Marcus J Schultz

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. pmc Performance of prognostic models in critically ill cancer patients - a review
    Sylvia den Boer
    Department of Intensive Care, Academic Medical Center, Universiteit van Amsterdam, Amsterdam, Netherlands
    Crit Care 9:R458-63. 2005
  2. pmc A systematic review on quality indicators for tight glycaemic control in critically ill patients: need for an unambiguous indicator reference subset
    Saeid Eslami
    Department of Medical Informatics, Academic Medical Center, University of Amsterdam, Meibergdreef, 1105 AZ Amsterdam, The Netherlands
    Crit Care 12:R139. 2008
  3. pmc The influence of volume and intensive care unit organization on hospital mortality in patients admitted with severe sepsis: a retrospective multicentre cohort study
    Linda Peelen
    Department of Medical Informatics, Academic Medical Center, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    Crit Care 11:R40. 2007
  4. pmc Evaluation of SOFA-based models for predicting mortality in the ICU: A systematic review
    Lilian Minne
    Department of Medical Informatics, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Crit Care 12:R161. 2008
  5. pmc Recombinant human activated protein C resets thrombin generation in patients with severe sepsis - a case control study
    Anne Cornelie J M de Pont
    Department of Intensive Care, Academic Medical Center, University of Amsterdam, The Netherlands
    Crit Care 9:R490-7. 2005
  6. pmc The effects of continuous venovenous hemofiltration on coagulation activation
    Catherine S C Bouman
    Department of Intensive Care, Academic Medical Center, University of Amsterdam, PO 22660, 1100 DD Amsterdam, The Netherlands
    Crit Care 10:R150. 2006
  7. pmc Factors that predict outcome of intensive care treatment in very elderly patients: a review
    Sophia E de Rooij
    Department of Geriatrics, Academic Medical Center, University of Amsterdam, Amsterdam
    Crit Care 9:R307-14. 2005
  8. ncbi request reprint Anticoagulant factor concentrates in disseminated intravascular coagulation: rationale for use and clinical experience
    E de Jonge
    Department of Intensive Care, Academic Medical Center, Amsterdam, The Netherlands
    Semin Thromb Hemost 27:667-74. 2001
  9. ncbi request reprint Decreased circulating levels of von Willebrand factor after intravenous administration of a rapidly degradable hydroxyethyl starch (HES 200/0.5/6) in healthy human subjects
    E de Jonge
    Department of Intensive Care, Academic Medical Centre, University of Amsterdam, P O Box 22660, 1100 DD Amsterdam, The Netherlands
    Intensive Care Med 27:1825-9. 2001
  10. ncbi request reprint Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial
    Evert de Jonge
    Department of Intensive Care, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands
    Lancet 362:1011-6. 2003

Detail Information

Publications143 found, 100 shown here

  1. pmc Performance of prognostic models in critically ill cancer patients - a review
    Sylvia den Boer
    Department of Intensive Care, Academic Medical Center, Universiteit van Amsterdam, Amsterdam, Netherlands
    Crit Care 9:R458-63. 2005
    ..The present analysis reviews the performance of general prognostic models and specific models for cancer patients to predict in-hospital mortality after ICU admission...
  2. pmc A systematic review on quality indicators for tight glycaemic control in critically ill patients: need for an unambiguous indicator reference subset
    Saeid Eslami
    Department of Medical Informatics, Academic Medical Center, University of Amsterdam, Meibergdreef, 1105 AZ Amsterdam, The Netherlands
    Crit Care 12:R139. 2008
    ..The objectives of this study were to systematically identify and summarize quality indicators of tight glycaemic control in critically ill patients, and to inspect the applicability of their definitions...
  3. pmc The influence of volume and intensive care unit organization on hospital mortality in patients admitted with severe sepsis: a retrospective multicentre cohort study
    Linda Peelen
    Department of Medical Informatics, Academic Medical Center, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    Crit Care 11:R40. 2007
    ..The aim of the study was to assess the influence of annual volume and factors related to intensive care unit (ICU) organization on in-hospital mortality among patients admitted to the ICU with severe sepsis...
  4. pmc Evaluation of SOFA-based models for predicting mortality in the ICU: A systematic review
    Lilian Minne
    Department of Medical Informatics, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Crit Care 12:R161. 2008
    ..To systematically review studies evaluating the performance of Sequential Organ Failure Assessment (SOFA)-based models for predicting mortality in patients in the intensive care unit (ICU)...
  5. pmc Recombinant human activated protein C resets thrombin generation in patients with severe sepsis - a case control study
    Anne Cornelie J M de Pont
    Department of Intensive Care, Academic Medical Center, University of Amsterdam, The Netherlands
    Crit Care 9:R490-7. 2005
    ..The aim of the present study was to evaluate the dynamics of the anticoagulant, anti-inflammatory and pro-fibrinolytic action of rhAPC in patients with severe sepsis, by comparing rhAPC-treated patients with case controls...
  6. pmc The effects of continuous venovenous hemofiltration on coagulation activation
    Catherine S C Bouman
    Department of Intensive Care, Academic Medical Center, University of Amsterdam, PO 22660, 1100 DD Amsterdam, The Netherlands
    Crit Care 10:R150. 2006
    ..In contrast to previous studies, CVVH was performed without anticoagulation...
