Tom van der Poll

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. pmc Inflammasome activation mediates inflammation and outcome in humans and mice with pneumococcal meningitis
    Madelijn Geldhoff
    Department of Neurology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    BMC Infect Dis 13:358. 2013
  2. pmc The role of TLR2 in the host response to pneumococcal pneumonia in absence of the spleen
    Adriana J J Lammers
    Center of Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    BMC Infect Dis 12:139. 2012
  3. doi request reprint Preclinical sepsis models
    Tom van der Poll
    Center of Infection and Immunity Amsterdam, Center of Experimental and Molecular Medicine, and Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Surg Infect (Larchmt) 13:287-92. 2012
  4. ncbi request reprint Crosstalk between inflammation and coagulation: the lessons of sepsis
    Tom van der Poll
    Center of Experimental and Molecular Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Curr Vasc Pharmacol 10:632-8. 2012
  5. pmc Characterization of a pneumococcal meningitis mouse model
    Barry Mook-Kanamori
    Department of Neurology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center, Amsterdam, The Netherlands
    BMC Infect Dis 12:71. 2012
  6. pmc Inhalation of beta 2 agonists impairs the clearance of nontypable Haemophilus influenzae from the murine respiratory tract
    Nico A Maris
    Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Respir Res 7:57. 2006
  7. pmc Activation of factor VII-activating protease in human inflammation: a sensor for cell death
    Femke Stephan
    Department of Immunopathology, Sanquin Research at CLB and Landsteiner Laboratory of AMC, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
    Crit Care 15:R110. 2011
  8. pmc Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit
    Cornelis P C de Jager
    Department of Emergency Medicine and Intensive Care, Jeroen Bosch Ziekenhuis, Tolbrugstraat 11, 5200 ME s Hertogenbosch, The Netherlands
    Crit Care 14:R192. 2010
  9. pmc Bench-to-bedside review: bacterial pneumonia with influenza - pathogenesis and clinical implications
    Koenraad F Van Der Sluijs
    Departments of Pulmonology and Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
    Crit Care 14:219. 2010
  10. pmc Impact of the factor V Leiden mutation on the outcome of pneumococcal pneumonia: a controlled laboratory study
    Marcel Schouten
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Room G2 130, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Crit Care 14:R145. 2010

Detail Information

Publications172 found, 100 shown here

  1. pmc Inflammasome activation mediates inflammation and outcome in humans and mice with pneumococcal meningitis
    Madelijn Geldhoff
    Department of Neurology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    BMC Infect Dis 13:358. 2013
    ..In a murine model of pneumococcal meningitis we examined the pathophysiological roles of two inflammasome proteins, NLRP3 (Nod-like receptor protein-3) and adaptor protein ASC (apoptosis-associated speck-like protein)...
  2. pmc The role of TLR2 in the host response to pneumococcal pneumonia in absence of the spleen
    Adriana J J Lammers
    Center of Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    BMC Infect Dis 12:139. 2012
    ....
  3. doi request reprint Preclinical sepsis models
    Tom van der Poll
    Center of Infection and Immunity Amsterdam, Center of Experimental and Molecular Medicine, and Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Surg Infect (Larchmt) 13:287-92. 2012
    ..The lack of therapeutic efficacy of numerous compounds in clinical sepsis trials, despite glorious results in animal models of sepsis, has raised doubt and debate about the usefulness of such models...
  4. ncbi request reprint Crosstalk between inflammation and coagulation: the lessons of sepsis
    Tom van der Poll
    Center of Experimental and Molecular Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Curr Vasc Pharmacol 10:632-8. 2012
    ..These protective APC effects do not rely on the anticoagulant properties of this protein. APC mutants that lack anticoagulant properties but retain the capacity to activate PAR1 are promising new drugs for sepsis treatment...
  5. pmc Characterization of a pneumococcal meningitis mouse model
    Barry Mook-Kanamori
    Department of Neurology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center, Amsterdam, The Netherlands
    BMC Infect Dis 12:71. 2012
    ..S. pneumoniae is the most common causative agent of meningitis, and is associated with high morbidity and mortality. We aimed to develop an integrated and representative pneumococcal meningitis mouse model resembling the human situation...
  6. pmc Inhalation of beta 2 agonists impairs the clearance of nontypable Haemophilus influenzae from the murine respiratory tract
    Nico A Maris
    Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Respir Res 7:57. 2006
    ..The aim of this study was to determine the effect of inhalation of beta2 agonists on the host immune response to respiratory tract infection with NTHi...
  7. pmc Activation of factor VII-activating protease in human inflammation: a sensor for cell death
    Femke Stephan
    Department of Immunopathology, Sanquin Research at CLB and Landsteiner Laboratory of AMC, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
    Crit Care 15:R110. 2011
    ..The aim of this study was to investigate FSAP activation in patients suffering from various inflammatory diseases of increasing severity...
  8. pmc Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit
    Cornelis P C de Jager
    Department of Emergency Medicine and Intensive Care, Jeroen Bosch Ziekenhuis, Tolbrugstraat 11, 5200 ME s Hertogenbosch, The Netherlands
    Crit Care 14:R192. 2010
    ..Likewise, the neutrophil-lymphocyte count ratio (NLCR) has been shown a simple promising method to evaluate systemic inflammation in critically ill patients...
