigating the structure of craving using structural equation modeling in analysis of the obsessive-compulsive drinking scale: a multinational study
    Wencke A J M de Wildt
    Jellinek Addiction Treatment Centre, Amsterdam, The Netherlands
    Alcohol Clin Exp Res 29:509-16. 2005
    ..The Obsessive-Compulsive Drinking Scale (OCDS) seems to measure certain aspects of craving, but its theoretical basis remains unclear. The aim of this study was to investigate the structure of alcohol craving, using OCDS data...
  42. doi request reprint Alcohol use disorders and the course of depressive and anxiety disorders
    Lynn Boschloo
    Department of Psychiatry, VU University Medical Centre, Amsterdam, The Netherlands
    Br J Psychiatry 200:476-84. 2012
    ..Inconsistent findings have been reported on the role of comorbid alcohol use disorders as risk factors for a persistent course of depressive and anxiety disorders...
  43. pmc Response inhibition during cue reactivity in problem gamblers: an fMRI study
    Ruth J van Holst
    Academic Medical Center, Department of Psychiatry, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e30909. 2012
    ..A gambling-related or positive context appears to facilitate response inhibition as indicated by lower brain activity and fewer behavioural errors in PRGs...
  44. ncbi request reprint Predictors of acamprosate efficacy: results from a pooled analysis of seven European trials including 1485 alcohol-dependent patients
    Roel Verheul
    Department of Clinical Psychology, University of Amsterdam, Amsterdam, The Netherlands
    Psychopharmacology (Berl) 178:167-73. 2005
    ..However, acamprosate prevents lapses or relapses only in a minority of patients. An important question, therefore, is whether there is a specific subgroup of patients who respond particularly well to acamprosate...
  45. doi request reprint Similar hyporesponsiveness of the dorsomedial prefrontal cortex in problem gamblers and heavy smokers during an inhibitory control task
    Michiel B de Ruiter
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Drug Alcohol Depend 121:81-9. 2012
    ..Studies in patients with substance use disorders point to hyporesponsiveness of the dorsomedial prefrontal cortex. However, no such data exist on behavioral addictions...
  46. doi request reprint Response perseveration and ventral prefrontal sensitivity to reward and punishment in male problem gamblers and smokers
    Michiel B de Ruiter
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neuropsychopharmacology 34:1027-38. 2009
    ..Response perseveration and ventral prefrontal hyporesponsiveness to monetary loss may be markers for maladaptive behavior seen in chemical and nonchemical addictions...
  47. ncbi request reprint Patterns of acquisitive crime during methadone maintenance treatment among patients eligible for heroin assisted treatment
    Bart P van der Zanden
    Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Room J1B 226, 1105 AZ Amsterdam, The Netherlands
    Drug Alcohol Depend 86:84-90. 2007
    ..To determine the patterns of acquisitive crime during methadone maintenance treatment among chronic, treatment-resistant heroin users eligible for heroin assisted treatment in the Netherlands...
  48. ncbi request reprint Validity of the EQ-5D as a generic health outcome instrument in a heroin-dependent population
    Bart P van der Zanden
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Room J1B 226, 1105 AZ Amsterdam, The Netherlands
    Drug Alcohol Depend 82:111-8. 2006
    ..To evaluate the validity of the EuroQol (EQ-5D) in a population of chronic, treatment-resistant heroin-dependent patients...
  49. ncbi request reprint Psychophysiological determinants and concomitants of deficient decision making in pathological gamblers
    Anna E Goudriaan
    Academic Medical Center, Department of Psychiatry, University of Amsterdam and Amsterdam Institute for Addiction Research, Amsterdam, The Netherlands
    Drug Alcohol Depend 84:231-9. 2006
    ....
  50. ncbi request reprint Validation of [(123)I]beta-CIT SPECT to assess serotonin transporters in vivo in humans: a double-blind, placebo-controlled, crossover study with the selective serotonin reuptake inhibitor citalopram
    Maartje M L de Win
    Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neuropsychopharmacology 30:996-1005. 2005
    ..Although we provide some evidence that [(123)I]beta-CIT SPECT may be used to measure SERTs in SERT-low cortical areas, these measurements must be interpreted with caution...
