Genomes and Genes
J W ten Cate
Affiliation: Academic Medical Center
Country: The Netherlands
- Evolution of therapies in deep vein thrombosis managementJ W ten Cate
Faculty of Medicine, University of Amsterdam, The Netherlands
Blood Coagul Fibrinolysis 10:S5-10. 1999..This review provides a brief overview of DVT prophylaxis and treatment, focusing on the historical developments in the use of heparin, and highlighting the likely direction of future progress...
- Is the prevalence of the factor V Leiden mutation in patients with pulmonary embolism and deep vein thrombosis really different?F Turkstra
Center for Haemostasis, Thrombosis, Artherosclerosis and Inflammation Research, Academic Medical Center, University of Amsterdam, The Netherlands
Thromb Haemost 81:345-8. 1999..Previous investigations have suggested a lower prevalence of the factor V Leiden mutation in patients with pulmonary embolism, as compared to patients with deep leg vein thrombosis...
- Prediction of the risk of bleeding during anticoagulant treatment for venous thromboembolismP M Kuijer
Center for Haemostasis, Thrombosis, Atherosclerosis, and Inflammation Research, University of Amsterdam, The Netherlands
Arch Intern Med 159:457-60. 1999....
- Platelet-activating factor antagonist TCV-309 attenuates the induction of the cytokine network in experimental endotoxemia in chimpanzeesB Kuipers
Center of Hemostasis, Thrombosis, Atherosclerosis and Inflammation Research, University of Amsterdam, The Netherlands
J Immunol 152:2438-46. 1994..PAF does not seem to be an important intermediate factor in endotoxin-induced neutrophilia or neutrophil degranulation...
- Inhibition of the release of soluble tumor necrosis factor receptors in experimental endotoxemia by an anti-tumor necrosis factor-alpha antibodyJ Jansen
Center for Hemostasis, Thrombosis, Atherosclerosis and Inflammation Research, University of Amsterdam, The Netherlands
J Clin Immunol 15:45-50. 1995..Our results indicate that tumor necrosis factor-alpha is a prime mediator of endotoxin-induced release of its own soluble receptors...
- Tumor necrosis factor is involved in the appearance of interleukin-1 receptor antagonist in endotoxemiaT van der Poll
Center of Hemostasis, Thrombosis, Atherosclerosis, and Inflammation Research, Academic Medical Center, University of Amsterdam, Netherlands
J Infect Dis 169:665-7. 1994..Neutralization of the early endotoxin-induced TNF activity by anti-TNF caused a marked reduction in IL-1RA concentrations (P < .05). These results indicate that TNF is an intermediate factor in IL-1RA release in endotoxemia...
- Detection and clinical relevance of human endotoxemiaA Sturk
Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands
Z Med Lab Diagn 31:147-58. 1990..94) and level of consensus to establish endotoxemia (93%) as compared to the house method. The commercial assay may therefore facilitate the introduction of endotoxin testing in other laboratories...
- Low molecular weight heparin(oid)s. Clinical investigations and practical recommendationsM T Nurmohamed
Centre for Hemostasis, Thrombosis, Atherosclerosis and Inflammation Research, Academic Medical Centre, Amsterdam, The Netherlands
Drugs 53:736-51. 1997..LMWH compounds have at least a similar efficacy and safety as UFH in haemodialysis. In addition, they simplify the anticoagulant regimen because of the efficacy of a single predialysis bolus injection...
- Interleukin 10 release during endotoxaemia in chimpanzees: role of platelet-activating factor and interleukin 6T van der Poll
Department of Internal Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
Scand J Immunol 43:122-5. 1996..IL-10 release elicited by injection of endotoxin is not mediated by PAF or IL6...
- Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genesA J Horrevoets
Departments of Biochemistry and Vascular Medicine of the Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Blood 93:3418-31. 1999..These results substantiate the complex change in the gene expression pattern of vascular endothelial cells, which accompanies the inflammatory reaction of atherosclerotic lesions...
- Differential display identification of 40 genes with altered expression in activated human smooth muscle cells. Local expression in atherosclerotic lesions of smags, smooth muscle activation-specific genesC J de Vries
Departments of Biochemistry and Vascular Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
J Biol Chem 275:23939-47. 2000..Moreover, we identified interesting candidate genes that may play a role in the differentiation of SMCs during atherogenesis...