Hanno L Tan

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi Sodium channel variants in heart disease: expanding horizons
    Hanno L Tan
    Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Cardiovasc Electrophysiol 17:S151-S157. 2006
  2. ncbi Lethal ECG changes hidden by therapeutic hypothermia
    Hanno L Tan
    Department of Cardiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, Netherlands
    Lancet 369:78. 2007
  3. ncbi Genetic control of sodium channel function
    Hanno L Tan
    Experimental and Molecular Cardiology Group, Department of Cardiology, Academic Medical Center, Room M0 052, P O Box 22700, 1100 DE, Amsterdam, The Netherlands
    Cardiovasc Res 57:961-73. 2003
  4. ncbi Exercise-induced ECG changes in Brugada syndrome
    Ahmad S Amin
    Heart Failure Research Center and Department of Cardiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Circ Arrhythm Electrophysiol 2:531-9. 2009
  5. ncbi Mechanism of right precordial ST-segment elevation in structural heart disease: excitation failure by current-to-load mismatch
    Mark G Hoogendijk
    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Heart Rhythm 7:238-48. 2010
  6. ncbi Tubulin polymerization modifies cardiac sodium channel expression and gating
    Simona Casini
    Department of Clinical and Experimental Cardiology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Cardiovasc Res 85:691-700. 2010
  7. ncbi Right-to-left ventricular diastolic delay in chronic thromboembolic pulmonary hypertension is associated with activation delay and action potential prolongation in right ventricle
    Maxim Hardziyenka
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Circ Arrhythm Electrophysiol 2:555-61. 2009
  8. ncbi Single cells isolated from human sinoatrial node: action potentials and numerical reconstruction of pacemaker current
    Arie O Verkerk
    Department of Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
    Conf Proc IEEE Eng Med Biol Soc 2007:904-7. 2007
  9. ncbi Intracellular calcium modulation of voltage-gated sodium channels in ventricular myocytes
    Simona Casini
    Department of Clinical and Experimental Cardiology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Meibergdreef 9, AZ 1105 Amsterdam, The Netherlands
    Cardiovasc Res 81:72-81. 2009
  10. ncbi Characterization of a novel SCN5A mutation associated with Brugada syndrome reveals involvement of DIIIS4-S5 linker in slow inactivation
    Simona Casini
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Cardiovasc Res 76:418-29. 2007

Detail Information

Publications75

  1. ncbi Sodium channel variants in heart disease: expanding horizons
    Hanno L Tan
    Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Cardiovasc Electrophysiol 17:S151-S157. 2006
    ..These structural changes may also be conducive to (reentrant) arrhythmias. Clearly, these observations highlight the cardiac Na channel as an interesting target for novel therapy strategies...
  2. ncbi Lethal ECG changes hidden by therapeutic hypothermia
    Hanno L Tan
    Department of Cardiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, Netherlands
    Lancet 369:78. 2007
  3. ncbi Genetic control of sodium channel function
    Hanno L Tan
    Experimental and Molecular Cardiology Group, Department of Cardiology, Academic Medical Center, Room M0 052, P O Box 22700, 1100 DE, Amsterdam, The Netherlands
    Cardiovasc Res 57:961-73. 2003
    ....
  4. ncbi Exercise-induced ECG changes in Brugada syndrome
    Ahmad S Amin
    Heart Failure Research Center and Department of Cardiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Circ Arrhythm Electrophysiol 2:531-9. 2009
    ..Yet, the effects of exercise on the BrS ECG phenotype have not been studied. We aimed to assess ECG responses to exercise in BrS and determine whether these responses are affected by the presence of an SCN5A mutation...
  5. ncbi Mechanism of right precordial ST-segment elevation in structural heart disease: excitation failure by current-to-load mismatch
    Mark G Hoogendijk
    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Heart Rhythm 7:238-48. 2010
    ..The Brugada sign has been associated with mutations in SCN5A and with right ventricular structural abnormalities. Their role in the Brugada sign and the associated ventricular arrhythmias is unknown...
  6. ncbi Tubulin polymerization modifies cardiac sodium channel expression and gating
    Simona Casini
    Department of Clinical and Experimental Cardiology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Cardiovasc Res 85:691-700. 2010
    ..5) function. Therefore, we investigated whether enhanced tubulin polymerization by TXL affects Na(v)1.5 function and expression and whether these effects are beta1-subunit-mediated...