  7. pmc Factors that predict outcome of intensive care treatment in very elderly patients: a review
    Sophia E de Rooij
    Department of Geriatrics, Academic Medical Center, University of Amsterdam, Amsterdam
    Crit Care 9:R307-14. 2005
    ..This report reviews available data on factors that determine outcome, on the value of prognostic models, and on preferences regarding life-sustaining treatments in (very) elderly intensive care unit (ICU) patients...
  8. ncbi request reprint Anticoagulant factor concentrates in disseminated intravascular coagulation: rationale for use and clinical experience
    E de Jonge
    Department of Intensive Care, Academic Medical Center, Amsterdam, The Netherlands
    Semin Thromb Hemost 27:667-74. 2001
    ..Data from large phase III trials of AT and APC as treatment of patients with severe sepsis will soon be available. Recombinant TFPI is currently in phase II clinical trials for severe sepsis...
  9. ncbi request reprint Decreased circulating levels of von Willebrand factor after intravenous administration of a rapidly degradable hydroxyethyl starch (HES 200/0.5/6) in healthy human subjects
    E de Jonge
    Department of Intensive Care, Academic Medical Centre, University of Amsterdam, P O Box 22660, 1100 DD Amsterdam, The Netherlands
    Intensive Care Med 27:1825-9. 2001
    ..This study was undertaken to investigate the effects of a rapidly degradable MMW-HES plasma substitute on primary haemostasis and blood coagulation in human subjects...
  10. ncbi request reprint Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial
    Evert de Jonge
    Department of Intensive Care, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands
    Lancet 362:1011-6. 2003
    ..We assessed the effects of SDD on intensive-care-unit (ICU) and hospital mortality, and on the acquisition of resistant bacteria in adult patients admitted to intensive care...
  11. ncbi request reprint [Intensive care medicine in the Netherlands, 1997-2001. I. Patient population and treatment outcome]
    E de Jonge
    Academisch Medisch Centrum Universiteit van Amsterdam, Postbus 22 660, 1100 DD Amsterdam
    Ned Tijdschr Geneeskd 147:1013-7. 2003
    ..To describe the patients admitted to intensive care units (ICUs) in the Netherlands between 1997-2001 and the treatment outcome...
  12. ncbi request reprint [The value of the pulmonary-artery catheter: not ruled out, but not proven either]
    E de Jonge
    Academisch Medisch Centrum Universiteit van Amsterdam, afd Intensive Care Volwassenen, Postbus 22 660, 1100 DD Amsterdam
    Ned Tijdschr Geneeskd 147:792-5. 2003
    ..However, based on the present evidence from the literature, the routine use of the pulmonary-artery catheter can no longer be defended...
  13. ncbi request reprint Tissue factor pathway inhibitor does not influence inflammatory pathways during human endotoxemia
    E de Jonge
    Department of Intensive Care, Academic Medical Center, University of Amsterdam, 1100 DD Amsterdam, The Netherlands
    J Infect Dis 183:1815-8. 2001
    ..Thus, complete prevention of coagulation activation by TFPI does not influence activation of inflammatory pathways during human endotoxemia...
  14. pmc Patients with cancer on the ICU: the times they are changing
    Evert de Jonge
    Department of Intensive Care, Academic Medical Center, 1100 DD Amsterdam, The Netherlands
    Crit Care 13:122. 2009
    ..Refusal of ICU admission should not be based on a diagnosis of cancer as the underlying condition. In contrast, these decisions should be based on the availability of treatment options, and on patients' own preferences...
  15. ncbi request reprint Current drug treatment strategies for disseminated intravascular coagulation
    E de Jonge
    Department of Intensive Care, Academic Medical Center, University of Amsterdam, The Netherlands
    Drugs 55:767-77. 1998
    ..Results of studies on protein C concentrate, thrombomodulin or inhibitors of tissue factor are promising, but the efficacy and safety of these novel strategies remains to be established in appropriate clinical trials...
  16. ncbi request reprint [Placement of central venous catheters and patient safety]
    E de Jonge
    Academisch Medisch Centrum Universiteit van Amsterdam, afd Intensive Care Volwassenen, Postbus 22 660, 1100 DD Amsterdam
    Ned Tijdschr Geneeskd 151:226-7. 2007
    ..It may also increase the success rate in subclavian vein catheterisation. To increase patient safety, the use of ultrasound when placing a central venous catheter should be embraced and become the standard of care...
  17. pmc Association between administered oxygen, arterial partial oxygen pressure and mortality in mechanically ventilated intensive care unit patients
    Evert de Jonge
    Department of Intensive Care, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Crit Care 12:R156. 2008
    ..The aim of this study was to investigate whether in-hospital mortality was associated with the administered fraction of oxygen in inspired air (FiO2) and achieved arterial partial pressure of oxygen (PaO2)...
  18. pmc Activation of coagulation by administration of recombinant factor VIIa elicits interleukin 6 (IL-6) and IL-8 release in healthy human subjects
    Evert de Jonge
    Department of Intensive Care, Academic Medical Center, University of Amsterdam, The Netherlands
    Clin Diagn Lab Immunol 10:495-7. 2003
    ..This increase was absent when the subjects were pretreated with recombinant nematode anticoagulant protein c2, the inhibitor of tissue factor-factor VIIa...
