Hergen Spits

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. doi request reprint Innate lymphoid cells--a proposal for uniform nomenclature
    Hergen Spits
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Nat Rev Immunol 13:145-9. 2013
  2. doi request reprint Innate lymphoid cells: emerging insights in development, lineage relationships, and function
    Hergen Spits
    Tytgat Institute of Liver and Intestinal Research of the Academic Medical Center, Amsterdam 1105 AZ, The Netherlands
    Annu Rev Immunol 30:647-75. 2012
  3. ncbi request reprint The aryl hydrocarbon receptor: a sentinel safeguarding the survival of immune cells in the gut
    Hergen Spits
    Tytgat Institute of Intestinal and Liver Research at the Academic Medical Center, Amsterdam, The Netherlands
    Immunity 36:5-7. 2012
  4. doi request reprint The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling
    Hergen Spits
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Centre, Amsterdam, The Netherlands
    Nat Immunol 12:21-7. 2011
  5. ncbi request reprint Another armament in gut immunity: lymphotoxin-mediated crosstalk between innate lymphoid and dendritic cells
    H Spits
    Tytgat Institute for Intestinal and Liver Research, Academic Medical Center Amsterdam, University of Amsterdam, 1105 BK Amsterdam, The Netherlands
    Cell Host Microbe 10:3-4. 2011
  6. doi request reprint Thymic stromal lymphopoietin induces early human B-cell proliferation and differentiation
    Ferenc A Scheeren
    Division of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Immunol 40:955-65. 2010
  7. doi request reprint In vivo modulation of gene expression by lentiviral transduction in "human immune system" Rag2-/- gamma c -/- mice
    Anja U van Lent
    Department of Cell Biology and Histology, Center for Immunology Amsterdam CIA, Academic Medical Center of the University of Amsterdam AMC UvA, Amsterdam, The Netherlands
    Methods Mol Biol 595:87-115. 2010
  8. pmc Spi-B inhibits human plasma cell differentiation by repressing BLIMP1 and XBP-1 expression
    Heike Schmidlin
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Blood 112:1804-12. 2008
  9. doi request reprint The Transcription Factor GATA3 Is Essential for the Function of Human Type 2 Innate Lymphoid Cells
    Jenny Mjösberg
    Tytgat Institute for Liver and Intestinal Research, University of Amsterdam, 1105BK Amsterdam, The Netherlands
    Immunity 37:649-59. 2012
  10. pmc Stimulated plasmacytoid dendritic cells impair human T-cell development
    Heike Schmidlin
    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Blood 108:3792-800. 2006

Collaborators

Detail Information

Publications42

  1. doi request reprint Innate lymphoid cells--a proposal for uniform nomenclature
    Hergen Spits
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Nat Rev Immunol 13:145-9. 2013
    ..Here, we propose that ILCs should be categorized into three groups based on the cytokines that they can produce and the transcription factors that regulate their development and function...
  2. doi request reprint Innate lymphoid cells: emerging insights in development, lineage relationships, and function
    Hergen Spits
    Tytgat Institute of Liver and Intestinal Research of the Academic Medical Center, Amsterdam 1105 AZ, The Netherlands
    Annu Rev Immunol 30:647-75. 2012
    ..We also discuss the potential roles of ILCs in the pathology of immune-mediated inflammatory and infectious diseases including allergy...
  3. ncbi request reprint The aryl hydrocarbon receptor: a sentinel safeguarding the survival of immune cells in the gut
    Hergen Spits
    Tytgat Institute of Intestinal and Liver Research at the Academic Medical Center, Amsterdam, The Netherlands
    Immunity 36:5-7. 2012
    ..How ILC numbers are maintained is unknown. In this issue of Immunity, Qiu et al. (2012) report that the transcription factor aryl hydrocarbon receptor controls survival and function of gut-residing ILCs...
  4. doi request reprint The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling
    Hergen Spits
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Centre, Amsterdam, The Netherlands
    Nat Immunol 12:21-7. 2011
    ..Analogous to helper T cell subsets, these evolutionarily conserved yet distinct ILCs seem to have important roles in protective immunity, and their dysregulation can promote immune pathology...
  5. ncbi request reprint Another armament in gut immunity: lymphotoxin-mediated crosstalk between innate lymphoid and dendritic cells
    H Spits
    Tytgat Institute for Intestinal and Liver Research, Academic Medical Center Amsterdam, University of Amsterdam, 1105 BK Amsterdam, The Netherlands
    Cell Host Microbe 10:3-4. 2011
    ..Tumanov et al. (Tumanov et al., 2011) demonstrate that crosstalk between ILCs and dendritic cells involving membrane-bound lymphotoxin in ILCs and its receptor is critical for protection against colitogenic bacteria...