  7. ncbi Right-to-left ventricular diastolic delay in chronic thromboembolic pulmonary hypertension is associated with activation delay and action potential prolongation in right ventricle
    Maxim Hardziyenka
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Circ Arrhythm Electrophysiol 2:555-61. 2009
    ..Why the synchrony between LV and RV is lost is unknown. We hypothesized that RV electrophysiological remodeling, notably, conduction slowing and action potential prolongation, contribute to this loss in synchrony...
  8. ncbi Single cells isolated from human sinoatrial node: action potentials and numerical reconstruction of pacemaker current
    Arie O Verkerk
    Department of Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
    Conf Proc IEEE Eng Med Biol Soc 2007:904-7. 2007
    ..We conclude that human sinoatrial node pacemaker cells functionally express If and that this If contributes to pacemaking in human sinoatrial node...
  9. ncbi Intracellular calcium modulation of voltage-gated sodium channels in ventricular myocytes
    Simona Casini
    Department of Clinical and Experimental Cardiology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Meibergdreef 9, AZ 1105 Amsterdam, The Netherlands
    Cardiovasc Res 81:72-81. 2009
    ....
  10. ncbi Characterization of a novel SCN5A mutation associated with Brugada syndrome reveals involvement of DIIIS4-S5 linker in slow inactivation
    Simona Casini
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Cardiovasc Res 76:418-29. 2007
    ..The G1319V mutation is located in the loop connecting transmembrane segments 4 and 5 in domain III (DIIIS4-S5), a region so far considered to be exclusively involved in fast inactivation...
  11. ncbi Early inflammatory response during the development of right ventricular heart failure in a rat model
    Maria E Campian
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands
    Eur J Heart Fail 12:653-8. 2010
    ..In right ventricular (RV) heart failure, little is known about the role of inflammatory activation. We aimed to study the role of inflammatory activation in RV heart failure by serial monitoring during disease progression...
  12. ncbi Right ventricular pacing improves haemodynamics in right ventricular failure from pressure overload: an open observational proof-of-principle study in patients with chronic thromboembolic pulmonary hypertension
    Maxim Hardziyenka
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, The Netherlands
    Europace 13:1753-9. 2011
    ..We aimed to establish whether RV pacing may resynchronize the onsets of RV and LV diastolic relaxation, and improve haemodynamics...
  13. ncbi A mutation in the human cardiac sodium channel (E161K) contributes to sick sinus syndrome, conduction disease and Brugada syndrome in two families
    Jeroen P P Smits
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, The Netherlands
    J Mol Cell Cardiol 38:969-81. 2005
    ....
  14. ncbi Active cascade screening in primary inherited arrhythmia syndromes: does it lead to prophylactic treatment?
    Nynke Hofman
    Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands
    J Am Coll Cardiol 55:2570-6. 2010
    ..The purpose of this study was to investigate the follow-up and treatment of the mutation-carrying relatives of a proband with an inherited arrhythmia syndrome...
  15. ncbi Electrophysiologic remodeling of the left ventricle in pressure overload-induced right ventricular failure
    Maxim Hardziyenka
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands
    J Am Coll Cardiol 59:2193-202. 2012
    ..The purpose of this study was to analyze the electrophysiologic remodeling of the atrophic left ventricle (LV) in right ventricular (RV) failure (RVF) after RV pressure overload...
  16. ncbi Activated human platelet products induce proarrhythmic effects in ventricular myocytes
    Jonas S S G De Jong
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Mol Cell Cardiol 51:347-56. 2011
    ..These changes may trigger and support reentrant arrhythmias in ischemia models of coronary thrombosis...
  17. ncbi Gender disparities in cardiac cellular electrophysiology and arrhythmia susceptibility in human failing ventricular myocytes
    Arie O Verkerk
    Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, The Netherlands
    Int Heart J 46:1105-18. 2005
    ..These gender disparities may be due to slightly larger depolarizing I(Ca,L) in conjunction with slightly smaller repolarizing I(QSS) and I(to1) in female myocytes...
  18. ncbi Role of sequence variations in the human ether-a-go-go-related gene (HERG, KCNH2) in the Brugada syndrome
    Arie O Verkerk
    Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Cardiovasc Res 68:441-53. 2005
    ..Other causally related genes still await identification. We evaluated the role of HERG (KCNH2), which encodes the alpha-subunit of the rapid delayed rectifier K(+) channel (I(Kr)), in BrS...
