Niels van Royen

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi Exogenous application of transforming growth factor beta 1 stimulates arteriogenesis in the peripheral circulation
    Niels van Royen
    Max Planck Institute for Physiological and Clinical Research, Department of Experimental Cardiology, Bad Nauheim, Germany
    FASEB J 16:432-4. 2002
  2. doi A critical review of clinical arteriogenesis research
    Niels van Royen
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Am Coll Cardiol 55:17-25. 2009
  3. ncbi START Trial: a pilot study on STimulation of ARTeriogenesis using subcutaneous application of granulocyte-macrophage colony-stimulating factor as a new treatment for peripheral vascular disease
    Niels van Royen
    Department of Cardiology, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Circulation 112:1040-6. 2005
  4. ncbi Local monocyte chemoattractant protein-1 therapy increases collateral artery formation in apolipoprotein E-deficient mice but induces systemic monocytic CD11b expression, neointimal formation, and plaque progression
    N van Royen
    Department of Cardiology, University of Amsterdam, Amsterdam, The Netherlands
    Circ Res 92:218-25. 2003
  5. ncbi Design of the START-trial: STimulation of ARTeriogenesis using subcutaneous application of GM-CSF as a new treatment for peripheral vascular disease. A randomized, double-blind, placebo-controlled trial
    Niels van Royen
    Department of Cardiology, University of Amsterdam, The Netherlands
    Vasc Med 8:191-6. 2003
  6. ncbi CD44 regulates arteriogenesis in mice and is differentially expressed in patients with poor and good collateralization
    N van Royen
    Department of Cardiology, Room B2 114, Academic Medical Center, University of Amsterdam, Meibergdreef 9 1105 AZ, Amsterdam, The Netherlands
    Circulation 109:1647-52. 2004
  7. pmc Expression of a retinoic acid signature in circulating CD34 cells from coronary artery disease patients
    Tineke C T M van der Pouw Kraan
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Van der Boechorststraat, 1081BT Amsterdam, The Netherlands
    BMC Genomics 11:388. 2010
  8. ncbi Abnormal monocyte recruitment and collateral artery formation in monocyte chemoattractant protein-1 deficient mice
    Michiel Voskuil
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Vasc Med 9:287-92. 2004
  9. ncbi Leukocyte subpopulations and arteriogenesis: specific role of monocytes, lymphocytes and granulocytes
    Imo E Hoefer
    Research Group for Experimental and Clinical Arteriogenesis, Department of Cardiology, University of Freiburg, Germany
    Atherosclerosis 181:285-93. 2005
  10. ncbi Modulation of collateral artery growth in a porcine hindlimb ligation model using MCP-1
    Michiel Voskuil
    Department of Cardiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 284:H1422-8. 2003

