G Tytgat

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi Review article: Helicobacter pylori: where are we and where are we going?
    G N Tytgat
    Department of Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands
    Aliment Pharmacol Ther 14:55-8. 2000
  2. ncbi Examination of small bowel enzymes in chronic diarrhea
    Marcellus Simadibrata
    Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Indonesia
    J Gastroenterol Hepatol 18:53-6. 2003
  3. ncbi The selective serotonin reuptake inhibitor fluoxetine does not change rectal sensitivity and symptoms in patients with irritable bowel syndrome: a double blind, randomized, placebo-controlled study
    Sjoerd D Kuiken
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Clin Gastroenterol Hepatol 1:219-28. 2003
  4. ncbi Esophagology: challenges and achievements in 2006
    Guido N J Tytgat
    Curr Opin Gastroenterol 22:396-8. 2006
  5. ncbi The pathogenicity of cytomegalovirus in inflammatory bowel disease: a systematic review and evidence-based recommendations for future research
    Daniel W Hommes
    Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands
    Inflamm Bowel Dis 10:245-50. 2004
  6. doi Endoscopist's view of the future role of the gastroenterologist in digestive oncology
    Guido N J Tytgat
    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Dig Dis 14:109-12. 2013
  7. doi Recent developments in gastroesophageal reflux disease and Barrett's esophagus: ANNO 2012
    Guido N J Tytgat
    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Dig Dis 13:291-5. 2012
  8. doi Etiopathogenetic principles and peptic ulcer disease classification
    G N J Tytgat
    Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Dig Dis 29:454-8. 2011
  9. ncbi Hyoscine butylbromide - a review on its parenteral use in acute abdominal spasm and as an aid in abdominal diagnostic and therapeutic procedures
    Guido N Tytgat
    Academisch Medisch Centrum, Amsterdam, The Netherlands
    Curr Med Res Opin 24:3159-73. 2008
  10. ncbi Contemporary understanding and management of reflux and constipation in the general population and pregnancy: a consensus meeting
    G N Tytgat
    Academisch Medisch Centrum, Amsterdam, The Netherlands
    Aliment Pharmacol Ther 18:291-301. 2003

Collaborators

Detail Information

Publications50

  1. ncbi Review article: Helicobacter pylori: where are we and where are we going?
    G N Tytgat
    Department of Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands
    Aliment Pharmacol Ther 14:55-8. 2000
    ..The long-term consequences of the rising resistance to the 'key' antimicrobials are so far unknown and speculative...
  2. ncbi Examination of small bowel enzymes in chronic diarrhea
    Marcellus Simadibrata
    Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Indonesia
    J Gastroenterol Hepatol 18:53-6. 2003
    ..In Indonesia, the proportion of daily carbohydrate intake is approximately 60-80%. A number of small bowel disorders can result in the impairment of absorption and enzyme deficiency. Chronic diarrhea is common in Indonesia...
  3. ncbi The selective serotonin reuptake inhibitor fluoxetine does not change rectal sensitivity and symptoms in patients with irritable bowel syndrome: a double blind, randomized, placebo-controlled study
    Sjoerd D Kuiken
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Clin Gastroenterol Hepatol 1:219-28. 2003
    ....
  4. ncbi Esophagology: challenges and achievements in 2006
    Guido N J Tytgat
    Curr Opin Gastroenterol 22:396-8. 2006
  5. ncbi The pathogenicity of cytomegalovirus in inflammatory bowel disease: a systematic review and evidence-based recommendations for future research
    Daniel W Hommes
    Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands
    Inflamm Bowel Dis 10:245-50. 2004
    ..We identified and analyzed more than 30 case reports and 9 case series. Based on these results, we propose a model for viral replication during inflammation and provide recommendations for future research...
  6. doi Endoscopist's view of the future role of the gastroenterologist in digestive oncology
    Guido N J Tytgat
    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Dig Dis 14:109-12. 2013
    ..This article reflects the spectrum of expertise that will be necessary to guarantee optimal service...
