Lukas J A Stalpers

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. pmc Experimental iodine-125 seed irradiation of intracerebral brain tumors in nude mice
    Joost J C Verhoeff
    Department of Neurosurgery, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Radiat Oncol 2:38. 2007
  2. pmc Prognostic factors for outcomes after whole-brain irradiation of brain metastases from relatively radioresistant tumors: a retrospective analysis
    Thekla Meyners
    Department of Radiation Oncology, University of Lubeck, Germany
    BMC Cancer 10:582. 2010
  3. pmc Concerns about anti-angiogenic treatment in patients with glioblastoma multiforme
    Joost J C Verhoeff
    Department of Radiation Oncology, Academic Medical Center, AZ Amsterdam, The Netherlands
    BMC Cancer 9:444. 2009
  4. ncbi request reprint Results of radiotherapy for drooling in amyotrophic lateral sclerosis
    Lukas J A Stalpers
    Department of Radiotherapy, Academic Medical Center, University of Amsterdam, The Netherlands
    Neurology 58:1308. 2002
  5. ncbi request reprint Hypnotherapy in radiotherapy patients: a randomized trial
    Lukas J A Stalpers
    Department of Radiotherapy, Academic Medical Centrum, University of Amsterdam, Amsterdam 1105 AZ, The Netherlands
    Int J Radiat Oncol Biol Phys 61:499-506. 2005
  6. doi request reprint Quantifying the combined effect of radiation therapy and hyperthermia in terms of equivalent dose distributions
    H Petra Kok
    Department of Radiation Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Electronic address
    Int J Radiat Oncol Biol Phys 88:739-45. 2014
  7. doi request reprint G0 cell cycle arrest alone is insufficient for enabling the repair of ionizing radiation-induced potentially lethal damage
    Chris van Bree
    Academic Medical Center, Laboratory for Experimental Oncology and Radiobiology, Department of Radiation Oncology, University of Amsterdam, Amsterdam, The Netherlands
    Radiat Res 170:184-91. 2008
  8. doi request reprint Angiogenesis inhibitor DC101 delays growth of intracerebral glioblastoma but induces morbidity when combined with irradiation
    Joost J C Verhoeff
    Center for Experimental and Molecular Medicine, University of Amsterdam, The Netherlands
    Cancer Lett 285:39-45. 2009
  9. ncbi request reprint Validation of existing prognostic models in patients with early-stage cervical cancer
    Petra Biewenga
    Department of Obstetrics and Gynecology, Academic Medical Center, Amsterdam, The Netherlands
    Gynecol Oncol 115:277-84. 2009
  10. doi request reprint Tumour control by whole brain irradiation of anti-VEGF-treated mice bearing intracerebral glioma
    Joost J C Verhoeff
    Department of Radiation Oncology, Academic Medical Center, Amsterdam, The Netherlands
    Eur J Cancer 45:3074-80. 2009

Collaborators

Detail Information

Publications41

  1. pmc Experimental iodine-125 seed irradiation of intracerebral brain tumors in nude mice
    Joost J C Verhoeff
    Department of Neurosurgery, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Radiat Oncol 2:38. 2007
    ..Therefore, we developed a stereotactic brachytherapy mouse model for high-dose focal irradiation of experimental intracerebral (orthotopic) brain tumors...
  2. pmc Prognostic factors for outcomes after whole-brain irradiation of brain metastases from relatively radioresistant tumors: a retrospective analysis
    Thekla Meyners
    Department of Radiation Oncology, University of Lubeck, Germany
    BMC Cancer 10:582. 2010
    ..Additionally, a potential benefit from escalating the radiation dose was investigated...
  3. pmc Concerns about anti-angiogenic treatment in patients with glioblastoma multiforme
    Joost J C Verhoeff
    Department of Radiation Oncology, Academic Medical Center, AZ Amsterdam, The Netherlands
    BMC Cancer 9:444. 2009
    ..Although patients benefit greatly from reduced cerebral oedema and intracranial pressure, this important clinical improvement on its own may not be considered as an anti-tumour effect...