  51. doi request reprint Long-term neuropsychological effects of ecstasy in middle-aged ecstasy/polydrug users
    Thelma Schilt
    Department of Psychonomics, University of Amsterdam, Roetersstraat 15, 1018 WB Amsterdam, The Netherlands
    Psychopharmacology (Berl) 207:583-91. 2010
    ..Little is known about ecstasy effects later in life, when serotonin levels and cognition decrease as a consequence of normal ageing...
  52. doi request reprint Reduced striatal brain volumes in non-medicated adult ADHD patients with comorbid cocaine dependence
    Guido A van Wingen
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Drug Alcohol Depend 131:198-203. 2013
    ..However, little is known about structural brain abnormalities that may differentiate ADHD patients with and without comorbid SUD...
  53. doi request reprint Neural responses associated with cue-reactivity in frequent cannabis users
    Janna Cousijn
    ADAPT lab, Department of Psychology, University of Amsterdam, Weesperplein 4, Amsterdam, The Netherlands
    Addict Biol 18:570-80. 2013
    ..However, among frequent users, cue-reactivity seems to be primarily associated with problem severity, not with amount of cannabis use. These findings imply neural cue-reactivity as a tool in assessing problem severity of cannabis use...
  54. doi request reprint Effects of modafinil on neural correlates of response inhibition in alcohol-dependent patients
    Lianne Schmaal
    Amsterdam Institute for Addiction Research, Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Biol Psychiatry 73:211-8. 2013
    ..However, very little is known about the underlying neural correlates of improvements in response inhibition following modafinil...
  55. doi request reprint Varenicline increases in vivo striatal dopamine D2/3 receptor binding: an ultra-high-resolution pinhole [123I]IBZM SPECT study in rats
    Cleo L Crunelle
    Department of Psychiatry and Amsterdam Institute for Addiction Research, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Nucl Med Biol 39:640-4. 2012
    ..Small-animal imaging offers the opportunity to perform serial assessments. We evaluated whether high-resolution pinhole single photon emission computed tomography (SPECT) imaging in rats was able to reproduce previous ex vivo findings...
  56. doi request reprint Craving and illicit heroin use among patients in heroin-assisted treatment
    Peter Blanken
    Central Committee on the Treatment of Heroin Addicts CCBH, University Medical Center Utrecht, Utrecht, The Netherlands
    Drug Alcohol Depend 120:74-80. 2012
    ..To investigate in heroin-assisted treatment (HAT) compared to methadone maintenance treatment (MMT): the course of heroin craving and illicit heroin use, their mutual association, and their association with multi-domain treatment response...
  57. doi request reprint Effect of early and late compliance on the effectiveness of acamprosate in the treatment of alcohol dependence
    Maarten W J Koeter
    Department of Psychiatry, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    J Subst Abuse Treat 39:218-26. 2010
    ..The aim of this study is to assess the influence of early and late compliance of acamprosate on attendance and abstinence duration in the treatment of alcohol dependence...
  58. doi request reprint Comorbidity and risk indicators for alcohol use disorders among persons with anxiety and/or depressive disorders: findings from the Netherlands Study of Depression and Anxiety (NESDA)
    Lynn Boschloo
    Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
    J Affect Disord 131:233-42. 2011
    ..This study examines comorbidity of alcohol abuse and alcohol dependence as well as its risk indicators among anxious and/or depressed persons, also considering temporal sequencing of disorders...
  59. ncbi request reprint Trauma, trauma-related distress, and perceived parental dysfunction: associations with severity of drinking problems in treated alcoholics
    Willie Langeland
    Amsterdam Institute for Addiction Research, Amsterdam, The Netherlands
    J Nerv Ment Dis 190:337-40. 2002
  60. ncbi request reprint Trauma, dissociation, and posttraumatic stress disorder in female borderline patients with and without substance abuse problems
    Louisa M C Van Den Bosch
    Academic Medical Centre, University of Amsterdam, The Netherlands
    Aust N Z J Psychiatry 37:549-55. 2003
    ....
  61. ncbi request reprint Neurocognitive functions in pathological gambling: a comparison with alcohol dependence, Tourette syndrome and normal controls
    Anna E Goudriaan
    Amsterdam Institute for Addiction Research and Academic Medical Centre, Department of Psychiatry, University of Amsterdam, Amsterdam, The Netherlands
    Addiction 101:534-47. 2006
    ..To study the specificity of these neurocognitive deficits, a substance dependence group (alcohol dependence) and an impulse control disorder group (Tourette syndrome) were included...
