W A van Gool

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. pmc Whether, when and how chronic inflammation increases the risk of developing late-onset Alzheimer's disease
    Piet Eikelenboom
    Valeriuskliniek, Valeriusplein 9, 1075 BG Amsterdam, The Netherlands
    Alzheimers Res Ther 4:15. 2012
  2. pmc Neuroinflammation in Alzheimer's disease wanes with age
    Jeroen J M Hoozemans
    Department of Pathology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    J Neuroinflammation 8:171. 2011
  3. pmc Microglia activation in sepsis: a case-control study
    Afina W Lemstra
    Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands
    J Neuroinflammation 4:4. 2007
  4. ncbi request reprint [Memantine for the treatment of dementia]
    W A van Gool
    Academisch Medisch Centrum, afd Neurologie, Postbus 22 700, 1100 DE Amsterdam
    Ned Tijdschr Geneeskd 147:2101-2. 2003
  5. ncbi request reprint Anti-inflammatory therapy in Alzheimer's disease: is hope still alive?
    W A van Gool
    Dept of Neurology, H2 222 2, Academic Medical Center, P O Box 22700, 1100 DE, Amsterdam, The Netherlands
    J Neurol 250:788-92. 2003
  6. ncbi request reprint Effect of hydroxychloroquine on progression of dementia in early Alzheimer's disease: an 18-month randomised, double-blind, placebo-controlled study
    W A van Gool
    Department of Neurology, Academic Medical Centre, PO Box 22700, 1100 DE, Amsterdam, Netherlands
    Lancet 358:455-60. 2001
  7. ncbi request reprint The two faces of Alzheimer's disease
    W A van Gool
    Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands
    J Neurol 247:500-5. 2000
  8. ncbi request reprint [The practice guideline 'Dementia' (second revision) from the Dutch College of General Practitioners; a response from the perspective of neurology]
    W A van Gool
    Academisch Medisch Centrum, afd Neurologie, Postbus 22 700, 1100 DE Amsterdam
    Ned Tijdschr Geneeskd 148:1179-81. 2004
  9. doi request reprint Systemic infection and delirium: when cytokines and acetylcholine collide
    Willem A van Gool
    Department of Neurology, Academic Medical Center, Amsterdam, Netherlands
    Lancet 375:773-5. 2010
  10. ncbi request reprint Multiple-level studies are needed to assess the true value of diagnostic tests for dementia
    Willem A van Gool
    Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands
    Arch Neurol 63:142-3. 2006

Collaborators

Detail Information

Publications56

  1. pmc Whether, when and how chronic inflammation increases the risk of developing late-onset Alzheimer's disease
    Piet Eikelenboom
    Valeriuskliniek, Valeriusplein 9, 1075 BG Amsterdam, The Netherlands
    Alzheimers Res Ther 4:15. 2012
    ..The view that peripheral inflammation can increase the risk of dementia in older people provides scope for prevention...
  2. pmc Neuroinflammation in Alzheimer's disease wanes with age
    Jeroen J M Hoozemans
    Department of Pathology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    J Neuroinflammation 8:171. 2011
    ..However, the age-dependent relationship between inflammation and clinical phenotype of AD has never been investigated...
  3. pmc Microglia activation in sepsis: a case-control study
    Afina W Lemstra
    Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands
    J Neuroinflammation 4:4. 2007
    ..The aim of this study was to investigate whether activation of microglia can be detected in patients who died of sepsis...
  4. ncbi request reprint [Memantine for the treatment of dementia]
    W A van Gool
    Academisch Medisch Centrum, afd Neurologie, Postbus 22 700, 1100 DE Amsterdam
    Ned Tijdschr Geneeskd 147:2101-2. 2003
    ..This should be avoided. Patients can expect to gain more benefit from ongoing, thorough and independent investigations than from hastily established emergency funds to finance the use of a drug with a limited and poorly defined efficacy...