  4. ncbi request reprint Results of radiotherapy for drooling in amyotrophic lateral sclerosis
    Lukas J A Stalpers
    Department of Radiotherapy, Academic Medical Center, University of Amsterdam, The Netherlands
    Neurology 58:1308. 2002
  5. ncbi request reprint Hypnotherapy in radiotherapy patients: a randomized trial
    Lukas J A Stalpers
    Department of Radiotherapy, Academic Medical Centrum, University of Amsterdam, Amsterdam 1105 AZ, The Netherlands
    Int J Radiat Oncol Biol Phys 61:499-506. 2005
    ..To determine whether hypnotherapy reduces anxiety and improves the quality of life in cancer patients undergoing curative radiotherapy (RT)...
  6. doi request reprint Quantifying the combined effect of radiation therapy and hyperthermia in terms of equivalent dose distributions
    H Petra Kok
    Department of Radiation Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Electronic address
    Int J Radiat Oncol Biol Phys 88:739-45. 2014
    ....
  7. doi request reprint G0 cell cycle arrest alone is insufficient for enabling the repair of ionizing radiation-induced potentially lethal damage
    Chris van Bree
    Academic Medical Center, Laboratory for Experimental Oncology and Radiobiology, Department of Radiation Oncology, University of Amsterdam, Amsterdam, The Netherlands
    Radiat Res 170:184-91. 2008
    ..Our data suggest that the induction of G(0) cell cycle arrest and the reduction of proliferation are not sufficient to enable PLD repair...
  8. doi request reprint Angiogenesis inhibitor DC101 delays growth of intracerebral glioblastoma but induces morbidity when combined with irradiation
    Joost J C Verhoeff
    Center for Experimental and Molecular Medicine, University of Amsterdam, The Netherlands
    Cancer Lett 285:39-45. 2009
    ..8 weeks in sham-treated mice to 10.3 weeks. Morbidity after combined treatment occurred after 5.9 weeks. Treatment with angiogenesis inhibitor DC101 delays tumor growth but it induces morbidity, by itself or combined with irradiation...
  9. ncbi request reprint Validation of existing prognostic models in patients with early-stage cervical cancer
    Petra Biewenga
    Department of Obstetrics and Gynecology, Academic Medical Center, Amsterdam, The Netherlands
    Gynecol Oncol 115:277-84. 2009
    ..We validated 12 existing prognostic models in an independent population of patients with early-stage cervical cancer...
  10. doi request reprint Tumour control by whole brain irradiation of anti-VEGF-treated mice bearing intracerebral glioma
    Joost J C Verhoeff
    Department of Radiation Oncology, Academic Medical Center, Amsterdam, The Netherlands
    Eur J Cancer 45:3074-80. 2009
    ..We investigated if invasive tumour growth can be controlled by combining anti-VEGF treatment with irradiation of tumour plus surrounding brain in an orthotopic murine model for GBM...
  11. ncbi request reprint How attachment style and locus of control influence patients' trust in their oncologist
    Marij A Hillen
    Department of Medical Psychology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Electronic address
    J Psychosom Res 76:221-6. 2014
    ..We examined how these personality characteristics influence trust as well as moderate the relation between oncologist communication and trust...
  12. ncbi request reprint Reduced activity of double-strand break repair genes in prostate cancer patients with late normal tissue radiation toxicity
    Bregje van Oorschot
    Laboratory for Experimental Oncology and Radiobiology LEXOR, Center for Molecular Medicine CeMM, Department of Radiation Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Electronic address
    Int J Radiat Oncol Biol Phys 88:664-70. 2014
    ..To investigate clinical parameters and DNA damage response as possible risk factors for radiation toxicity in the setting of prostate cancer...
