Research Topics
| L RenemanSummaryAffiliation: Academic Medical Center Country: The Netherlands Publications
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Detail Information
Publications
Comparative in vivo study of iodine-123-labeled beta-CIT and nor-beta-CIT binding to serotonin transporters in rat brainL Reneman
Graduate School of Neurosciences, Department of Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands
Synapse 34:77-80. 1999....
Preliminary evidence of hippocampal damage in chronic users of ecstasyBjørnar den Hollander
Graduate School of Neurosciences, Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands
J Neurol Neurosurg Psychiatry 83:83-5. 2012..032). These data provide preliminary evidence that ecstasy users may be prone to incurring hippocampal damage, in line with previous reports of acute hippocampal sclerosis and subsequent atrophy in chronic users of this drug...- Memory function and serotonin transporter promoter gene polymorphism in ecstasy (MDMA) usersLiesbeth Reneman
Graduate School of Neurosciences, Department of Radiology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
J Psychopharmacol 20:389-99. 2006..No effect of 5-HTTLPR or gender on memory function or MDMA use was observed... - Validity of [123I]beta-CIT SPECT in detecting MDMA-induced serotonergic neurotoxicityLiesbeth Reneman
Department of Nuclear Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
Synapse 46:199-205. 2002.... - Use of amphetamine by recreational users of ecstasy (MDMA) is associated with reduced striatal dopamine transporter densities: a [123I]beta-CIT SPECT study--preliminary reportLiesbeth Reneman
Department of Nuclear Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Psychopharmacology (Berl) 159:335-40. 2002..However, little is known about the effects of ecstasy use or the combination of ecstasy and amphetamine use on dopamine (DA) neurones in the human brain... - The acute and chronic effects of MDMA ("ecstasy") on cortical 5-HT2A receptors in rat and human brainLiesbeth Reneman
Graduate School of Neurosciences, Department of Nuclear Medicine Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
Neuropsychopharmacology 26:387-96. 2002..The combined results of this study suggest a compensatory upregulation of post-synaptic 5-HT(2A) receptors in the occipital cortex of ex-MDMA users due to low synaptic 5-HT levels... - Effects of dose, sex, and long-term abstention from use on toxic effects of MDMA (ecstasy) on brain serotonin neuronsL Reneman
Departments of Nuclear Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, Netherlands
Lancet 358:1864-9. 2001..We investigated the effects of moderate and heavy MDMA use, sex differences, and long-term effects of MDMA use on serotonin neurons in different brain regions... - Cortical serotonin transporter density and verbal memory in individuals who stopped using 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy"): preliminary findingsL Reneman
Department of Nuclear Medicine, F2 210, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Arch Gen Psychiatry 58:901-6. 2001..We investigated the long-term effects of MDMA use on cortical 5-HT neurons in humans and memory function, because brain 5-HT has been implicated in memory function... - Effects of ecstasy (MDMA) on the brain in abstinent users: initial observations with diffusion and perfusion MR imagingL Reneman
Graduate School of Neurosciences, Department of Nuclear Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Radiology 220:611-7. 2001..To evaluate the effects of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) on the human brain by using diffusion and perfusion magnetic resonance (MR) imaging... - Neuroimaging findings with MDMA/ecstasy: technical aspects, conceptual issues and future prospectsLiesbeth Reneman
Graduate School of Neurosciences, Department of Radiology, Academic Medical Centre, University of Amsterdam, The Netherlands
J Psychopharmacol 20:164-75. 2006..Because most studies have had a retrospective design, in which evidence is indirect and differs in the degree to which any causal links can be implied, longitudinal studies in human ecstasy users are needed to draw definite conclusions... - Memory disturbances in "Ecstasy" users are correlated with an altered brain serotonin neurotransmissionL Reneman
Graduate School of Neurosciences, Department of Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands
Psychopharmacology (Berl) 148:322-4. 2000..Since loss of 5-HT neurons has been implicated in memory loss, it is important to establish whether MDMA use may produce changes in postsynaptic 5-HT receptors and memory function in humans... - Addition of a 5-HT receptor agonist to methylphenidate potentiates the reduction of [123I]FP-CIT binding to dopamine transporters in rat frontal cortex and hippocampusL Reneman
Graduate School of Neurosciences, Department of Nuclear Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
Synapse 39:193-200. 2001..These findings suggest potential harmful effects of concomitant use of drugs directly activating 5-HT2 receptors in patients using methylphenidate... - Dopamine transporter density in young patients with schizophrenia assessed with [123]FP-CIT SPECTJ Lavalaye
Department of Psychiatry, Academic Medical Center, Tafelbergweg 25, 1105 BC Amsterdam, The Netherlands
Schizophr Res 47:59-67. 2001..56, p=0.014).Concluding, functional changes in the dopaminergic system in schizophrenia are not likely to be reflected in a change in DA transporter density. Moreover, DA transporter density does not seem to be altered by AP medication... - Dopamine D2 receptor occupancy by olanzapine or risperidone in young patients with schizophreniaJ Lavalaye
Department of Psychiatry, Academic Medical Centre, Amsterdam, The Netherlands
Psychiatry Res 92:33-44. 1999..The lower incidence of prolactin elevation with olanzapine, compared to risperidone, may not be attributed to a lower D2 receptor occupancy... - Effect of age and gender on dopamine transporter imaging with [123I]FP-CIT SPET in healthy volunteersJ Lavalaye
Graduate School of Neurosciences Amsterdam, Department of Nuclear Medicine, Academic Medical Center, The Netherlands