  9. pmc Bench-to-bedside review: bacterial pneumonia with influenza - pathogenesis and clinical implications
    Koenraad F Van Der Sluijs
    Departments of Pulmonology and Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
    Crit Care 14:219. 2010
    ....
  10. pmc Impact of the factor V Leiden mutation on the outcome of pneumococcal pneumonia: a controlled laboratory study
    Marcel Schouten
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Room G2 130, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Crit Care 14:R145. 2010
    ..We here determined the effect of the FVL mutation on coagulation, inflammation, bacterial outgrowth and outcome in murine pneumococcal pneumonia...
  11. pmc Activated protein C ameliorates coagulopathy but does not influence outcome in lethal H1N1 influenza: a controlled laboratory study
    Marcel Schouten
    Center for Experimental and Molecular Medicine CEMM, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2 130, Amsterdam, The Netherlands
    Crit Care 14:R65. 2010
    ..We determined the impact of lethal influenza A (H1N1) infection on systemic and pulmonary coagulation and inflammation, and the effect of recombinant mouse (rm-) APC here on...
  12. pmc Diabetes and sepsis outcomes--it is not all bad news
    Sachin Yende
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Crit Care 13:117. 2009
    ..Their main conclusion was that diabetes patients, relative to non-diabetics, were less likely to develop respiratory failure and more likely to develop renal failure during the course of sepsis...
  13. pmc Nebulized antithrombin limits bacterial outgrowth and lung injury in Streptococcus pneumoniae pneumonia in rats
    Jorrit J Hofstra
    Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands
    Crit Care 13:R145. 2009
    ..We evaluated the effect of nebulized anticoagulants on pulmonary coagulopathy and inflammation in a rat model of Streptococcus pneumoniae pneumonia...
  14. pmc Enterococcal surface protein Esp is not essential for cell adhesion and intestinal colonization of Enterococcus faecium in mice
    Esther Heikens
    Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands
    BMC Microbiol 9:19. 2009
    ..faecium strains. To investigate whether Esp facilitates bacterial adherence and intestinal colonization of E. faecium, we used human colorectal adenocarcinoma cells (Caco-2 cells) and an experimental colonization model in mice...
  15. pmc Tissue factor as an initiator of coagulation and inflammation in the lung
    Tom van der Poll
    Academic Medical Center, University of Amsterdam, Center for Infection and Immunity Amsterdam and Center of Experimental and Molecular Medicine, 1105 AZ Amsterdam, The Netherlands
    Crit Care 12:S3. 2008
    ..This review presents the most recent data on the crosstalk between TF-mediated coagulation and inflammation, with a specific emphasis on these processes in the lung...
  16. doi request reprint Stimulation of acetylcholine receptors impairs host defence during pneumococcal pneumonia
    I A J Giebelen
    Academic Medical Center, Meibergdreef 9, Room G2 130, 1105 AZ Amsterdam, The Netherlands
    Eur Respir J 33:375-81. 2009
    ..pneumoniae did not reveal an anti-inflammatory effect of nicotine either. The present data suggest that nicotine transiently impairs host defence in pneumococcal pneumonia...
  17. ncbi request reprint Immunotherapy of sepsis
    T van der Poll
    Department of Infectious Diseases, Tropical Medicine, and AIDS, Academic Medical Centre, University of Amsterdam, Netherlands
    Lancet Infect Dis 1:165-74. 2001
    ..As a result of these studies our knowledge of the pathogenesis of sepsis has increased considerably. This review focuses on immunomodulatory strategies that have reached the phase of clinical evaluation in patients with sepsis...
  18. doi request reprint Regulation of pro-and anti-inflammatory host responses
    Tom van der Poll
    Academic Medical Center, University of Amsterdam, Center for Experimental and Molecular Medicine and Center for Infection and Immunity Amsterdam, Amsterdam, The Netherlands
    Contrib Microbiol 17:125-36. 2011
    ..This chapter discusses key components of the pro- and anti-inflammatory response to sepsis and the regulation thereof...
  19. doi request reprint The effect of inflammation on coagulation and vice versa
    Tom van der Poll
    Center of Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Curr Opin Infect Dis 24:273-8. 2011
    ..This review summarizes recently acquired knowledge on the bimodal interactions between coagulation and inflammation in infection...
  20. doi request reprint Pathogenesis, treatment, and prevention of pneumococcal pneumonia
    Tom van der Poll
    Centre for Infection and Immunity Amsterdam, Centre for Experimental and Molecular Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Lancet 374:1543-56. 2009
    ....
  21. pmc Activated protein C inhibits local coagulation after intrapulmonary delivery of endotoxin in humans
    Tom van der Poll
    Department of Medicine, Academic Medical Center, Room G2 130, Meibergdreef 9, 1105AZ Amsterdam, Netherlands
    Am J Respir Crit Care Med 171:1125-8. 2005
    ..Activated protein C (APC) has systemic anticoagulant effects in patients with sepsis...
  22. ncbi request reprint Regulatory role of cytokines in disseminated intravascular coagulation
    T van der Poll
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Semin Thromb Hemost 27:639-51. 2001
    ..Cytokines have been implicated as important mediators in these hemostatic alterations. This article summarizes recent insights into which cytokines are likely to be involved in the procoagulant response to systemic infection...
