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Genomes and GenesSpecies | Andre B P van KuilenburgSummaryAffiliation: Academic Medical Center Country: The Netherlands Publications
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Publications
Evaluation of 5-fluorouracil pharmacokinetic models and therapeutic drug monitoring in cancer patientsAndré Bp van Kuilenburg
Academic Medical Center, University of Amsterdam, Emma Children s Hospital and Department of Clinical Chemistry, Laboratory Genetic Metabolic Diseases, F0 220, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Pharmacogenomics 14:799-811. 2013..These Michaelis-Menten models also allow the use of a limited sampling strategy and offer the opportunity to predict a priori the 5-FU plasma concentrations in patients receiving adapted doses of 5-FU...- ß-ureidopropionase deficiency: phenotype, genotype and protein structural consequences in 16 patientsAndre B P van Kuilenburg
Academic Medical Center, Emma Children s Hospital, Department of Clinical Chemistry, Laboratory Genetic Metabolic Diseases, 1105 AZ Amsterdam, The Netherlands
Biochim Biophys Acta 1822:1096-108. 2012..Two mutations were identified in several unrelated ß-ureidopropionase patients, indicating that ß-ureidopropionase deficiency may be more common than anticipated... 
A radiochemical assay for beta-ureidopropionase using radiolabeled N-carbamyl-beta-alanine obtained via hydrolysis of [2-(14)C]5, 6-dihydrouracilA B Van Kuilenburg
Academic Medical Center, University of Amsterdam, Emma Children s Hospital and Department of Clinical Chemistry, Amsterdam, 1100 DE, The Netherlands
Anal Biochem 272:250-3. 1999..5 +/- 1.9 microM. The assay proved to be very accurate and sensitive with an intraassay coefficient of variation of 2% and a detection limit of 28 pmol for the product CO(2)...- Activity of pyrimidine degradation enzymes in normal tissuesA B P van Kuilenburg
Academic Medical Center, University of Amsterdam, Emma Children s Hospital and Departments of Clinical Chemistry, Amsterdam, The Netherlands
Nucleosides Nucleotides Nucleic Acids 25:1211-4. 2006..However, significant residual activities of DPD, DHP and beta-UP were also present in a variety of other tissues, especially in bronchus... - A pivotal role for beta-aminoisobutyric acid and oxidative stress in dihydropyrimidine dehydrogenase deficiency?A B P van Kuilenburg
Academic Medical Center, University of Amsterdam, Emma Children s Hospital and Department of Clinical Chemistry, Amsterdam, The Netherlands
Nucleosides Nucleotides Nucleic Acids 25:1103-6. 2006..In contrast, slightly elevated levels of 8-OHdG were detected in urine from DPD patients with an age >2 year, suggesting the presence of increased oxidative stress... - Genetic analysis of the first 4 patients with beta-ureidopropionase deficiencyA B P van Kuilenburg
Department of Clinical Chemistry, Academic Medical Center, Emma Children s Hospital, Amsterdam, The Netherlands
Nucleosides Nucleotides Nucleic Acids 25:1093-8. 2006..The alanine at position 85 was not conserved in other eukaryotic beta-ureidopropionase protein sequences... - Screening for dihydropyrimidine dehydrogenase deficiency: to do or not to do, that's the questionAndre B P van Kuilenburg
Department of Clinical Chemistry, Academic Medical Center, University of Amsterdam, Emma Children s Hospital, Amsterdam, The Netherlands
Cancer Invest 24:215-7. 2006.... - Dihydropyrimidinase deficiency: Phenotype, genotype and structural consequences in 17 patientsAndre B P van Kuilenburg
Laboratory Genetic Metabolic Diseases, Department of Clinical Chemistry, Academic Medical Center, Emma Children s Hospital, 1105 AZ Amsterdam, The Netherlands
Biochim Biophys Acta 1802:639-48. 2010..S379R and p.L7V mutations were likely to cause structural destabilization and protein misfolding. Four mutations were identified in multiple unrelated DHP patients, indicating that DHP deficiency may be more common than anticipated... - Analysis of pyrimidine synthesis de novo intermediates in urine during crisis of a patient with ornithine transcarbamylase deficiencyA B P van Kuilenburg