  7. doi Recent developments in gastroesophageal reflux disease and Barrett's esophagus: ANNO 2012
    Guido N J Tytgat
    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Dig Dis 13:291-5. 2012
    ..The long-term results of the combination of resection and ablation are exiting and at least comparable to surgical resection...
  8. doi Etiopathogenetic principles and peptic ulcer disease classification
    G N J Tytgat
    Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Dig Dis 29:454-8. 2011
    ..Partial prophylaxis of ASA/NSAID-induced ulceration is possible with PPI maintenance therapy, but novel ways to strengthen the mucosal defense are urgently awaited...
  9. ncbi Hyoscine butylbromide - a review on its parenteral use in acute abdominal spasm and as an aid in abdominal diagnostic and therapeutic procedures
    Guido N Tytgat
    Academisch Medisch Centrum, Amsterdam, The Netherlands
    Curr Med Res Opin 24:3159-73. 2008
    ..With the generic and trade name of the drug combined with various search terms related to the relevant clinical applications, a thorough literature search was performed in the Medline and EMBASE databases in April 2008...
  10. ncbi Contemporary understanding and management of reflux and constipation in the general population and pregnancy: a consensus meeting
    G N Tytgat
    Academisch Medisch Centrum, Amsterdam, The Netherlands
    Aliment Pharmacol Ther 18:291-301. 2003
    ..Lack of definitive guidelines in pharmacy and general practice medicine further exacerbates the decision dilemma...
  11. ncbi Role of surveillance in intestinal metaplasia of the esophagus and gastroesophageal junction
    Guido N J Tytgat
    Department of Gastroenterology and Hepatology, Academic Medical Center at the University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    World J Surg 27:1021-5. 2003
    ..Furthermore, special attention is given to the endoscopic detection of dysplasia and early malignancy. Finally, the costs of endoscopic surveillance and its effect on mortality rates from esophageal adenocarcinoma are discussed...
  12. ncbi New algorithm for the treatment of gastro-oesophageal reflux disease
    G N Tytgat
    Department of Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands
    Aliment Pharmacol Ther 27:249-56. 2008
    ..Guidelines usually do not provide a clear guidance for all healthcare professionals with whom the patient may consult...
  13. ncbi Cancer of the esophagus and gastric cardia: recent advances
    G N J Tytgat
    Academic Medical Centre, Amsterdam, NL
    Dis Esophagus 17:10-26. 2004
    ....
  14. ncbi Are there unmet needs in acid suppression?
    G N J Tytgat
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Best Pract Res Clin Gastroenterol 18:67-72. 2004
    ..Moreover, rebound acid secretion after abrupt stopping of PPI therapy may favour early symptomatic relapse, necessating step-down therapy to prevent prolongation of the need of acid suppression...
  15. ncbi Clinical and laboratory studies of the antacid and raft-forming properties of Rennie alginate suspension
    G N Tytgat
    Academisch Medisch Centrum, Amsterdam, The Netherlands
    Aliment Pharmacol Ther 23:759-65. 2006
    ..Acid pockets at the gastro-oesophageal junction escape buffering from meals in the stomach. Combining high-dose antacid with alginate may therefore be of benefit in gastro-oesophageal reflux disease...
  16. ncbi Hyoscine butylbromide: a review of its use in the treatment of abdominal cramping and pain
    Guido N Tytgat
    Academisch Medisch Centrum, Amsterdam, The Netherlands
    Drugs 67:1343-57. 2007
    ..In summary, hyoscine butylbromide appears to be a valuable treatment option for patients with symptoms of abdominal pain or discomfort associated with cramping...
  17. ncbi Reflections on the future of gastroenterology--unmet needs
    G N J Tytgat
    Academic Medical Center, Amsterdam, The Netherlands
    Adv Med Sci 52:7-10. 2007
  18. ncbi The value of esophageal histology in the diagnosis of gastroesophageal reflux disease in patients with heartburn and normal endoscopy
    Guido N J Tytgat
    Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Curr Gastroenterol Rep 10:231-4. 2008
    ..This may change if future studies reveal a high sensitivity and specificity of biopsies obtained from the squamocolumnar junction and the tops of the mucosal folds at 2 cm and 4 to 5 cm in patients with neGERD...