  6. doi request reprint Thymic stromal lymphopoietin induces early human B-cell proliferation and differentiation
    Ferenc A Scheeren
    Division of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Immunol 40:955-65. 2010
    ..TSLP was capable of increasing the proportion and the absolute numbers of more mature human B cells. Overall, we provide evidence that TSLP supports human B-cell differentiation from fetal hematopoietic progenitors...
  7. doi request reprint In vivo modulation of gene expression by lentiviral transduction in "human immune system" Rag2-/- gamma c -/- mice
    Anja U van Lent
    Department of Cell Biology and Histology, Center for Immunology Amsterdam CIA, Academic Medical Center of the University of Amsterdam AMC UvA, Amsterdam, The Netherlands
    Methods Mol Biol 595:87-115. 2010
    ..Using this mouse model, the human immune system can be assessed for both fundamental and pre-clinical purposes...
  8. pmc Spi-B inhibits human plasma cell differentiation by repressing BLIMP1 and XBP-1 expression
    Heike Schmidlin
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Blood 112:1804-12. 2008
    ..We propose a novel role for Spi-B in maintenance of germinal center and memory B cells by direct repression of major plasma cell factors and thereby plasma cell differentiation...
  9. doi request reprint The Transcription Factor GATA3 Is Essential for the Function of Human Type 2 Innate Lymphoid Cells
    Jenny Mjösberg
    Tytgat Institute for Liver and Intestinal Research, University of Amsterdam, 1105BK Amsterdam, The Netherlands
    Immunity 37:649-59. 2012
    ..Hence, we identify GATA3, potently regulated by TSLP, as an essential transcription factor for the function of human ILC2s...
  10. pmc Stimulated plasmacytoid dendritic cells impair human T-cell development
    Heike Schmidlin
    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Blood 108:3792-800. 2006
    ..It is evident from our data that IFN-alpha inhibits the IL-7R signal transduction pathway, although this could not be attributed to interference with either IL-7R proximal (STAT5, Akt/PKB, Erk1/2) or distal (p27(kip1), pRb) events...
  11. ncbi request reprint Delta-like1-induced Notch1 signaling regulates the human plasmacytoid dendritic cell versus T-cell lineage decision through control of GATA-3 and Spi-B
    Wendy Dontje
    Department of Cell Biology and Histology of the AMC, University of Amsterdam, The Netherlands
    Blood 107:2446-52. 2006
    ..These data indicate that DL1-induced activation of the Notch1 pathway controls the lineage commitment of early thymic precursors by altering the levels between Spi-B and GATA-3...
  12. pmc STAT3-mediated up-regulation of BLIMP1 Is coordinated with BCL6 down-regulation to control human plasma cell differentiation
    SEAN A DIEHL
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 180:4805-15. 2008
    ..Thus, up-regulation of BLIMP1 alone is not sufficient for differentiation of primary human B cells into plasma cells; concomitant down-regulation of BCL6 is absolutely required for completion of the plasma cell differentiation program...
  13. ncbi request reprint Monitoring the effect of gene silencing by RNA interference in human CD34+ cells injected into newborn RAG2-/- gammac-/- mice: functional inactivation of p53 in developing T cells
    Ramon Gimeno
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, Netherlands
    Blood 104:3886-93. 2004
    ..Inactivating p53 did not affect the development of CD34(+) cells into various mature leukocyte subsets, including T cells, but it conferred resistance to gamma-irradiation and other p53-dependent apoptotic stimuli to the T cells...
  14. pmc The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development
    Remko Schotte
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, Netherlands
    J Exp Med 200:1503-9. 2004
    ..However, in contrast to Spi-B, PU.1 knock down inhibited B cell and myeloid cell development as well. These results identify Spi-B as a key regulator of human pDC development...
  15. ncbi request reprint Development and activation of regulatory T cells in the human fetus
    Tom Cupedo
    Department of Cell Biology and Histology, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands
    Eur J Immunol 35:383-90. 2005
    ..Upon activation, FoxP3+CD4+CD25+ Treg suppress potentially deleterious responses by autoreactive lymphocytes and maintain homeostasis within the developing fetus...
  16. ncbi request reprint Functional human antigen-specific T cells produced in vitro using retroviral T cell receptor transfer into hematopoietic progenitors
    Anja U van Lent
    Department of Cell Biology and Histology, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 179:4959-68. 2007
    ..Therapeutic applications may arise from these results because they provide a way to produce large numbers of autologous mature Ag-specific T cells in vitro from undifferentiated hemopoietic progenitors...