Academic Medical Center, University of Amsterdam, Emma Children s Hospital, Laboratory Genetic Metabolic Diseases, Amsterdam, The Netherlands
Nucleosides Nucleotides Nucleic Acids 25:1251-5. 2006..The level of pyrimidine excretion appeared to be independent of the ammonia levels in blood, which were only mildly increased... - Determination of 5-fluorouracil in plasma with HPLC-tandem mass spectrometryA B P van Kuilenburg
Academic Medical Center, University of Amsterdam, Emma Children s Hospital and Department of Clinical Chemistry, Amsterdam, The Netherlands
Nucleosides Nucleotides Nucleic Acids 25:1257-60. 2006..98). Thus, HPLC with electrospray ionization tandem mass spectrometry allows the rapid analysis of 5FU levels in plasma and could, therefore, be used for therapeutic drug monitoring... - Determination of thymidine phosphorylase activity in human blood cells and fibroblasts by a nonradiochemical assay using reversed-phase high-performance liquid chromatographyA B P van Kuilenburg
Academic Medical Center, Emma Children s Hospital and Department of Clinical Chemistry, University of Amsterdam, Amsterdam, The Netherlands
Nucleosides Nucleotides Nucleic Acids 25:1261-4. 2006..The activity of TP in leukocytes proved to be intermediate compared to the TP activity observed in PBM cells and granulocytes. The activity of TP also was readily detectable in human fibroblasts... - Increased dihydropyrimidine dehydrogenase activity associated with mild toxicity in patients treated with 5-fluorouracil and leucovorinAndre B P van Kuilenburg
Academic Medical Center, University of Amsterdam, Emma Children s Hospital and Department of Clinical Chemistry, P O Box 22700, 1100 DE Amsterdam, The Netherlands
Eur J Cancer 43:459-65. 2007..002). Patients with a high-normal DPD activity proved to be at risk of developing mild toxicity upon treatment with 5FU-leucovorin, suggesting an important role of DPD in the aetiology of toxicity associated with catabolites of 5FU... - HPLC-electrospray tandem mass spectrometry for rapid determination of dihydropyrimidine dehydrogenase activityAndre B P van Kuilenburg
Emma Children s Hospital and Department of Clinical Chemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Clin Chem 53:528-30. 2007..We developed a rapid and specific method to measure the DPD activity in peripheral blood mononuclear cells using HPLC tandem-mass spectrometry (HPLC-MS/MS)... - Clinical, biochemical and genetic findings in two siblings with a dihydropyrimidinase deficiencyAndre B P van Kuilenburg
Academic Medical Center, University of Amsterdam, Emma Children s Hospital, P O Box 22700, 1100 DE Amsterdam, The Netherlands
Mol Genet Metab 91:157-64. 2007.... - Analysis of severely affected patients with dihydropyrimidine dehydrogenase deficiency reveals large intragenic rearrangements of DPYD and a de novo interstitial deletion del(1)(p13.3p21.3)Andre B P van Kuilenburg
Department of Clinical Chemistry, Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Hum Genet 125:581-90. 2009..Our study showed for the first time the presence of genomic deletions affecting DPYD in 7% (5/72) of all DPD deficient patients. Therefore, screening of DPD deficient patients for genomic deletions should be considered... - Beta-alanine and beta-aminoisobutyric acid levels in two siblings with dihydropyrimidinase deficiencyA B P van Kuilenburg
Academic Medical Center, Department of Clinical Chemistry, University of Amsterdam, Amsterdam, The Netherlands
Nucleosides Nucleotides Nucleic Acids 27:825-9. 2008..Thus, the relevance of the shortage of beta-aminoisobutyric acid for the onset of a clinical phenotype in patients with DHP deficiency remains to be established... - Pharmacokinetics of 5-fluorouracil in patients heterozygous for the IVS14+1G > A mutation in the dihydropyrimidine dehydrogenase geneA B P van Kuilenburg
Academic Medical Center, Emma Children s Hospital and Department of Clinical Chemistry, University of Amsterdam, Amsterdam, The Netherlands
Nucleosides Nucleotides Nucleic Acids 27:692-8. 2008..Thus, a DPD deficiency could be predicted from 5FU blood concentrations measured after the administration of a test dose of 5FU... - Altered dihydropyrimidine dehydrogenase activity associated with mild toxicity in patients treated with 5-fluorouracil containing chemotherapyAndre B P van Kuilenburg