  23. ncbi request reprint Coagulation and inflammation
    T van der Poll
    Laboratory of Experimental Internal Medicine, and Department of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Endotoxin Res 7:301-4. 2001
    ..Furthermore, evidence is discussed that mediators traditionally involved in the regulation of the hemostatic balance may also influence other inflammatory pathways...
  24. ncbi request reprint Host-pathogen interactions in sepsis
    Tom van der Poll
    Academic Medical Centre, University of Amsterdam, Centre for Infection and Immunity Amsterdam, Netherlands
    Lancet Infect Dis 8:32-43. 2008
    ..This Review summarises current knowledge of microbial pathogenesis and host-pathogen interactions during sepsis and the ensuing development of potential therapeutics...
  25. ncbi request reprint Endogenous tissue-type plasminogen activator is protective during Escherichia coli-induced abdominal sepsis in mice
    Rosemarijn Renckens
    Center of Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Immunol 177:1189-96. 2006
    ..coli peritonitis. These findings identify a novel protective function of tPA in abdominal sepsis caused by E. coli that seems independent of its role in the generation of plasmin...
  26. ncbi request reprint Salmeterol enhances pulmonary fibrinolysis in healthy volunteers
    Nico A Maris
    Center for Experimental and Molecular Medicine Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Crit Care Med 35:57-63. 2007
    ..Although salmeterol, a beta2-adrenoceptor agonist with profound bronchodilatory properties, has been studied extensively, the effects of this compound on the pulmonary hemostatic balance are not elucidated...
  27. ncbi request reprint Involvement of the platelet-activating factor receptor in host defense against Streptococcus pneumoniae during postinfluenza pneumonia
    Koenraad F Van Der Sluijs
    Laboratory of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 290:L194-9. 2006
    ..These data indicate that the pneumococcus uses the PAFR leading to severe pneumonia in a host previously exposed to influenza A...
  28. pmc The urokinase receptor (uPAR) facilitates clearance of Borrelia burgdorferi
    Joppe W R Hovius
    Center for Experimental and Molecular Medicine CEMM, Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands
    PLoS Pathog 5:e1000447. 2009
    ..In conclusion, in B. burgdorferi infection, uPAR is required for phagocytosis and adequate eradication of the spirochete from the heart by a mechanism that is independent of binding of uPAR to uPA or its role in the fibrinolytic system...
  29. ncbi request reprint Mice lacking SIGNR1 have stronger T helper 1 responses to Mycobacterium tuberculosis
    Catharina W Wieland
    Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, The Netherlands
    Microbes Infect 9:134-41. 2007
    ..Therefore, our data suggest that although SIGNR1 has a similar binding specificity as DC-SIGN, its role is limited during murine M. tuberculosis infection...
  30. ncbi request reprint Lipopolysaccharide binding protein-deficient mice have a normal defense against pulmonary mycobacterial infection
    Judith Branger
    Department of Experimental Internal Medicine, Academic Medical Center, Room F4 222, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Clin Immunol 116:174-81. 2005
    ..The clearance of pulmonary infection with the non-pathogenic M. smegmatis was also unaltered in LBP-/- mice. These data suggest that LBP does not contribute to an effective host response in M. tuberculosis infection...
  31. ncbi request reprint Lipoteichoic acid-induced lung inflammation depends on TLR2 and the concerted action of TLR4 and the platelet-activating factor receptor
    Sylvia Knapp
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 180:3478-84. 2008
    ....
  32. pmc Endogenous interleukin-18 improves the early antimicrobial host response in severe melioidosis
    W Joost Wiersinga
    Academic Medical Center, Meibergdreef 9, Room G2 132, 1105 AZ Amsterdam, The Netherlands
    Infect Immun 75:3739-46. 2007
    ..Together, these data indicate that the enhanced production of IL-18 in melioidosis is an essential part of a protective immune response to this severe infection...
  33. doi request reprint Urokinase receptor is necessary for bacterial defense against pneumonia-derived septic melioidosis by facilitating phagocytosis
    W Joost Wiersinga
    Center for Infection and Immunity Amsterdam, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 184:3079-86. 2010
    ..pseudomallei by facilitating the migration of neutrophils toward the primary site of infection and subsequently facilitating the phagocytosis of B. pseudomallei...
  34. ncbi request reprint Activation of neutrophils and inhibition of the proinflammatory cytokine response by endogenous granulocyte colony-stimulating factor in murine pneumococcal pneumonia
    Sylvia Knapp
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Infect Dis 189:1506-15. 2004
    ..During pneumococcal pneumonia, G-CSF is produced locally at the site of the infection, where it exerts both pro- and anti-inflammatory effects...
  35. ncbi request reprint Activation of coagulation and inhibition of fibrinolysis in the lung after inhalation of lipopolysaccharide by healthy volunteers
    Nico A Maris
    Department of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Thromb Haemost 93:1036-40. 2005
    ..Inhalation of LPS by healthy humans reproduces major features of the procoagulant response to inflammatory and infectious lung diseases and may be used as a novel model to evaluate pathogenetic mechanisms and new interventions...
  36. doi request reprint Priming of alveolar macrophages upon instillation of lipopolysaccharide in the human lung
    Jacobien J Hoogerwerf
    Academic Medical Center, Center for Experimental and Molecular Medicine, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Am J Respir Cell Mol Biol 42:349-56. 2010
    ..The current data demonstrate that LPS instillation in the human lung primes alveolar macrophages for further stimulation with either LPS or LTA, possibly by sustained p38 mitogen-activated protein kinase activation...
