S J van Deventer

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi The future of inflammatory bowel disease therapy
    S J H van Deventer
    Department of Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands
    Inflamm Bowel Dis 8:301-5; discussion 306. 2002
  2. ncbi A place for TACE
    S J H van Deventer
    Department of Gastroenterology, Academic Medical Centre, Amsterdam, The Netherlands
    Gut 51:5-6. 2002
  3. ncbi [Activated protein C, coagulation, inflammation, and treatment of severe sepsis]
    S J van Deventer
    afd Maag, Darm en Leverziekten, Academisch Medisch Centrum, Postbus 22 660, 1100 DD Amsterdam
    Ned Tijdschr Geneeskd 145:613-6. 2001
  4. ncbi Cytokine and cytokine receptor polymorphisms in infectious disease
    S J van Deventer
    Laboratory for Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Intensive Care Med 26:S98-102. 2000
  5. ncbi A phase II dose ranging, double-blind, placebo-controlled study of alicaforsen enema in subjects with acute exacerbation of mild to moderate left-sided ulcerative colitis
    S J H van Deventer
    Academisch Medisch Centrum, Poli Inglammatoire Darmzietkten, Meibergdreef, Amsterdam Ziodoost, The Netherlands
    Aliment Pharmacol Ther 23:1415-25. 2006
  6. ncbi Anti-tumour necrosis factor therapy in Crohn's disease: where are we now?
    S J H van Deventer
    Department of Experimental Medicine, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Gut 51:362-3. 2002
  7. ncbi A randomised, controlled, double blind, escalating dose study of alicaforsen enema in active ulcerative colitis
    S J H van Deventer
    Academisch Medisch Centrum, Room G2, 129, Poli Inglammatoire Darmzietkten, Meibergdreef 9, NL 1105 AZ, Amsterdam Ziodoost, The Netherlands
    Gut 53:1646-51. 2004
  8. ncbi p38 mitogen-activated protein kinase inhibition increases cytokine release by macrophages in vitro and during infection in vivo
    B van den Blink
    Department of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Immunol 166:582-7. 2001
  9. ncbi Reduced ex vivo chemokine production by polymorphonuclear cells after in vivo exposure of normal humans to endotoxin
    M J Schultz
    Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Infect Dis 182:1264-7. 2000
  10. ncbi Interleukin-12 induces sustained activation of multiple host inflammatory mediator systems in chimpanzees
    F N Lauw
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Infect Dis 179:646-52. 1999

Detail Information

Publications90

  1. ncbi The future of inflammatory bowel disease therapy
    S J H van Deventer
    Department of Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands
    Inflamm Bowel Dis 8:301-5; discussion 306. 2002
  2. ncbi A place for TACE
    S J H van Deventer
    Department of Gastroenterology, Academic Medical Centre, Amsterdam, The Netherlands
    Gut 51:5-6. 2002
  3. ncbi [Activated protein C, coagulation, inflammation, and treatment of severe sepsis]
    S J van Deventer
    afd Maag, Darm en Leverziekten, Academisch Medisch Centrum, Postbus 22 660, 1100 DD Amsterdam
    Ned Tijdschr Geneeskd 145:613-6. 2001
    ..In addition to these effects on thrombin formation, activated protein C directly reduces pro-inflammatory responses by as yet unknown mechanisms...
  4. ncbi Cytokine and cytokine receptor polymorphisms in infectious disease
    S J van Deventer
    Laboratory for Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Intensive Care Med 26:S98-102. 2000
    ..In contrast, mutations in the IL-12 and IFNgamma receptor (and possibly the endotoxin receptor) genes are associated with recurrent bacterial infections, whereas TNFR1 mutations cause fever of unknown origin...
  5. ncbi A phase II dose ranging, double-blind, placebo-controlled study of alicaforsen enema in subjects with acute exacerbation of mild to moderate left-sided ulcerative colitis
    S J H van Deventer
    Academisch Medisch Centrum, Poli Inglammatoire Darmzietkten, Meibergdreef, Amsterdam Ziodoost, The Netherlands
    Aliment Pharmacol Ther 23:1415-25. 2006
    ..Alicaforsen is an antisense oligonucleotide designed to inhibit expression of human intercellular adhesion molecule 1. Previous clinical studies have demonstrated activity of alicaforsen enema in ulcerative colitis and pouchitis...
  6. ncbi Anti-tumour necrosis factor therapy in Crohn's disease: where are we now?