  13. doi request reprint Cell survival and radiosensitisation: modulation of the linear and quadratic parameters of the LQ model (Review)
    Nicolaas A P Franken
    Department of Radiotherapy, Laboratory for Experimental Oncology and Radiobiology, Center for Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Int J Oncol 42:1501-15. 2013
    ..The LQ model provides a useful tool in the quantification of the effects of radiosensitising agents. These insights will help optimize fractionation schedules in multimodality treatments...
  14. doi request reprint Do radiation oncologists tailor information to patients needs? And, if so, does it affect patients?
    Kirsten F L Douma
    Department of Medical Psychology, Academic Medical Center, Amsterdam, The Netherlands
    Acta Oncol 51:512-20. 2012
    ..e. satisfaction, health, anxiety and self-efficacy...
  15. doi request reprint Long-term results of salvage radiotherapy for the treatment of recurrent cervical carcinoma after prior surgery
    Cornelis J A Haasbeek
    Department of Radiotherapy, Academic Medical Center, Amsterdam, The Netherlands
    Radiother Oncol 89:197-204. 2008
    ..This paper presents our experience with treatment of this patient group by salvage radiotherapy with curative intent...
  16. ncbi request reprint Enhancement of effects of irradiation by gemcitabine in a glioblastoma cell line and cell line spheroids
    Mine Genc
    Department of Radiotherapy, Academic Medical Center, University of Amsterdam, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    J Cancer Res Clin Oncol 130:45-51. 2004
    ..To determine the cytotoxicity of, and radioenhancement by, gemcitabine on a glioma cell line grown as a monolayer and as spheroid cultures...
  17. ncbi request reprint Negligible radiation protection of endothelial cells by vascular endothelial growth factor
    Mila Donker
    Laboratory of Experimental Oncology and Radiobiology LEXOR, Department of Radiation Oncology, University of Amsterdam, The Netherlands
    Oncol Rep 18:709-14. 2007
    ..We therefore hypothesize that the high VEGF-levels found in GBM in vivo do not reduce the radiosensitivity of endothelial cells, which is thought to contribute to the strong radioresistance of the tumor vasculature...
  18. ncbi request reprint Two radiation regimens and prognostic factors for brain metastases in nonsmall cell lung cancer patients
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Cancer 110:1077-82. 2007
    ..A short course of WBRT would be preferable to longer regimens if it could provide similar survival. This retrospective study of NSCLC patients compared longer treatment programs with short-course WBRT with 5 x 4 Gy given during 5 days...
  19. ncbi request reprint Effect of single dose irradiation on human glioblastoma spheroids in vitro
    Fabian Fehlauer
    Department of Radiation Oncology, University of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    Oncol Rep 11:477-85. 2004
    ..Particularly early changes in proliferation and apoptosis can be observed in spheroids. Individual response differences suggest spheroids of human gliomas to be useful for monitoring radiosurgery effects...
  20. ncbi request reprint Prognostic factors for local control and survival after radiotherapy of metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Germany
    J Clin Oncol 24:3388-93. 2006
    ..To evaluate potential prognostic factors for local control and survival after radiotherapy of metastatic spinal cord compression (MSCC)...
  21. ncbi request reprint Defining the appropriate radiotherapy regimen for metastatic spinal cord compression in non-small cell lung cancer patients
    Dirk Rades
    Department of Radiation Oncology, University Medical Center Hamburg Eppendorf, University Hospital Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    Eur J Cancer 42:1052-6. 2006
    ..94). Short-course and long-course RT appear similarly effective for MSCC in NSCLC patients. As 1 x 8 Gy and 5 x 4 Gy showed comparable results, 1 x 8 Gy can be considered appropriate...