  62. ncbi request reprint Craving and withdrawal as core symptoms of alcohol dependence
    Carla de Bruijn
    St Lucas Andreas Hospital, Department of Psychiatry, Amsterdam, The Netherlands
    J Nerv Ment Dis 192:494-502. 2004
    ..Although the total prevalence of any alcohol use disorder did not differ between DSM-IV and CWM, the distinction between normality and abuse and between abuse and dependence was better for the CWM categories...
  63. doi request reprint A voxel-based morphometry study comparing problem gamblers, alcohol abusers, and healthy controls
    Ruth J van Holst
    Academic Medical Center, Department of Psychiatry, University of Amsterdam, Meibergdreef 5, 1100 DD Amsterdam, The Netherlands
    Drug Alcohol Depend 124:142-8. 2012
    ....
  64. doi request reprint Co-occurrence of obsessive-compulsive disorder and substance use disorder in the general population
    Rianne M Blom
    Department of Psychiatry, Academical Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Addiction 106:2178-85. 2011
    ..The aim of this study is to compare the co-occurrence of OCD with SUD to the co-occurrence of SUD with other psychiatric disorders in a representative community sample...
  65. doi request reprint Outcome of long-term heroin-assisted treatment offered to chronic, treatment-resistant heroin addicts in the Netherlands
    Peter Blanken
    Central Committee on the Treatment of Heroin Addicts, University Medical Centre Utrecht, Stratenum 5th Floor, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Addiction 105:300-8. 2010
    ..To describe 4-year treatment retention and treatment response among chronic, treatment-resistant heroin-dependent patients offered long-term heroin-assisted treatment (HAT) in the Netherlands...
  66. ncbi request reprint Predicting ecstasy use among young people at risk: a prospective study of initially ecstasy-naive subjects
    Hylke K E Vervaeke
    Bonger Institute for Criminology, University of Amsterdam, Amsterdam, The Netherlands
    J Drug Educ 38:131-46. 2008
    ..Our results suggest that targeted prevention activities should focus in particular on young people who have strong intentions to take ecstasy, especially if they are also regular smokers of cannabis...
  67. ncbi request reprint Striatal dopamine D2 receptor binding and dopamine release during cue-elicited craving in recently abstinent opiate-dependent males
    Fleur Zijlstra
    Department of Nuclear Medicine, Academic Medical Centre, Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 18:262-70. 2008
    ..Chronic craving and anhedonia were positively correlated with DA release. Treatment strategies that increase D2Rs may, therefore, be an interesting approach to prevent relapse in opiate addiction...
  68. ncbi request reprint Feasibility and validity of low-budget telephonic follow-up interviews in routine outcome monitoring of substance abuse treatment
    Suzan C C Oudejans
    Amsterdam Institute for Addiction Research, Department of Psychiatry, Academic Medical Center, University of Amsterdam, Meibergdreef 5, Amsterdam 1105 AZ, The Netherlands
    Addiction 104:1138-46. 2009
    ..However, follow-up interviews are time-consuming and costly. This study examines the feasibility and validity of low-budget telephonic follow-up interviews for ROM in a substance abuse treatment centre (SATC)...
  69. doi request reprint Dose-dependent and sustained effects of varenicline on dopamine D2/3 receptor availability in rats
    Cleo L Crunelle
    Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 21:205-10. 2011
    ..These observations suggest that increased DRD2/3 availability may contribute to varenicline's efficacy for smoking cessation and show promise for varenicline as a treatment of other types of drug dependence...
  70. ncbi request reprint Population pharmacokinetics of caffeine and its metabolites theobromine, paraxanthine and theophylline after inhalation in combination with diacetylmorphine
    Anthe S Zandvliet
    Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands
    Basic Clin Pharmacol Toxicol 96:71-9. 2005
    ..Pharmacokinetics of caffeine after inhalation and intravenous administration are to a large extent similar. The bioavailability of inhaled caffeine is approximately 60% in experienced smokers...
  71. ncbi request reprint Decision making in pathological gambling: a comparison between pathological gamblers, alcohol dependents, persons with Tourette syndrome, and normal controls
    Anna E Goudriaan
    Amsterdam Institute for Addiction Research, Academic Medical Centre, University of Amsterdam, The Netherlands
    Brain Res Cogn Brain Res 23:137-51. 2005
    ..Deficits in decision making and feedback processing in PG should be addressed in treatment and incorporated more explicitly in theoretical models of PG...