    S J H van Deventer
    Department of Experimental Medicine, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Gut 51:362-3. 2002
  7. ncbi A randomised, controlled, double blind, escalating dose study of alicaforsen enema in active ulcerative colitis
    S J H van Deventer
    Academisch Medisch Centrum, Room G2, 129, Poli Inglammatoire Darmzietkten, Meibergdreef 9, NL 1105 AZ, Amsterdam Ziodoost, The Netherlands
    Gut 53:1646-51. 2004
    ..To evaluate the safety and efficacy of an enema formulation of alicaforsen, an antisense inhibitor of intercellular adhesion molecule, after 1, 3, and 6 months...
  8. ncbi p38 mitogen-activated protein kinase inhibition increases cytokine release by macrophages in vitro and during infection in vivo
    B van den Blink
    Department of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Immunol 166:582-7. 2001
    ....
  9. ncbi Reduced ex vivo chemokine production by polymorphonuclear cells after in vivo exposure of normal humans to endotoxin
    M J Schultz
    Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Infect Dis 182:1264-7. 2000
    ..Thus, intravenous injection of LPS induces a refractory state of PMNL that is not caused by soluble factors produced in response to in vivo exposure to LPS...
  10. ncbi Interleukin-12 induces sustained activation of multiple host inflammatory mediator systems in chimpanzees
    F N Lauw
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Infect Dis 179:646-52. 1999
    ..These data may contribute to understanding the role of IL-12 in the pathogenesis of sepsis syndrome and the toxicity found after repeated injections of IL-12...
  11. ncbi The effect of pseudomonas exotoxin A on cytokine production in whole blood exposed to Pseudomonas aeruginosa
    M J Schultz
    Department of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, The Netherlands
    FEMS Immunol Med Microbiol 29:227-32. 2000
    ..The effect of P-ExA on cytokine production may offer a disadvantage to the host with respect to clearance of the infection...
  12. ncbi The effect of a metalloproteinase inhibitor (GI5402) on tumor necrosis factor-alpha (TNF-alpha) and TNF-alpha receptors during human endotoxemia
    P E Dekkers
    Academic Medical Center, University of Amsterdam, Laboratory of Experimental Internal Medicine, Amsterdam, The Netherlands
    Blood 94:2252-8. 1999
    ..Furthermore, unlike in vitro, no evidence has been found in vivo with MP inhibition for a potential proinflammatory effect due to increases in membrane-bound TNF-alpha and TNF-alpha receptor number...
  13. ncbi Proinflammatory effects of IL-10 during human endotoxemia
    F N Lauw
    Department of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 165:2783-9. 2000
    ..These data indicate that high-dose IL-10 treatment in patients with inflammatory disorders can be associated with undesired proinflammatory effects...
  14. ncbi Tissue factor pathway inhibitor does not influence inflammatory pathways during human endotoxemia
    E de Jonge
    Department of Intensive Care, Academic Medical Center, University of Amsterdam, 1100 DD Amsterdam, The Netherlands
    J Infect Dis 183:1815-8. 2001
    ..Thus, complete prevention of coagulation activation by TFPI does not influence activation of inflammatory pathways during human endotoxemia...
  15. ncbi Lymph of patients with a systemic inflammatory response syndrome inhibits lipopolysaccharide-induced cytokine production
    L C Lemaire
    Department of Surgery, Academic Medical Center, University of Amsterdam, The Netherlands
    J Infect Dis 178:883-6. 1998
    ..01); lymph of controls also inhibited cytokine production (P < .01), although to a lesser extent. This study suggests that LPS tolerance may occur both in the intra- and extravascular compartments...
  16. ncbi IC14, an anti-CD14 antibody, inhibits endotoxin-mediated symptoms and inflammatory responses in humans
    A Verbon
    Department of Infectious Diseases, Tropical Medicine, and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 166:3599-605. 2001
    ..These data provide the first proof of principle that blockade of CD14 is associated with reduced LPS responsiveness in humans in vivo...
  17. ncbi Levels of inhibitors of tumor necrosis factor alpha and interleukin 1beta in urine and sera of patients with urosepsis
    D P Olszyna
    Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, University of Amsterdam, Amsterdam, The Netherlands
    Infect Immun 66:3527-34. 1998
    ..These findings indicate that during urosepsis, the antiinflammatory cytokine response is generated predominantly at the systemic level...
  18. ncbi Interleukin 10 release during endotoxaemia in chimpanzees: role of platelet-activating factor and interleukin 6
    T van der Poll
    Department of Internal Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Scand J Immunol 43:122-5. 1996
    ..IL-10 release elicited by injection of endotoxin is not mediated by PAF or IL6...