Collaborators

Detail Information

Publications29

  1. ncbi Exogenous application of transforming growth factor beta 1 stimulates arteriogenesis in the peripheral circulation
    Niels van Royen
    Max Planck Institute for Physiological and Clinical Research, Department of Experimental Cardiology, Bad Nauheim, Germany
    FASEB J 16:432-4. 2002
    ..10.11 +/- 0.04 x 10(5), P<0.05). TGF-beta1 had no direct pro-angiogenic effect on human umbilical vein endothelial cells in a spheroid model of angiogenesis and inhibited the angiogenic effects of vascular endothelial growth factor...
  2. doi A critical review of clinical arteriogenesis research
    Niels van Royen
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Am Coll Cardiol 55:17-25. 2009
    ..In a reversed bedside-to-bench approach, the characterization of ribonucleic acid and protein expression patterns in these patients generated new targets for therapeutic arteriogenesis...
  3. ncbi START Trial: a pilot study on STimulation of ARTeriogenesis using subcutaneous application of granulocyte-macrophage colony-stimulating factor as a new treatment for peripheral vascular disease
    Niels van Royen
    Department of Cardiology, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Circulation 112:1040-6. 2005
    ..Experimental models showed beneficial effects of GM-CSF on collateral artery growth in the peripheral circulation. Thus, in the present study, we evaluated the effects of GM-CSF in patients with peripheral artery disease...
  4. ncbi Local monocyte chemoattractant protein-1 therapy increases collateral artery formation in apolipoprotein E-deficient mice but induces systemic monocytic CD11b expression, neointimal formation, and plaque progression
    N van Royen
    Department of Cardiology, University of Amsterdam, Amsterdam, The Netherlands
    Circ Res 92:218-25. 2003
    ..However, the local treatment did not preclude systemic effects on atherogenesis, leading to increased atherosclerotic plaque formation and changes in cellular content of plaques...
  5. ncbi Design of the START-trial: STimulation of ARTeriogenesis using subcutaneous application of GM-CSF as a new treatment for peripheral vascular disease. A randomized, double-blind, placebo-controlled trial
    Niels van Royen
    Department of Cardiology, University of Amsterdam, The Netherlands
    Vasc Med 8:191-6. 2003
    ..Iliac flow reserve and conductance will be measured by magnetic resonance imaging...
  6. ncbi CD44 regulates arteriogenesis in mice and is differentially expressed in patients with poor and good collateralization
    N van Royen
    Department of Cardiology, Room B2 114, Academic Medical Center, University of Amsterdam, Meibergdreef 9 1105 AZ, Amsterdam, The Netherlands
    Circulation 109:1647-52. 2004
    ..CD44 glycoproteins are involved in leukocyte extravasation but also in the regulation of growth factor activation, stability, and signaling. Here, we explored the role of CD44 during arteriogenesis...
  7. pmc Expression of a retinoic acid signature in circulating CD34 cells from coronary artery disease patients
    Tineke C T M van der Pouw Kraan
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Van der Boechorststraat, 1081BT Amsterdam, The Netherlands
    BMC Genomics 11:388. 2010
    ..Knowledge is still scarce about the transcriptional programs used by CD34+ cells from peripheral blood, and how these are affected in coronary artery disease (CAD) patients...
  8. ncbi Abnormal monocyte recruitment and collateral artery formation in monocyte chemoattractant protein-1 deficient mice
    Michiel Voskuil
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Vasc Med 9:287-92. 2004
    ....
  9. ncbi Leukocyte subpopulations and arteriogenesis: specific role of monocytes, lymphocytes and granulocytes
    Imo E Hoefer
    Research Group for Experimental and Clinical Arteriogenesis, Department of Cardiology, University of Freiburg, Germany
    Atherosclerosis 181:285-93. 2005
    ..The role of these two cell types in arteriogenesis remains yet to be clarified, which was the aim of the current study...
  10. ncbi Modulation of collateral artery growth in a porcine hindlimb ligation model using MCP-1
    Michiel Voskuil
    Department of Cardiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 284:H1422-8. 2003
    ..05). Modulation of the process of arteriogenesis is feasible in this large animal model via intra-arterial infusion of the Cys-Cys-chemokine MCP-1...
  11. pmc Blocking interferon {beta} stimulates vascular smooth muscle cell proliferation and arteriogenesis
    Stephan H Schirmer
    Department of Cardiology, Saarland University Hospital, 66421 Homburg Saar, Germany
    J Biol Chem 285:34677-85. 2010
    ..Inhibition of IFNβ stimulates VSMC proliferation and collateral artery growth...
  12. doi Suppression of inflammatory signaling in monocytes from patients with coronary artery disease
    Stephan H Schirmer
    Department of Cardiology, Academic Medical Center, University of Amsterdam, 1105AZ Amsterdam, The Netherlands
    J Mol Cell Cardiol 46:177-85. 2009
    ..Transcriptome differences of circulating cells possibly play less of a role than hitherto thought in the individual patient's susceptibility to atherosclerotic CAD, when appropriately matched for clinical symptoms and medication taken...
  13. ncbi Aspirin, but not clopidogrel, reduces collateral conductance in a rabbit model of femoral artery occlusion
    Imo E Hoefer
    Research Group for Arteriogenesis, Department of Cardiology, University of Freiburg, Freiburg, Germany
    J Am Coll Cardiol 46:994-1001. 2005
    ..The objective of this study was to test the potential of aspirin and clopidogrel to influence collateral artery growth (arteriogenesis)...
  14. doi Galectin-2 expression is dependent on the rs7291467 polymorphism and acts as an inhibitor of arteriogenesis
    Anja M van der Laan
    Department of Cardiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Eur Heart J 33:1076-84. 2012