  37. ncbi request reprint Recombinant human activated protein C inhibits local and systemic activation of coagulation without influencing inflammation during Pseudomonas aeruginosa pneumonia in rats
    Goda Choi
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Crit Care Med 35:1362-8. 2007
    ..We investigated the role of the protein C system in pneumonia caused by Pseudomonas aeruginosa, the organism that is predominantly involved in ventilator-associated pneumonia...
  38. ncbi request reprint Local activation of the tissue factor-factor VIIa pathway in patients with pneumonia and the effect of inhibition of this pathway in murine pneumococcal pneumonia
    Anita W Rijneveld
    Center of Infection and Immunity Amsterdam, Laboratory of Experimental Internal Medicine, Department of Pulmonology, University of Amsterdam, The Netherlands
    Crit Care Med 34:1725-30. 2006
    ..The objective of this study was to determine the role of TF-FVIIa in pneumonia caused by Streptococcus pneumoniae, the most important causative organism in community-acquired pneumonia and a major cause of sepsis...
  39. doi request reprint Role of toll-like receptors 2 and 4, and the receptor for advanced glycation end products in high-mobility group box 1-induced inflammation in vivo
    Marieke A D van Zoelen
    Center for Infection and Immunity Amsterdam and daggerCenter for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Shock 31:280-4. 2009
    ..These data indicate that HMGB-1 induces release of cytokines, activation of coagulation, and neutrophil recruitment in vivo via a mechanism that at least in part depends on TLR-4 and RAGE...
  40. pmc Interleukin-18 facilitates the early antimicrobial host response to Escherichia coli peritonitis
    Sebastiaan Weijer
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room L0185, 1105 AZ Amsterdam, The Netherlands
    Infect Immun 71:5488-97. 2003
    ..These data suggest that endogenous IL-18 plays an important role in the early antibacterial host response during E. coli-induced peritonitis...
  41. pmc Toll-like receptor 2 impairs host defense in gram-negative sepsis caused by Burkholderia pseudomallei (Melioidosis)
    W Joost Wiersinga
    Center for Infection and Immunity Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    PLoS Med 4:e248. 2007
    ..Melioidosis is a severe infection caused by the gram-negative bacterium, Burkholderia pseudomallei, that is endemic in Southeast Asia. We aimed to characterize the expression and function of TLRs in septic melioidosis...
  42. ncbi request reprint IL-10 is an important mediator of the enhanced susceptibility to pneumococcal pneumonia after influenza infection
    Koenraad F Van Der Sluijs
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Immunol 172:7603-9. 2004
    ..This increased susceptibility to secondary bacterial pneumonia is at least in part caused by excessive IL-10 production and reduced neutrophil function in the lungs...
  43. pmc The role of Toll-like receptor 2 in inflammation and fibrosis during progressive renal injury
    Jaklien C Leemans
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 4:e5704. 2009
    ..Together, these data demonstrate that TLR2 can initiate renal inflammation during progressive renal injury and that the absence of TLR2 does not affect the development of chronic renal injury and fibrosis...
  44. pmc Interleukin-1 receptor-associated kinase M-deficient mice demonstrate an improved host defense during Gram-negative pneumonia
    Jacobien J Hoogerwerf
    Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Mol Med 18:1067-75. 2012
    ..These data indicate that IRAK-M impairs host defense during pneumonia caused by a common gram-negative respiratory pathogen...
  45. doi request reprint CD14 impairs host defense against gram-negative sepsis caused by Burkholderia pseudomallei in mice
    W Joost Wiersinga
    Centers for Infection and Immunity Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    J Infect Dis 198:1388-97. 2008
    ..We have recently shown that during melioidosis, a severe infection caused by the gram-negative bacterium Burkholderia pseudomallei, TLR2 but not TLR4 impacts the immune response of the intact host in vivo...
  46. doi request reprint Receptor for advanced glycation end products is detrimental during influenza A virus pneumonia
    Marieke A D van Zoelen
    Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Virology 391:265-73. 2009
    ..These data suggest that RAGE is detrimental during IAV pneumonia...
  47. doi request reprint Impact of endogenous protein C on pulmonary coagulation and injury during lethal H1N1 influenza in mice
    Marcel Schouten
    Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2 130, 1105 AZ Amsterdam, The Netherlands
    Am J Respir Cell Mol Biol 45:789-94. 2011
    ....
  48. ncbi request reprint The acute-phase response and serum amyloid A inhibit the inflammatory response to Acinetobacter baumannii Pneumonia
    Rosemarijn Renckens
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Infect Dis 193:187-95. 2006
    ..Acinetobacter baumannii is an emerging pathogen in nosocomial pneumonia. Trauma and postsurgical patients display a profound acute-phase protein response and are susceptible to pneumonia...
  49. ncbi request reprint LPS-binding protein-deficient mice have an impaired defense against Gram-negative but not Gram-positive pneumonia
    Judith Branger
    Department of Experimental Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Int Immunol 16:1605-11. 2004
    ..These data suggest that LBP is important for a protective immune response in Klebsiella pneumonia, but does not contribute to an effective host response in pneumococcal pneumonia...
