C J F Van Noorden

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. pmc Mutational profiling of kinases in glioblastoma
    Fonnet E Bleeker
    Department of Oncology, University of Torino, SP 142, km 3, 95, Candiolo, Torino, 10060, Italy Candiolo Cancer Institute FPO, IRCCS, Candiolo, Torino, Italy
    BMC Cancer 14:718. 2014
  2. pmc Increased mitochondrial activity in a novel IDH1-R132H mutant human oligodendroglioma xenograft model: in situ detection of 2-HG and α-KG
    Anna C Navis
    Department of Pathology, Radboud University Nijmegen Medical Centre, PO Box 9101, Nijmegen, 6500 HB, The Netherlands
    Acta Neuropathol Commun 1:18. 2013
  3. pmc CD34 marks angiogenic tip cells in human vascular endothelial cell cultures
    Martin J Siemerink
    Ocular Angiogenesis Group, Department of Ophthalmology and Department of Cell Biology and Histology, University of Amsterdam, Academic Medical Center, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    Angiogenesis 15:151-63. 2012
  4. pmc Experimental iodine-125 seed irradiation of intracerebral brain tumors in nude mice
    Joost J C Verhoeff
    Department of Neurosurgery, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Radiat Oncol 2:38. 2007
  5. pmc The prognostic IDH1( R132 ) mutation is associated with reduced NADP+-dependent IDH activity in glioblastoma
    Fonnet E Bleeker
    Neurosurgical Center Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Acta Neuropathol 119:487-94. 2010
  6. ncbi request reprint Adaptational changes in kinetic parameters of G6PDH but not of PGDH during contamination-induced carcinogenesis in livers of North Sea flatfish
    C J Van Noorden
    Academic Medical Center, University of Amsterdam, Department of Cell Biology and Histology, The Netherlands
    Biochim Biophys Acta 1342:141-8. 1997
  7. ncbi request reprint Metabolic mapping by enzyme histochemistry in living animals, tissues and cells
    C J F Van Noorden
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Physiol Pharmacol 60:125-9. 2009
  8. ncbi request reprint A quantitative method to determine the orientation of collagen fibers in the dermis
    Maril L Noorlander
    Academic Medical Center, University of Amsterdam, Departments of Cell Biology and Histology, Amsterdam, The Netherlands
    J Histochem Cytochem 50:1469-74. 2002
  9. ncbi request reprint Direct comparison of enzyme histochemical and immunohistochemical methods to localize an enzyme
    Cornelis J F Van Noorden
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, The Netherlands
    Mar Environ Res 54:575-7. 2002
  10. pmc Imaging enzymes at work: metabolic mapping by enzyme histochemistry
    Cornelis J F Van Noorden
    Department of Cell Biology and Histology, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Histochem Cytochem 58:481-97. 2010

Collaborators

Detail Information

Publications53

  1. pmc Mutational profiling of kinases in glioblastoma
    Fonnet E Bleeker
    Department of Oncology, University of Torino, SP 142, km 3, 95, Candiolo, Torino, 10060, Italy Candiolo Cancer Institute FPO, IRCCS, Candiolo, Torino, Italy
    BMC Cancer 14:718. 2014
    ..Glioblastoma is a highly malignant brain tumor for which no cure is available. To identify new therapeutic targets, we performed a mutation analysis of kinase genes in glioblastoma...
  2. pmc Increased mitochondrial activity in a novel IDH1-R132H mutant human oligodendroglioma xenograft model: in situ detection of 2-HG and α-KG
    Anna C Navis
    Department of Pathology, Radboud University Nijmegen Medical Centre, PO Box 9101, Nijmegen, 6500 HB, The Netherlands
    Acta Neuropathol Commun 1:18. 2013
    ..We here report on the analyses of E478 xenografts at the genetic, histologic and metabolic level...
  3. pmc CD34 marks angiogenic tip cells in human vascular endothelial cell cultures
    Martin J Siemerink
    Ocular Angiogenesis Group, Department of Ophthalmology and Department of Cell Biology and Histology, University of Amsterdam, Academic Medical Center, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    Angiogenesis 15:151-63. 2012
    ..This novel strategy may open alternative avenues for future studies of molecular processes and functions in tip cells in angiogenesis...