  5. ncbi request reprint Anti-inflammatory therapy in Alzheimer's disease: is hope still alive?
    W A van Gool
    Dept of Neurology, H2 222 2, Academic Medical Center, P O Box 22700, 1100 DE, Amsterdam, The Netherlands
    J Neurol 250:788-92. 2003
    ..We conclude that studies on primary prevention of AD are the logical next step in testing the inflammatory hypothesis of AD...
  6. ncbi request reprint Effect of hydroxychloroquine on progression of dementia in early Alzheimer's disease: an 18-month randomised, double-blind, placebo-controlled study
    W A van Gool
    Department of Neurology, Academic Medical Centre, PO Box 22700, 1100 DE, Amsterdam, Netherlands
    Lancet 358:455-60. 2001
    ..We aimed to establish the effect of the anti-inflammatory drug hydroxychloroquine on the progression of dementia...
  7. ncbi request reprint The two faces of Alzheimer's disease
    W A van Gool
    Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands
    J Neurol 247:500-5. 2000
    ..It may provide a more realistic perspective, and it holds promise for new opportunities for prevention and treatment...
  8. ncbi request reprint [The practice guideline 'Dementia' (second revision) from the Dutch College of General Practitioners; a response from the perspective of neurology]
    W A van Gool
    Academisch Medisch Centrum, afd Neurologie, Postbus 22 700, 1100 DE Amsterdam
    Ned Tijdschr Geneeskd 148:1179-81. 2004
    ..The fact that the cognitive examination is treated as part of the history taking will, most probably, negatively affect the quality of the diagnostic evaluation...
  9. doi request reprint Systemic infection and delirium: when cytokines and acetylcholine collide
    Willem A van Gool
    Department of Neurology, Academic Medical Center, Amsterdam, Netherlands
    Lancet 375:773-5. 2010
    ..Agents that either restore cholinergic control of microglia or directly inhibit neuroinflammation warrant testing in clinical trials...
  10. ncbi request reprint Multiple-level studies are needed to assess the true value of diagnostic tests for dementia
    Willem A van Gool
    Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands
    Arch Neurol 63:142-3. 2006
  11. pmc Can we prevent, delay, or shorten the course of dementia?
    Willem A van Gool
    Department of Neurology, Academic Medical Centre, Amsterdam, Netherlands
    PLoS Med 3:e430. 2006
  12. doi request reprint Symptoms of apathy are associated with progression from mild cognitive impairment to Alzheimer's disease in non-depressed subjects
    E Richard
    Department of Neurology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 33:204-9. 2012
    ..Apathy may be associated with an increased risk of cognitive decline. The objective of this study was to investigate if apathy predicts the progression from MCI to Alzheimer's disease (AD)...
  13. ncbi request reprint 14-3-3 testing in diagnosing Creutzfeldt-Jakob disease: a prospective study in 112 patients
    A W Lemstra
    Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands
    Neurology 55:514-6. 2000
    ..To study the sensitivity and specificity of 14-3-3 testing in a prospective series of patients suspected of having Creutzfeldt-Jakob disease (CJD)...
  14. ncbi request reprint The early involvement of the innate immunity in the pathogenesis of late-onset Alzheimer's disease: neuropathological, epidemiological and genetic evidence
    P Eikelenboom
    Department of Neurology, Academic Medical Center, University of Amsterdam, Valeriusplein 9, 1075 BG, The Netherlands
    Curr Alzheimer Res 8:142-50. 2011
    ....
  15. ncbi request reprint Quantitative spectral electroencephalography in predicting survival in patients with early Alzheimer disease
    J J Claus
    Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands
    Arch Neurol 55:1105-11. 1998
    ..To determine whether measures of quantitative spectral electroencephalography (EEG) can predict survival in patients with early Alzheimer disease...