  19. ncbi Mycobacterial lipoarabinomannan induces an inflammatory response in the mouse lung. A role for interleukin-1
    N P Juffermans
    Laboratory of Experimental Internal Medicine, Department of Internal Medicine, Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Am J Respir Crit Care Med 162:486-9. 2000
    ..Also, lung TNF-alpha levels were lower in IL-1R(-/-) mice. LAM may be an important stimulator of innate immunity in infection with M. tuberculosis via mechanisms that involve endogenous IL-1 activity...
  20. ncbi Upregulation of monocyte urokinase plasminogen activator receptor during human endotoxemia
    P E Dekkers
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands NL
    Infect Immun 68:2156-60. 2000
    ..These data suggest that infectious stimuli may influence monocyte function in vivo by enhancing the expression of uPAR...
  21. ncbi Impairment of host defence by exotoxin A in Pseudomonas aeruginosa pneumonia in mice
    M J Schultz
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    J Med Microbiol 50:822-7. 2001
    ..These data suggest that P-ExA impairs host defence during pneumonia caused by P. aeruginosa by a mechanism that does not involve effects on neutrophil influx, cytokines, chemokines or NO formation...
  22. ncbi Interleukin 10 inhibits the release of CC chemokines during human endotoxemia
    D P Olszyna
    Department of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Infect Dis 181:613-20. 2000
    ....
  23. ncbi Elevated plasma concentrations of interferon (IFN)-gamma and the IFN-gamma-inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis
    F N Lauw
    Laboratory of Experimental Internal Medicine, Department of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Infect Dis 180:1878-85. 1999
    ..This effect of anti-IL-12 was further enhanced by anti-IL-18. These data suggest that during gram-negative sepsis, IFN-gamma production is controlled at least in part by endogenous IL-18, IL-12, and IL-15...
  24. ncbi Tumor necrosis factor and interleukin-1 inhibitors as markers of disease activity of tuberculosis
    N P Juffermans
    Department of Internal Medicine, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, The Netherlands
    Am J Respir Crit Care Med 157:1328-31. 1998
    ..We conclude that serum concentrations of sTNFRs I and II and IL-1ra may serve as markers of disease activity of TB. Sequential measurements of these cytokine inhibitors may be useful in the monitoring of antituberculous therapy...
  25. ncbi Elevated chemokine concentrations in sera of human immunodeficiency virus (HIV)-seropositive and HIV-seronegative patients with tuberculosis: a possible role for mycobacterial lipoarabinomannan
    N P Juffermans
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Infect Immun 67:4295-7. 1999
    ..Lipoarabinomannan induced IL-8, MCP-1, and MIP-1beta in vitro, which was partly inhibited by anti-tumor necrosis factor antibody...
  26. ncbi Depletion of alveolar macrophages exerts protective effects in pulmonary tuberculosis in mice
    J C Leemans
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 166:4604-11. 2001
    ..These data demonstrate that depletion of AMs is protective during pulmonary tuberculosis...
  27. ncbi Chemotactic activity of CXC chemokines interleukin-8, growth-related oncogene-alpha, and epithelial cell-derived neutrophil-activating protein-78 in urine of patients with urosepsis
    D P Olszyna
    Academic Medical Center, Dept of Experimental Internal Medicine, 1105 AZ Amsterdam, The Netherlands
    J Infect Dis 182:1731-7. 2000
    ..During urosepsis, CXC chemokines are predominantly produced within the urinary tract, where they are involved in the recruitment of neutrophils to the urinary compartment...
  28. ncbi Induction of cell-associated chemokines after endotoxin administration to healthy humans
    D P Olszyna
    Department of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Infect Immun 69:2736-8. 2001
    ..IL-8 was also recovered from mononuclear and polymorphonuclear cells. Cell-associated chemokines may more accurately reflect their production than plasma concentrations...
  29. ncbi Intravenous infusion of erythromycin inhibits CXC chemokine production, but augments neutrophil degranulation in whole blood stimulated with Streptococcus pneumoniae
    M J Schultz
    Laboratory of Experimental Internal Medicine, Department of Intensive Care, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Antimicrob Chemother 46:235-40. 2000
    ..05). These results indicate the ability of erythromycin to reduce CXC chemokine production and to enhance neutrophil degranulation in human blood...
  30. ncbi Thalidomide inhibits granulocyte responses in healthy humans after ex vivo stimulation with bacterial antigens
    N P Juffermans
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Antimicrob Agents Chemother 45:1547-9. 2001
    ..A single oral dose of thalidomide attenuates neutrophil activation upon ex vivo stimulation with bacterial antigens...