  19. ncbi Review article: management of mild and severe gastro-oesophageal reflux disease
    G N J Tytgat
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Aliment Pharmacol Ther 17:52-6. 2003
    ....
  20. ncbi Efficacy and safety of oral ridogrel in the treatment of ulcerative colitis: two multicentre, randomized, double-blind studies
    G N J Tytgat
    Academisch Medisch Centrum, Amsterdam Zuidoost, The Netherlands
    Aliment Pharmacol Ther 16:87-99. 2002
    ..Ridogrel at low doses inhibits thromboxane synthase. Oral ridogrel, from 5 mg once daily to 150 mg twice daily, improves the endoscopic appearance of colonic mucosa and clinical manifestations in mild to moderate ulcerative colitis...
  21. ncbi Treatment of peptic ulcer
    G N Tytgat
    Academic Medical Center, Department of Gastroenterology and Hepatology, Amsterdam, The Netherlands
    Digestion 59:446-52. 1998
    ..Whether higher doses are occasionally necessary in H. pylori-negative ulcers, requires further study. Acid-suppressant therapy, even when prolonged, so far appears safe and well tolerated...
  22. ncbi Barrett's esophagus: is it all that bad?
    G N Tytgat
    Academic Medical Center, Department of Gastroenterology and Hepatology, Amsterdam, The Netherlands
    Can J Gastroenterol 13:385-8. 1999
    ..Therefore, implementation of an endoscopic surveillance program for patients in whom intestinal metaplasia has been detected in the distal esophagus or at the esophagogastric junction seems to be a reasonable option...
  23. ncbi Ulcers and gastritis
    G N Tytgat
    Academic Medical Center, Dept of Gastroenterology and Hepatology, Amsterdam, The Netherlands
    Endoscopy 32:108-17. 2000
    ..Eradication therapy is largely dominated by proton-pump inhibitor triple therapies, although the efficacy of these is declining. Bismuth triple therapy and quadruple therapy continue to be valid alternatives...
  24. ncbi Helicobacter pylori: past, present and future
    G Tytgat
    Academic Medical Center, Amsterdam Zuidoost, The Netherlands
    J Gastroenterol Hepatol 15:G30-3. 2000
    ..The long-term consequences of the rising resistance to the 'key' antimicrobials are so far unknown, because few data are available on therapeutic outcomes in routine practice outside pharmaceutical trials...
  25. ncbi Review article: long-term use of proton pump inhibitors in GORD--help or hindrance?
    G N Tytgat
    Department of Gastroenterology and Hepatology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam Zuidoost, The Netherlands
    Aliment Pharmacol Ther 15:6-9. 2001
    ..We conclude that the therapeutic balance tips toward proton pump inhibitors for treatment of GORD because their limitations are largely surpassed by excellent clinical efficacy, tolerance, and lack of serious adverse effects...
  26. ncbi Shortcomings of the first-generation proton pump inhibitors
    G N Tytgat
    Academic Medical Centre, Department of Gastroenterology and Hepatology, Amsterdam, The Netherlands
    Eur J Gastroenterol Hepatol 13:S29-33. 2001
    ....
  27. ncbi A physician with a positive hepatitis C virus RNA test after a needlestick injury
    Christine J Weegink
    Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands
    Eur J Gastroenterol Hepatol 15:1367-9. 2003
    ..The rationale of the decision to continue therapy is discussed. This information may be useful for clinicians confronted with a similar dilemma...
  28. ncbi Geographic pathology of Helicobacter pylori gastritis
    Yi Liu
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Helicobacter 10:107-13. 2005
    ..pylori-infected patients from different geographical areas using the same grading system. The prevalence of atrophy and intestinal metaplasia were also compared with the respective gastric cancer incidence in the different countries...