  4. pmc Experimental iodine-125 seed irradiation of intracerebral brain tumors in nude mice
    Joost J C Verhoeff
    Department of Neurosurgery, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Radiat Oncol 2:38. 2007
    ..Therefore, we developed a stereotactic brachytherapy mouse model for high-dose focal irradiation of experimental intracerebral (orthotopic) brain tumors...
  5. pmc The prognostic IDH1( R132 ) mutation is associated with reduced NADP+-dependent IDH activity in glioblastoma
    Fonnet E Bleeker
    Neurosurgical Center Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Acta Neuropathol 119:487-94. 2010
    ..The low NADPH levels may sensitize glioblastoma to irradiation and chemotherapy, thus explaining the prolonged survival of patients with mutated glioblastoma...
  6. ncbi request reprint Adaptational changes in kinetic parameters of G6PDH but not of PGDH during contamination-induced carcinogenesis in livers of North Sea flatfish
    C J Van Noorden
    Academic Medical Center, University of Amsterdam, Department of Cell Biology and Histology, The Netherlands
    Biochim Biophys Acta 1342:141-8. 1997
    ....
  7. ncbi request reprint Metabolic mapping by enzyme histochemistry in living animals, tissues and cells
    C J F Van Noorden
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Physiol Pharmacol 60:125-9. 2009
    ..Chromogenic and fluorogenic staining methods are discussed here in the context of metabolic mapping in living animals, unfixed cryostat sections of tissues and living cells...
  8. ncbi request reprint A quantitative method to determine the orientation of collagen fibers in the dermis
    Maril L Noorlander
    Academic Medical Center, University of Amsterdam, Departments of Cell Biology and Histology, Amsterdam, The Netherlands
    J Histochem Cytochem 50:1469-74. 2002
    ....
  9. ncbi request reprint Direct comparison of enzyme histochemical and immunohistochemical methods to localize an enzyme
    Cornelis J F Van Noorden
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, The Netherlands
    Mar Environ Res 54:575-7. 2002
    ..It can be concluded that enzyme histochemical methods are the methods of choice to localize enzymes because they detect the functional activity of an enzyme, they are relatively simple and their sensitivity is high...
  10. pmc Imaging enzymes at work: metabolic mapping by enzyme histochemistry
    Cornelis J F Van Noorden
    Department of Cell Biology and Histology, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Histochem Cytochem 58:481-97. 2010
    ..This review critically evaluates the methods that are available at present for metabolic mapping in living animals, unfixed cryostat sections of tissues, and living cells, and refers to protocols of the methods of choice...
  11. ncbi request reprint A simple histochemical assay to detect cancer cells
    C J Van Noorden
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, The Netherlands
    Folia Histochem Cytobiol 38:99-102. 2000
    ..Pancreatic cancer can be discriminated from pancreatitis with 100% certainty. Therefore, the assay is an excellent tool for the pathologist to provide additional information in difficult cases of diagnosis of cancer and for prognosis...
  12. ncbi request reprint Heterogeneous suppression of experimentally induced colon cancer metastasis in rat liver lobes by inhibition of extracellular cathepsin B
    C J Van Noorden
    Academic Medical Center, University of Amsterdam, Laboratory of Cell Biology and Histology, The Netherlands
    Clin Exp Metastasis 16:159-67. 1998
    ....
  13. ncbi request reprint Controlled light-exposure microscopy reduces photobleaching and phototoxicity in fluorescence live-cell imaging
    R A Hoebe
    Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 316, 1098 SM Amsterdam, The Netherlands
    Nat Biotechnol 25:249-53. 2007
    ..In addition, CLEM increases the dynamic range of the fluorescence intensity at least twofold...
  14. pmc Interactions between colon cancer cells and hepatocytes in rats in relation to metastasis
    O R F Mook
    Department of Cell Biology and Histology, University of Amsterdam, Amsterdam, The Netherlands
    J Cell Mol Med 12:2052-61. 2008
    ....