  22. ncbi request reprint Short-course radiotherapy (RT) for metastatic spinal cord compression (MSCC) due to renal cell carcinoma: results of a retrospective multi-center study
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 49:846-52; discussion 852. 2006
    ..Our study compares short-course (1 x 8 Gy, 5 x 4 Gy) and long-course RT (10 x 3 Gy, 15 x 2.5 Gy, 20 x 2 Gy) for functional outcome in MSCC patients with renal cell carcinoma...
  23. ncbi request reprint Short-course radiotherapy is not optimal for spinal cord compression due to myeloma
    Dirk Rades
    Department of Radiation Oncology, University Hospital, Hamburg, Germany
    Int J Radiat Oncol Biol Phys 64:1452-7. 2006
    ..To investigate the suitability of short-course radiotherapy (RT) for spinal cord compression (SCC) in myeloma patients...
  24. ncbi request reprint Comparison of 1 x 8 Gy and 10 x 3 Gy for functional outcome in patients with metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Int J Radiat Oncol Biol Phys 62:514-8. 2005
    ..This study investigates a reduction of the overall treatment time to only one day by comparing 1 x 8 Gy to the multi-fractionated 10 x 3 Gy for functional outcome...
  25. ncbi request reprint [Effectiveness and toxicity of reirradiation (Re-RT) for metastatic spinal cord compression (MSCC)]
    Dirk Rades
    Klinik und Poliklinik für Strahlentherapie und Radioonkologie, Universitatsklinikum, Hamburg Eppendorf
    Strahlenther Onkol 181:595-600. 2005
    ..Many radiation oncologists are concerned about spinal Re-RT, because it may result in a high cumulative EQD2. This study investigates effectiveness and feasibility of Re-RT for in-field recurrence of MSCC...
  26. ncbi request reprint Spinal reirradiation after short-course RT for metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Int J Radiat Oncol Biol Phys 63:872-5. 2005
    ..To investigate the feasibility and effectiveness of reirradiation (re-RT) for in-field recurrence of metastatic spinal cord compression after primary RT with 1 x 8 Gy or 5 x 4 Gy...
  27. ncbi request reprint Evaluation of five radiation schedules and prognostic factors for metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    J Clin Oncol 23:3366-75. 2005
    ..To study five radiotherapy (RT) schedules and potential prognostic factors for functional outcome in metastatic spinal cord compression (MSCC)...
  28. ncbi request reprint Single-dose brachytherapy versus metal stent placement for the palliation of dysphagia from oesophageal cancer: multicentre randomised trial
    Marjolein Y V Homs
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre Rotterdam, Rotterdam, Netherlands
    Lancet 364:1497-504. 2004
    ..We undertook a randomised trial to compare the outcomes of brachytherapy and stent placement in patients with oesophageal cancer...
  29. pmc Analysis of gene expression using gene sets discriminates cancer patients with and without late radiation toxicity
    J Peter Svensson
    Department of Toxicogenetics, Leiden University Medical Center, Leiden, Netherlands
    PLoS Med 3:e422. 2006
    ..Assuming that genetic susceptibility impacts this risk, we hypothesized that the cellular response of normal tissue to X-rays could discriminate patients with and without late radiation toxicity...
  30. ncbi request reprint Prognostic factors for functional outcome and survival after reirradiation for in-field recurrences of metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Cancer 113:1090-6. 2008
    ..The purpose of the current study was to retrospectively investigate clinical outcome and potential prognostic factors after reirradiation (Re-RT) for in-field recurrence of metastatic spinal cord compression (MSCC)...
  31. ncbi request reprint Functional outcome and survival after radiotherapy of metastatic spinal cord compression in patients with cancer of unknown primary
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Int J Radiat Oncol Biol Phys 67:532-7. 2007
    ..Patients with cancer of unknown primary (CUP) account for about 10% of patients with metastatic spinal cord compression (MSCC). This study aims to define the appropriate radiation regimen for these patients...