  19. ncbi request reprint Effects of selective decontamination of digestive tract on mortality and antibiotic resistance in the intensive-care unit
    Evert de Jonge
    Department of Intensive Care, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    Curr Opin Crit Care 11:144-9. 2005
    ..In this article, we will review the concept on which SDD is based and the present knowledge of the effects of SDD on mortality and antibiotic resistance...
  20. ncbi request reprint Effects of different plasma substitutes on blood coagulation: a comparative review
    E de Jonge
    Department of Intensive Care, Academic Medical Center, University of Amsterdam, 1100 DD Amsterdam, The Netherlands
    Crit Care Med 29:1261-7. 2001
    ..To compare the effects of different colloid plasma substitutes on blood coagulation and postoperative blood loss...
  21. doi request reprint Risk factors and outcome of transfusion-related acute lung injury in the critically ill: a nested case-control study
    Alexander P J Vlaar
    Intensive Care Department, Academic Medical Center, Amsterdam, The Netherlands
    Crit Care Med 38:771-8. 2010
    ..To determine the incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of critically ill patients...
  22. doi request reprint Nebulized anticoagulants limit coagulopathy but not inflammation in pseudomonas aeruginosa-induced pneumonia in rats
    Alexander D Cornet
    Laboratory of Experimental Intensive Care and Anesthesiology LEICA, Academic Medical Center, University of Amsterdam, The Netherlands
    Shock 36:417-23. 2011
    ..Nebulization of rh-APC or plasma-derived AT attenuated pulmonary coagulopathy, but not bacterial clearance or inflammation, in a rat model of P. aeruginosa pneumonia...
  23. ncbi request reprint Recombinant human activated protein C inhibits local and systemic activation of coagulation without influencing inflammation during Pseudomonas aeruginosa pneumonia in rats
    Goda Choi
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Crit Care Med 35:1362-8. 2007
    ..We investigated the role of the protein C system in pneumonia caused by Pseudomonas aeruginosa, the organism that is predominantly involved in ventilator-associated pneumonia...
  24. doi request reprint A short course of infusion of a hydrogen sulfide-donor attenuates endotoxemia induced organ injury via stimulation of anti-inflammatory pathways, with no additional protection from prolonged infusion
    Hamid Aslami
    Laboratory of Experimental Intensive Care and Anesthesiology LEICA, Academic Medical Center, Amsterdam, The Netherlands
    Cytokine 61:614-21. 2013
    ..Co-incubation with a neutralizing IL-10 antibody partly abrogated the decrease in TNF-α levels. In conclusion, a short course of H(2)S infusion reduced organ injury during endotoxemia, at least in part via upregulation of IL-10...
  25. doi request reprint Weaning automation with adaptive support ventilation: a randomized controlled trial in cardiothoracic surgery patients
    Dave A Dongelmans
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Anesth Analg 108:565-71. 2009
    ....
  26. ncbi request reprint Evaluation of short-term consequences of hypoglycemia in an intensive care unit
    Titia M Vriesendorp
    Department of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Crit Care Med 34:2714-8. 2006
    ..Little is known about the consequences of hypoglycemia in this setting. We examined short-term consequences (seizures, coma, and death) of hypoglycemia in the intensive care unit...
  27. ncbi request reprint Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents alveolar coagulation in patients without lung injury
    Goda Choi
    Dept of Intensive Care Medicine, Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Anesthesiology 105:689-95. 2006
    ..The authors sought to determine the effects of mechanical ventilation on the alveolar hemostatic balance in patients without preexistent lung injury...
  28. doi request reprint Nebulized anticoagulants limit pulmonary coagulopathy, but not inflammation, in a model of experimental lung injury
    Jorrit J Hofstra
    Laboratory of Experimental Intensive Care and Anesthesiology LEICA, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Aerosol Med Pulm Drug Deliv 23:105-11. 2010
    ..Pulmonary coagulopathy may contribute to an adverse outcome in lung injury. We assessed the effects of local anticoagulant therapy on bronchoalveolar and systemic haemostasis in a rat model of endotoxemia-induced lung injury...
  29. ncbi request reprint Antithrombin inhibits bronchoalveolar activation of coagulation and limits lung injury during Streptococcus pneumoniae pneumonia in rats
    Goda Choi
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Crit Care Med 36:204-10. 2008
    ..We investigated the role of these natural anticoagulants in Streptococcus pneumoniae pneumonia...
  30. ncbi request reprint The incidence and microbial spectrum of ventilator-associated pneumonia after tracheotomy in a selective decontamination of the digestive tract-setting
    Denise P Veelo
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Infect 56:20-6. 2008
    ..Selective decontamination of the digestive tract (SDD) aims to prevent VAP in critically ill patients, including those after tracheotomy. We determined the incidence and microbial spectrum of VAP after tracheotomy in a SDD-setting...
  31. pmc Soluble receptor for advanced glycation end products as an indicator of pulmonary vascular injury after cardiac surgery
    Pieter R Tuinman
    Department of Intensive Care Medicine and Laboratory of Experimental Intensive Care and Anesthesiology L, E, I, C, A, Academic Medical Center, Meibergdreef 9, Amsterdam 1105, AZ, The Netherlands
    BMC Pulm Med 13:76. 2013
    ..Cardiac surgery is frequently complicated by an acute vascular lung injury and this may be mediated, at least in part, by the (soluble) receptor for advanced glycation end products (sRAGE)...