Eur J Nucl Med 27:867-9. 2000..The intriguing finding of a higher dopamine transporter density in females than in males is in line with findings from animal studies... - Dopamine transporter density in patients with tardive dyskinesia: a single photon emission computed tomography studyJ Lavalaye
Department of Nuclear Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Psychopharmacology (Berl) 155:107-9. 2001..Tardive dyskinesia occurs frequently in schizophrenic patients chronically treated with classical antipsychotic medication. It may be caused by loss of dopaminergic cells, due to free radicals as a product of high synaptic dopamine levels... - Prefrontal N-acetylaspartate is strongly associated with memory performance in (abstinent) ecstasy users: preliminary reportL Reneman
Graduate School of Neurosciences, Department of Nuclear Medicine, Academic Medical Center, 1105 AZ, Amsterdam, The Netherlands
Biol Psychiatry 50:550-4. 2001..76, p =.01). CONCLUSIONS: Greater decrements in memory function predicted lower NAA/Cr levels-and by inference greater neuronal dysfunction-in the prefrontal cortex of MDMA users... - Lasting effects of chronic fluoxetine treatment on the late developing rat brain: age-dependent changes in the serotonergic neurotransmitter system assessed by pharmacological MRIA Klomp
Department of Radiology, Academic Medical Centre Amsterdam, Netherlands
Neuroimage 59:218-26. 2012..e. during adolescence... - Higher occupancy of muscarinic receptors by olanzapine than risperidone in patients with schizophrenia. A[123I]-IDEX SPECT studyJ Lavalaye
Department of Psychiatry, Academic Medical Center, Amsterdam, The Netherlands
Psychopharmacology (Berl) 156:53-7. 2001..Substantial occupancy of muscarinic receptors may be an explanation for the low incidence of extrapyramidal side effects induced by olanzapine... - Feasibility of ASL-based phMRI with a single dose of oral citalopram for repeated assessment of serotonin functionA Klomp
Brain Imaging Centre, Academic Medical Centre, Amsterdam, The Netherlands Department of Radiology, Academic Medical Centre, Amsterdam, The Netherlands Electronic address
Neuroimage 63:1695-700. 2012..We therefore conclude that the test-retest reliability of PASL phMRI with an oral citalopram challenge is low, limiting the technique's sensitivity to time-dependent changes and consequently its use as a (clinical) research tool... - Mapping serotonergic dysfunction in MDMA (ecstasy) users using pharmacological MRIM L J Schouw
Department of Radiology, Academic Medical Center, University of Amsterdam, The Netherlands
Eur Neuropsychopharmacol 22:537-45. 2012..MDMA users had higher impulsivity scores and felt more uncomfortable after citalopram infusion, compared with control subjects. Our findings indicate that phMRI is very well suited for in-vivo assessment of 5-HT dysfunction... - Validation of [(123)I]beta-CIT SPECT to assess serotonin transporters in vivo in humans: a double-blind, placebo-controlled, crossover study with the selective serotonin reuptake inhibitor citalopramMaartje M L de Win
Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Neuropsychopharmacology 30:996-1005. 2005..Although we provide some evidence that [(123)I]beta-CIT SPECT may be used to measure SERTs in SERT-low cortical areas, these measurements must be interpreted with caution... - Reduced N-acetylaspartate levels in the frontal cortex of 3,4-methylenedioxymethamphetamine (Ecstasy) users: preliminary resultsLiesbeth Reneman
Academic Medical Center, Department of Nuclear Medicine F2-210, Graduate School of Neurosciences, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
AJNR Am J Neuroradiol 23:231-7. 2002..These data suggest that MDMA may be a neurotoxin in humans, as it is in animals... - Cerebral impairment in chronic solvent-induced encephalopathyIeke Visser
Academic Psychiatric Center AMC, Amsterdam, The Netherlands
Ann Neurol 63:572-80. 2008..To detect preclinical, solvent-related effects, we also studied the FST circuitry in solvent-exposed, but asymptomatic workers... - A prospective cohort study on sustained effects of low-dose ecstasy use on the brain in new ecstasy usersMaartje M L de Win
Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Neuropsychopharmacology 32:458-70. 2007..Additional studies are needed to replicate these findings... - Mood disorders and serotonin transporter density in ecstasy users--the influence of long-term abstention, dose, and genderMaartje M L de Win
Department of Radiology G1 229, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
Psychopharmacology (Berl) 173:376-82. 2004..Neurotoxic effects of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") on the serotonin (5-HT) system have been described in animals and humans, but little is known about long-term effects of ecstasy use on mood... - Ecstasy use and self-reported depression, impulsivity, and sensation seeking: a prospective cohort studyMaartje M L de Win
Department of Radiology, University of Amsterdam, Academic Medical Center, The Netherlands
J Psychopharmacol 20:226-35. 2006..However, low level ecstasy use may increase (certain aspects of) sensation seeking... - Validity of in vivo [123I]beta-CIT SPECT in detecting MDMA-induced neurotoxicity in ratsMaartje M L de Win
Department of Radiology, University of Amsterdam, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Eur Neuropsychopharmacol 14:185-9. 2004..These data show that [(123)I]beta-CIT SPECT may be able to detect MDMA-induced loss of SERTs. Therefore, this may be a promising technique to perform serial studies on MDMA-induced serotonergic neurotoxicity in living small animals... - The Netherlands XTC Toxicity (NeXT) study: objectives and methods of a study investigating causality, course, and clinical relevanceMaartje M L de Win
Department of Radiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
Int J Methods Psychiatr Res 14:167-85. 2005..The combined results will lead to conclusions that can be used in prevention messages, clinical decision making, and the development of an (inter)national ecstasy policy... - Ecstasy in the brain: a model for neuroimagingRobin A Hurley
Mental Health Care Line, Houston Veterans Affairs Medical Center, Houston, Texas, USA
J Neuropsychiatry Clin Neurosci 14:125-9. 2002