W Scheper

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. pmc Intracellular accumulation of aggregated pyroglutamate amyloid beta: convergence of aging and Aβ pathology at the lysosome
    Line De Kimpe
    Department of Genome Analysis, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Age (Dordr) 35:673-87. 2013
  2. ncbi request reprint Rab6 is increased in Alzheimer's disease brain and correlates with endoplasmic reticulum stress
    W Scheper
    Neurogenetics Laboratory, Academic Medical Center, Amsterdam, The Netherlands
    Neuropathol Appl Neurobiol 33:523-32. 2007
  3. ncbi request reprint Rab6 membrane association is dependent of Presenilin 1 and cellular phosphorylation events
    Wiep Scheper
    Neurogenetics Laboratory, Academic Medical Center, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    Brain Res Mol Brain Res 122:17-23. 2004
  4. ncbi request reprint Alternative splicing in the N-terminus of Alzheimer's presenilin 1
    Wiep Scheper
    Neurogenetics Laboratory, Academic Medical Center, Amsterdam, The Netherlands
    Neurogenetics 5:223-7. 2004
  5. ncbi request reprint Protein quality control in Alzheimer's disease: a fatal saviour
    W Scheper
    Neurogenetics Laboratory, Academic Medical Center, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    Curr Drug Targets CNS Neurol Disord 4:283-92. 2005
  6. pmc The unfolded protein response and proteostasis in Alzheimer disease: preferential activation of autophagy by endoplasmic reticulum stress
    Wiep Scheper
    Department of Genome Analysis and Department of Neurology Academic Medical Center University of Amsterdam Amsterdam, The Netherlands
    Autophagy 7:910-1. 2011
  7. ncbi request reprint Endoplasmic reticulum protein quality control in neurodegenerative disease: the good, the bad and the therapy
    Wiep Scheper
    Academic Medical Center, Neurogenetics Laboratory, Department of Neurology, University of Amsterdam, P O Box 22660, 1100 DD Amsterdam, The Netherlands
    Curr Med Chem 16:615-26. 2009
  8. ncbi request reprint Activation of the unfolded protein response in Parkinson's disease
    J J M Hoozemans
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Biochem Biophys Res Commun 354:707-11. 2007
  9. ncbi request reprint The significance of neuroinflammation in understanding Alzheimer's disease
    P Eikelenboom
    Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Neural Transm 113:1685-95. 2006
  10. pmc Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's disease
    D A T Nijholt
    Department of Genome Analysis, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Cell Death Differ 18:1071-81. 2011