  15. ncbi request reprint Induction and detection of bystander effects after combined treatment of cells with 5-bromo-2'-deoxyurine, Hoechst 33 258 and ultraviolet A light
    Y Xiao
    Department of Cell Biology and Histology, Academic Medical Centre, M3 352, University of Amsterdam, PO Box 22700, NL 1100 DE Amsterdam, The Netherlands
    Int J Radiat Biol 80:105-14. 2004
    ..A combined treatment of cells with 5-bromo-2'-deoxyurine (BrdU), Hoechst 33 258 and ultraviolet A (UVA) light was used to introduce chromosomal aberrations in cells for the study of bystander effects in non-labelled cells...
  16. ncbi request reprint Effects of mechanical compression of a fibrous tissue interface on bone with or without high-density polyethylene particles in a rabbit model of prosthetic loosening
    F H R De Man
    Departments of Orthopaedic Surgery, Academic Medical Center, University of Amsterdam, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    J Bone Joint Surg Am 87:1522-33. 2005
    ..We tested the hypothesis that compression of a fibrous membrane with or without the presence of high-density polyethylene particles leads to bone degradation...
  17. doi request reprint Rapid combined light and electron microscopy on large frozen biological samples
    I M C Vogels
    Department of Cell Biology and Histology, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    J Microsc 235:252-8. 2009
    ..Combined LM and EM analysis revealed that these elements resemble cartilage showing enchondral mineralization and aberrant muscle fibres with characteristics of skeletal muscle cells...
  18. pmc Endogenous activated protein C is essential for immune-mediated cancer cell elimination from the circulation
    G L van Sluis
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Cancer Lett 306:106-10. 2011
    ..Overall, we thus show that endogenous APC is essential for immune-mediated cancer cell elimination...
  19. doi request reprint Noise effects and filtering in controlled light exposure microscopy
    R A Hoebe
    Centre for Microscopy Research CMO, Department of Cell Biology and Histology, Academic Medical Centre, Amsterdam, The Netherlands
    J Microsc 240:197-206. 2010
    ..It opens the possibility to use controlled light exposure microscopy even in high noise (low signal to noise ratio) imaging to further reduce phototoxicity and photobleaching...
  20. doi request reprint Quantitative determination of the reduction of phototoxicity and photobleaching by controlled light exposure microscopy
    R A Hoebe
    Centre for Microscopy Research CMO, Department of Cell Biology and Histology, Academic Medical Centre, Amsterdam, The Netherlands
    J Microsc 231:9-20. 2008
    ..Here, we introduce the CLEM factor as a quantitative measure of reduction in phototoxicity and photobleaching. Finally, we give a guideline to optimize the effect of CLEM without compromising image quality...
  21. pmc Colon cancer metastasis in mouse liver is not affected by hypercoagulability due to Factor V Leiden mutation
    C P W Klerk
    Academic Medical Center, Department of Cell Biology and Histology, University of Amsterdam, The Netherlands
    J Cell Mol Med 11:561-8. 2007
    ..Fibrin deposition and thus inhibition of fibrin formation by anticoagulants do not seem to affect tumour development in this model...
  22. ncbi request reprint The genomic profile of human malignant glioma is altered early in primary cell culture and preserved in spheroids
    P C de Witt Hamer
    Department of Neurosurgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Oncogene 27:2091-6. 2008
    ..This implies that glioma cell culture data have to be handled with the highest caution...
  23. doi request reprint Active caspase-3 is removed from cells by release of caspase-3-enriched vesicles
    A N Böing
    Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands
    Biochim Biophys Acta 1833:1844-52. 2013
    ..Furthermore, we hypothesize that packaging of caspase-3 into membrane vesicles contributes to cellular homeostasis by the removal of caspase-3, and concurrently, protects the cells' environment from direct exposure to caspase-3 activity...