  16. ncbi request reprint Slowing on quantitative spectral EEG is a marker for rate of subsequent cognitive and functional decline in early Alzheimer disease
    J J Claus
    Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands
    Alzheimer Dis Assoc Disord 12:167-74. 1998
    ..The results suggest that slowing on qEEG is a marker for subsequent rate of cognitive and functional decline in mildly demented AD patients, independent of demographic or disease characteristics...
  17. ncbi request reprint Emerging treatments in dementia
    P Scheltens
    Department of Neurology, Academisch Ziekenhuis VU, Amsterdam, The Netherlands
    Eur Neurol 38:184-9. 1997
    ..The question of heterogeneity may be solved when different therapeutic strategies are found for different subtypes. The focus of future plans should be on preventive strategies combined with an early diagnosis...
  18. doi request reprint Meta-analysis of CSF and MRI biomarkers for detecting preclinical Alzheimer's disease
    B Schmand
    Department of Neurology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Psychol Med 40:135-45. 2010
    ..We evaluated the claim that these biomarkers can detect preclinical AD before behavioural (i.e. memory) symptoms arise...
  19. ncbi request reprint Neuroinflammation in Alzheimer's disease and prion disease
    P Eikelenboom
    Department of Psychiatry, Graduate School of Neurosciences, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Glia 40:232-9. 2002
    ....
  20. ncbi request reprint The significance of neuroinflammation in understanding Alzheimer's disease
    P Eikelenboom
    Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Neural Transm 113:1685-95. 2006
    ..We also discuss the possibilities of inflammation-based therapeutic strategies in AD...
  21. ncbi request reprint Vascular risk factors and dementia--towards prevention strategies
    E Richard
    Department of Neurology, Academic Medical Centre, University of Amsterdam, The Netherlands
    Neth J Med 68:284-90. 2010
    ..Major challenges for future studies are to select the optimal population, set the optimal treatment targets and select clinically relevant outcome parameters...
  22. doi request reprint Dyshoric capillary cerebral amyloid angiopathy mimicking Creutzfeldt-Jakob disease
    L S M Eurelings
    Academic Medical Center, University of Amsterdam, Dept of Neurology, H2 225, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    J Neurol Sci 295:131-4. 2010
    ..Cerebral amyloid angiopathy (CAA) is a common finding in Alzheimer's disease, and in rare cases this is particularly capillary CAA with dyshoric changes...
  23. ncbi request reprint [Cholinergic deficiency syndrome as an indicator for the cholinesterase inhibitors]
    A W Lemstra
    Academisch Medisch Centrum Universiteit van Amsterdam, afd Neurologie, Postbus 22 660, 1100 DD Amsterdam
    Ned Tijdschr Geneeskd 147:2201-3. 2003
    ..Symptoms resulting from cholinergic deficiency might be a much better target for treatment than cognitive deficits...
  24. doi request reprint Three sides of the same coin: measuring global cognitive impairment with the MMSE, ADAS-cog and CAMCOG
    Hans Wouters
    Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, The Netherlands
    Int J Geriatr Psychiatry 25:770-9. 2010
    ..This hampers comparisons when either of these instruments is used. The extent to which these instruments share a common dimension of global cognitive impairment and how their scores relate was examined...
  25. ncbi request reprint Vascular Care in Patients With Alzheimer Disease With Cerebrovascular Lesions Slows Progression of White Matter Lesions on MRI: The Evaluation of Vascular Care in Alzheimer's Disease (EVA) Study
    Edo Richard
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, Postbus 22660, 1100 DD, The Netherlands
    Stroke 41:554-6. 2010
    ..Treatment aimed at vascular risk factors in patients with early Alzheimer disease may be beneficial, possibly in an even earlier stage of the disease...
  26. doi request reprint Prevention of dementia by intensive vascular care (PreDIVA): a cluster-randomized trial in progress
    Edo Richard
    Department of Neurology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Alzheimer Dis Assoc Disord 23:198-204. 2009
    ..Here, we report the outline of a pragmatic study that will attempt to answer this question and we describe the prevalence of cardiovascular risk factors in the target population...