  50. ncbi request reprint Thrombomodulin mutant mice with a strongly reduced capacity to generate activated protein C have an unaltered pulmonary immune response to respiratory pathogens and lipopolysaccharide
    Anita W Rijneveld
    Academic Medical Center, University of Amsterdam, The Netherlands
    Blood 103:1702-9. 2004
    ..These data suggest that the capacity of TM to generate APC does not play a role of importance in the pulmonary response to respiratory pathogens or LPS...
  51. ncbi request reprint Influenza-induced expression of indoleamine 2,3-dioxygenase enhances interleukin-10 production and bacterial outgrowth during secondary pneumococcal pneumonia
    Koenraad F Van Der Sluijs
    Department of Pulmonology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Infect Dis 193:214-22. 2006
    ....
  52. doi request reprint Ligands of the receptor for advanced glycation end products, including high-mobility group box 1, limit bacterial dissemination during Escherichia coli peritonitis
    Marieke A D van Zoelen
    Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Crit Care Med 38:1414-22. 2010
    ..High-mobility group box 1 is a high-affinity binding ligand for the receptor for advanced glycation end products with cytokine activities and plays a role in sepsis...
  53. ncbi request reprint C1 inhibitor treatment improves host defense in pneumococcal meningitis in rats and mice
    Petra J G Zwijnenburg
    Department of Pediatrics, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Infect Dis 196:115-23. 2007
    ..C1-inh treatment increased bacterial clearance, possibly through an up-regulation of CR3. Hence, C1-inh may be a useful agent in the treatment of pneumococcal meningitis...
  54. doi request reprint Endogenous MCP-1 promotes lung inflammation induced by LPS and LTA
    Marieke A D van Zoelen
    Center for Infection and Immunity Amsterdam, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Mol Immunol 48:1468-76. 2011
    ..These data suggest that MCP-1 is a proinflammatory mediator during pulmonary inflammation induced by either LPS or LTA...
  55. doi request reprint Plasminogen activator inhibitor-1 regulates neutrophil influx during acute pyelonephritis
    Joris J T H Roelofs
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Kidney Int 75:52-9. 2009
    ..Our study shows that PAI-1 is critically involved in host defense against E. coli-induced acute pyelonephritis, in part, by modulating neutrophil influx...
  56. ncbi request reprint Platelet-activating factor receptor-deficient mice show an unaltered clearance of nontypeable Haemophilus influenzae from their respiratory tract
    Judith Branger
    Department of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Shock 22:543-7. 2004
    ..These data indicate that the PAFR does not interfere with the clearance of NTHi from the respiratory tract...
  57. ncbi request reprint Matrix metalloproteinase-9 deficiency impairs host defense against abdominal sepsis
    Rosemarijn Renckens
    Laboratory of Experimental Internal Medicine, Academic Medical Center Rm G2 132, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Immunol 176:3735-41. 2006
    ..Moreover, MMP-9(-/-) mice developed more severe distant organ damage during infection. These data suggest that MMP-9 is an essential component of an effective host response to E. coli peritonitis...
  58. pmc Neutrophils are essential for rapid clearance of Enterococcus faecium in mice
    Masja Leendertse
    Center for Infection and Immunity Amsterdam, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
    Infect Immun 77:485-91. 2009
    ..In conclusion, attraction of neutrophils to the primary site of E. faecium infection is important for a rapid clearance of this bacterium, thereby attenuating a systemic inflammatory response...
  59. doi request reprint Receptor for advanced glycation end products facilitates host defense during Escherichia coli-induced abdominal sepsis in mice
    Marieke A D van Zoelen
    Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Infect Dis 200:765-73. 2009
    ..The receptor for advanced glycation end products (RAGE) mediates a variety of inflammatory responses...
  60. doi request reprint Differential dose-dependent effects of prednisolone on shedding of endothelial adhesion molecules during human endotoxemia
    Lucienne C Lemaire
    Center for Experimental and Molecular Medicine, Academic Medical Center, Room G2 132, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Immunol Lett 121:93-6. 2008
    ..Levels of sICAM-1 were not affected by prednisolone. Together, the data suggest that prednisolone differentially and dose-dependently influences the release of soluble endothelial adhesion molecules during human endotoxemia...
  61. ncbi request reprint Inhibition of coagulation, fibrinolysis, and endothelial cell activation by a p38 mitogen-activated protein kinase inhibitor during human endotoxemia
    Judith Branger
    Department of Infectious Disease, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Blood 101:4446-8. 2003
    ..Activation of p38 MAPK plays an important role in the procoagulant and endothelial cell response after in vivo exposure to LPS...
  62. doi request reprint Nebulized anticoagulants limit pulmonary coagulopathy, but not inflammation, in a model of experimental lung injury
    Jorrit J Hofstra
    Laboratory of Experimental Intensive Care and Anesthesiology LEICA, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Aerosol Med Pulm Drug Deliv 23:105-11. 2010
    ..Pulmonary coagulopathy may contribute to an adverse outcome in lung injury. We assessed the effects of local anticoagulant therapy on bronchoalveolar and systemic haemostasis in a rat model of endotoxemia-induced lung injury...