  24. ncbi request reprint Induction of chromosome aberrations in unirradiated chromatin after partial irradiation of a cell nucleus
    G Ludwikow
    Center for Microscopical Research, Department of Cell Biology, University of Amsterdam, Amsterdam, The Netherlands
    Int J Radiat Biol 78:239-47. 2002
    ..Here we tested whether non-irradiated DNA participates in the formation of chromosome aberrations when complex DNA DSB are induced elsewhere in the nucleus...
  25. pmc Active HIF-1 in the normal human retina
    John M Hughes
    Department of Ophthalmology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Histochem Cytochem 58:247-54. 2010
    ..In human retina, staining of VEGF, GLUT-1, and CAIX was found. Our observations indicate that active HIF-1 signaling occurs constitutively in the normal human and rat retina, suggesting that HIF-1 has a physiological role in the retina...
  26. doi request reprint Noninvasive magnetic resonance imaging of the development of individual colon cancer tumors in rat liver
    Olaf R F Mook
    University of Amsterdam, Amsterdam, The Netherlands
    Biotechniques 44:529-35. 2008
    ..Therefore, it should preferably be used for dedicated applications rather than for high-throughput assessment of total tumor load in animals...
  27. ncbi request reprint Post-translational regulation of glucose-6-phosphate dehydrogenase activity in (pre)neoplastic lesions in rat liver
    Wilma M Frederiks
    Academic Medical Center, University of Amsterdam, Department of Cell Biology and Histology, Amsterdam, The Netherlands
    J Histochem Cytochem 51:105-12. 2003
    ..Amounts of G6PD protein and mRNA were similar in lesions and in extralesional liver parenchyma. These results demonstrate that G6PD is strongly activated post-translationally in (pre)neoplastic lesions to produce NADPH...
  28. ncbi request reprint Endogenous interferon gamma protects against cholestatic liver injury in mice
    Miguel E Sewnath
    Department of Surgery, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Hepatology 36:1466-77. 2002
    ....
  29. ncbi request reprint Metabolic control analysis aimed at the ribose synthesis pathways of tumor cells: a new strategy for antitumor drug development
    Joan Boren
    Department of Biochemistry and Molecular Biology, University of Barcelona, Catalonia, Spain
    Mol Biol Rep 29:7-12. 2002
    ....
  30. ncbi request reprint Clonal xenobiotic resistance during pollution-induced toxic injury and hepatocellular carcinogenesis in liver of female flounder (Platichthys flesus (L.))
    Angela Koehler
    Department of Ecotoxicology, Alfred Wegener Institute for Marine and Polar Research, Am Handelshafen 12, Haus C, Bremerhaven 27570, Germany
    Acta Histochem 106:155-70. 2004
    ....
  31. ncbi request reprint NADPH production by the pentose phosphate pathway in the zona fasciculata of rat adrenal gland
    Wilma M Frederiks
    Department of Cell Biology and Histology, Academic Medical Center, Amsterdam, The Netherlands
    J Histochem Cytochem 55:975-80. 2007
    ..Complete inhibition of G6PD by androsterones suggests that there is feedback regulation of steroid hormone biosynthesis via G6PD...
  32. ncbi request reprint Visualization of early events in tumor formation of eGFP-transfected rat colon cancer cells in liver
    Olaf R F Mook
    Department of Cell Biology and Histology, Academic Medical Centre, Amsterdam, The Netherlands
    Hepatology 38:295-304. 2003
    ..In conclusion, initial steps in the classic metastatic cascade such as adhesion to endothelium and extravasation are not essential for colon cancer metastasis in liver...
  33. ncbi request reprint Quantification of viability in organotypic multicellular spheroids of human malignant glioma using lactate dehydrogenase activity: a rapid and reliable automated assay
    Philip C De Witt Hamer
    Academic Medical Centre, University of Amsterdam, Dept of Neurosurgery, Room H2 230, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    J Histochem Cytochem 53:23-34. 2005
    ..We conclude that quantification of viability in cryostat sections of organotypic multicellular spheroids from malignant glioma can be performed reliably and reproducibly with this approach...