  19. ncbi Overlap syndrome of cardiac sodium channel disease in mice carrying the equivalent mutation of human SCN5A-1795insD
    Carol Ann Remme
    Department of Cardiology, Academic Medical Center, Room K2 110, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Circulation 114:2584-94. 2006
    ..We investigated the electrophysiological characteristics of a transgenic model of the murine equivalent mutation 1798insD...
  20. ncbi Engineering physiologically controlled pacemaker cells with lentiviral HCN4 gene transfer
    Gerard J J Boink
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Gene Med 10:487-97. 2008
    ....
  21. ncbi Facilitatory and inhibitory effects of SCN5A mutations on atrial fibrillation in Brugada syndrome
    Ahmad S Amin
    Heart Failure Research Center, Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Europace 13:968-75. 2011
    ..Here, we examined the relation between SCN5A mutations, atrial conduction velocity, atrial structural changes, and atrial ectopic activity in BrS...
  22. ncbi Cardiac ion channels in health and disease
    Ahmad S Amin
    Heart Failure Research Center, University of Amsterdam, Amsterdam, The Netherlands
    Heart Rhythm 7:117-26. 2010
    ..This review discusses ion channels that contribute to action potential formation in healthy hearts and their role in inherited and acquired diseases...
  23. ncbi Contribution of inherited heart disease to sudden cardiac death in childhood
    Nynke Hofman
    Department of Clinical Genetics, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Pediatrics 120:e967-73. 2007
    ..We aimed to establish the cause of sudden cardiac death in the children of whom the family was referred to our cardiogenetics department and the diagnostic yield of these investigations...
  24. ncbi Type of SCN5A mutation determines clinical severity and degree of conduction slowing in loss-of-function sodium channelopathies
    Paola G Meregalli
    Department of Cardiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Heart Rhythm 6:341-8. 2009
    ..The penetrance and expressivity of the disease are highly variable, and new tools for risk stratification are needed...
  25. ncbi Bosentan as a bridge to pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension
    Herre J Reesink
    Department of Pulmonology, University of Amsterdam, Amsterdam, The Netherlands
    J Thorac Cardiovasc Surg 139:85-91. 2010
    ....
  26. ncbi Fever-induced QTc prolongation and ventricular arrhythmias in individuals with type 2 congenital long QT syndrome
    Ahmad S Amin
    Heart Failure Research Center, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    J Clin Invest 118:2552-61. 2008
    ....
  27. ncbi Effects of muscarinic receptor stimulation on Ca2+ transient, cAMP production and pacemaker frequency of rabbit sinoatrial node cells
    Marcel M G J van Borren
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Basic Res Cardiol 105:73-87. 2010
    ..Thus, we provide functional evidence for the contribution of the Ca (i) (2+) transient to ACh-induced inhibition of pacemaker activity and cAMP content in rabbit SAN cells...
  28. ncbi Cardiac sodium channelopathies
    Ahmad S Amin
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Pflugers Arch 460:223-37. 2010
    ....
  29. ncbi Nodoventricular accessory pathways in PRKAG2-dependent familial preexcitation syndrome reveal a disorder in cardiac development
    Hanno L Tan
    Heart Failure Research Center, Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circ Arrhythm Electrophysiol 1:276-81. 2008
    ..Yet, histopathologic proof is still lacking. We aimed to provide such proof...
  30. ncbi Imaging of programmed cell death in arrhythmogenic right ventricle cardiomyopathy/dysplasia
    Maria E Campian
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 38:1500-6. 2011
    ..We aimed to establish whether cardiac apoptosis can be assessed noninvasively in patients with ARVC/D...
  31. ncbi Cardiac sodium channels and inherited electrophysiologic disorders: a pharmacogenetic overview
    Jeroen P P Smits
    University of Amsterdam, Academic Medical Center, Department of Cardiology, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Expert Opin Pharmacother 9:537-49. 2008
    ..An overview is given of the known risks of development of the previously mentioned complications of commonly prescribed drugs in patients affected with Na channel-related diseases and the underlying mechanisms...
  32. ncbi Incidence, causes, and outcomes of out-of-hospital cardiac arrest in children. A comprehensive, prospective, population-based study in the Netherlands
    Abdennasser Bardai
    Heart Failure Research Center, Department of Cardiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands
    J Am Coll Cardiol 57:1822-8. 2011
    ....
  33. ncbi SCN5A mutations in Brugada syndrome are associated with increased cardiac dimensions and reduced contractility
    Frans van Hoorn
    Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e42037. 2012
    ..We aimed to determine whether clinical evidence may be obtained that Na(v)1.5 is involved in maintaining cardiac structural integrity...