  32. pmc Nebulized fibrinolytic agents improve pulmonary fibrinolysis but not inflammation in rat models of direct and indirect acute lung injury
    Jorrit J Hofstra
    Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 8:e55262. 2013
    ..Nebulized fibrinolytic agents could exert lung-protective effects, via promotion of fibrinolysis as well as anti-inflammation...
  33. ncbi request reprint Transfusion-related acute lung injury in cardiac surgery patients is characterized by pulmonary inflammation and coagulopathy: a prospective nested case-control study
    Alexander P J Vlaar
    Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Crit Care Med 40:2813-20. 2012
    ..The objective of the present study was to determine inflammation and coagulation pathways involved in the onset of transfusion-related acute lung injury...
  34. doi request reprint Supernatant of aged erythrocytes causes lung inflammation and coagulopathy in a "two-hit" in vivo syngeneic transfusion model
    Alexander P J Vlaar
    Department of Intensive Care Medicine, Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, Amsterdam, The Netherlands
    Anesthesiology 113:92-103. 2010
    ..Using a syngeneic in vivo transfusion model, we investigated whether transfusion of stored rat erythrocytes causes lung injury in healthy and in lipopolysaccharide-primed rats in a "two-hit" model of lung injury...
  35. pmc Plasma levels of surfactant protein D and KL-6 for evaluation of lung injury in critically ill mechanically ventilated patients
    Rogier M Determann
    Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
    BMC Pulm Med 10:6. 2010
    ..In the present study we investigated whether plasma levels of lung-specific biological markers can be used to evaluate lung injury in patients with ALI/ARDS and patients without lung injury at onset of mechanical ventilation...
  36. doi request reprint Perioperative hyperinsulinaemic normoglycaemic clamp causes hypolipidaemia after coronary artery surgery
    C J Zuurbier
    Department of Anaesthesiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Br J Anaesth 100:442-50. 2008
    ..The present study examines lipids and other substrates during and after on-pump coronary artery bypass grafting and how they are affected by a hyperinsulinaemic normoglycaemic clamp...
  37. ncbi request reprint Recombinant nematode anticoagulant protein c2, an inhibitor of tissue factor/factor VIIa, attenuates coagulation and the interleukin-10 response in human endotoxemia
    A C J M de Pont
    Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Thromb Haemost 2:65-70. 2004
    ..v. dose rNAPc2 completely blocked endotoxin-induced thrombin generation without affecting the fibrinolytic response. In addition, rNAPc2 attenuated the endotoxin-induced rise in IL-10, without affecting the rises in other cytokines...
  38. pmc Early intravenous unfractionated heparin and outcome in acute lung injury and acute respiratory distress syndrome: a retrospective propensity matched cohort study
    Jorrit J Hofstra
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, AZ, Amsterdam, The Netherlands
    BMC Pulm Med 12:43. 2012
    ..We hypothesized that an intravenous therapeutic dose of unfractionated heparin would favorably influence outcome of critically ill patients diagnosed with ALI...
  39. pmc Implementing glucose control in intensive care: a multicenter trial using statistical process control
    Saeid Eslami
    Department of Medical Informatics, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    Intensive Care Med 36:1556-65. 2010
    ..In this study we investigated GC performance over time during implementation of GC strategies within three intensive care units (ICUs) and in routine clinical practice...
  40. ncbi request reprint Adaptive support ventilation: a translational study evaluating the size of delivered tidal volumes
    Denise P Veelo
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Int J Artif Organs 33:302-9. 2010
    ..We studied calculated V(T)s in a computer simulation model, and V(T)s delivered in a test lung setting as well as in clinical practice...
  41. doi request reprint Compartmental apoptosis and neutrophil accumulation in severe peritonitis
    J W Olivier Van Till
    Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Surg Res 164:321-8. 2010
    ..This study examines the relation of these processes, and their expression in the abdominal, systemic, and bronchoalveolar compartments in patients with severe peritonitis...
  42. ncbi request reprint Manual hyperinflation of intubated and mechanically ventilated patients in Dutch intensive care units--a survey into current practice and knowledge
    Frederique Paulus
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Intensive Crit Care Nurs 25:199-207. 2009
    ..Therefore we examined current practice and knowledge of basic principles of manual hyperinflation (MH) in intubated and mechanically ventilated patients among intensive care unit nurses in the Netherlands...
  43. doi request reprint The effect of blood transfusion on pulmonary permeability in cardiac surgery patients: a prospective multicenter cohort study
    Alexander P J Vlaar
    Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Transfusion 52:82-90. 2012
    ..Mediators of increased pulmonary vascular leakage after transfusion are unknown. We hypothesized that factors may include antibodies or bioactive lipids, which have been implicated in transfusion-related acute lung injury...
  44. doi request reprint Recombinant human soluble tumor necrosis factor-alpha receptor fusion protein partly attenuates ventilator-induced lung injury
    Esther K Wolthuis
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, C3 423, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Shock 31:262-6. 2009
    ..The number of caspase 3-positive cells was significantly higher in etanercept-treated animals. Inhibition of TNF by etanercept attenuates, in part, MV-induced changes...