  34. ncbi request reprint Effects of statins and farnesyltransferase inhibitors on the development and progression of cancer
    Matthijs R Graaf
    Department of Clinical Pharmacy, Academic Medical Centre Amsterdam, P O Box 22660, 1100 DD Amsterdam, The Netherlands
    Cancer Treat Rev 30:609-41. 2004
    ....
  35. ncbi request reprint Interleukin-1 receptor type I gene-deficient bile duct-ligated mice are partially protected against endotoxin
    Miguel E Sewnath
    Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Hepatology 35:149-58. 2002
    ....
  36. ncbi request reprint Rapid alignment of collagen fibers in the dermis of undermined and not undermined skin stretched with a skin-stretching device
    Paris Melis
    Department of Surgical Research, Academic Medical Center, University of Amsterdam, The Netherlands
    Plast Reconstr Surg 109:674-80; discussion 681-2. 2002
    ..These dynamic changes in collagen fibers explain the significantly decreased wound closing tension resulting from skin stretching and explain how skin stretches beyond its inherent extensibility...
  37. ncbi request reprint Loss of peroxisomes causes oxygen insensitivity of the histochemical assay of glucose-6-phosphate dehydrogenase activity to detect cancer cells
    Wilma M Frederiks
    Department of Cell Biology and Histology, Academic Medical Center, Meibergdreef 15 1105 AZ, Amsterdam, The Netherlands
    J Histochem Cytochem 55:175-81. 2007
    ..It is concluded that absence of SH-sensitive G6PD activity in peroxisomes in cancer cells is responsible for the oxygen-insensitivity phenomenon...
  38. ncbi request reprint Glucose-6-phosphate dehydrogenase: the key to sex-related xenobiotic toxicity in hepatocytes of European flounder (Platichthys flesus L.)?
    Katja Winzer
    Department of Ecotoxicology and Ecophysiology, Alfred Wegener Institute for Polar and Marine Research, Bremerhaven, Germany
    Aquat Toxicol 56:275-88. 2002
    ..Moreover, the strong inhibition of G6PDH in livers of female flounder may explain higher susceptibility for xenobiotic toxicity and, therefore, potentially a higher risk to develop liver cancer...
  39. ncbi request reprint CD26/DPPIV signal transduction function, but not proteolytic activity, is directly related to its expression level on human Th1 and Th2 cell lines as detected with living cell cytochemistry
    Emil P Boonacker
    Academic Medical Center, University of Amsterdam, Department of Cell Biology and Histology, Amsterdam, The Netherlands
    J Histochem Cytochem 50:1169-77. 2002
    ..Western blotting and zymography of Th1 and Th2 whole-cell lysates demonstrated similar patterns. This study shows that two functions of one molecule can be controlled differentially...
  40. ncbi request reprint Fluorogenic substrate [Ala-Pro]2-cresyl violet but not Ala-Pro-rhodamine 110 is cleaved specifically by DPPIV activity: a study in living Jurkat cells and CD26/DPPIV-transfected Jurkat cells
    Emil Boonacker
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Histochem Cytochem 51:959-68. 2003
    ....
  41. ncbi request reprint Sex-specific biotransformation and detoxification after xenobiotic exposure of primary cultured hepatocytes of European flounder (Platichthys flesus L.)
    Katja Winzer
    Biologische Anstalt Helgoland in der Stiftung Alfred Wegener Institut, 27570 Bremerhaven, Handelshafen, Germany
    Aquat Toxicol 59:17-33. 2002
    ..These findings may explain the higher susceptibility of female flounder to toxic and carcinogenic compounds in the marine environment...
  42. ncbi request reprint Oxygenation and microcirculation during skin stretching in undermined and nonundermined skin
    Paris Melis
    Department of Plastic, Reconstructive and Hand Surgery, Academic Medical Center, University of Amsterdam, The Netherlands
    Plast Reconstr Surg 112:1295-301. 2003
    ..Furthermore, laser Doppler flowmetry seemed to produce atypical signals in monitoring of skin viability of wound edges closed with a skin-stretching device...