  63. ncbi request reprint A thrombomodulin mutation that impairs activated protein C generation results in uncontrolled lung inflammation during murine tuberculosis
    Sebastiaan Weijer
    Academic Medical Center Amsterdam, Laboratory of Experimental Internal Medicine, Room G2 130, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Blood 106:2761-8. 2005
    ..These data suggest that a TM mutation that impairs APC generation results in uncontrolled lung inflammation during tuberculosis...
  64. ncbi request reprint The MyD88-dependent, but not the MyD88-independent, pathway of TLR4 signaling is important in clearing nontypeable haemophilus influenzae from the mouse lung
    Catharina W Wieland
    Laboratory of Experimental Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 175:6042-9. 2005
    ..These data suggest that the MyD88-dependent pathway of TLR4 is important for an effective innate immune response to respiratory tract infection caused by NTHi...
  65. ncbi request reprint Absence of thrombin-activatable fibrinolysis inhibitor protects against sepsis-induced liver injury in mice
    Rosemarijn Renckens
    Laboratory of Experimental Internal Medicine, Amsterdam, The Netherlands
    J Immunol 175:6764-71. 2005
    ..These data argue against an important part for TAFI in the regulation of the procoagulant-fibrinolytic balance in sepsis and reveals a thus far unknown role of TAFI in the occurrence of hepatic necrosis...
  66. ncbi request reprint Expression profile and function of triggering receptor expressed on myeloid cells-1 during melioidosis
    W Joost Wiersinga
    Center for Infection and Immunity Amsterdam, Amsterdam, 1105 AZ, The Netherlands
    J Infect Dis 196:1707-16. 2007
    ..We aimed to characterize TREM-1 expression and function during sepsis caused by Burkholderia pseudomallei (melioidosis)...
  67. ncbi request reprint Antithrombin inhibits bronchoalveolar activation of coagulation and limits lung injury during Streptococcus pneumoniae pneumonia in rats
    Goda Choi
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Crit Care Med 36:204-10. 2008
    ..We investigated the role of these natural anticoagulants in Streptococcus pneumoniae pneumonia...
  68. pmc Mice overexpressing p40 in lungs have reduced leucocyte influx and slightly impaired resistance during tuberculosis
    Jaklien C Leemans
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Immunology 117:409-18. 2006
    ..This suggests a novel antagonistic role for p40 homodimers in regulating the chemotactic bioactivity of IL-12 after pulmonary mycobacterial infection...
  69. doi request reprint Lung inflammation induced by lipoteichoic acid or lipopolysaccharide in humans
    Jacobien J Hoogerwerf
    Center for Infection and Immunity Amsterdam, University of Amsterdam, Amsterdam, The Netherlands
    Am J Respir Crit Care Med 178:34-41. 2008
    ..Recognition of pathogen-associated molecular patterns by Toll-like receptors (TLRs) is considered to be important for an appropriate immune response against pathogens that enter the lower airways...
  70. doi request reprint Endogenous beta-adrenergic receptors inhibit lipopolysaccharide-induced pulmonary cytokine release and coagulation
    Ida A J Giebelen
    Center for Infection and Immunity Amsterdam CINIMA, University of Amsterdam, Amsterdam, The Netherlands
    Am J Respir Cell Mol Biol 39:373-9. 2008
    ..This study suggests that beta-adrenergic receptors, which are widely expressed in the lungs, serve as negative regulators of pulmonary cytokine release and coagulation induced by LPS and less so during LTA-induced pulmonary inflammation...
  71. ncbi request reprint Toll-like receptor 4 plays a protective role in pulmonary tuberculosis in mice
    Judith Branger
    Department of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Int Immunol 16:509-16. 2004
    ..These data suggest that TLR4 plays a protective role in host defense against lung infection by M. tuberculosis...
  72. ncbi request reprint IL-1 receptor type 1 gene-deficient mice demonstrate an impaired host defense against pneumococcal meningitis
    Petra J G Zwijnenburg
    Department of Pediatrics, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Immunol 170:4724-30. 2003
    ..The mortality was significantly higher and earlier in the course of the disease in IL-1R(-/-) mice. These results demonstrate that endogenous IL-1 is required for an adequate host defense in pneumococcal meningitis...
  73. ncbi request reprint Local stimulation of alpha7 cholinergic receptors inhibits LPS-induced TNF-alpha release in the mouse lung
    Ida A J Giebelen
    Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Shock 28:700-3. 2007
    ..These data indicate that local administration of GTS-21 inhibits TNF-alpha release in the lung during LPS-induced inflammation...
  74. pmc Toll-like receptor-4 coordinates the innate immune response of the kidney to renal ischemia/reperfusion injury
    Wilco P Pulskens
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 3:e3596. 2008
    ..In conclusion, we identified TLR4 as a cellular sentinel for acute renal damage that subsequently controls the induction of an innate immune response...
  75. pmc The acute-phase response impairs host defence against Enterococcus faecium peritonitis
    Masja Leendertse
    Centre for Infection and Immunity Amsterdam CINIMA, Amsterdam, The Netherlands
    Immunology 128:e335-42. 2009
    ..These data indicate that the acute-phase response impairs host defence against E. faecium, suggesting that this condition may contribute to the increased vulnerability of critically ill patients to enterococcal infections...