Collaborators

Detail Information

Publications26

  1. pmc Intracellular accumulation of aggregated pyroglutamate amyloid beta: convergence of aging and Aβ pathology at the lysosome
    Line De Kimpe
    Department of Genome Analysis, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Age (Dordr) 35:673-87. 2013
    ..The results presented in this study support a model where Aβ pathology and aging converge, leading to accumulation of the degradation-resistant pE-modified Aβ in the lysosomes, lysosomal dysfunction, and neurodegeneration...
  2. ncbi request reprint Rab6 is increased in Alzheimer's disease brain and correlates with endoplasmic reticulum stress
    W Scheper
    Neurogenetics Laboratory, Academic Medical Center, Amsterdam, The Netherlands
    Neuropathol Appl Neurobiol 33:523-32. 2007
    ..Our data suggest that ER and post-ER protein quality control mechanisms are activated early in the pathology of AD...
  3. ncbi request reprint Rab6 membrane association is dependent of Presenilin 1 and cellular phosphorylation events
    Wiep Scheper
    Neurogenetics Laboratory, Academic Medical Center, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    Brain Res Mol Brain Res 122:17-23. 2004
    ..Moreover, we demonstrate that this regulation of Rab6 membrane association is dependent on PS1. The possible implications for APP processing and AD are discussed...
  4. ncbi request reprint Alternative splicing in the N-terminus of Alzheimer's presenilin 1
    Wiep Scheper
    Neurogenetics Laboratory, Academic Medical Center, Amsterdam, The Netherlands
    Neurogenetics 5:223-7. 2004
    ..To our knowledge this is the first study showing a functional difference between PS1 splice variants. The possible consequences for APP processing and the pathogenesis of AD are discussed...
  5. ncbi request reprint Protein quality control in Alzheimer's disease: a fatal saviour
    W Scheper
    Neurogenetics Laboratory, Academic Medical Center, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    Curr Drug Targets CNS Neurol Disord 4:283-92. 2005
    ..In this review, we will discuss the role of protein quality control in the neurotoxicity of Abeta...
  6. pmc The unfolded protein response and proteostasis in Alzheimer disease: preferential activation of autophagy by endoplasmic reticulum stress
    Wiep Scheper
    Department of Genome Analysis and Department of Neurology Academic Medical Center University of Amsterdam Amsterdam, The Netherlands
    Autophagy 7:910-1. 2011
    ..Our data suggest that autophagy is the major degradational pathway following UPR activation in neuronal cells and indicate a connection between UPR activation and autophagic pathology in AD brain...
  7. ncbi request reprint Endoplasmic reticulum protein quality control in neurodegenerative disease: the good, the bad and the therapy
    Wiep Scheper
    Academic Medical Center, Neurogenetics Laboratory, Department of Neurology, University of Amsterdam, P O Box 22660, 1100 DD Amsterdam, The Netherlands
    Curr Med Chem 16:615-26. 2009
    ..In this review we will focus on the protein quality control systems in the endoplasmic reticulum (ER) and address the involvement of ER quality control in neurodegenerative disease as well as its potential as therapeutic target...
  8. ncbi request reprint Activation of the unfolded protein response in Parkinson's disease
    J J M Hoozemans
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Biochem Biophys Res Commun 354:707-11. 2007
    ..These data show that the UPR is activated in PD and that UPR activation is closely associated with the accumulation and aggregation of alpha-synuclein...
  9. ncbi request reprint The significance of neuroinflammation in understanding Alzheimer's disease
    P Eikelenboom
    Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Neural Transm 113:1685-95. 2006
    ..We also discuss the possibilities of inflammation-based therapeutic strategies in AD...
  10. pmc Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's disease
    D A T Nijholt
    Department of Genome Analysis, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Cell Death Differ 18:1071-81. 2011
    ..Our data suggest that autophagy is the major degradational pathway following UPR activation in neuronal cells and indicate a connection between UPR activation and autophagic pathology in AD brain...
  11. ncbi request reprint The unfolded protein response is activated in Alzheimer's disease
    J J M Hoozemans
    Neurogenetics Laboratory, Academic Medical Center, University of Amsterdam, P O Box 22660, 1100 DD, Amsterdam, The Netherlands
    Acta Neuropathol 110:165-72. 2005
    ..Although the initial participation of the UPR in AD pathogenesis might be neuroprotective, sustained activation of the UPR in AD might initiate or mediate neurodegeneration...
  12. ncbi request reprint Removing protein aggregates: the role of proteolysis in neurodegeneration
    D A T Nijholt
    Academic Medical Center, Department of Genome Analysis, P O Box 22660, 1100 DD Amsterdam, The Netherlands
    Curr Med Chem 18:2459-76. 2011
    ..These differences have important implications for the design of therapeutic strategies. The opportunities and caveats of targeting the UPS and autophagy/lysosomal system as a therapeutic strategy in neurodegeneration will be discussed...
  13. ncbi request reprint Always around, never the same: pathways of amyloid beta induced neurodegeneration throughout the pathogenic cascade of Alzheimer's disease
    J J M Hoozemans
    Academic Medical Center, Neurogenetics Laboratory, P O Box 22660, 1100 DD Amsterdam, The Netherlands
    Curr Med Chem 13:2599-605. 2006