  43. ncbi request reprint Biochemical and cytochemical evaluation of heterozygote individuals with glucose-6-phosphate dehydrogenase deficiency
    Nilgun Gurbuz
    Department of Biochemistry, Akdeniz University, Faculty of Medicine, 07070 Antalya, Turkey
    Acta Histochem 107:261-7. 2005
    ..Therefore, this method can be used routinely to detect heterozygous G6PD deficiency...
  44. ncbi request reprint Antiprotease therapy in cancer: hot or not?
    Tamara T Lah
    Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Veccna pot 111, 1000 Ljubljana, Slovenia
    Expert Opin Biol Ther 6:257-79. 2006
    ..Moreover, metronomic therapy is an attractive approach using low doses of inhibitors for prolonged periods of time without interruption to specifically target endothelial cells that are involved in angiogenesis...
  45. ncbi request reprint Can you trust your cryostat? Reproducibility of cryostat section thickness
    Philip C De Witt Hamer
    Department of Neurosurgery, Academic Medical Center, University of Amsterdam, The Netherlands
    Microsc Res Tech 69:835-8. 2006
    ..7% for motorized sectioning and 3.3% for manual sectioning. In conclusion, section thickness is similarly reproducible after manual sectioning compared with motorized sectioning, if not better...
  46. ncbi request reprint Current perspectives on antiangiogenesis strategies in the treatment of malignant gliomas
    Marnix Jansen
    Department of Pathology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Brain Res Brain Res Rev 45:143-63. 2004
    ..Future research on endothelial markers expressed on tumor-associated vasculature as well as endothelial responses to cytotoxic treatment will provide new avenues for molecularly targeted therapy in malignant gliomas...
  47. pmc Angiogenesis is not impaired in connective tissue growth factor (CTGF) knock-out mice
    Esther J Kuiper
    Ocular Angiogenesis Group, Department of Ophthalmology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Histochem Cytochem 55:1139-47. 2007
    ..Our data show that downregulation of CTGF levels does not affect neovascularization, indicating distinct roles of VEGF and CTGF in angiogenesis and fibrosis in eye conditions...
  48. ncbi request reprint The need for metabolic mapping in living cells and tissues
    Emil Boonacker
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Acta Histochem 106:89-96. 2004
    ....
  49. ncbi request reprint Effect of VEGF-A on expression of profibrotic growth factor and extracellular matrix genes in the retina
    Esther J Kuiper
    Ocular Angiogenesis Group, Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Invest Ophthalmol Vis Sci 48:4267-76. 2007
    ..The authors hypothesize that VEGF directly contributes to BM thickening in the diabetic retina by inducing expression of profibrotic growth factors and extracellular matrix (ECM) components...
  50. ncbi request reprint Cholestatic interleukin-6-deficient mice succumb to endotoxin-induced liver injury and pulmonary inflammation
    Miguel E Sewnath
    Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Am J Respir Crit Care Med 169:413-20. 2004
    ..Although endogenous IL-6 is not important in the development of liver injury after experimentally induced obstructive jaundice, this cytokine plays an important role in decreasing hypersensitivity to endotoxin in cholestatic mice...
  51. ncbi request reprint Reduced nicotinamide adenine dinucleotide phosphate and the higher incidence of pollution-induced liver cancer in female flounder
    Angela Koehler
    Alfred Wegener Institute for Marine and Polar Research, Bremerhaven, Germany
    Environ Toxicol Chem 22:2703-10. 2003
    ..The data reviewed here suggest that these sex-related differences in NADPH metabolism are a major cause of the higher incidence of liver cancer in female flounder in polluted environments...
  52. ncbi request reprint Validity of bioluminescence measurements for noninvasive in vivo imaging of tumor load in small animals
    Clara P W Klerk
    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Biotechniques 43:7-13, 30. 2007
    ....
  53. ncbi request reprint The role of gelatinases in colorectal cancer progression and metastasis
    Olaf R F Mook
    Academic Medical Center, University of Amsterdam, Department of Cell Biology and Histology, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    Biochim Biophys Acta 1705:69-89. 2004
    ..Therefore, it is concluded that the use of MMP inhibitors to treat cancer should be considered carefully...