Marieke AD van Zoelen
Affiliation: Academic Medical Center
Country: The Netherlands
van Zoelen M, Bakhtiari K, Dessing M, Van T Veer C, Spek C, Tanck M, et al
. Ethyl pyruvate exerts combined anti-inflammatory and anticoagulant effects on human monocytic cells. Thromb Haemost. 2006;96:789-93 pubmed
..These results demonstrate for the first time that EP is a compound with combined anti-inflammatory and anticoagulant effects. ..
van Zoelen M, de Vos A, Larosa G, Draing C, von Aulock S, van der Poll T. Intrapulmonary delivery of ethyl pyruvate attenuates lipopolysaccharide- and lipoteichoic acid-induced lung inflammation in vivo. Shock. 2007;28:570-5 pubmed
..These data suggest that intrapulmonary delivery of EP diminishes lung inflammation induced by LPS or LTA, at least in part by targeting alveolar macrophages and respiratory epithelial cells. ..
van Zoelen M, Van Der Sluijs K, Achouiti A, Florquin S, Braun Pater J, Yang H, et al
. Receptor for advanced glycation end products is detrimental during influenza A virus pneumonia. Virology. 2009;391:265-73 pubmed publisher
..These data suggest that RAGE is detrimental during IAV pneumonia. ..
van Zoelen M, Florquin S, Meijers J, de Beer R, de Vos A, de Boer O, et al
. Platelet-activating factor receptor contributes to host defense against Pseudomonas aeruginosa pneumonia but is not essential for the accompanying inflammatory and procoagulant response. J Immunol. 2008;180:3357-65 pubmed
..Additionally, our results indicate that PAFR signaling is not essential for the induction of a local and systemic inflammatory and procoagulant response to Pseudomonas pneumonia. ..
van Zoelen M, Schouten M, de Vos A, Florquin S, Meijers J, Nawroth P, et al
. The receptor for advanced glycation end products impairs host defense in pneumococcal pneumonia. J Immunol. 2009;182:4349-56 pubmed publisher
..These data suggest that RAGE plays a detrimental role in the host response to S. pneumoniae pneumonia by facilitating the bacterial growth and dissemination and concurrently enhancing the pulmonary inflammatory and procoagulant response...
van Zoelen M, Schmidt A, Florquin S, Meijers J, de Beer R, de Vos A, et al
. Receptor for advanced glycation end products facilitates host defense during Escherichia coli-induced abdominal sepsis in mice. J Infect Dis. 2009;200:765-73 pubmed publisher
..coli lipopolysaccharide. These data are the first to suggest that intact RAGE signaling contributes to an effective antibacterial defense during E. coli sepsis, thereby limiting the accompanying inflammatory and procoagulant response. ..
van Zoelen M, Yang H, Florquin S, Meijers J, Akira S, Arnold B, et al
. Role of toll-like receptors 2 and 4, and the receptor for advanced glycation end products in high-mobility group box 1-induced inflammation in vivo. Shock. 2009;31:280-4 pubmed publisher
..These data indicate that HMGB-1 induces release of cytokines, activation of coagulation, and neutrophil recruitment in vivo via a mechanism that at least in part depends on TLR-4 and RAGE. ..
van Zoelen M, Florquin S, de Beer R, Pater J, Verstege M, Meijers J, et al
. Urokinase plasminogen activator receptor-deficient mice demonstrate reduced hyperoxia-induced lung injury. Am J Pathol. 2009;174:2182-9 pubmed publisher
van Zoelen M, Verstege M, Draing C, de Beer R, Van T Veer C, Florquin S, et al
. Endogenous MCP-1 promotes lung inflammation induced by LPS and LTA. Mol Immunol. 2011;48:1468-76 pubmed publisher
..These data suggest that MCP-1 is a proinflammatory mediator during pulmonary inflammation induced by either LPS or LTA. ..