  17. pmc T cell-independent development and induction of somatic hypermutation in human IgM+ IgD+ CD27+ B cells
    Ferenc A Scheeren
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Exp Med 205:2033-42. 2008
    ..Using Rag2(-/-)gamma(C)(-/-) mice on a Nude background, we demonstrated that development and induction of SHMs of human IgM(+)IgD(+)CD27(+) B cells can occur in a T cell-independent manner...
  18. ncbi request reprint Human telomerase reverse transcriptase-transduced human cytotoxic T cells suppress the growth of human melanoma in immunodeficient mice
    Natascha C V Verra
    Division of Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Cancer Res 64:2153-61. 2004
    ....
  19. doi request reprint Synergy between IL-15 and Id2 promotes the expansion of human NK progenitor cells, which can be counteracted by the E protein HEB required to drive T cell development
    Remko Schotte
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 184:6670-9. 2010
    ....
  20. pmc Antigen-specific monoclonal antibodies isolated from B cells expressing constitutively active STAT5
    Ferenc A Scheeren
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 6:e17189. 2011
    ..Fully human monoclonal antibodies directed against specific pathogens have a high therapeutic potential, but are difficult to generate...
  21. doi request reprint Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161
    Jenny M Mjösberg
    Tytgat Institute for Liver and Intestinal Research, University of Amsterdam, Amsterdam, The Netherlands
    Nat Immunol 12:1055-62. 2011
    ..There was enrichment for CRTH2(+) ILCs in nasal polyps of chronic rhinosinusitis, a typical type 2 inflammatory disease. Our data identify a unique type of human ILC that provides an innate source of T helper type 2 (T(H)2) cytokines...
  22. pmc Generation of stable monoclonal antibody-producing B cell receptor-positive human memory B cells by genetic programming
    Mark J Kwakkenbos
    AIMM Therapeutics, Academic Medical Center, Amsterdam, The Netherlands
    Nat Med 16:123-8. 2010
    ..This method provides a new tool to study B cell biology and signal transduction through antigen-specific B cell receptors and for the rapid generation of high-affinity human monoclonal antibodies...
  23. doi request reprint Isolation and in vitro generation of gene-manipulated human plasmacytoid and conventional dendritic cells
    Remko Schotte
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam AMC UvA, Amsterdam, The Netherlands
    Methods Mol Biol 595:67-85. 2010
    ....
  24. ncbi request reprint Development of human lymphoid cells
    Bianca Blom
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam 1105 AZ, The Netherlands
    Annu Rev Immunol 24:287-320. 2006
    ....
  25. doi request reprint Th1- and Th2-like subsets of innate lymphoid cells
    Jochem Bernink
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands
    Immunol Rev 252:133-8. 2013
    ..Here, we discuss how ILCs can be categorized and summarize the current knowledge of Th1- and Th2-like ILCs with regard to the molecular mechanisms of development, effector functions, and their interplay with other cell types...
  26. doi request reprint Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues
    Jochem H Bernink
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Nat Immunol 14:221-9. 2013
    ..The frequency of the ILC1 subset was much higher in inflamed intestine of people with Crohn's disease, which indicated a role for these IFN-γ-producing ILC1 cells in the pathogenesis of gut mucosal inflammation...
  27. ncbi request reprint Transient accumulation of human mature thymocytes and regulatory T cells with CD28 superagonist in "human immune system" Rag2(-/-)gammac(-/-) mice
    Nicolas Legrand
    Department of Cell Biology and Histology, Academic Medical Center of the University of Amsterdam AMC UvA, Amsterdam, The Netherlands
    Blood 108:238-45. 2006
    ..Superagonist anti-CD28 therapy could therefore be of clinical interest in humans, both for beneficial effect on thymic T-cell production as well as regulatory T-cell accumulation...
  28. doi request reprint Experimental model for the study of the human immune system: production and monitoring of "human immune system" Rag2-/-gamma c-/- mice
    Nicolas Legrand
    Department of Cell Biology and Histology, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands
    Methods Mol Biol 415:65-82. 2008
    ..We describe here how to produce and monitor such "human immune system" (HIS) (BALB-Rag/gamma) mice, which offer large prospects for experimental study of the human immune system and as a preclinical screening tool...
  29. ncbi request reprint Developmental origin of pre-DC2
    Bianca Blom
    Division of Immunology, Plesmanlaan 121, Amsterdam, The Netherlands
    Hum Immunol 63:1072-80. 2002
    ..The challenge of the near future will be to determine the role of pre-DC2 during thymic T cell development...