  45. doi request reprint The role of bronchoalveolar hemostasis in the pathogenesis of acute lung injury
    Jorrit Jan H Hofstra
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Semin Thromb Hemost 34:475-84. 2008
    ....
  46. ncbi request reprint Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injury
    Esther K Wolthuis
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Anesthesiology 108:46-54. 2008
    ..The authors sought to determine the effects of short-term mechanical ventilation on local inflammatory responses in patients without preexisting lung injury...
  47. doi request reprint sTREM-1 is a potential useful biomarker for exclusion of ongoing infection in patients with secondary peritonitis
    Rogier M Determann
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Cytokine 46:36-42. 2009
    ..86 (95% CI 0.69-0.94) below a cut-off level of 160 pg/ml. In clinical practice, abdominal fluid sTREM-1 levels may be useful for exclusion but not detection of ongoing abdominal infection after surgery for secondary peritonitis...
  48. doi request reprint Supernatant of stored platelets causes lung inflammation and coagulopathy in a novel in vivo transfusion model
    Alexander P J Vlaar
    Department of Intensive Care Medicine, Academic Medical Center, Amsterdam
    Blood 116:1360-8. 2010
    ..In a "2-hit" model, aged PLTs contribute to pulmonary and systemic coagulopathy, which may be mediated by LysoPCs, which accumulate in the supernatant of PLTs during storage...
  49. ncbi request reprint Management of tracheostomy: a survey of Dutch intensive care units
    Denise P Veelo
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Respir Care 53:1709-15. 2008
    ..To determine tracheostomy-management practices in Dutch intensive care units (ICUs) and post-ICU step-down facilities...
  50. doi request reprint Ventilator-induced lung injury is mediated by the NLRP3 inflammasome
    Maria T Kuipers
    Laboratory of Experimental Intensive Care and Anesthesiology LEICA, and Center of Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Anesthesiology 116:1104-15. 2012
    ..The innate immune response is important in ventilator-induced lung injury (VILI) but the exact pathways involved are not elucidated. The authors studied the role of the intracellular danger sensor NLRP3 inflammasome...
  51. pmc Pre-treatment with allopurinol or uricase attenuates barrier dysfunction but not inflammation during murine ventilator-induced lung injury
    Maria T Kuipers
    Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e50559. 2012
    ..Ventilator-induced lung injury (VILI) is mediated by the NLRP3 inflammasome and increased uric acid levels in lung lavage fluid are reported. We studied levels in human lung injury and the contribution of uric acid in experimental VILI...
  52. pmc Soluble urokinase-type plasminogen activator receptor levels in patients with burn injuries and inhalation trauma requiring mechanical ventilation: an observational cohort study
    Yara Backes
    Department of Intensive Care Medicine, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Crit Care 15:R270. 2011
    ..The aim of this study was to investigate the diagnostic and prognostic value of systemic and pulmonary levels of suPAR in burn patients with inhalation trauma who need mechanical ventilation...
  53. pmc Correction of subclinical coagulation disorders before percutaneous dilatational tracheotomy
    Denise P Veelo
    Department of Intensive Care Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Blood Transfus 10:213-20. 2012
    ..However, it is currently unclear whether PDT can be performed safely in patients in an Intensive Care Unit (ICU) with uncorrected mild coagulation disorders...
  54. ncbi request reprint Pulmonary activation of coagulation and inhibition of fibrinolysis after burn injuries and inhalation trauma
    Jorrit J Hofstra
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Trauma 70:1389-97. 2011
    ..Pulmonary coagulopathy is intrinsic to pneumonia and other forms of acute lung injury. We hypothesized patients with burn injuries and inhalation trauma to have similar alterations in pulmonary coagulation and fibrinolysis...
  55. pmc Blood transfusion during cardiac surgery is associated with inflammation and coagulation in the lung: a case control study
    Pieter R Tuinman
    Department of Intensive Care Medicine and Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, Meibergdreef 9, Amsterdam NL 1105 AZ, The Netherlands
    Crit Care 15:R59. 2011
    ..We hypothesized that blood transfusion is associated with changes in pulmonary and systemic inflammation and coagulation occurring in patients who do not meet the clinical diagnosis of transfusion-related acute lung injury (TRALI)...
  56. ncbi request reprint Procoagulant and fibrinolytic activity in cerebrospinal fluid from adults with bacterial meningitis
    Martijn Weisfelt
    Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands
    J Infect 54:545-50. 2007
    ..This study investigated levels of coagulation and fibrinolysis factors in cerebrospinal fluid (CSF) from adults with bacterial meningitis in relation to development of brain infarction...
  57. ncbi request reprint Reliability of height and weight estimates in patients acutely admitted to intensive care units
    Rogier M Determann
    Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Crit Care Nurse 27:48-55; quiz 56. 2007
  58. pmc Mechanical ventilation with lower tidal volumes does not influence the prescription of opioids or sedatives
    Esther K Wolthuis
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Crit Care 11:R77. 2007
    ....
  59. ncbi request reprint On-demand rather than daily-routine chest radiography prescription may change neither the number nor the impact of chest computed tomography and ultrasound studies in a multidisciplinary intensive care unit
    Anke Kröner
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Anesthesiology 108:40-5. 2008
    ..Elimination of daily-routine chest radiographs (CXRs) may influence chest computed tomography (CT) and ultrasound practice in critically ill patients...