  72. ncbi request reprint The three year course of alcohol use disorders in the general population: DSM-IV, ICD-10 and the Craving Withdrawal Model
    Carla de Bruijn
    University Medical Centre Untrecht, Department of Psychiatry, Utrecht, The Netherlands
    Addiction 101:385-92. 2006
    ..The latter is an alternative classification, which requires craving and withdrawal for alcohol dependence and raises the alcohol abuse threshold to two criteria...
  73. ncbi request reprint Prediction of relapse to frequent heroin use and the role of methadone prescription: an analysis of the Amsterdam Cohort Study among drug users
    Fabian Termorshuizen
    Municipal Health Service, Amsterdam, Cluster Infectious Diseases, Department of HIV and STI Research, Nieuwe Achtergracht 100, 1018 WT Amsterdam, The Netherlands
    Drug Alcohol Depend 79:231-40. 2005
    ..Other factors, such as no occasional use of heroin during the episode, no use of cocaine, and having a non-using partner, seem to be equally important...
  74. ncbi request reprint Measuring craving: an attempt to connect subjective craving with cue reactivity
    Wendy Ooteman
    Amsterdam Institute for Addiction Research, Amsterdam, The Netherlands
    Alcohol Clin Exp Res 30:57-69. 2006
    ..It is hypothesized that this questionnaire will show higher concordance with measures of cue reactivity than existing self-report craving questionnaires...
  75. ncbi request reprint Memory function and serotonin transporter promoter gene polymorphism in ecstasy (MDMA) users
    Liesbeth Reneman
    Graduate School of Neurosciences, Department of Radiology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Psychopharmacol 20:389-99. 2006
    ..No effect of 5-HTTLPR or gender on memory function or MDMA use was observed...
  76. doi request reprint Guidelines for allocating outpatient alcohol abusers to levels of care: Predictive validity
    Maarten J M Merkx
    Amsterdam Institute for Addiction Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Addict Behav 36:570-5. 2011
    ..The a priori allocation guidelines were followed for only a minority of the patients, and using them did not improve treatment outcome. Further work is needed to improve the content of the treatment allocation guidelines...
  77. ncbi request reprint Allocation of substance use disorder patients to appropriate levels of care: feasibility of matching guidelines in routine practice in Dutch treatment centres
    Maarten J M Merkx
    Amsterdam Institute for Addiction Research, Amsterdam, The Netherlands
    Addiction 102:466-74. 2007
    ..To examine the feasibility of implementing evidence-based guidelines for patient-treatment-matching to levels of care in two Dutch substance abuse treatment centres...
  78. ncbi request reprint The Netherlands XTC Toxicity (NeXT) study: objectives and methods of a study investigating causality, course, and clinical relevance
    Maartje M L de Win
    Department of Radiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Int J Methods Psychiatr Res 14:167-85. 2005
    ..The combined results will lead to conclusions that can be used in prevention messages, clinical decision making, and the development of an (inter)national ecstasy policy...
  79. ncbi request reprint Psychiatric comorbidity in treatment-seeking alcoholics: the role of childhood trauma and perceived parental dysfunction
    Willie Langeland
    Amsterdam Institute for Addiction Research, Department of Psychiatry, Vrije Universiteit, Amsterdam, The Netherlands
    Alcohol Clin Exp Res 28:441-7. 2004
    ....
  80. pmc Decision making as a predictor of first ecstasy use: a prospective study
    Thelma Schilt
    Department of Psychiatry PB 0 429, Amsterdam Institute for Addiction Research Academic Medical Center, University of Amsterdam, PO Box 75867, 1070 AW Amsterdam, The Netherlands
    Psychopharmacology (Berl) 203:519-27. 2009
    ..Few studies investigated predictors for ecstasy use. Self-reported impulsivity does not predict the initiation of ecstasy use; the question is if neuropsychological indicators of impulsivity can predict first ecstasy use...
  81. ncbi request reprint Neuroimaging findings with MDMA/ecstasy: technical aspects, conceptual issues and future prospects
    Liesbeth Reneman
    Graduate School of Neurosciences, Department of Radiology, Academic Medical Centre, University of Amsterdam, The Netherlands
    J Psychopharmacol 20:164-75. 2006
    ..Because most studies have had a retrospective design, in which evidence is indirect and differs in the degree to which any causal links can be implied, longitudinal studies in human ecstasy users are needed to draw definite conclusions...