  34. ncbi Pacemaker current (I(f)) in the human sinoatrial node
    Arie O Verkerk
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur Heart J 28:2472-8. 2007
    ..I(f) is becoming a novel therapy target to modulate heart rate. Yet, no studies have demonstrated that I(f) is functionally present and contributes to pacemaking in human SAN. We aimed to study I(f) properties in human SAN...
  35. ncbi Impact of onsite or dispatched automated external defibrillator use on survival after out-of-hospital cardiac arrest
    Jocelyn Berdowski
    Department of Cardiology, Academic Medical Center University of Amsterdam, Netherlands
    Circulation 124:2225-32. 2011
    ..The objective of this study was to determine whether actual use of onsite or dispatched AED reduces the time to first shock compared with no AED use and thereby improves survival...
  36. ncbi Pathophysiological mechanisms of Brugada syndrome: depolarization disorder, repolarization disorder, or more?
    Paola G Meregalli
    Department of Cardiology, Room M0 105, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Cardiovasc Res 67:367-78. 2005
    ....
  37. ncbi Slow and discontinuous conduction conspire in Brugada syndrome: a right ventricular mapping and stimulation study
    Pieter G Postema
    Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circ Arrhythm Electrophysiol 1:379-86. 2008
    ..The pathophysiological basis of the arrhythmias and type-1 BrS-ECG is unresolved. We studied the electrophysiological characteristics of the RV endocardium in BrS...
  38. ncbi Is sodium current present in human sinoatrial node cells?
    Arie O Verkerk
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Int J Biol Sci 5:201-4. 2009
    ....
  39. ncbi Genetically determined differences in sodium current characteristics modulate conduction disease severity in mice with cardiac sodium channelopathy
    Carol Ann Remme
    Heart Failure Research Center, Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Room K2 110, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Circ Res 104:1283-92. 2009
    ..In particular, the sodium channel subunit beta4 (SCN4B) may constitute a potential genetic modifier of conduction and cardiac sodium channel disease...
  40. ncbi Diagnostic value of flecainide testing in unmasking SCN5A-related Brugada syndrome
    Paola G Meregalli
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Cardiovasc Electrophysiol 17:857-64. 2006
    ..CONCLUSION: Flecainide testing is a valid and safe tool to identify SCN5A-related BrS patients. Baseline ECGs do not predict test outcomes, but point to conduction slowing as a core mechanism in BrS...
  41. ncbi Effects of heart failure on brain-type Na+ channels in rabbit ventricular myocytes
    Arie O Verkerk
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Europace 9:571-7. 2007
    ..Heart failure (HF) alters pacemaker activity and excitation-contraction coupling. Here, we studied whether HF alters brain-type Na(+) channel properties...
  42. ncbi Implantable cardioverter-defibrillators have reduced the incidence of resuscitation for out-of-hospital cardiac arrest caused by lethal arrhythmias
    Michiel Hulleman
    Department of Cardiology, Room G4 229, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands
    Circulation 126:815-21. 2012
    ..We sought to establish the contribution of implantable cardioverter-defibrillator (ICD) therapy to this decline...
  43. ncbi Variants in the 3' untranslated region of the KCNQ1-encoded Kv7.1 potassium channel modify disease severity in patients with type 1 long QT syndrome in an allele-specific manner
    Ahmad S Amin
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur Heart J 33:714-23. 2012
    ..We aimed to study whether this can be explained by single nucleotide polymorphisms (SNPs) in KCNQ1's 3' untranslated region (3'UTR)...
  44. ncbi Electrocardiographic evidence of ventricular repolarization remodelling during atrial fibrillation
    Hanno L Tan
    Department of Clinical and Experimental Cardiology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Europace 10:99-104. 2008
    ..We hypothesized that this is caused by changes in ventricular repolarization during AF. We aimed to establish whether such 'ventricular repolarization remodelling' occurs...
  45. ncbi Local depolarization abnormalities are the dominant pathophysiologic mechanism for type 1 electrocardiogram in brugada syndrome a study of electrocardiograms, vectorcardiograms, and body surface potential maps during ajmaline provocation
    Pieter G Postema
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    J Am Coll Cardiol 55:789-97. 2010
    ....