  32. ncbi request reprint Differential effect of surgery and radiotherapy on neurocognitive functioning and health-related quality of life in WHO grade I meningioma patients
    David van Nieuwenhuizen
    Department of Neurology, VU University Medical Center, De Boelelaan 1117 1118, 1081 HV, Amsterdam, The Netherlands
    J Neurooncol 84:271-8. 2007
    ..Potential treatment-related neurotoxicity and the indolent course of the disease mainly feed the controversy concerning the optimal timing of surgery and radiotherapy in meningioma patients...
  33. ncbi request reprint Radiotherapy of metastatic spinal cord compression in very elderly patients
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Int J Radiat Oncol Biol Phys 67:256-63. 2007
    ..This study investigated the results of radiotherapy (RT) for metastatic spinal cord compression (MSCC) in the very elderly, because few data are available for these patients...
  34. ncbi request reprint Is short-course radiotherapy with high doses per fraction the appropriate regimen for metastatic spinal cord compression in colorectal cancer patients?
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    Strahlenther Onkol 182:708-12. 2006
    ..5 Gy given in 3 weeks, 20 x 2 Gy given in 4 weeks) and whether higher doses per fraction (more cell kill) and shorter overall treatment time (less repopulation) can compensate for lower total doses...
  35. ncbi request reprint Reduction of overall treatment time in patients irradiated for more than three brain metastases
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Int J Radiat Oncol Biol Phys 69:1509-13. 2007
    ..Regarding the poor survival of these patients, a shorter RT regimen would be preferable if it provides a similar outcome as that with 10 x 3 Gy. This study compared 20 Gy in five fractions (5 x 4 Gy) within 5 days to 10 x 3 Gy...
  36. ncbi request reprint Long-term improvement in treatment outcome after radiotherapy and hyperthermia in locoregionally advanced cervix cancer: an update of the Dutch Deep Hyperthermia Trial
    Martine Franckena
    Department of Radiation Oncology, Hyperthermia Unit, Erasmus Medical Center Rotterdam, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 70:1176-82. 2008
    ..In this study, we evaluate long-term results of the Dutch Deep Hyperthermia Trial after 12 years of follow-up...
  37. ncbi request reprint Evaluation of 2 whole-brain radiotherapy schedules and prognostic factors for brain metastases in breast cancer patients
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Cancer 110:2587-92. 2007
    ..This retrospective study compared survival and local control within the brain resulting from short-course WBRT with longer programs in 207 breast cancer patients...
  38. ncbi request reprint Genetic profiling of a distant second glioblastoma multiforme after radiotherapy: Recurrence or second primary tumor?
    Krista A van Nifterik
    Department of Radiation Oncology, Division of Radiobiology, Vrije Universiteit Medical Center, Faculty of Medicine, Amsterdam, The Netherlands
    J Neurosurg 105:739-44. 2006
    ..The genetic profiles of the tumors were compared to discriminate between distant recurrence and a second primary tumor...
  39. ncbi request reprint Whole-brain radiotherapy with 20 Gy in 5 fractions for brain metastases in patients with cancer of unknown primary (CUP)
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Strahlenther Onkol 183:631-6. 2007
    ..This study compares short-course RT with 20 Gy in 5 fractions (5 x 4 Gy) given over 5 days to longer programs in CUP patients...
  40. ncbi request reprint Differential radiosensitizing potential of temozolomide in MGMT promoter methylated glioblastoma multiforme cell lines
    Krista A van Nifterik
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 69:1246-53. 2007
    ..To investigate the radiosensitizing potential of temozolomide (TMZ) for human glioblastoma multiforme (GBM) cell lines using single-dose and fractionated gamma-irradiation...
  41. ncbi request reprint Outcome after radiotherapy alone for metastatic spinal cord compression in patients with oligometastases
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    J Clin Oncol 25:50-6. 2007
    ..To investigate outcome and prognosis of metastatic spinal cord compression (MSCC) patients with oligometastatic disease treated with radiotherapy alone...