  60. pmc Ventilation with lower tidal volumes as compared with conventional tidal volumes for patients without acute lung injury: a preventive randomized controlled trial
    Rogier M Determann
    Department of Intensive Care Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Crit Care 14:R1. 2010
    ..We compared the effect of conventional with lower tidal volumes on pulmonary inflammation and development of lung injury in critically ill patients without ALI at the onset of mechanical ventilation...
  61. doi request reprint Adaptive support ventilation with protocolized de-escalation and escalation does not accelerate tracheal extubation of patients after nonfast-track cardiothoracic surgery
    Dave A Dongelmans
    Department of Intensive Care Medicine, G3 212, Academic Medical Center, Amsterdam, The Netherlands
    Anesth Analg 111:961-7. 2010
    ....
  62. doi request reprint The practice of reporting transfusion-related acute lung injury: a national survey among clinical and preclinical disciplines
    Alexander P J Vlaar
    Department of Intensive Care Medicine and Department of Hematology, Academic Medical Center, Amsterdam, The Netherlands
    Transfusion 50:443-51. 2010
    ..g., sepsis) predisposes to TRALI. TRALI is a clinical diagnosis. Disciplines involved in managing TRALI may differ in decision-making on the reporting of TRALI...
  63. ncbi request reprint Influence of severity of illness, medication and selective decontamination on defecation
    Johan I van der Spoel
    Onze Lieve Vrouwe Gasthuis, Department of Intensive Care, Oosterpark 9, 1091 AC Amsterdam, The Netherlands
    Intensive Care Med 32:875-80. 2006
    ..To describe the pattern of defecation in critically ill ventilated patients and the influence of selective decontamination (SDD) and other medication...
  64. ncbi request reprint Reduced ex vivo chemokine production by polymorphonuclear cells after in vivo exposure of normal humans to endotoxin
    M J Schultz
    Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Infect Dis 182:1264-7. 2000
    ..Thus, intravenous injection of LPS induces a refractory state of PMNL that is not caused by soluble factors produced in response to in vivo exposure to LPS...
  65. ncbi request reprint Prospective validation of the International Society of Thrombosis and Haemostasis scoring system for disseminated intravascular coagulation
    Kamran Bakhtiari
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Crit Care Med 32:2416-21. 2004
    ..The aim of this study was to prospectively validate this scoring system and assess its feasibility, sensitivity, and specificity in a consecutive series of intensive care patients...
  66. pmc Usefulness of suPAR as a biological marker in patients with systemic inflammation or infection: a systematic review
    Yara Backes
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Intensive Care Med 38:1418-28. 2012
    ..We reviewed the usefulness of systemic levels of suPAR in the care of critically ill patients with sepsis, SIRS, and bacteremia, focusing on its diagnostic and prognostic value...
  67. doi request reprint Effect of a clinical decision support system on adherence to a lower tidal volume mechanical ventilation strategy
    Saeid Eslami
    Department of Medical Informatics, Academic Medical Center, Universiteit van Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Crit Care 24:523-9. 2009
    ..The purpose of the study was to measure the effect of a computerized decision support system (CDSS) on adherence to tidal volume (V(T)) recommendations...
  68. ncbi request reprint Adoption of lower tidal volume ventilation improves with feedback and education
    Esther K Wolthuis
    Department of Intensive Care Medicine, C3 329, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Respir Care 52:1761-6. 2007
    ..To determine whether feedback and education improve adoption of lung-protective mechanical ventilation (ie, with lower tidal volume [V(T)])...
  69. ncbi request reprint Adaptive support ventilation with percutaneous dilatational tracheotomy: a clinical study
    Denise P Veelo
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Anesth Analg 107:938-40. 2008
    ..In a minority of patients (26%), minute ventilation had to be adjusted to achieve similar Paco(2) values...
  70. pmc Plasma CC16 levels are associated with development of ALI/ARDS in patients with ventilator-associated pneumonia: a retrospective observational study
    Rogier M Determann
    Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
    BMC Pulm Med 9:49. 2009
    ..This study was designed to assess and compare the diagnostic accuracy of biological markers for ALI/ARDS with ventilator-associated pneumonia (VAP)...
  71. ncbi request reprint Lung epithelial injury markers are not influenced by use of lower tidal volumes during elective surgery in patients without preexisting lung injury
    Rogier M Determann
    Department of Intensive Care Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 294:L344-50. 2008
    ..Mechanical ventilation with lower tidal volumes and PEEP did not have a different effect on levels of biomarkers of lung epithelial injury compared with conventional mechanical ventilation...
  72. ncbi request reprint Acute phase response impairs host defense against Pseudomonas aeruginosa pneumonia in mice
    Rosemarijn Renckens
    Center for Infection and Immunity Amsterdam, University of Amsterdam, The Netherlands
    Crit Care Med 36:580-7. 2008
    ..The objective was to study the influence of the acute phase response induced by sterile tissue injury on pulmonary host defense...
  73. pmc The clinical value of daily routine chest radiographs in a mixed medical-surgical intensive care unit is low
    Marleen E Graat
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Crit Care 10:R11. 2006
    ..We conducted this study to evaluate how frequently unexpected predefined major abnormalities are identified with daily routine CXRs, and how often these findings lead to a change in care for intensive care unit (ICU) patients...