  46. ncbi Right ventricular failure following chronic pressure overload is associated with reduction in left ventricular mass evidence for atrophic remodeling
    Maxim Hardziyenka
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands
    J Am Coll Cardiol 57:921-8. 2011
    ..We sought to study whether patients with right ventricular failure (RVF) secondary to chronic thromboembolic pulmonary hypertension (CTEPH) have reduced left ventricular (LV) mass, and whether LV mass reduction is caused by atrophy...
  47. ncbi T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells
    Martijn L Bakker
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Room L2 108, 1105 AZ, Amsterdam, The Netherlands
    Cardiovasc Res 94:439-49. 2012
    ..Here, we explore the role of TBX3 in the adult heart and investigate whether TBX3 is able to reprogramme terminally differentiated working cardiomyocytes into pacemaker cells...
  48. ncbi Differential changes in QTc duration during in-hospital haloperidol use
    Marieke T Blom
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 6:e23728. 2011
    ..To evaluate changes in QT duration during low-dose haloperidol use, and determine associations between clinical variables and potentially dangerous QT prolongation...
  49. ncbi Genome-wide association study identifies a susceptibility locus at 21q21 for ventricular fibrillation in acute myocardial infarction
    Connie R Bezzina
    Department of Experimental Cardiology, University of Amsterdam, Amsterdam, The Netherlands
    Nat Genet 42:688-91. 2010
    ..This locus has not previously been implicated in arrhythmia susceptibility...
  50. ncbi Echocardiographic determinants of the clinical condition in patients with a systemic right ventricle
    Michiel M Winter
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Echocardiography 27:1247-55. 2010
    ....
  51. ncbi Genotype-specific onset of arrhythmias in congenital long-QT syndrome: possible therapy implications
    Hanno L Tan
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circulation 114:2096-103. 2006
    ..This disparity may point to different arrhythmia mechanisms and may affect therapy strategies. We studied whether the proportion of pause-dependent TdP onset varies among LQTS genotypes...
  52. ncbi Sudden unexplained death: heritability and diagnostic yield of cardiological and genetic examination in surviving relatives
    Hanno L Tan
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circulation 112:207-13. 2005
    ..9 presymptomatic carriers per family. Simple procedures (examining many relatives) and routine tests (resting/exercise ECG) constitute excellent diagnostic strategies. Molecular genetics provide strong supportive information...
  53. ncbi Inherited arrhythmia syndromes
    Arthur Am Wilde
    Experimental and Molecular Cardiology Group, Academic Medical Center, Amsterdam, The Netherlands
    Circ J 71:A12-9. 2007
    ..It is likely that this development will further increase the knowledge of the (patho-) physiology of these disease entities, but also of more common arrhythmia syndromes...
  54. ncbi Diagnostic criteria for congenital long QT syndrome in the era of molecular genetics: do we need a scoring system?
    Nynke Hofman
    Department of Clinical Genetics, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Eur Heart J 28:575-80. 2007
    ..Nowadays, a certain diagnosis can often be made by DNA testing. We aimed to establish the predictive power of the Schwartz and Keating criteria, using DNA testing as a reference, and to determine the best diagnostic strategy...
  55. ncbi Right ventricular fibrosis and conduction delay in a patient with clinical signs of Brugada syndrome: a combined electrophysiological, genetic, histopathologic, and computational study
    Ruben Coronel
    Experimental and Molecular Cardiology Group, Academic Medical Center, Amsterdam, The Netherlands
    Circulation 112:2769-77. 2005
    ..The mechanism of ECG changes and arrhythmogenesis in Brugada syndrome (BS) patients is unknown...
  56. ncbi Assessment of inflammation in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia
    Maria E Campian
    University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 37:2079-85. 2010
    ..We aimed to establish whether cardiac inflammation can be assessed non-invasively in ARVC/D patients...
  57. ncbi Duration of right ventricular contraction predicts the efficacy of bosentan treatment in patients with pulmonary hypertension
    Marielle G J Duffels
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Eur J Echocardiogr 10:433-8. 2009
    ..We hypothesized that baseline RV contraction duration predicts efficacy of endothelin receptor antagonist, bosentan...
  58. ncbi Diagnostic yield in sudden unexplained death and aborted cardiac arrest in the young: the experience of a tertiary referral center in The Netherlands
    Christian van der Werf
    Heart Failure Research Center, Department of Cardiology, Academic Medical Center, University of Amsterdam, The Netherlands
    Heart Rhythm 7:1383-9. 2010
    ..The causes of aborted cardiac arrest (ACA) in this age group likely are similar to those in sudden cardiac death. However, there is a paucity of recent data on this topic...