  76. doi request reprint Deficiency of alpha7 cholinergic receptors facilitates bacterial clearance in Escherichia coli peritonitis
    Ilona A J Giebelen
    Center for Infection and Immunity Amsterdam, University of Amsterdam, Amsterdam, The Netherlands
    J Infect Dis 198:750-7. 2008
    ..The efferent vagus nerve can inhibit inflammation via interaction between acetylcholine and alpha7 cholinergic receptors...
  77. ncbi request reprint Urothelial CD44 facilitates Escherichia coli infection of the murine urinary tract
    Kasper M A Rouschop
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 177:7225-32. 2006
    ..The results provide evidence that CD44 on urothelial cells facilitates E. coli UTI. Disruption of the interaction between CD44 and HA in the bladder may provide a new approach to prevent and to treat UTI...
  78. ncbi request reprint CD4+ cells play a limited role in murine lung infection with Mycobacterium kansasii
    Catharina W Wieland
    Laboratory of Experimental Internal Medicine, G2 132, Academic Medical Center, University of Amsterdam, The Netherlands
    Am J Respir Cell Mol Biol 34:167-73. 2006
    ..kansasii. These data suggest that CD4+ cells, IFN-gamma, and an intact T helper cell type 1 response play a limited role in protective immunity against pulmonary M. kansasii infection...
  79. pmc Hyperglycemia enhances coagulation and reduces neutrophil degranulation, whereas hyperinsulinemia inhibits fibrinolysis during human endotoxemia
    Michiel E Stegenga
    Center for Infection and Immunity Amsterdam, Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Blood 112:82-9. 2008
    ..These data suggest that type 2 diabetes patients may be especially vulnerable to prothrombotic events during inflammatory states...
  80. ncbi request reprint Prednisolone dose-dependently influences inflammation and coagulation during human endotoxemia
    Martijn D de Kruif
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 178:1845-51. 2007
    ..These data indicate that prednisolone dose-dependently and differentially influences the systemic activation of different host response pathways during human endotoxemia...
  81. ncbi request reprint Inhibition of the tissue factor/factor VIIa pathway does not influence the inflammatory or antibacterial response to abdominal sepsis induced by Escherichia coli in mice
    Sebastian Weijer
    Laboratory of Experimental Internal Medicine and Department of Infectious Diseases, Tropical Medicine, and AIDS, University of Amsterdam, The Netherlands
    J Infect Dis 189:2308-17. 2004
    ..Inhibition of the tissue factor (TF)/factor (F) VIIa pathway has been shown to attenuate the activation of coagulation and to prevent death in a primate model of sepsis caused by gram-negative bacteria...
  82. ncbi request reprint Natural anticoagulants limit lipopolysaccharide-induced pulmonary coagulation but not inflammation
    G Choi
    Department of Intensive Care Medicine, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Eur Respir J 30:423-8. 2007
    ..Natural inhibitors of coagulation prevent bronchoalveolar activation of coagulation, but do not induce major alterations of the pulmonary inflammatory response in rat endotoxaemia...
  83. pmc Elimination of interleukin 6 attenuates coagulation activation in experimental endotoxemia in chimpanzees
    T van der Poll
    Center for Hemostasis, Thrombosis, Atherosclerosis and Inflammation Research, University of Amsterdam, The Netherlands
    J Exp Med 179:1253-9. 1994
    ..IL-6 is, however, an important intermediate factor in activation of coagulation in low grade endotoxemia in chimpanzees...
  84. ncbi request reprint Effect of interleukin 10 on the release of the CXC chemokines growth related oncogene GRO-alpha and epithelial cell-derived neutrophil activating peptide (ENA)-78 during human endotoxemia
    D P Olszyna
    Department of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Room G2-132, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Immunol Lett 78:41-4. 2001
    ..In vitro, IL-10 dose-dependently attenuated LPS-induced release of both GRO-alpha and ENA-78 in whole blood and in cultures of isolated polymorphonuclear and mononuclear cells...
  85. ncbi request reprint Impairment of host defence by exotoxin A in Pseudomonas aeruginosa pneumonia in mice
    M J Schultz
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    J Med Microbiol 50:822-7. 2001
    ..These data suggest that P-ExA impairs host defence during pneumonia caused by P. aeruginosa by a mechanism that does not involve effects on neutrophil influx, cytokines, chemokines or NO formation...
  86. ncbi request reprint Platelet-activating factor antagonist TCV-309 attenuates the induction of the cytokine network in experimental endotoxemia in chimpanzees
    B Kuipers
    Center of Hemostasis, Thrombosis, Atherosclerosis and Inflammation Research, University of Amsterdam, The Netherlands
    J Immunol 152:2438-46. 1994
    ..PAF does not seem to be an important intermediate factor in endotoxin-induced neutrophilia or neutrophil degranulation...
  87. ncbi request reprint Vagus nerve stimulation inhibits activation of coagulation and fibrinolysis during endotoxemia in rats
    D J van Westerloo
    Center for Infection and Immunity Amsterdam, CINIMA, Amsterdam, The Netherlands
    J Thromb Haemost 4:1997-2002. 2006
    ..Electrical vagus nerve stimulation (VNS) has been found to inhibit tumor necrosis factor (TNF)-alpha release during endotoxemia in rodents...