Emma Children s Hospital and Department of Clinical Chemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Nucleosides Nucleotides Nucleic Acids 27:726-32. 2008.... - Determination of thymidine phosphorylase activity by a non-radiochemical assay using reversed-phase high-performance liquid chromatographyAndre B P van Kuilenburg
Academic Medical Center, University of Amsterdam, Emma Children s Hospital and Department of Clinical Chemistry, 1100 DE Amsterdam, The Netherlands
J Chromatogr B Analyt Technol Biomed Life Sci 820:271-275. 2005..8 pmol. The assay was linear with reaction times, up to at least 4 h, and protein concentrations up to at least 65 microg/ml. Population analysis showed no differences in TP activity between man and women or with increasing age... - beta-Ureidopropionase deficiency: an inborn error of pyrimidine degradation associated with neurological abnormalitiesAndre B P van Kuilenburg
Department of Clinical Chemistry, Emma Children s Hospital, The Netherlands
Hum Mol Genet 13:2793-801. 2004..Thus, a beta-ureidopropionase deficiency might not be as rare as is generally considered... - Analysis of pyrimidine synthesis "de novo" intermediates in urine and dried urine filter- paper strips with HPLC-electrospray tandem mass spectrometryAndre B P van Kuilenburg
Academic Medical Center, University of Amsterdam, Emma Children s Hospital and Departments of Clinical Chemistry, Amsterdam, The Netherlands
Clin Chem 50:2117-24. 2004..Until now, no procedure was available that allowed the analysis of all of these metabolites in a single analytical run. We describe a rapid, specific method to measure these metabolites by HPLC-tandem mass spectrometry... - Pitfalls in the diagnosis of patients with a partial dihydropyrimidine dehydrogenase deficiencyA B Van Kuilenburg
Laboratory Genetic Metabolic Diseases, F0 224, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Clin Chem 46:9-17. 2000..To identify patients suffering from complete or partial DPD deficiency and to identify pitfalls that can preclude the proper diagnosis of patients with partial DPD deficiency, a sensitive and accurate assay is necessary... - Identification of a cDNA encoding an isoform of human CTP synthetaseA B Van Kuilenburg
Academic Medical Center, University of Amsterdam, Emma Children s Hospital and Department of Clinical Chemistry, Laboratory Genetic Metabolic Diseases, PO Box 22700, 1100 DE, Amsterdam, The Netherlands
Biochim Biophys Acta 1492:548-52. 2000..The gene encoding type II CTP synthetase has been localized on chromosome Xp22... - Clinical implications of dihydropyrimidine dehydrogenase (DPD) deficiency in patients with severe 5-fluorouracil-associated toxicity: identification of new mutations in the DPD geneA B Van Kuilenburg
Academic Medical Center, University of Amsterdam, Emma Children s Hospital and Department of Clinical Chemistry, The Netherlands
Clin Cancer Res 6:4705-12. 2000..Our results demonstrated that at least 57% (8 of 14) of the patients with a reduced DPD activity have a molecular basis for their deficient phenotype... - Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: frequency of the common IVS14+1G>A mutation causing DPD deficiencyA B Van Kuilenburg
Emma Children s Hospital and Department of Clinical Chemistry, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
Clin Cancer Res 7:1149-53. 2001..In our view, the apparently high prevalence of the IVS14+1G>A mutation in the normal population, with 1.8% heterozygotes, warrants genetic screening for the presence of this mutation in cancer patients before the administration of 5FU... - Detection of beta-ureidopropionase deficiency with HPLC-electrospray tandem mass spectrometry and confirmation of the defect at the enzyme levelA B Van Kuilenburg
Academic Medical Center, University of Amsterdam, Emma Children s Hospital and Department of Clinical Chemistry, The Netherlands
J Inherit Metab Dis 24:725-32. 2001..Thus, HPLC-tandem mass specrometry proved to be a powerful tool for the initial diagnosis of patients with deficiency of beta-ureidopropionase... 