  82. doi request reprint Measurements in the Addictions for Triage and Evaluation (MATE): an instrument based on the World Health Organization family of international classifications
    Gerard M Schippers
    Amsterdam Institute for Addiction Research, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Addiction 105:862-71. 2010
    ..Conceptually, the MATE was constructed according to the ICD and International Classification of Functioning (ICF) in the World Health Organization (WHO) classification system. Two of the ICF-related modules were newly designed...
  83. ncbi request reprint An increase in overdose mortality during the first 2 weeks after entering or re-entering methadone treatment in Amsterdam
    Marcel C A Buster
    Department of Epidemiology, Documentationa nd Health Promotion, Municipal Health Service, Amsterdam, The Netherlands
    Addiction 97:993-1001. 2002
    ..This study describes the incidence of overdose mortality in relation to time after (re)entering or leaving treatment...
  84. ncbi request reprint Using concept mapping to design an indicator framework for addiction treatment centres
    Udo Nabitz
    Free University of Amsterdam, Amsterdam, The Netherlands
    Int J Qual Health Care 17:193-201. 2005
    ..The objective of this study is to determine an indicator framework for addiction treatment centres based on the demands of stakeholders and in alignment with the European Foundation for Quality Management (EFQM) Excellence Model...
  85. doi request reprint Striatal dopamine transporter availability associated with polymorphisms in the dopamine transporter gene SLC6A3
    Elisabeth M van de Giessen
    Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Nucl Med 50:45-52. 2009
    ..Other polymorphisms in the DAT gene were not extensively studied. Therefore, we investigated whether polymorphisms in both 3' and 5' ends of the DAT gene show association with in vivo striatal DAT expression...
  86. doi request reprint Varenicline increases striatal dopamine D(2/3) receptor binding in rats
    Cleo L Crunelle
    Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Addict Biol 14:500-2. 2009
    ..Varenicline increases dopamine D(2/3) receptor availability in drug-naïve rats. Therefore, varenicline may be an effective treatment for addictions other than smoking...
  87. ncbi request reprint Mood disorders and serotonin transporter density in ecstasy users--the influence of long-term abstention, dose, and gender
    Maartje M L de Win
    Department of Radiology G1 229, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Psychopharmacology (Berl) 173:376-82. 2004
    ..Neurotoxic effects of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") on the serotonin (5-HT) system have been described in animals and humans, but little is known about long-term effects of ecstasy use on mood...
  88. ncbi request reprint Pharmacological treatments for heroin and cocaine addiction
    Wim van den Brink
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Tafelbergweg 25, 1105 BC Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 13:476-87. 2003
    ..To provide an overview of the pharmacological options for the treatment of heroin- and cocaine-dependent patients based on known biochemical pathways to addiction and the chronic disease model as a starting point for treatment planning...
  89. ncbi request reprint Chasing the dragon, related to the impaired lung function among heroin users
    Marcel Buster
    Municipal Health Service, Department of Epidemiology, Documentation and Health Promotion, PO Box 2200, 1000 CE, Amsterdam, The Netherlands
    Drug Alcohol Depend 68:221-8. 2002
    ..To describe the pulmonary function and prevalence of dyspnoea among methadone patients and to study the relation with exposure to heroin by inhaling...
  90. ncbi request reprint The COMT val158met polymorphism and brain morphometry in healthy young adults
    Janneke Zinkstok
    Department of Psychiatry, Academic Medical Center of the University of Amsterdam, The Netherlands
    Neurosci Lett 405:34-9. 2006
    ..These results suggest that the COMT val(158)met polymorphism may affect age-related differences in gray and white matter density in females...
  91. ncbi request reprint Use of amphetamine by recreational users of ecstasy (MDMA) is associated with reduced striatal dopamine transporter densities: a [123I]beta-CIT SPECT study--preliminary report
    Liesbeth Reneman
    Department of Nuclear Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Psychopharmacology (Berl) 159:335-40. 2002
    ..However, little is known about the effects of ecstasy use or the combination of ecstasy and amphetamine use on dopamine (DA) neurones in the human brain...