  31. ncbi Endotoxin down-regulates monocyte and granulocyte interleukin-6 receptors without influencing gp130 expression in humans
    P E Dekkers
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    J Infect Dis 181:1055-61. 2000
    ..Monocytes and granulocytes may down-regulate IL-6R at their surface upon their first interaction with bacterial antigens...
  32. ncbi Detection and clinical relevance of human endotoxemia
    A Sturk
    Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands
    Z Med Lab Diagn 31:147-58. 1990
    ..94) and level of consensus to establish endotoxemia (93%) as compared to the house method. The commercial assay may therefore facilitate the introduction of endotoxin testing in other laboratories...
  33. ncbi Soluble granzymes are released during human endotoxemia and in patients with severe infection due to gram-negative bacteria
    F N Lauw
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Infect Dis 182:206-13. 2000
    ..The interaction between the cytokine network and granzymes may play an important immunoregulatory role during bacterial infections...
  34. ncbi Reduced Th1, but not Th2, cytokine production by lymphocytes after in vivo exposure of healthy subjects to endotoxin
    F N Lauw
    Laboratory of Experimental Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Infect Immun 68:1014-8. 2000
    ..LPS exposure influences lymphocyte cytokine production, resulting in a shift toward a Th2 cytokine response, an effect that may be mediated in part by soluble factors present in serum after LPS administration in vivo...
  35. ncbi Lipopolysaccharide regulates macrophage fluid phase pinocytosis via CD14-dependent and CD14-independent pathways
    M P Peppelenbosch
    Laboratory for Experimental Internal Medicine, G2 130 Academic Medical Centre, Amsterdam, The Netherlands
    Blood 93:4011-8. 1999
    ..Furthermore, as addition of LPS to macrophages effected pinocytosis but not Fc receptor-mediated endocytosis, these two processes are independently regulated in macrophages...
  36. ncbi CXC chemokine receptor 2 contributes to host defense in murine urinary tract infection
    D P Olszyna
    Department of Experimental Internal Medicine and Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine, and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Infect Dis 184:301-7. 2001
    ..CXC chemokines play an important role in the development of a local inflammatory response to UTI...
  37. ncbi Known bacterial virulence factors do not explain the variation in urinary cytokine levels in patients with urosepsis
    J M Prins
    Department of Internal Medicine, Academic Medical Center, Amsterdam, Netherlands
    FEMS Immunol Med Microbiol 16:283-9. 1996
    ..Other factors than known bacterial virulence factors apparently contribute to the wide variation in urinary cytokine levels in urinary tract infection...
  38. ncbi Leptin is a growth factor for colonic epithelial cells
    J C Hardwick
    Department of Experimental Internal Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Gastroenterology 121:79-90. 2001
    ..The aim of this study was to investigate whether leptin is a growth factor for colonic epithelial cells...
  39. ncbi A single oral dose of thalidomide enhances the capacity of lymphocytes to secrete gamma interferon in healthy humans
    A Verbon
    Department of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, The Netherlands
    Antimicrob Agents Chemother 44:2286-90. 2000
    ..05). Thus, a single oral dose of thalidomide causes a Th1-type response in healthy humans. This finding offers a potential explanation for the positive effect of thalidomide in patients with mycobacterial and HIV infections...
  40. ncbi Increased oxygen consumption after cardiac surgery is associated with the inflammatory response to endotoxemia
    H M Oudemans-van Straaten
    Intensive Care Department, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
    Intensive Care Med 22:294-300. 1996
    ....
  41. ncbi Divergent roles of tumor necrosis factor and platelet-activating factor in endotoxin-induced release of monocyte chemoattractant protein 1 and macrophage inflammatory protein 1beta in chimpanzees
    P E Dekkers
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Infect Immun 67:5480-2. 1999
    ..Anti-tumor necrosis factor alpha monoclonal antibody completely prevented MCP-1 release and simultaneously enhanced the secretion of MIP-1beta. Levels of MIP-1beta and MCP-1 release were differentially regulated during endotoxemia...
  42. ncbi TNF-alpha compensates for the impaired host defense of IL-1 type I receptor-deficient mice during pneumococcal pneumonia
    A W Rijneveld
    Department of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 167:5240-6. 2001
    ..These data suggest that TNF is more important for host defense against pneumococcal pneumonia than IL-1, and that the impaired early host defense in IL-1R(-/-) mice is compensated for by TNF at a later phase...
  43. ncbi The metalloproteinase inhibitor GI5402 inhibits endotoxin-induced soluble CD27 and CD16 release in healthy humans
    P E Dekkers
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Infect Immun 68:3036-9. 2000
    ..Oral administration of the metalloproteinase inhibitor GI5402 attenuated the release of soluble CD27 and CD16 into the circulation after intravenous endotoxin injection in healthy humans...