  29. ncbi Outcome of peptic ulcer bleeding, nonsteroidal anti-inflammatory drug use, and Helicobacter pylori infection
    Dewkoemar Ramsoekh
    Department of Gastroenterology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Clin Gastroenterol Hepatol 3:859-64. 2005
    ..NSAIDs and Helicobacter pylori are risk factors for the development of peptic ulcers. A prospective study was conducted to determine prevalence of NSAID use, H pylori infection, and outcome of peptic ulcer bleeding...
  30. ncbi Intestinal metaplasia of the esophagus or esophagogastric junction: evidence of distinct clinical, pathologic, and histochemical staining features
    Johanna W van Sandick
    Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands
    Am J Clin Pathol 117:117-25. 2002
    ..IM-EGJ and IM-CLE should be considered as separate entities. Further research is needed to evaluate whether neoplastic progression of IM-EGJ is related to its mucin profile...
  31. ncbi A randomized crossover study comparing light-induced fluorescence endoscopy with standard videoendoscopy for the detection of early neoplasia in Barrett's esophagus
    Mohammed A Kara
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Gastrointest Endosc 61:671-8. 2005
    ..The aim of this study was to compare LIFE with standard endoscopy (SE) in a randomized crossover study...
  32. ncbi Discussion on antro-fundic dysfunction in functional dyspepsia
    Guy E E Boeckxstaens
    Division of Gastroenterology, Academia Medical Center, Amsterdam, The Netherlands
    Gastroenterology 126:381-2. 2004
  33. ncbi Cyclooxygenase-2 expression during carcinogenesis in the human stomach
    Bastiaan P van Rees
    Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands
    J Pathol 196:171-9. 2002
    ..COX-2 expression increases during tumour progression in the stomach, suggesting a role for COX-2 expression in gastric tumourigenesis...
  34. ncbi The presence and mucin histochemistry of cardiac type mucosa at the esophagogastric junction
    Willem A Marsman
    Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands
    Am J Gastroenterol 99:212-7. 2004
    ..As a contribution to this debate, we evaluated the presence of cardiac mucosa at the esophagogastric junction (EGJ) in a random group of patients who presented at our endoscopy unit...
  35. ncbi Conscious sedation for EUS of the esophagus and stomach: a double-blind, randomized, controlled trial comparing midazolam with placebo
    Peter I Bonta
    Department of Gastroenterology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Gastrointest Endosc 57:842-7. 2003
    ..A double-blind, prospective, randomized trial was conducted to compare midazolam with a placebo for EUS of the esophagus and stomach and to assess patient tolerance and endoscopic feasibility...
  36. ncbi Role of endogenous nitric oxide in regulating antropyloroduodenal motility in humans
    Sjoerd D Kuiken
    Division of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Am J Gastroenterol 97:1661-7. 2002
    ..Therefore, we investigated the effect of the NO synthase inhibitor N(G)-monomethyl-L-arginine (L-NMMA) on antral, pyloric, and small intestinal postprandial motility in healthy volunteers...
  37. ncbi Invasive carcinoma after endoscopic ablative therapy for high-grade dysplasia in Barrett's oesophagus
    Richard van Hillegersberg
    Department of Surgery, Academic Medical Centre, Amsterdam, The Netherlands
    Dig Surg 20:440-4. 2003
    ..Patients with high-grade dysplasia (HGD) in Barrett's oesophagus carry a significant risk of developing adenocarcinoma. Endoscopic mucosal resection (EMR) and photodynamic therapy (PDT) aim at the radical ablation of the dysplastic area...
  38. ncbi Postoperative ileus is maintained by intestinal immune infiltrates that activate inhibitory neural pathways in mice
    Wouter J de Jonge
    Department of Gastroenterology and Hepatology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Gastroenterology 125:1137-47. 2003
    ..We aimed to study its pathophysiology in a murine model by determining gastric emptying after manipulation of the small intestine...
  39. ncbi Follow-up for high-grade dysplasia in Barrett's esophagus
    Mohammed A Kara
    Department of Gastroenterology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Gastrointest Endosc Clin N Am 13:513-33, viii. 2003
    ..Furthermore, the article will also discuss endoscopic techniques currently available for surveillance of these patients and make recommendations regarding surveillance intervals and the optimal biopsy protocol...