  88. ncbi request reprint Intravenous infusion of erythromycin inhibits CXC chemokine production, but augments neutrophil degranulation in whole blood stimulated with Streptococcus pneumoniae
    M J Schultz
    Laboratory of Experimental Internal Medicine, Department of Intensive Care, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Antimicrob Chemother 46:235-40. 2000
    ..05). These results indicate the ability of erythromycin to reduce CXC chemokine production and to enhance neutrophil degranulation in human blood...
  89. pmc Upregulation of monocyte urokinase plasminogen activator receptor during human endotoxemia
    P E Dekkers
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands NL
    Infect Immun 68:2156-60. 2000
    ..These data suggest that infectious stimuli may influence monocyte function in vivo by enhancing the expression of uPAR...
  90. pmc Levels of inhibitors of tumor necrosis factor alpha and interleukin 1beta in urine and sera of patients with urosepsis
    D P Olszyna
    Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, University of Amsterdam, Amsterdam, The Netherlands
    Infect Immun 66:3527-34. 1998
    ..These findings indicate that during urosepsis, the antiinflammatory cytokine response is generated predominantly at the systemic level...
  91. ncbi request reprint Interleukin 10 inhibits the release of CC chemokines during human endotoxemia
    D P Olszyna
    Department of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Infect Dis 181:613-20. 2000
    ....
  92. pmc Induction of cell-associated chemokines after endotoxin administration to healthy humans
    D P Olszyna
    Department of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Infect Immun 69:2736-8. 2001
    ..IL-8 was also recovered from mononuclear and polymorphonuclear cells. Cell-associated chemokines may more accurately reflect their production than plasma concentrations...
  93. ncbi request reprint IL-10-deficient mice demonstrate multiple organ failure and increased mortality during Escherichia coli peritonitis despite an accelerated bacterial clearance
    M E Sewnath
    Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 166:6323-31. 2001
    ..coli peritonitis, it protects mice from lethality by attenuating the development of a systemic inflammatory response syndrome by a mechanism that involves inhibition of TNF release...
  94. pmc Concurrent upregulation of urokinase plasminogen activator receptor and CD11b during tuberculosis and experimental endotoxemia
    N P Juffermans
    Laboratory of Experimental Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Infect Immun 69:5182-5. 2001
    ..In healthy volunteers, LPS induced increases in monocyte and granulocyte uPAR and CD11b...
  95. ncbi request reprint Rationale for restoration of physiological anticoagulant pathways in patients with sepsis and disseminated intravascular coagulation
    M Levi
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Crit Care Med 29:S90-4. 2001
    ....
  96. ncbi request reprint Interleukin 10 release during endotoxaemia in chimpanzees: role of platelet-activating factor and interleukin 6
    T van der Poll
    Department of Internal Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Scand J Immunol 43:122-5. 1996
    ..IL-10 release elicited by injection of endotoxin is not mediated by PAF or IL6...
  97. ncbi request reprint Inhibition of the release of soluble tumor necrosis factor receptors in experimental endotoxemia by an anti-tumor necrosis factor-alpha antibody
    J Jansen
    Center for Hemostasis, Thrombosis, Atherosclerosis and Inflammation Research, University of Amsterdam, The Netherlands
    J Clin Immunol 15:45-50. 1995
    ..Our results indicate that tumor necrosis factor-alpha is a prime mediator of endotoxin-induced release of its own soluble receptors...
  98. ncbi request reprint Disturbed alveolar fibrin turnover during pneumonia is restricted to the site of infection
    G Choi
    Dept of Intensive Care Medicine, Academic Medical Centre, University of Amsterdam, C3 423, Meibergdreef 9, 1108 AZ, Amsterdam, The Netherlands
    Eur Respir J 24:786-9. 2004
    ..Furthermore, in infected lungs, fibrinolysis was depressed, with high levels of plasminogen activator inhibitor type 1. In conclusion, ventilator-associated pneumonia is characterised by a hypercoagulant state at the site of infection...
  99. pmc Thalidomide inhibits granulocyte responses in healthy humans after ex vivo stimulation with bacterial antigens
    N P Juffermans
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Antimicrob Agents Chemother 45:1547-9. 2001
    ..A single oral dose of thalidomide attenuates neutrophil activation upon ex vivo stimulation with bacterial antigens...
  100. ncbi request reprint Chemotactic activity of CXC chemokines interleukin-8, growth-related oncogene-alpha, and epithelial cell-derived neutrophil-activating protein-78 in urine of patients with urosepsis
    D P Olszyna
    Academic Medical Center, Dept of Experimental Internal Medicine, 1105 AZ Amsterdam, The Netherlands
    J Infect Dis 182:1731-7. 2000
    ..During urosepsis, CXC chemokines are predominantly produced within the urinary tract, where they are involved in the recruitment of neutrophils to the urinary compartment...
  101. ncbi request reprint Soluble tumor necrosis factor receptors as surrogate markers for the assessment of zidovudine treatment in asymptomatic HIV-1 infection
    M H Godfried
    Department of Internal Medicine, University of Amsterdam, The Netherlands
    J Acquir Immune Defic Syndr Hum Retrovirol 10:531-9. 1995
    ..Thus, in contrast to CD4+ counts and neopterin levels, sTNFR concentrations, especially those of the type II STNFR, appear to be valuable surrogate markers for monitoring the efficacy of ZDV treatment in asymptomatic HIV-1 infection...