Intragenic deletions and a deep intronic mutation affecting pre-mRNA splicing in the dihydropyrimidine dehydrogenase gene as novel mechanisms causing 5-fluorouracil toxicityAndre B P van Kuilenburg
Department of Clinical Chemistry, Academic Medical Center, Emma Children s Hospital, University of Amsterdam, Amsterdam, The Netherlands
Hum Genet 128:529-38. 2010..We conclude that screening for DPD deficiency should include a search for genomic rearrangements and aberrant splicing...- Novel disease-causing mutations in the dihydropyrimidine dehydrogenase gene interpreted by analysis of the three-dimensional protein structureAndre B P van Kuilenburg
Academic Medical Center, University of Amsterdam, Emma Children s Hospital and Department of Chemistry, The Netherlands
Biochem J 364:157-63. 2002..Our data demonstrate for the first time the possible consequences of missense mutations in the DPD gene on the function and stability of the DPD enzyme... - Increased risk of grade IV neutropenia after administration of 5-fluorouracil due to a dihydropyrimidine dehydrogenase deficiency: high prevalence of the IVS14+1g>a mutationAndre B P van Kuilenburg
Emma Children s Hospital and Department of Clinical Chemistry, Academic Medical Center, University of Amsterdam, The Netherlands
Int J Cancer 101:253-8. 2002.... - Dihydropyrimidine dehydrogenase deficiency caused by a novel genomic deletion c.505_513del of DPYDA B P van Kuilenburg
Academic Medical Center, Amsterdam, The Netherlands
Nucleosides Nucleotides Nucleic Acids 29:509-14. 2010..No DPD activity could be detected in peripheral blood mononuclear cells. Analysis of the gene encoding DPD (DPYD) showed that the patient was homozygous for a novel c.505_513del (p.169_171del) mutation in exon 6 of DPYD... - High prevalence of the IVS14 + 1G>A mutation in the dihydropyrimidine dehydrogenase gene of patients with severe 5-fluorouracil-associated toxicityAndré B Van Kuilenburg
Academic Medical Center, University of Amsterdam, Emma Children s Hospital and Department of Clinical Chemistry, Amsterdam, The Netherlands
Pharmacogenetics 12:555-8. 2002..The apparently high prevalence of the IVS14 + 1G>A mutation warrants genetic screening for this mutation in cancer patients before the administration of 5FU... - Identification of purine nucleoside phosphorylase deficiency in dried blood spots by a non-radiochemical assay using reversed-phase high-performance liquid chromatographyA B P van Kuilenburg
Academic Medical Center, Emma Children s Hospital, Laboratory Genetic Metabolic Diseases, Amsterdam, The Netherlands
Nucleosides Nucleotides Nucleic Acids 29:466-70. 2010..614A > C mutation (p.E205A) in the PNP gene was 34% compared to controls. Thus, the analysis of the PNP activity in blood spots can readily detect patients with a PNP deficiency... - Pharmacogenetic and clinical aspects of dihydropyrimidine dehydrogenase deficiencyAndre B P van Kuilenburg
Academic Medical Center, University of Amsterdam, Laboratory of Genetic Metabolic Diseases, Emma Children s Hospital and Department of Clinical Chemistry, PO Box 22700, 1100 DE Amsterdam
Ann Clin Biochem 40:41-5. 2003.... - Determination of adenosine deaminase activity in dried blood spots by a nonradiochemical assay using reversed-phase high-performance liquid chromatographyA B P van Kuilenburg
Academic Medical Center, Emma Children s Hospital, Laboratory Genetic Metabolic Diseases, Amsterdam, The Netherlands
Nucleosides Nucleotides Nucleic Acids 29:461-5. 2010..In addition, increased ADA activity as found in a rare form of congenital anemia can be assessed, as observed in a bloodspot from a patient diagnosed with Diamond Blackfan anemia (ADA activity 150 nmol/mg/h)... - New insights in dihydropyrimidine dehydrogenase deficiency: a pivotal role for beta-aminoisobutyric acid?Andre B P van Kuilenburg
Emma Children s Hospital and Department of Clinical Chemistry, Academic Medical Center, University of Amsterdam, The Netherlands
Biochem J 379:119-24. 2004..Furthermore, the observation that the R-enantiomer of beta-AIB is abundantly present in the urine of DPD patients suggests that significant cross-over exists between the thymine and valine catabolic pathways... - Quantification of 5,6-dihydrouracil by HPLC-electrospray tandem mass spectrometryAndre B P van Kuilenburg
Academic Medical Center, University of Amsterdam, Emma Children s Hospital and Department of Clinical Chemistry, PO Box 22700, 1100 DE Amsterdam, The Netherlands