  74. pmc Selective decontamination of the digestive tract reduces mortality in critically ill patients
    Marcus J Schultz
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Crit Care 7:107-10. 2003
  75. ncbi request reprint Struggle for implementation of new strategies in intensive care medicine: anticoagulation, insulin, and lower tidal volumes
    Marcus J Schultz
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Crit Care 20:199-204. 2005
    ..This manuscript focuses on the potential reasons that underlie this problem...
  76. doi request reprint Mild hypothermia reduces ventilator-induced lung injury, irrespective of reducing respiratory rate
    Hamid Aslami
    Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, Meibergdreef 9, Amsterdam, The Netherlands
    Transl Res 159:110-7. 2012
    ..In conclusion, hypothermia protected from lung injury in a physiologic VILI model by reducing inflammation. Decreasing the respiratory rate mildly did not enhance protection...
  77. ncbi request reprint Determinants of tidal volumes with adaptive support ventilation: a multicenter observational study
    Dave A Dongelmans
    Department of Intensive Care Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Anesth Analg 107:932-7. 2008
    ..We determined tidal volumes (Vt) and factors that influence Vt with this mode of microprocessor-controlled mechanical ventilation (MV)...
  78. pmc Determinants of transfusion decisions in a mixed medical-surgical intensive care unit: a prospective cohort study
    Alexander P J Vlaar
    Department of Intensive Care Medicine, Laboratory of Experimental Intensive Care and Anesthesiology, M0 228, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands
    Blood Transfus 7:106-10. 2009
    ..Insight into physicians' transfusion decisions may aid efforts to restrict transfusion practice...
  79. doi request reprint Adaptive support ventilation may deliver unwanted respiratory rate-tidal volume combinations in patients with acute lung injury ventilated according to an open lung concept
    Dave A Dongelmans
    Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Anesthesiology 114:1138-43. 2011
    ..We hypothesized that adaptive support ventilation in an open lung ventilator strategy would deliver higher V(T)s to patients with acute lung injury...
  80. ncbi request reprint Early procoagulant shift in the bronchoalveolar compartment of patients with secondary peritonitis
    J W Olivier Van Till
    Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands
    J Infect Dis 194:1331-9. 2006
    ..The effect of a primarily extrapulmonary infection on coagulation and fibrinolysis in the pulmonary compartment is unclear...
  81. ncbi request reprint Time to wean after tracheotomy differs among subgroups of critically ill patients: retrospective analysis in a mixed medical/surgical intensive care unit
    Ary Jan Wj van der Lely
    Department of Intensive Care Medicine, University of Amsterdam, Amsterdam, Netherlands
    Respir Care 51:1408-15. 2006
    ..To determine the time to wean from mechanical ventilation and time spent off the ventilator per day after tracheotomy in critically ill patients in a 28-bed mixed medical and surgical intensive care unit (ICU) in Amsterdam, Netherlands...
  82. pmc Elimination of daily routine chest radiographs in a mixed medical-surgical intensive care unit
    Marleen E Graat
    Department of Intensive Care Medicine, Academic Medical Center, Mail stop C3 329, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Intensive Care Med 33:639-44. 2007
    ..To determine the impact of elimination of daily routine chest radiographs (CXRs) in a mixed medical-surgical intensive care unit (ICU) on utility of on demand CXRs, length of stay (LOS) in ICU, readmission rate, and mortality rate...
  83. ncbi request reprint Rationale for restoration of physiological anticoagulant pathways in patients with sepsis and disseminated intravascular coagulation
    M Levi
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Crit Care Med 29:S90-4. 2001
    ....
  84. ncbi request reprint Serum cystatin C-A useful endogenous marker of renal function in intensive care unit patients at risk for or with acute renal failure?
    Annick A N M Royakkers
    Department of Intensive Care, Tergooi Hospitals, location Blaricum, Rijksstraatweg 1, 1261 AN Blaricum, The Netherlands
    Curr Med Chem 14:2314-7. 2007
    ..Cystatin C could be an important tool both to recognize early renal dysfunction and to identify renal recovery while on CRRT in the critically ill patient, however, we are in need of more studies...
  85. pmc Decision making in interhospital transport of critically ill patients: national questionnaire survey among critical care physicians
    Erik Jan van Lieshout
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, Netherlands
    Intensive Care Med 34:1269-73. 2008
    ..This study assessed the relative importance of clinical and transport-related factors in physicians' decision-making regarding the interhospital transport of critically ill patients...
  86. ncbi request reprint A change in the Dutch Directive on Medical Research Involving Human Subjects strongly increases the number of eligible intensive care patients: an observational study
    Denise P Veelo
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Intensive Care Med 32:1845-50. 2006
    ..In addition, we determined how family members experience their role as acting representative for giving informed consent, and in turn whether patients feel their representatives would do well representing them...
  87. ncbi request reprint Elimination of daily routine chest radiographs does not change on-demand radiography practice in post-cardiothoracic surgery patients
    Onno Mets
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Thorac Cardiovasc Surg 134:139-44. 2007
    ..We sought to determine the effect of elimination of daily routine chest radiographs on chest radiographic practice in cardiothoracic surgery patients in the intensive care unit and the post-intensive care unit ward...