  44. ncbi Expression and activation of NF-kappa B in the antrum of the human stomach
    G R van den Brink
    Departments of Experimental Internal Medicine, Pathology, and Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands
    J Immunol 164:3353-9. 2000
    ..This correlation is direct evidence of the importance of NF-kappa B-dependent signal transduction for neutrophil influx in H. pylori-associated gastritis...
  45. ncbi Concurrent upregulation of urokinase plasminogen activator receptor and CD11b during tuberculosis and experimental endotoxemia
    N P Juffermans
    Laboratory of Experimental Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Infect Immun 69:5182-5. 2001
    ..In healthy volunteers, LPS induced increases in monocyte and granulocyte uPAR and CD11b...
  46. ncbi Blockade of endogenous IL-18 ameliorates TNBS-induced colitis by decreasing local TNF-alpha production in mice
    T ten Hove
    Laboratory of Experimental Internal Medicine G2-136, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Gastroenterology 121:1372-9. 2001
    ..In these mice, significant reductions in total colitis score and colon weight were also observed. CONCLUSIONS: These findings show that inhibition of rhIL-18BPa bioactivity, via rhIL-18BPa, may be beneficial for the treatment of IBD...
  47. ncbi Effect of interleukin 10 on the release of the CXC chemokines growth related oncogene GRO-alpha and epithelial cell-derived neutrophil activating peptide (ENA)-78 during human endotoxemia
    D P Olszyna
    Department of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Room G2-132, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Immunol Lett 78:41-4. 2001
    ..In vitro, IL-10 dose-dependently attenuated LPS-induced release of both GRO-alpha and ENA-78 in whole blood and in cultures of isolated polymorphonuclear and mononuclear cells...
  48. ncbi Endogenous interferon-gamma impairs bacterial clearance from lungs during Pseudomonas aeruginosa pneumonia
    M J Schultz
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Eur Cytokine Netw 12:39-44. 2001
    ..Remarkably, IFN-gammaR(-/-) mice had higher nitric oxide levels in the BALF at 24 hours after infection (P < 0.05). Endogenous IFN-gamma impairs rather than augments host defense during pneumonia caused by P. aeruginosa...
  49. ncbi Current drug treatment strategies for disseminated intravascular coagulation
    E de Jonge
    Department of Intensive Care, Academic Medical Center, University of Amsterdam, The Netherlands
    Drugs 55:767-77. 1998
    ..Results of studies on protein C concentrate, thrombomodulin or inhibitors of tissue factor are promising, but the efficacy and safety of these novel strategies remains to be established in appropriate clinical trials...
  50. ncbi Anti- and proinflammatory cytokines in the pathogenesis of tissue damage in Crohn's disease
    D W Hommes
    Laboratory for Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Curr Opin Clin Nutr Metab Care 3:191-5. 2000
    ....
  51. ncbi Experimental pneumococcal meningitis in mice: a model of intranasal infection
    P J Zwijnenburg
    Department of Pediatrics, University Hospital Vrije Universiteit, and Department of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands
    J Infect Dis 183:1143-6. 2001
    ..These results indicate that this murine model mimics important features of human disease and allow for the use of this model for studying issues related to the pathophysiology and the treatment of pneumococcal meningitis...
  52. ncbi Correlation of repressed transcription of alpha-tocopherol transfer protein with serum alpha-tocopherol during hepatocarcinogenesis
    C G Wu
    Department of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Int J Cancer 71:686-90. 1997
    ..Our data suggest that repressed transcription of alpha-TTP is associated with a decrease of serum alpha-tocopherol and with hepatic carcinogenesis...
  53. ncbi Immunotherapy of Crohn's disease
    C Van Montfrans
    Laboratory of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Mediators Inflamm 7:149-52. 1998
    ..Altogether, these results hold promise for future management of Crohn's disease, where disease-modifying interventions and strategies that effectively maintain disease remission will play a key role...
  54. ncbi Prevalence of subclinical anterior uveitis in adult patients with inflammatory bowel disease
    F D Verbraak
    Department of Ophthalmology, Academic Medical Center, University of Amsterdam, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    Br J Ophthalmol 85:219-21. 2001
    ..To assess the prevalence of subclinical anterior uveitis in adult patients with inflammatory bowel disease...
  55. ncbi NF-kappaB, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps
    J C Hardwick
    Department of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Oncogene 20:819-27. 2001
    ..In the case of NF-kappaB this coincides with the cellular localisation of COX-2. These results support evidence that NSAIDs may act through effects on stromal cells rather than epithelial cells...