Clin Chem 50:236-8. 2004 - Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracilAndre B P van Kuilenburg
Academic Medical Center, University of Amsterdam, Emma Children s Hospital and Department of Clinical Chemistry, PO Box 22700, 1100 DE Amsterdam, The Netherlands
Eur J Cancer 40:939-50. 2004..The IVS14+1G>A mutation proved to be the most common one and was detected in 24-28% of all patients suffering from severe 5-FU toxicity. Thus, a deficiency of DPD appears to be an important pharmacogenetic syndrome... - Identification of two novel mutations C79X and R235Q in the dihydropyrimidine dehydrogenase gene in a patient presenting with hematuriaA B P van Kuilenburg
Academic Medical Center, Department of Clinical Chemistry, University of Amsterdam, Emma Children s Hospital, Amsterdam, The Netherlands
Nucleosides Nucleotides Nucleic Acids 27:809-15. 2008..Analysis of the crystal structure of pig DPD suggested that the R235Q mutation might interfere with the binding of FAD and the electron flow between the NADPH and the pyrimidine substrate site of DPD... - Cyclopentenyl cytosine primes SK-N-BE(2)c neuroblastoma cells for cytarabine toxicityJörgen Bierau
Department of Clinical Chemistry, Emma Children s Hospital, Academic Medical Center, University of Amsterdam, The Netherlands
Int J Cancer 103:387-92. 2003..In contrast, AraC alone did not induce caspase-3 activity. Our results demonstrate that low concentrations of CPEC profoundly increase the cytostatic properties of AraC toward SK-N-BE(2)c human neuroblastoma cells... - Cyclopentenyl cytosine-induced activation of deoxycytidine kinase increases gemcitabine anabolism and cytotoxicity in neuroblastomaJörgen Bierau
Academic Medical Center, Department of Clinical Chemistry and Emma Children s Hospital, University of Amsterdam, 1100 Amsterdam, DE, The Netherlands
Cancer Chemother Pharmacol 57:105-13. 2006..In conclusion, the combination of dFdC and CPEC is highly toxic to neuroblastoma in vitro... - Dihydropyrimidinase deficiency and severe 5-fluorouracil toxicityAndre B P van Kuilenburg
Academic Medical Center, University of Amsterdam, Emma Children s Hospital, and Department of Clinical Chemistry, 1100 DE Amsterdam, The Netherlands
Clin Cancer Res 9:4363-7. 2003..5%. Our results show that a partial DHP deficiency is a novel pharmacogenetic disorder associated with severe 5FU toxicity... - Retinoic acid reduces the cytotoxicity of cyclopentenyl cytosine in neuroblastoma cellsJörgen Bierau
Academic Medical Center, University of Amsterdam, Department of Clinical Chemistry and Emma Children s Hospital, P O Box 22700, 1100 DE, Amsterdam, The Netherlands
FEBS Lett 527:229-33. 2002..Retinoic acid likely confers resistance of neuroblastoma cells to CPEC in part by slowing down proliferation, and in part by shifting the synthesis of CTP towards the salvage of cytidine, thereby bypassing CTP synthetase... - Fenretinide induces mitochondrial ROS and inhibits the mitochondrial respiratory chain in neuroblastomaRoos Cuperus
Laboratory Genetic Metabolic Diseases, Department of Pediatrics Emma Children s Hospital, Academic Medical Centre, University of Amsterdam, P O Box 22700, 1100 DE, Amsterdam, The Netherlands
Cell Mol Life Sci 67:807-16. 2010..The cytotoxicity of fenretinide was exerted through the generation of mitochondrial ROS and, at higher concentrations, also through inhibition of the mitochondrial respiratory chain... - Evaluation of 5-fluorouracil pharmacokinetics in cancer patients with a c.1905+1G>A mutation in DPYD by means of a Bayesian limited sampling strategyAndre B P van Kuilenburg
Academic Medical Center, University of Amsterdam, Emma Childrens Hospital and Department of Clinical Chemistry, Amsterdam, The
Clin Pharmacokinet 51:163-74. 2012..The aim of this study was to evaluate the pharmacokinetics of 5FU and to develop a limited sampling strategy to detect decreased 5FU elimination in patients with a c.1905+1G>A-related DPD deficiency... - Promising effects of the 4HPR-BSO combination in neuroblastoma monolayers and spheroidsRoos Cuperus
Laboratory of Genetic Metabolic Diseases and Department of Pediatrics Emma Children s Hospital, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
Free Radic Biol Med 51:1213-20. 2011..This indicates that the 4HPR-BSO combination might be a promising new strategy in the treatment of neuroblastoma... - Synergistic interaction between cisplatin and gemcitabine in neuroblastoma cell lines and multicellular tumor spheroidsOdette G Besançon