    ..Knowledge on factors involved in human arteriogenesis is scarce. Thus, the aim of the present study is to identify targets in monocytes that are critical for arteriogenesis in patients with CAD...
  15. doi Local cytokine concentrations and oxygen pressure are related to maturation of the collateral circulation in humans
    Stephan H Schirmer
    Department of Cardiology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Am Coll Cardiol 53:2141-7. 2009
    ..Our aim was to determine cytokine and oxygen gradients over the collateral circulation in humans...
  16. doi Endothelial glycocalyx dimensions are reduced in growing collateral arteries and modulate leucocyte adhesion in arteriogenesis
    Sebastian Grundmann
    Department of Cardiology, AMC, University of Amsterdam, The Netherlands
    J Cell Mol Med 13:3463-74. 2009
    ..Although complete abrogation led to attenuated arteriogenesis, shedding of glycocalyx components is observed during collateral artery growth...
  17. doi Interferon-beta signaling is enhanced in patients with insufficient coronary collateral artery development and inhibits arteriogenesis in mice
    Stephan H Schirmer
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands
    Circ Res 102:1286-94. 2008
    ..Inhibition of IFN-beta signaling may serve as a novel approach for the stimulation of collateral artery growth...
  18. ncbi A new intra-arterial delivery platform for pro-arteriogenic compounds to stimulate collateral artery growth via transforming growth factor-beta1 release
    Sebastian Grundmann
    Department of Cardiology, AMC, University of Amsterdam, Amsterdam, The Netherlands
    J Am Coll Cardiol 50:351-8. 2007
    ..The purpose of this study was to develop a cytokine-eluting stent to stimulate collateral artery growth (arteriogenesis) in the peripheral circulation of the rabbit via local transforming growth factor (TGF)-beta1 release...
  19. ncbi Direct evidence for tumor necrosis factor-alpha signaling in arteriogenesis
    Imo E Hoefer
    Department of Cardiology, University of Freiburg, Germany
    Circulation 105:1639-41. 2002
    ..We hypothesized that arteriogenesis is reduced in mice lacking functional TNF-alpha or p55 receptor. To test this hypothesis, we developed a novel microsphere-based murine model of hindlimb perfusion measurement...
  20. doi Acute haemodynamic effects of accelerated idioventricular rhythm in primary percutaneous coronary intervention
    Ronak Delewi
    Department of Cardiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    EuroIntervention 7:467-71. 2011
    ..Accelerated idioventricular rhythm (AIVR) is very frequently observed in primary percutaneous coronary intervention (PCI), however knowledge of the haemodynamic effects is lacking...
  21. ncbi Experimental models of arteriogenesis: differences and implications
    Imo E Hoefer
    Department of Experimental Cardiology, UMC, University of Utrecht, The Netherlands
    Lab Anim (NY) 35:36-44. 2006
    ....
  22. ncbi Differential expression of GAPDH and beta3-actin in growing collateral arteries
    Elisabeth Deindl
    Max Planck Institute, Department of Experimental Cardiology, Bad Nauheim, Germany
    Mol Cell Biochem 236:139-46. 2002
    ..From these results we conclude that the 18S rRNA, but not the GAPDH- or beta-actin mRNA is an appropriate internal control for relative quantitation of gene expression under conditions of cell proliferation in growing vessels...
  23. doi Forkhead box protein P1 as a downstream target of transforming growth factor-β induces collagen synthesis and correlates with a more stable plaque phenotype
    Pieter T Bot
    Department of Cardiology, AMC Amsterdam, The Netherlands
    Atherosclerosis 218:33-43. 2011
    ..We studied FoxP1 expression in atherosclerotic tissue, correlated FoxP1 expression with plaque characteristics and identified associations between FoxP1 and plaque proteins...
  24. doi Prevalence and impact of a chronic total occlusion in a non-infarct-related artery on long-term mortality in diabetic patients with ST elevation myocardial infarction
    Bimmer E P M Claessen
    Department of Cardiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Heart 96:1968-72. 2010
    ..The prevalence of CTO in a non-IRA was studied and its impact on long-term mortality in STEMI patients with DM was investigated...
  25. doi The coronary collateral circulation: genetic and environmental determinants in experimental models and humans
    Paul F A Teunissen
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    J Mol Cell Cardiol 52:897-904. 2012
    ..The present review focuses on this heterogeneity of genetic as well as non-genetic determinants of the coronary collateral circulation. This article is part of a Special Issue entitled "Coronary Blood Flow"...
  26. ncbi Therapeutic manipulation of the collateral circulation--future directions
    Niels van Royen
    Department of Cardiology, University of Amsterdam, Amsterdam, The Netherlands
    Coron Artery Dis 15:399-403. 2004
    ..Future studies in this field will have to cope with problems of substance choice, clinical detection methods and unwanted side-effects...
  27. doi Targeting angiogenesis to restore the microcirculation after reperfused MI
    Anja M van der Laan
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Nat Rev Cardiol 6:515-23. 2009
    ....
  28. doi Magnetic resonance imaging-defined areas of microvascular obstruction after acute myocardial infarction represent microvascular destruction and haemorrhage
    Lourens F H J Robbers
    Department of Cardiology, Room ZH, 5F013, PO Box 7057, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Eur Heart J 34:2346-53. 2013
    ..However, the exact histopathological correlate of the contrast-devoid core and its relation to IMH is unknown...
  29. pmc Effect of additional treatment with EXenatide in patients with an Acute Myocardial Infarction (EXAMI): study protocol for a randomized controlled trial
    Martijn Scholte
    Department of Cardiology, VU University Medical Center, De Boelelaan 11171081 HV Amsterdam, The Netherlands
    Trials 12:240. 2011
    ....