  27. doi request reprint Characteristics of dyshoric capillary cerebral amyloid angiopathy
    Edo Richard
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Neuropathol Exp Neurol 69:1158-67. 2010
    ..These results suggest that capCAA is pathologically and possibly pathogenetically distinct from larger vessel CAA, and that it is associated with a high APOE-ε4 allele frequency...
  28. doi request reprint Adaptive cognitive testing in cerebrovascular disease and vascular dementia
    Hans Wouters
    Department of Clinical Epidemiology, Biostatistics and Bioinformatics, University of Amsterdam, NL 1100 DD Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 28:486-92. 2009
    ..Longer tests (e.g. the CAMCOG) are precise but inefficient, whereas brief tests (e.g. the MMSE) are efficient but imprecise...
  29. doi request reprint Adaptive cognitive testing in dementia
    Hans Wouters
    Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Centre, Amsterdam, The Netherlands
    Int J Methods Psychiatr Res 18:118-27. 2009
    ..91) as the original CAMCOG. These results were replicated in an independent sample (n = 170). We conclude that tailored testing with CAT enables much more efficient screening for dementia than testing with an extensive instrument...
  30. doi request reprint Neuroinflammation in plaque and vascular beta-amyloid disorders: clinical and therapeutic implications
    Piet Eikelenboom
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neurodegener Dis 5:190-3. 2008
    ..The cerebral beta-amyloid (Abeta) disorders show a great variability in the distribution of parenchymal and vascular amyloid deposits...
  31. doi request reprint Revising the ADAS-cog for a more accurate assessment of cognitive impairment
    Hans Wouters
    Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, The Netherlands
    Alzheimer Dis Assoc Disord 22:236-44. 2008
    ..This assumes items to have (1) equal measurement precision and (2) hierarchically ordered categories...
  32. ncbi request reprint Cholinesterase inhibitors in dementia: yes, no, or maybe?
    Afina W Lemstra
    Academic Medical Centre, Department of Neurology, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    Age Ageing 36:625-7. 2007
  33. pmc Treatment of cardiovascular risk factors to prevent cognitive decline and dementia: a systematic review
    Suzanne A Ligthart
    Department of General Practice, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Vasc Health Risk Manag 6:775-85. 2010
    ..So far, few randomized controlled trials have focused on lowering the vascular risk profile to prevent or postpone cognitive decline or dementia...
  34. ncbi request reprint The cholinergic deficiency syndrome and its therapeutic implications
    Afina W Lemstra
    Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands
    Gerontology 49:55-60. 2003
    ..CDS is suggested to occur in various neurodegenerative diseases like Alzheimer's disease, Lewy body dementia and Parkinson's disease and to respond well to cholinesterase inhibitor therapy...
  35. ncbi request reprint The neuroinflammatory response in plaques and amyloid angiopathy in Alzheimer's disease: therapeutic implications
    Annemieke J M Rozemuller
    Dept Neuropathology, Academic Medical Center, 1100 DE Amsterdam, The Netherlands
    Curr Drug Targets CNS Neurol Disord 4:223-33. 2005
    ..The implications of the reviewed studies for an inflammation-based therapeutical approach in AD will be discussed...
  36. ncbi request reprint Methodological issues in a cluster-randomized trial to prevent dementia by intensive vascular care
    E Richard
    Academic Medical Center, University of Amsterdam, Department of Neurology, Amsterdam, The Netherlands
    J Nutr Health Aging 14:315-7. 2010
    ..Description of methodological issues in a trial designed to evaluate if a multi-component intervention aimed at vascular risk factors can prevent dementia...
  37. ncbi request reprint Neuroinflammatory perspectives on the two faces of Alzheimer's disease
    P Eikelenboom
    Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Neural Transm 111:281-94. 2004
    ..Here we review the evidence that inflammation related events could be a critical etiological factor in certain forms of the sporadic AD...