  30. ncbi request reprint Human thymus regeneration and T cell reconstitution
    Nicolas Legrand
    Department of Cell Biology and Histology, Academic Medical Center at the University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    Semin Immunol 19:280-8. 2007
    ..This may require rejuvenation of the thymus. Alternatively, approaches to generate mature T cells independent of the thymus have gained considerable interest...
  31. ncbi request reprint The transcription factor Spi-B is expressed in plasmacytoid DC precursors and inhibits T-, B-, and NK-cell development
    Remko Schotte
    Division of Immunology of the Netherlands Cancer Institute, Amsterdam, The Netherlands
    Blood 101:1015-23. 2003
    ..Our results indicate that Spi-B is involved in the control of pDC development by limiting the capacity of progenitor cells to develop into other lymphoid lineages...
  32. pmc The loss of PTEN allows TCR alphabeta lineage thymocytes to bypass IL-7 and Pre-TCR-mediated signaling
    Thijs J Hagenbeek
    Department of Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Exp Med 200:883-94. 2004
    ..These double- and triple-deficient mice all develop normal levels of CD4CD8 double negative and double positive thymocytes. These data indicate that PTEN is an important regulator of proliferation of developing T cells in the thymus...
  33. doi request reprint Transcriptional control of innate lymphoid cells
    Jenny Mjösberg
    Tytgat Institute for Liver and Intestinal Research, The Academic Medical Center, Amsterdam, The Netherlands
    Eur J Immunol 42:1916-23. 2012
    ..Here we review the current knowledge with regard to the transcription factors involved in the development and functions of ILCs...
  34. ncbi request reprint Generation of regulatory gut-homing human T lymphocytes using ex vivo interleukin 10 gene transfer
    Catherine Van Montfrans
    Department of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Gastroenterology 123:1877-88. 2002
    ..Ex vivo gene transfer of the interleukin (IL)-10 gene to gut-homing CD4(+) cells may lead to improved long-term management...
  35. doi request reprint IL-22-producing CD4+ T cells: middle-men between the immune system and its environment
    Sara Trifari
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands
    Eur J Immunol 40:2369-71. 2010
    ..A paper in the current issue of the European Journal of Immunology indicates that the ligand-dependent transcription factor aryl hydrocarbon receptor is important for regulating IL-22 production of this new class of human Th cells...
  36. pmc Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy
    Eric A Reits
    Division of Tumor Biology, The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands
    J Exp Med 203:1259-71. 2006
    ..Our findings indicate that directed radiotherapy can improve the efficacy of tumor immunotherapy...
  37. pmc IL-6 triggers IL-21 production by human CD4+ T cells to drive STAT3-dependent plasma cell differentiation in B cells
    SEAN A DIEHL
    Department of Medicine Immunobiology, University of Vermont, Burlington, VT 05405, USA
    Immunol Cell Biol 90:802-11. 2012
    ....
  38. ncbi request reprint Intrathymic and extrathymic development of human plasmacytoid dendritic cell precursors in vivo
    Kees Weijer
    Division of Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands
    Blood 99:2752-9. 2002
    ..These data indicate that the thymus and the peripheral pDC2 develop independently of each other...
  39. doi request reprint Type 2 innate lymphoid cells-new members of the "type 2 franchise" that mediate allergic airway inflammation
    Jenny Mjösberg
    Tytgat Institute of Intestinal and Liver Research, Academic Medical Center, Amsterdam, The Netherlands
    Eur J Immunol 42:1093-6. 2012
    ..This study sheds light over the relative contribution of ILC2s versus T helper type 2 cells (Th2) in type 2 mediated allergen-specific inflammation in the airways as discussed in this commentary...
  40. doi request reprint Humanized mice for modeling human infectious disease: challenges, progress, and outlook
    Nicolas Legrand
    Department of Cell Biology and Histology, Academic Medical Center of the University of Amsterdam, Amsterdam 1105 AZ, The Netherlands
    Cell Host Microbe 6:5-9. 2009
    ..Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases...
  41. ncbi request reprint Ectopic hTERT expression extends the life span of human CD4+ helper and regulatory T-cell clones and confers resistance to oxidative stress-induced apoptosis
    Rosalie M Luiten
    Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Blood 101:4512-9. 2003
    ..Taken together, these results show that ectopic hTERT expression not only protects proliferating T cells from replicative senescence but also confers resistance to apoptosis induced by oxidative stress...
  42. pmc IL-21 is expressed in Hodgkin lymphoma and activates STAT5: evidence that activated STAT5 is required for Hodgkin lymphomagenesis
    Ferenc A Scheeren
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Blood 111:4706-15. 2008
    ..Data from experiments using reporter assays and overexpression of constitutively active IKK2 support the hypothesis that the STAT5 and nuclear factor-kappaB (NF-kappaB) pathways collaborate in HL genesis...