  88. ncbi request reprint Endotoxin down-regulates monocyte and granulocyte interleukin-6 receptors without influencing gp130 expression in humans
    P E Dekkers
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    J Infect Dis 181:1055-61. 2000
    ..Monocytes and granulocytes may down-regulate IL-6R at their surface upon their first interaction with bacterial antigens...
  89. ncbi request reprint Predisposing factors for hypoglycemia in the intensive care unit
    Titia M Vriesendorp
    Department of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Crit Care Med 34:96-101. 2006
    ..In this study we examined the association between predefined circumstances and the occurrence of hypoglycemia in the intensive care unit...
  90. pmc Induction of cell-associated chemokines after endotoxin administration to healthy humans
    D P Olszyna
    Department of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Infect Immun 69:2736-8. 2001
    ..IL-8 was also recovered from mononuclear and polymorphonuclear cells. Cell-associated chemokines may more accurately reflect their production than plasma concentrations...
  91. ncbi request reprint Short-term and long-term mortality in very elderly patients admitted to an intensive care unit
    S E de Rooij
    Department of Internal Medicine, Academic Medical Center, 22700, 1100 DE, Amsterdam, The Netherlands
    Intensive Care Med 32:1039-44. 2006
    ..To report short-term and long-term mortality of very elderly ICU patients and to determine independent risk factors for short-term and long-term mortality..
  92. ncbi request reprint Recombinant human activated protein C (Xigris)
    M Levi
    Department of Internal Medicine, Academic Medical Centre, University of Amsterdam, The Netherlands
    Int J Clin Pract 56:542-5. 2002
    ....
  93. ncbi request reprint Regulatory role of cytokines in disseminated intravascular coagulation
    T van der Poll
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Semin Thromb Hemost 27:639-51. 2001
    ..Cytokines have been implicated as important mediators in these hemostatic alterations. This article summarizes recent insights into which cytokines are likely to be involved in the procoagulant response to systemic infection...
  94. pmc Reduced Th1, but not Th2, cytokine production by lymphocytes after in vivo exposure of healthy subjects to endotoxin
    F N Lauw
    Laboratory of Experimental Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Infect Immun 68:1014-8. 2000
    ..LPS exposure influences lymphocyte cytokine production, resulting in a shift toward a Th2 cytokine response, an effect that may be mediated in part by soluble factors present in serum after LPS administration in vivo...
  95. ncbi request reprint Predilution versus postdilution during continuous venovenous hemofiltration: a comparison of circuit thrombogenesis
    Anne Cornelie J M de Pont
    Departments of Intensive Care, Academic Medical Center, University of Amsterdam, The Netherlands
    ASAIO J 52:416-22. 2006
    ..In summary, predilution and postdilution did not differ with respect to extracorporeal circuit thrombogenesis. During postdilution, baseline platelet count and maximal prefilter pressure were inversely related with circuit survival time...
  96. ncbi request reprint An evaluation of Patient Data Management Systems in Dutch intensive care
    N F de Keizer
    Department of Medical Informatics, Academic Medical Center, Amsterdam, The Netherlands
    Intensive Care Med 24:167-71. 1998
    ..To assess the agreement between the functions of seven configurations of Patient Data Management Systems (PDMS) and the Dutch specifications prepared by the users prior to use...
  97. ncbi request reprint Differential effects of a perioperative hyperinsulinemic normoglycemic clamp on the neurohumoral stress response during coronary artery surgery
    H B van Wezel
    Department of Anesthesia, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Clin Endocrinol Metab 91:4144-53. 2006
    ..The present study was designed to quantify the effects of a perioperative hyperinsulinemic normoglycemic clamp on the neurohumoral stress response during CABG...
  98. ncbi request reprint [Admission of elderly patients to intensive care]
    S E J A de Rooij
    Academisch Medisch Centrum Universiteit van Amsterdam, Postbus 22 660, DD Amsterdam
    Ned Tijdschr Geneeskd 149:2215-20. 2005
    ..New prognostic models should be developed specifically to predict both survival and functional outcome in individual elderly patients after admission to ICU...
  99. ncbi request reprint Reliability and accuracy of Sequential Organ Failure Assessment (SOFA) scoring
    D G T Arts
    Department of Medical Informatics, Academic Medical Center Universiteit van Amsterdam, Amsterdam, Netherlands
    Crit Care Med 33:1988-93. 2005
    ..The Sequential Organ Failure Assessment (SOFA) score was developed to quantify the severity of patients' illness, based on the degree of organ dysfunction. This study aimed to evaluate the accuracy and the reliability of SOFA scoring...
  100. pmc Identification of high-risk subgroups in very elderly intensive care unit patients
    Sophia E de Rooij
    Department of Geriatrics, Academic Medical Center, University of Amsterdam, Meibergdreef 9 1105 AZ, Amsterdam, The Netherlands
    Crit Care 11:R33. 2007
    ..Aside from having good overall performance, the model was designed to reliably and specifically identify subgroups at very high risk of dying...
  101. ncbi request reprint Applying PRIM (Patient Rule Induction Method) and logistic regression for selecting high-risk subgroups in very elderly ICU patients
    Barry Nannings
    Department of Medical Informatics, Academic Medical Centre, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Int J Med Inform 77:272-9. 2008
    ..To apply the Patient Rule Induction Method (PRIM) to identify very elderly Intensive Care (IC) patients at high risk of mortality, and compare the results with those of a conventional logistic regression model...