  38. ncbi request reprint [Clinical algorithm for cerebrospinal fluid test of 14-3-3 protein in diagnosis of Creutzfeldt-Jacob disease]
    A W Lemstra
    afd Neurologie, Academisch Medisch Centrum, Postbus 22700, 1100 DE Amsterdam
    Ned Tijdschr Geneeskd 145:1467-71. 2001
    ..To study whether an algorithm that includes additional diagnostic information could increase the specificity of the 14-3-3 protein testing in patients suspected to suffer from Creutzfeldt-Jakob disease (CJD)...
  39. ncbi request reprint The diagnostic value of electroencephalography in mild senile Alzheimer's disease
    J J Claus
    Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands
    Clin Neurophysiol 110:825-32. 1999
    ..We investigated the diagnostic value of the visually assessed electroencephalogram (EEG) in patients with mild Alzheimer's disease (AD), using the grand total of EEG (GTE) score...
  40. ncbi request reprint Identification of responders to rivastigmine: a prospective cohort study
    Afina W Lemstra
    Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 25:60-6. 2008
    ..This study aimed to describe a clinical profile based on a combination of specific neuropsychological test scores and clinical symptoms associated with a favourable response to rivastigmine...
  41. doi request reprint Pre-operative inflammatory markers and the risk of postoperative delirium in elderly patients
    Afina W Lemstra
    Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands
    Int J Geriatr Psychiatry 23:943-8. 2008
    ..In light of the ageing/inflammation theory, we investigated the association of these markers with delirium in not acutely ill, elderly patients...
  42. ncbi request reprint Vascular care in patients with Alzheimer's disease with cerebrovascular lesions-a randomized clinical trial
    Edo Richard
    Academic Medical Centre, University of Amsterdam, Postbus 22660, Amsterdam 1100DD, The Netherlands
    J Am Geriatr Soc 57:797-805. 2009
    ..To investigate whether vascular care slows dementia progression in patients with Alzheimer's disease with cerebrovascular lesions on neuroimaging...
  43. ncbi request reprint [Novel therapeutic approach to amyloidosis: no implications as yet for patients with Alzheimer's disease]
    A W Lemstra
    Academisch Medisch Centrum Universiteit van Amsterdam, afd Neurologie, Postbus 22 700, 1100 DE Amsterdam
    Ned Tijdschr Geneeskd 146:1720-3. 2002
    ..This offers opportunities for treating amyloidosis and possibly other protein folding diseases. Understanding the mechanism of this unique disease process and the different elements involved is necessary for future drug development...
  44. ncbi request reprint [Rivastigmine for Alzheimer disease; evaluation of preliminary results and of structured assessment of efficacy]
    E Richard
    afd Neurologie, Academisch Medisch Centrum, Meibergdreef 9, 1105 AZ Amsterdam
    Ned Tijdschr Geneeskd 146:24-7. 2002
    ..Evaluation of the initial experiences with rivastigmine in Alzheimer's disease...
  45. ncbi request reprint The age gap between patients in clinical studies and in the general population: a pitfall for dementia research
    Niels Schoenmaker
    Department of Neurology, Academic Medical Centre, Amsterdam, Netherlands
    Lancet Neurol 3:627-30. 2004
    ..Research on dementia has a lot to gain from the study of patients that more appropriately reflect the population at risk...
  46. pmc Transient Parkinsonism in isolated extrapontine myelinolysis
    Bart Post
    Department of Neurology and Clinical Neurophysiology, Academic Medical Center, Amsterdam, The Netherlands
    Neurol Sci 30:325-8. 2009
    ..During a 4-year follow-up, both the clinical features of Parkinsonism and the changes on magnetic resonance imaging resolved. Parkinsonism due to EPM should be recognized as it has a good prognosis...