  56. ncbi Erythromycin inhibits tumor necrosis factor alpha and interleukin 6 production induced by heat-killed Streptococcus pneumoniae in whole blood
    M J Schultz
    Department of Infectious Diseases, Tropical Medicine and AIDS, University of Amsterdam, The Netherlands
    Antimicrob Agents Chemother 42:1605-9. 1998
    ..Inhibition of TNF contributed to erythromycin-induced inhibition of IL-6 synthesis. Inhibition of TNF and IL-6 production by erythromycin may have a negative impact on host defense mechanisms during pneumococcal pneumonia...
  57. ncbi Narrow-band imaging compared with conventional colonoscopy for the detection of dysplasia in patients with longstanding ulcerative colitis
    E Dekker
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Endoscopy 39:216-21. 2007
    ..The aim of this study was to compare the accuracy of narrow-band imaging (NBI), a new imaging technique, with standard colonoscopy for the detection of neoplasia in patients with longstanding ulcerative colitis...
  58. ncbi Multiple signal transduction pathways regulate TNF-induced actin reorganization in macrophages: inhibition of Cdc42-mediated filopodium formation by TNF
    M Peppelenbosch
    Ludwig Institute for Cancer Research, London, United Kingdom
    J Immunol 162:837-45. 1999
    ..We conclude that different domains of TNFR-1 mediate distinct changes in the Mphi cytoskeleton, and that the ability of TNF to inhibit Mphi chemotaxis may be due to decreased filopodium formation downstream of Cdc42...
  59. ncbi A prospective randomized study of hydrophilic polymer-coated polyurethane versus polyethylene stents in distal malignant biliary obstruction
    A M van Berkel
    Dept of Gastroenterology and Hepatology C2 220, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Endoscopy 35:478-82. 2003
    ..We compared the patency rates with this new stent with the standard Amsterdam-type polyethylene (PE) stent in a prospective randomized trial...
  60. ncbi Hapten-induced colitis associated with maintained Th1 and inflammatory responses in IFN-gamma receptor-deficient mice
    L Camoglio
    Laboratory of Experimental Internal Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Immunol 30:1486-95. 2000
    ..Importantly, the production of Th1 cytokines (e. g. IFN-gamma and TNF-alpha) by caudal lymph node T lymphocytes was enhanced rather than decreased in IFNgammaR1(- / -) mice with no evidence for default Th2 development...
  61. ncbi Mice lacking the multidrug resistance protein 1 are resistant to Streptococcus pneumoniae-induced pneumonia
    M J Schultz
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 166:4059-64. 2001
    ..We conclude that mrp1(-/-) mice are resistant against pneumococcal pneumonia by a mechanism that involves increased release of LTB(4). These results identify mrp1 as a novel target for adjunctive therapy in pneumonia...
  62. ncbi The abnormal lipid spectrum in malignant obstructive jaundice in relation to endotoxin sensitivity and the result of preoperative biliary drainage
    N Kimmings
    Department of Surgery, Academic Medical Center, Municipal Hospital Slotervaart, Amsterdam, The Netherlands
    Surgery 129:282-91. 2001
    ..CONCLUSIONS: Preoperative biliary drainage normalizes the changed lipid profile and the endotoxin-stimulating capacity of cholestatic plasma, and this signifies a change in sensitivity to endotoxin...
  63. ncbi Factor VIIa/tissue factor-induced signaling via activation of Src-like kinases, phosphatidylinositol 3-kinase, and Rac
    H H Versteeg
    Laboratory for Experimental Internal Medicine, G2 130, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Biol Chem 275:28750-6. 2000
    ..We propose that this Src family member/PI3K/Rac-dependent signaling pathway is a major mediator of factor VIIa/TF effects in pathophysiology...
  64. ncbi Urine interleukin-8 is a marker for urinary tract infection in postoperative patients
    D P Olszyna
    Dept. of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Infection 29:274-7. 2001
    ..Urine IL-8 was elevated on the day UTI was diagnosed, while remaining low in controls. CONCLUSION: In this patient group with postoperative UTI, urine IL-8 was a better marker for the early host response than urine IL-6...
  65. ncbi Macrophages present pinocytosed exogenous antigen via MHC class I whereas antigen ingested by receptor-mediated endocytosis is presented via MHC class II
    M P Peppelenbosch
    Laboratory for Experimental Internal Medicine, Academic Medical Centre, Amsterdam, The Netherlands
    J Immunol 165:1984-91. 2000
    ....