  40. ncbi Gene therapy for esophageal carcinoma: the use of an explant model to test adenoviral vectors ex vivo
    Willem A Marsman
    Department of Experimental Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Cancer Gene Ther 11:289-96. 2004
    ..The transduction was limited and localized in specific cells. RGD-targeted adenovirus did not show an improved transduction in this system...
  41. pmc Assessment of clarithromycin-resistant Helicobacter pylori among patients in Shanghai and Guangzhou, China, by primer-mismatch PCR
    Zhi jun Pan
    Department of Medical Microbiology, Academic Medical Center, Amsterdam, The Netherlands
    J Clin Microbiol 40:259-61. 2002
    ..The remaining isolates were primer-mismatch PCR negative and susceptible to clarithromycin. The conclusion is that the prevalence of clarithromycin-resistant H. pylori isolates among these Chinese patients is 5%...
  42. ncbi Helicobacter pylori in intensive care
    Peter H J van der Voort
    Intensive Care Med 30:1245-6. 2004
  43. ncbi Oral S(+)-ketamine does not change visceral perception in health
    Sjoerd D Kuiken
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Dig Dis Sci 49:1745-51. 2004
    ..sKET does not reduce visceral perception or gastric motility in healthy volunteers. The role of sKET in conditions characterized by visceral hypersensitivity needs to be studied further...
  44. ncbi Duration of antibiotic therapy for cholangitis after successful endoscopic drainage of the biliary tract
    Anja U G van Lent
    Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, Amsterdam, The Netherlands
    Gastrointest Endosc 55:518-22. 2002
    ..It is unknown whether it is necessary to continue therapy with antibiotics once biliary drainage is achieved and signs of systemic inflammation have subsided...
  45. ncbi Intragastric balloon for treatment-resistant obesity: safety, tolerance, and efficacy of 1-year balloon treatment followed by a 1-year balloon-free follow-up
    Elisabeth M H Mathus-Vliegen
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Gastrointest Endosc 61:19-27. 2005
    ..Therefore, fundamental requirements for optimal balloon designs were defined. The aim of the present study was to investigate the effectiveness, the safety, and the tolerance of a new intragastric balloon...
  46. ncbi Molecular evidence for the same clonal origin of both components of an adenosquamous Barrett carcinoma
    Bastiaan P van Rees
    Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands
    Gastroenterology 122:784-8. 2002
    ..These findings suggest that this biphasic tumor has a monoclonal origin. The divergence presumably occurred late in the tumorigenesis of this carcinoma...
  47. ncbi Agreement between endoscopic and histological gastric atrophy scores
    Yi Liu
    Department of Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Postbus 22660, 1100 DD, Amsterdam, The Netherlands
    J Gastroenterol 40:123-7. 2005
    ..This study was conducted to investigate the strength of agreement between the endoscopic atrophic border (EAB) and the histological score for atrophy...
  48. ncbi The development and validation of an endoscopic grading system for Barrett's esophagus: the Prague C & M criteria
    Prateek Sharma
    Department of Veterans Affairs Medical Center, University of Kansas School of Medicine, Kansas City, Missouri, USA
    Gastroenterology 131:1392-9. 2006
    ..We aimed to develop and validate explicit, consensus-driven criteria for the endoscopic diagnosis and grading of BE...
  49. ncbi Reflections by an endoscopist
    Guido N J Tytgat
    Organisation Mondiale de Gastroenterologie OMGE, World Organization of Gastroenterology, Amsterdam, The Netherlands
    Gastrointest Endosc 58:S46-7. 2003
  50. ncbi Abnormal distribution of the interstitial cells of cajal in an adult patient with pseudo-obstruction and megaduodenum
    Guy E Boeckxstaens
    Division of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Am J Gastroenterol 97:2120-6. 2002
    ..These findings suggest that abnormalities in ICC may contribute to the disturbed motility in some myopathic forms of intestinal pseudo-obstruction...