C J F Van Noorden


Affiliation: Academic Medical Center
Country: The Netherlands


  1. Kastelein A, Vos L, de Jong K, van Baal J, Nieuwland R, Van Noorden C, et al. Embryology, anatomy, physiology and pathophysiology of the peritoneum and the peritoneal vasculature. Semin Cell Dev Biol. 2018;: pubmed publisher
    ..Pathological processes are described to illustrate physiological and pathophysiological characteristics of the peritoneum. ..
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    Van Noorden C, Jonges T, Van Marle J, Bissell E, Griffini P, Jans M, et al. Heterogeneous suppression of experimentally induced colon cancer metastasis in rat liver lobes by inhibition of extracellular cathepsin B. Clin Exp Metastasis. 1998;16:159-67 pubmed
  3. Verbovšek U, Van Noorden C, Lah T. Complexity of cancer protease biology: Cathepsin K expression and function in cancer progression. Semin Cancer Biol. 2015;35:71-84 pubmed publisher
    ..Finally, the application of CatK inhibitors, which are already in clinical trials for treatment of osteoporosis, has a potential to attenuate cancer aggressiveness. ..
  4. Aderetti D, Hira V, Molenaar R, Van Noorden C. The hypoxic peri-arteriolar glioma stem cell niche, an integrated concept of five types of niches in human glioblastoma. Biochim Biophys Acta Rev Cancer. 2018;1869:346-354 pubmed publisher
    ..Our concept should be rigidly tested in the near future and applied to develop therapies to expel and keep GSCs out of their protective niches to render them more vulnerable to standard therapies. ..
  5. Botman D, Tigchelaar W, Van Noorden C. Determination of glutamate dehydrogenase activity and its kinetics in mouse tissues using metabolic mapping (quantitative enzyme histochemistry). J Histochem Cytochem. 2014;62:802-12 pubmed publisher
    ..In conclusion, GDH activity in mice is highest in the liver with NAD(+) as a coenzyme and highest GDH activity was determined at a glutamate concentration of 10 mM. ..
  6. Botman D, Tigchelaar W, Van Noorden C. Determination of phosphate-activated glutaminase activity and its kinetics in mouse tissues using metabolic mapping (quantitative enzyme histochemistry). J Histochem Cytochem. 2014;62:813-26 pubmed publisher
    ..In conclusion, PAG is mainly active in mouse kidney, brain and liver, and shows different kinetics depending on which type of PAG is expressed. ..
  7. Peters A, Van Noorden C. Single Cell Cytochemistry Illustrated by the Demonstration of Glucose-6-Phosphate Dehydrogenase Deficiency in Erythrocytes. Methods Mol Biol. 2017;1560:3-13 pubmed publisher
    ..The ultimate goal in the coming years will be nanoscopy of living cells so that the molecular dynamics can be studied. Cytochemistry will undoubtedly play a critical role in these developments. ..
  8. Hira V, Van Noorden C, Carraway H, Maciejewski J, Molenaar R. Novel therapeutic strategies to target leukemic cells that hijack compartmentalized continuous hematopoietic stem cell niches. Biochim Biophys Acta Rev Cancer. 2017;1868:183-198 pubmed publisher
    ..Finally, we list clinical trials of therapies that tackle LSCs in HSC niches to circumvent their protection against chemotherapy. ..
  9. Vittori M, Khurshed M, Picavet D, Van Noorden C, Strus J. Development of calcium bodies in Hylonsicus riparius (Crustacea: Isopoda). Arthropod Struct Dev. 2018;47:199-213 pubmed publisher
    ..Mineral is deposited in calcium bodies as soon as they are present. ..

More Information


  1. Wisniewska Kruk J, Klaassen I, Vogels I, Magno A, Lai C, Van Noorden C, et al. Molecular analysis of blood-retinal barrier loss in the Akimba mouse, a model of advanced diabetic retinopathy. Exp Eye Res. 2014;122:123-31 pubmed publisher