    ..Insight into the role of different Abeta species during AD pathogenesis is essential for the development of disease modifying drugs and therapeutical strategies...
  14. ncbi request reprint Increased Abeta1-42 production sensitizes neuroblastoma cells for ER stress toxicity
    S M Chafekar
    Neurogenetics Laboratory, VU University Medical Center, 1081 HV Amsterdam, The Netherlands
    Curr Alzheimer Res 5:469-74. 2008
    ..Our data indicate that increased Abeta1-42 production sensitizes neuroblastoma cells for ER stress toxicity...
  15. ncbi request reprint Protein quality control in neurodegeneration: walking the tight rope between health and disease
    E M Hol
    Research group Cellular Quality Control, Netherlands Institute for Neuroscience, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands
    J Mol Neurosci 34:23-33. 2008
    ..Here we review the role of protein quality control in neurodegeneration and aim to distinguish protective and destructive responses to aggregates in order to find targets for therapeutic intervention...
  16. ncbi request reprint The unfolded protein response affects neuronal cell cycle protein expression: implications for Alzheimer's disease pathogenesis
    Jeroen J M Hoozemans
    Department of Neuropathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Exp Gerontol 41:380-6. 2006
    ..These data suggest that activation of the UPR affects cell cycle protein expression in neurons during neurodegeneration in AD...
  17. pmc Pontocerebellar hypoplasia type 2: a neuropathological update
    Peter G Barth
    Department of Neuropathology, Academic Medical Centre, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Acta Neuropathol 114:373-86. 2007
    ..Immunohistochemical evaluation of the endoplasmic reticulum stress response is negative. We conclude that the neuropathological findings in PCH-2 are sufficiently specific to enable an unequivocal diagnosis based on neuropathology...
  18. ncbi request reprint From alpha to omega with Abeta: targeting the multiple molecular appearances of the pathogenic peptide in Alzheimer's disease
    L De Kimpe
    Neurogenetics Laboratory, Academic Medical Center, PAmsterdam, The Netherlands
    Curr Med Chem 17:198-212. 2010
    ....
  19. ncbi request reprint Abeta 1-42 induces mild endoplasmic reticulum stress in an aggregation state-dependent manner
    Sidhartha M Chafekar
    Neurogenetics Laboratory, University of Amsterdam, Amsterdam, The Netherlands
    Antioxid Redox Signal 9:2245-54. 2007
    ..Because UPR activation is observed in AD brain at a stage that precedes the massive fibrillar Abeta deposition and tangle formation, this may indicate a role for nonfibrillar Abeta in the induction of the UPR in AD neurons...
  20. doi request reprint The pre-eclampsia gene STOX1 controls a conserved pathway in placenta and brain upregulated in late-onset Alzheimer's disease
    Marie van Dijk
    Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
    J Alzheimers Dis 19:673-9. 2010
    ..Similar in vitro results were seen in trophoblast. Our data indicate that STOX1 controls a conserved pathway shared between placenta and brain with overexpression in LOAD...
  21. ncbi request reprint Pin1 levels are downregulated during ER stress in human neuroblastoma cells
    Yolanda S Kap
    Neurogenetics Laboratory, Academic Medical Center, PO Box 22700, Amsterdam, 1100 DE, The Netherlands
    Neurogenetics 8:21-7. 2007
    ..This study creates a starting point to investigate whether modulation of the ER stress response may prevent or delay tau pathology in AD...
  22. ncbi request reprint Branched KLVFF tetramers strongly potentiate inhibition of beta-amyloid aggregation
    Sidhartha M Chafekar
    Neurogenetics Laboratory, Academic Medical Center, P O Box 22660, 1100 DD Amsterdam, The Netherlands
    Chembiochem 8:1857-64. 2007
    ..Our data lead us to propose that conjugates that bear multiple copies of KLVFF might be useful as therapeutic agents for the treatment of Alzheimer's disease...
  23. ncbi request reprint Coordination of N-glycosylation and protein translocation across the endoplasmic reticulum membrane by Sss1 protein
    Wiep Scheper
    University of Cambridge, Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 2XY, United Kingdom
    J Biol Chem 278:37998-8003. 2003
    ..Our data suggest that Sss1p coordinates translocation across the ER membrane and N-linked glycosylation of secretory proteins...
  24. ncbi request reprint Protein translocation across the endoplasmic reticulum membrane in cold-adapted organisms
    Karin Römisch
    University of Cambridge, CIMR, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 2XY, UK
    J Cell Sci 116:2875-83. 2003
    ..Collectively, our data suggest that the limited amino-acid changes in Sec61alpha from fishes may be functionally significant and represent adaptive changes that enhance channel function in the cold...
  25. ncbi request reprint Ubiquitin proteasome system as a pharmacological target in neurodegeneration
    Elly M Hol
    Netherlands Institute for Neuroscience, Research group Cellular Quality Control, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands
    Expert Rev Neurother 6:1337-47. 2006
    ..The potential of pharmacological intervention within this system in patients suffering from neurodegenerative diseases will be evaluated...
  26. doi request reprint Oligomer-specific Abeta toxicity in cell models is mediated by selective uptake
    Sidhartha M Chafekar
    Neurogenetics Laboratory Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Biochim Biophys Acta 1782:523-31. 2008
    ..Inhibition of uptake specifically inhibits oligomer but not fibril toxicity. Our study indicates that selective uptake of oligomers is a determinant of oligomer specific Abeta toxicity...