  66. ncbi Lipopolysaccharide recognition, internalisation, signalling and other cellular effects
    S H Diks
    Laboratory for Experimental Internal Medicine, Amsterdam Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    J Endotoxin Res 7:335-48. 2001
    ..Finally, we shall investigate how current knowledge may explain endotoxin neutralisation and subsequent detoxification, either through LPS internalisation or via LPS immobilisation, or through the actions of LPS-binding molecules...
  67. ncbi Sonic hedgehog regulates gastric gland morphogenesis in man and mouse
    G R van den Brink
    Department of Experimental Internal Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Gastroenterology 121:317-28. 2001
    ..We investigated whether Sonic hedgehog (Shh), an established polarizing signal protein during development, is expressed and functional in the adult human and murine stomach...
  68. ncbi Distribution and kinetics of lipoprotein-bound endotoxin
    J H Levels
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Infect Immun 69:2821-8. 2001
    ....
  69. ncbi Role of endogenous interleukin-12 in immune response to staphylococcal enterotoxin B in mice
    F N Lauw
    Laboratory of Experimental Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Infect Immun 69:5949-52. 2001
    ..These data suggest that the role of IL-12 in SEB-induced responses is limited to sustaining gamma interferon release by an IL-18-independent mechanism...
  70. ncbi Effect of preoperative oral immune-enhancing nutritional supplement on patients at high risk of infection after cardiac surgery: a randomised placebo-controlled trial
    R Tepaske
    Department of Intensive, University of Amsterdam, Academic Medical Centre, Amsterdam, Netherlands
    Lancet 358:696-701. 2001
    ....
  71. ncbi Abrogation of IFN-gamma mediated epithelial barrier disruption by serine protease inhibition
    L E M Willemsen
    Numico Research BV, Wageningen, The Netherlands
    Clin Exp Immunol 142:275-84. 2005
    ..Since inhibition of serine protease activity abrogates IFN-gamma mediated barrier disruption this may be an important target for therapeutic intervention...
  72. ncbi Regulation of the p21Ras-MAP kinase pathway by factor VIIa
    H H Versteeg
    Laboratory for Experimental Internal Medicine, Academic Medical Centre, Amsterdam, The Netherlands
    J Thromb Haemost 1:1012-8. 2003
    ....
  73. ncbi Effects of anti-tumour necrosis factor-alpha therapy on the quality of life in Crohn's disease
    B P J van Balkom
    Department of Gastroenterology, University Hospital Maastricht, NL-6202 AZ Maastricht, The Netherlands
    Aliment Pharmacol Ther 16:1101-7. 2002
    ..Inflammatory Crohn's disease and a young age at diagnosis were predictors for a better response to infliximab therapy. CONCLUSIONS: Infliximab therapy improves all dimensions of the quality of life in patients with Crohn's disease...
  74. ncbi Interleukin-6, C-reactive protein, and expression of human leukocyte antigen-DR on peripheral blood mononuclear cells in patients after laparoscopic vs. conventional bowel resection: a randomized study
    M S Dunker
    Department of Surgery, Academic Medical Center Amsterdam, Amsterdam, The Netherlands
    Dis Colon Rectum 46:1238-44. 2003
    ..CONCLUSIONS: These data suggest that surgical trauma did not significantly affect the immune status of patients with respect to the measured parameters in terms of either the approach or the extent of bowel resection...
  75. ncbi T cell apoptosis and inflammatory bowel disease
    M P Peppelenbosch
    Department of Gastroenterology and Hepatology, C2-330, Academic Medical Centre, Meibergdreef 9, NL-1105 AZ Amsterdam, The Netherlands
    Gut 53:1556-8. 2004
  76. ncbi A dose escalating, placebo controlled, double blind, single dose and multidose, safety and tolerability study of fontolizumab, a humanised anti-interferon gamma antibody, in patients with moderate to severe Crohn's disease
    W Reinisch
    Universitaetsklinik Innere Medizin IV, Abteilung Gastroenterologie and Hepatologie, Vienna, Austria
    Gut 55:1138-44. 2006
    ..This study was designed to evaluate the safety of fontolizumab, a humanised anti-interferon gamma antibody, in patients with moderate to severe Crohn's disease (CD)...
  77. ncbi Lipopolysaccharide is transferred from high-density to low-density lipoproteins by lipopolysaccharide-binding protein and phospholipid transfer protein
    J H M Levels
    Department of Experimental Vascular Medicine, Academic Medical Center, G1 114, P O Box 22660, 1100 DD Amsterdam, The Netherlands
    Infect Immun 73:2321-6. 2005
    ..We postulate that HDL remodeling induced by LBP- and PLTP-mediated LPS transfer may contribute to the plasma lipoprotein dyslipidemia characteristic of the acute-phase response to infection...