  59. ncbi Organ explant culture of neonatal rat ventricles: a new model to study gene and cell therapy
    A Dénise den Haan
    Heart Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 8:e59290. 2013
    ..We conclude that organ explant cultures of neonatal rat ventricle are structurally and electrophysiologically similar to freshly isolated tissue and a suitable new model to study the effects of gene and cell therapy...
  60. ncbi Epilepsy is a risk factor for sudden cardiac arrest in the general population
    Abdennasser Bardai
    Heart Failure Research Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e42749. 2012
    ..We assessed whether the risk for SCA is increased in epilepsy by determining the risk for SCA among people with active epilepsy in a community-based study...
  61. ncbi Delay in right ventricular activation contributes to Brugada syndrome
    Raymond Tukkie
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circulation 109:1272-7. 2004
    ..CONCLUSIONS: These results indicate that both proposed mechanisms of Brugada syndrome may be operative...
  62. ncbi Serial noninvasive assessment of apoptosis during right ventricular disease progression in rats
    Maria E Campian
    Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands
    J Nucl Med 50:1371-7. 2009
    ....
  63. ncbi A common polymorphism in KCNH2 (HERG) hastens cardiac repolarization
    Connie R Bezzina
    Experimental and Molecular Cardiology Group, Room M0 052, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Cardiovasc Res 59:27-36. 2003
    ....
  64. ncbi Drugs and Brugada syndrome patients: review of the literature, recommendations, and an up-to-date website (www.brugadadrugs.org)
    Pieter G Postema
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Heart Rhythm 6:1335-41. 2009
    ..Importantly, many drugs have been reported to induce the characteristic Brugada syndrome-linked ECG abnormalities and/or (fatal) ventricular tachyarrhythmias...
  65. ncbi Familial Brugada syndrome uncovered by hyperkalaemic diabetic ketoacidosis
    Pieter G Postema
    Department of Cardiology, Academic Medical Center, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands
    Europace 13:1509-10. 2011
    ..Diabetic ketoacidosis with hyperkalaemia may uncover an inheritable arrhythmia syndrome that may put the patient and his/her next of kin at risk for a sudden death, irrespective of diabetes mellitus...
  66. ncbi Gene therapy to create biological pacemakers
    Gerard J J Boink
    Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Med Biol Eng Comput 45:167-76. 2007
    ..This review considers the strengths and the weaknesses of the different approaches and discusses some of the different viral vectors currently used...
  67. ncbi A novel echocardiographic predictor of in-hospital mortality and mid-term haemodynamic improvement after pulmonary endarterectomy for chronic thrombo-embolic pulmonary hypertension
    Maxim Hardziyenka
    Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Eur Heart J 28:842-9. 2007
    ....
  68. ncbi Atriofascicular accessory pathway
    Hanno L Tan
    Department of Cardiology, University Medical Center Utrecht and the Heart Lung Center Utrecht, Utrecht, The Netherlands
    J Cardiovasc Electrophysiol 15:118. 2004
  69. ncbi Sequence of echocardiographic changes during development of right ventricular failure in rat
    Maxim Hardziyenka
    Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Am Soc Echocardiogr 19:1272-9. 2006
    ..Echocardiographic analysis permits accurate determination of the stage of disease development in MCT-induced RV failure...
  70. ncbi A calcium sensor in the sodium channel modulates cardiac excitability
    Hanno L Tan
    Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville 37232, Tennessee, USA
    Nature 415:442-7. 2002
    ....
  71. ncbi Relation between basic and clinical electrophysiologic characteristics in Brugada syndrome: facts or fiction?
    Arthur A M Wilde
    J Cardiovasc Electrophysiol 14:412-4. 2003
  72. ncbi Pharmacological rescue of mutant ion channels
    Connie R Bezzina
    Cardiovasc Res 55:229-32. 2002
  73. ncbi Understanding torsade de pointes: a bridge to tailored drug therapy?
    Hanno L Tan
    Cardiovasc Drugs Ther 16:87-8. 2002
  74. ncbi Fever increases the risk for cardiac arrest in the Brugada syndrome
    Ahmad S Amin
    Ann Intern Med 149:216-8. 2008
  75. ncbi Diagnostic criteria for congenital long QT syndrome in the era of molecular genetics: do we need a scoring system?
    Nynke Hofman
    Eur Heart J 28:1399. 2007