  47. ncbi request reprint The association of neuroleptic sensitivity in Lewy body disease with a false positive clinical diagnosis of Creutzfeldt-Jakob disease
    A W Lemstra
    Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands
    Int J Geriatr Psychiatry 21:1031-5. 2006
    ..Dementia with Lewy bodies (DLB) and Creutzfeldt-Jakob disease (CJD) share clinical features like cognitive decline, motor disturbances en psychiatric symptoms. Overlapping symptoms may cause physicians to mistake DLB for CJD...
  48. doi request reprint Neuroinflammation - an early event in both the history and pathogenesis of Alzheimer's disease
    Piet Eikelenboom
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neurodegener Dis 7:38-41. 2010
    ..Objectives: To show that the interest in inflammation in Alzheimer's disease (AD) is not only an early event in the history of AD but that inflammation is also an early event in the pathogenesis of AD...
  49. doi request reprint Hyperhomocysteinemia and Alzheimer's disease: A systematic review
    Floris van Dam
    Jellinek Mentrum City Center Psychiatric Outpatient Clinic, Roetersstraat 210, 1018 WE, Amsterdam, The Netherlands
    Arch Gerontol Geriatr 48:425-30. 2009
    ..Prospective studies on the relation between folate, vitamins B(6) and B(12) levels and the risk of developing AD are warranted, preferably in the form of RCTs...
  50. doi request reprint Aspirin in Alzheimer's disease: increased risk of intracerebral hemorrhage: cause for concern?
    Hanneke Thoonsen
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Stroke 41:2690-2. 2010
    ..Here, we evaluate the literature on the risk of ICH as a complication in patients with AD treated with aspirin...
  51. ncbi request reprint A deletion in DJ-1 and the risk of dementia--a population-based survey
    Alejandro Arias Vasquez
    Genetic Epidemiology Unit, Department of Epidemiology and Biostatistics, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Neurosci Lett 372:196-9. 2004
    ..All subjects were heterozygous for the deletion and related to a common ancestor within eight generations. Our results suggest it is unlikely that haploinsufficiency in the DJ-1 gene imparts an increased risk for dementia...
  52. ncbi request reprint Cholinesterase inhibitors for Alzheimer disease
    Willem A van Gool
    JAMA 289:2359; author reply 2360-1. 2003
  53. ncbi request reprint Early symptoms in the prodromal phase of delirium: a prospective cohort study in elderly patients undergoing hip surgery
    Jos F M de Jonghe
    Department of Clinical Psychology, Medical Center Alkmaar, Alkmaar, The Netherlands
    Am J Geriatr Psychiatry 15:112-21. 2007
    ..The authors investigated prodromal delirium symptoms in elderly patients undergoing hip surgery...
  54. doi request reprint Long-term cognitive outcome of delirium in elderly hip surgery patients. A prospective matched controlled study over two and a half years
    Martin G Kat
    Department of Geriatric Medicine, Medical Center Alkmaar, Alkmaar, The Netherlands
    Dement Geriatr Cogn Disord 26:1-8. 2008
    ..To study the outcome of delirium in elderly hip surgery patients...
  55. ncbi request reprint Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study
    Kees J Kalisvaart
    Department of Geriatric Medicine, Medical Center Alkmaar, Alkmaar, The Netherlands
    J Am Geriatr Soc 53:1658-66. 2005
    ..To study the effectiveness of haloperidol prophylaxis on incidence, severity, and duration of postoperative delirium in elderly hip-surgery patients at risk for delirium...
  56. ncbi request reprint Risk factors and prediction of postoperative delirium in elderly hip-surgery patients: implementation and validation of a medical risk factor model
    Kees J Kalisvaart
    Department of Geriatric Medicine, Medical Center Alkmaar, 1800 AM Alkmaar, The Netherlands
    J Am Geriatr Soc 54:817-22. 2006
    ..To evaluate risk factors for postoperative delirium in a cohort of elderly hip-surgery patients and to validate a medical risk stratification model...