Academic Medical Center, University of Amsterdam, Laboratory Genetic Metabolic Diseases, PO Box 22700, 1100 DE Amsterdam, The Netherlands
Cancer Lett 319:23-30. 2012..Therefore, we feel that inclusion of gemcitabine into cisplatin-containing regiments might be a promising new strategy for the treatment of neuroblastoma... - Identification of three novel mutations in the dihydropyrimidine dehydrogenase gene associated with altered pre-mRNA splicing or protein functionAndre B P van Kuilenburg
Academic Medical Center, University of Amsterdam, Emma Children s Hospital and Department of Clinical Chemistry, P O Box 22700, NL 1100 DE Amsterdam, The Netherlands
Biol Chem 386:319-24. 2005..The identification of these novel mutations in DPYD will allow the identification of patients with an increased risk of developing severe 5FU-associated toxicity... - Cyclopentenyl cytosine has biological and anti-tumour activity, but does not enhance the efficacy of gemcitabine and radiation in two animal tumour modelsChris van Bree
Department of Radiation Oncology, Laboratory for Experimental Oncology and Radiobiology, Academic Medical Centre University of Amsterdam, 1100 DE Amsterdam, The Netherlands
Int J Oncol 34:813-9. 2009..In conclusion, future clinical development of CPEC as a modulator of gemcitabine combined with radiation is unlikely... - 5-fluorocytosine-related bone-marrow depression and conversion to fluorouracil: a pilot studyAndras Vermes
Department of Clinical Pharmacy, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Fundam Clin Pharmacol 16:39-47. 2002..These findings may be explained by the fact that our patients received 5-FC intravenously instead of orally, therefore not allowing active conversion of 5-FC to 5-FU by the human intestinal microflora... - Cholestasis is associated with hepatic microvascular dysfunction and aberrant energy metabolism before and during ischemia-reperfusionJaap J Kloek
Department of Experimental Surgery, Academic Medical Center, Amsterdam, The Netherlands
Antioxid Redox Signal 17:1109-23. 2012.... - 6-mercaptopurine inhibits atherosclerosis in apolipoprotein e*3-leiden transgenic mice through atheroprotective actions on monocytes and macrophagesThijs W H Pols
Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netherlands
Arterioscler Thromb Vasc Biol 30:1591-7. 2010..Here, we aimed to gain knowledge on the action of 6-MP in atherosclerosis, with a focus on monocytes and macrophages... - Pleiotropic effects of fenretinide in neuroblastoma cell lines and multicellular tumor spheroidsRoos Cuperus
Laboratory Genetic Metabolic Diseases and Department of Pediatrics Emma Children s Hospital, Academic Medical Centre, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
Int J Oncol 32:1011-9. 2008..Our results suggest that 4-HPR might be a promising agent for the treatment of micrometastases and high-risk neuroblastoma... - Cyclopentenyl cytosine increases the phosphorylation and incorporation into DNA of 1-beta-D-arabinofuranosyl cytosine in a human T-lymphoblastic cell lineArnauld C Verschuur
Laboratory of Genetic Metabolic Diseases, Division of Clinical Chemistry, Academic Medical Centre, University of Amsterdam, Emma Kinderziekenhuis AMC, Amsterdam, The Netherlands
Int J Cancer 98:616-23. 2002..The modulation by CPEC of araC metabolism was accompanied by a synergistic increase of araC-induced apoptosis and by an additive effect on the araC-induced growth inhibition... - Paradoxical elevated thiopurine S-methyltransferase activity after pancytopenia during azathioprine therapy: potential influence of red blood cell ageNanne K H de Boer
Gastroenterology and Hepatology, VU University Medical Center, Amsterdam, The Netherlands
Ther Drug Monit 30:390-3. 2008..Determination of a patient's TPMT status by phenotyping should therefore not be performed just after bone marrow depression or in cases of activated erythropoieses... - Mycophenolate mofetil inhibits T-cell proliferation in kidney transplant recipients without lowering intracellular dGTP and GTPSanjay U C Sankatsing
Division of Infectious Diseases, Tropical Medicine and AIDS, Department of Internal Medicine, and Center for Infection and Immunity Amsterdam CINIMA, University of Amsterdam, Amsterdam, The Netherlands
Transpl Int 21:1066-71. 2008..MMF inhibits T-lymphocyte proliferation in kidney transplant recipients without lowering intracellular dGTP or GTP levels. This suggests another mechanism underlying its immunosuppressive capacity...