  92. ncbi request reprint Pathological gambling: a comprehensive review of biobehavioral findings
    Anna E Goudriaan
    Academic Medical Center University of Amsterdam, Amsterdam Institute for Addicition Research, The Netherlands
    Neurosci Biobehav Rev 28:123-41. 2004
    ..A framework for future studies is suggested, indicating the need for studies that integrate knowledge from different research areas, and that employ stricter diagnostic screening methods and inclusion of clinical control groups...
  93. ncbi request reprint Deuterodiacetylmorphine as a marker for use of illicit heroin by addicts in a heroin-assisted treatment program
    Marjolein G Klous
    Slotervaart Hospital, Department of Pharmacy and Pharmacology, Amsterdam, The Netherlands
    J Anal Toxicol 29:564-9. 2005
    ..Addition of stable, isotopically labelled heroin to pharmaceutical, smokable heroin is considered to be a feasible strategy for the detection of co-use of illicit heroin by patients in heroin-assisted treatment...
  94. doi request reprint Screening for substance abuse among adolescents validity of the CAGE-AID in youth mental health care
    Christianne Couwenbergh
    Department of Psychiatry, Radboud University Nijmegen Medical Centre and Karakter University Centre for Child and Adolescent Psychiatry, Nijmegen, The Netherlands
    Subst Use Misuse 44:823-34. 2009
    ..To examine the diagnostic accuracy of the four-item self-report and parent-report versions of the CAGE-AID as a screen for substance-use disorders (SUD) among adolescents in mental health care...
  95. ncbi request reprint Diagnosing dissociative disorders in The Netherlands: a pilot study with the Structured Clinical Interview for DSM-III-R Dissociative Disorders
    S Boon
    Regional Institute for Mental Health RIAGG Zuid Nieuw West, Amsterdam, The Netherlands
    Am J Psychiatry 148:458-62. 1991
    ....
  96. ncbi request reprint Alcohol abuse and dependence criteria as predictors of a chronic course of alcohol use disorders in the general population
    Carla de Bruijn
    University Medical Centre, Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Alcohol Alcohol 40:441-6. 2005
    ..To investigate whether DSM-IV abuse and dependence criteria and the ICD-10 criterion for craving differentially predict a chronic course of alcohol use disorders (AUD) in the general population...
  97. ncbi request reprint Static and dynamic patient characteristics as predictors of criminal recidivism: A prospective study in a Dutch forensic psychiatric sample
    Martien W G Philipse
    Department of Research and Assessment, Pompestichting Institute for Forensic Mental Health, Nij megen, The Netherlands
    Law Hum Behav 30:309-27. 2006
    ..It is concluded that a small set of static predictors yielded a good estimate of future reconvictions; inclusion of dynamic predictors did not add predictive power...
  98. ncbi request reprint Assessment of cognitive brain function in ecstasy users and contributions of other drugs of abuse: results from an FMRI study
    Gerry Jager
    Department of Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    Neuropsychopharmacology 33:247-58. 2008
    ..This could be related to the different neurotransmitter systems these drugs predominantly act upon, that is, serotonin (ecstasy) vs dopamine (amphetamine) systems...
  99. ncbi request reprint Neurophysiological evidence for abnormal cognitive processing of drug cues in heroin dependence
    Ingmar H A Franken
    Institute of Psychology, Erasmus University, Woudestein J5 43, PO Box 1738, 3000 DR, Rotterdam, The Netherlands
    Psychopharmacology (Berl) 170:205-12. 2003
    ..Recent studies provide evidence for specific aspects of cue processing in addictive disorders...
  100. ncbi request reprint Innovations in agonist maintenance treatment of opioid-dependent patients
    Christian Haasen
    Department of Psychiatry, University Medical Center Eppendorf, Center for Interdisciplinary Addiction Research, Hamburg, Germany
    Curr Opin Psychiatry 19:631-6. 2006
    ..To provide an overview of published studies on agonist maintenance treatment options for opioid-dependent patients...
  101. ncbi request reprint Behavioural aspects of impulsivity in alcoholics with and without a cluster-B personality disorder
    Geert Dom
    Psychiatric Centre Alexian Brothers, Provinciesteenweg 408, Boechout, 2530, Belgium
    Alcohol Alcohol 41:412-20. 2006
    ..e. self-reported impulsivity and neuropsychological indicators such as behavioural control and delay of gratification...