  78. ncbi Infliximab therapy in Crohn's disease: safety issues
    D W Hommes
    Department of Gastroenterology and Hepatology, Academic Medical Centre, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Neth J Med 61:100-4. 2003
    ..This review discusses some immunological aspects that are relevant for infliximab therapy and provides guidelines for daily practice...
  79. ncbi New biological therapies in inflammatory bowel disease
    S J H van Deventer
    Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Best Pract Res Clin Gastroenterol 17:119-30. 2003
    ..Other new approaches include ex vivo generation of regulatory T lymphocytes and antibodies that target and kill (subpopulations of) memory T lymphocytes...
  80. ncbi Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease
    T ten Hove
    Academic Medical Centre University of Amsterdam, Department of Experimental Internal Medicine, Amsterdam, The Netherlands
    Gut 50:206-11. 2002
    ..Because Crohn's disease is considered to be mediated by uncontrolled activation of mucosal T lymphocytes, we hypothesised that infliximab could induce apoptosis of T lymphocytes...
  81. ncbi Dichotomal role of inhibition of p38 MAPK with SB 203580 in experimental colitis
    T ten Hove
    Laboratory of Experimental Internal Medicine, Academic Medical Centre, Amsterdam, The Netherlands
    Gut 50:507-12. 2002
    ..In this paper we describe the effects of a specific p38 MAPK inhibitor, SB 203580, in trinitrobenzene sulphonic acid (TNBS) induced colitis in mice...
  82. ncbi Small therapeutic molecules for the treatment of inflammatory bowel disease
    S J H van Deventer
    Department of Hepato-Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands
    Gut 50:III47-53. 2002
    ..This review summarises the current status of the development of small therapeutic molecules for inflammatory bowel disease...
  83. ncbi Treatment of Crohn's disease with recombinant human interleukin 10 induces the proinflammatory cytokine interferon gamma
    H Tilg
    Department of Medicine, Division of Gastroenterology and Hepatology, University Hospital Innsbruck, Austria
    Gut 50:191-5. 2002
    ..Interleukin 10 (IL-10) exerts anti-inflammatory actions by counteracting many biological effects of interferon gamma (IFN-gamma)...
  84. ncbi Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract
    G R van den Brink
    Department of Experimental Internal Medicine, Academic Medical Centre, Amsterdam, The Netherlands
    Gut 51:628-33. 2002
    ....
  85. ncbi Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets
    D W Hommes
    Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands
    Gut 52:144-51. 2003
    ..Here, our current understanding of the MAP kinase pathway is reviewed, as well as recent advances in the design of novel agents that are able to modulate the activity of these signalling cascades...
  86. ncbi A coculture model mimicking the intestinal mucosa reveals a regulatory role for myofibroblasts in immune-mediated barrier disruption
    L E M Willemsen
    Numico Research BV, Wageningen, The Netherlands
    Dig Dis Sci 47:2316-24. 2002
    ..The effects were also found to depend on the route of LPMC stimulation. Additional analyses suggested that the regulatory role of myofibroblasts in barrier integrity involves production of growth factors...
  87. ncbi Endoscopic treatment of strictures in Crohn's disease
    G W Erkelens
    Department of Gastroenterology, Reinier de Graaf Group, Postbus 5011, 2600 GA Delft, Amsterdam, The Netherlands
    Best Pract Res Clin Gastroenterol 18:201-7. 2004
    ..Other endoscopic therapies and new developments are also discussed in this chapter...
  88. ncbi Taming the mucosal immune response in Crohn's disease
    S J H van Deventer
    Department of Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands
    Best Pract Res Clin Gastroenterol 16:1035-43. 2002
    ..This may require repair of the underlying genetic mutation, restoration of defects of apoptosis, or generation of regulatory T-lymphocytes...
  89. ncbi Immunopathogenesis of IBD: insufficient suppressor function in the gut?
    I L Huibregtse
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Gut 56:584-92. 2007
  90. ncbi Short chain fatty acids stimulate epithelial mucin 2 expression through differential effects on prostaglandin E(1) and E(2) production by intestinal myofibroblasts
    L E M Willemsen
    Numico Research BV, Wageningen, The Netherlands
    Gut 52:1442-7. 2003
    ..This mechanism involving functional interaction between myofibroblasts and epithelial cells may play an important role in the mucoprotective effect of bacterial fermentation products...