L Reneman

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Comparative in vivo study of iodine-123-labeled beta-CIT and nor-beta-CIT binding to serotonin transporters in rat brain
    L Reneman
    Graduate School of Neurosciences, Department of Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Synapse 34:77-80. 1999
  2. doi request reprint Incidental head and neck findings on MRI in young healthy volunteers: prevalence and clinical implications
    L Reneman
    Department of Neuroradiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    AJNR Am J Neuroradiol 33:1971-4. 2012
  3. doi request reprint The effects of Psychotropic drugs On Developing brain (ePOD) study: methods and design
    Marco A Bottelier
    Brain Imaging Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    BMC Psychiatry 14:48. 2014
  4. doi request reprint Preliminary evidence of hippocampal damage in chronic users of ecstasy
    Bjørnar den Hollander
    Graduate School of Neurosciences, Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 83:83-5. 2012
  5. ncbi request reprint The acute and chronic effects of MDMA ("ecstasy") on cortical 5-HT2A receptors in rat and human brain
    Liesbeth Reneman
    Graduate School of Neurosciences, Department of Nuclear Medicine Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
    Neuropsychopharmacology 26:387-96. 2002
  6. ncbi request reprint Use of amphetamine by recreational users of ecstasy (MDMA) is associated with reduced striatal dopamine transporter densities: a [123I]beta-CIT SPECT study--preliminary report
    Liesbeth Reneman
    Department of Nuclear Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Psychopharmacology (Berl) 159:335-40. 2002
  7. ncbi request reprint Validity of [123I]beta-CIT SPECT in detecting MDMA-induced serotonergic neurotoxicity
    Liesbeth Reneman
    Department of Nuclear Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
    Synapse 46:199-205. 2002
  8. ncbi request reprint Neuroimaging findings with MDMA/ecstasy: technical aspects, conceptual issues and future prospects
    Liesbeth Reneman
    Graduate School of Neurosciences, Department of Radiology, Academic Medical Centre, University of Amsterdam, The Netherlands
    J Psychopharmacol 20:164-75. 2006
  9. ncbi request reprint Memory function and serotonin transporter promoter gene polymorphism in ecstasy (MDMA) users
    Liesbeth Reneman
    Graduate School of Neurosciences, Department of Radiology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Psychopharmacol 20:389-99. 2006
  10. ncbi request reprint Effects of dose, sex, and long-term abstention from use on toxic effects of MDMA (ecstasy) on brain serotonin neurons
    L Reneman
    Departments of Nuclear Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, Netherlands
    Lancet 358:1864-9. 2001

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Comparative in vivo study of iodine-123-labeled beta-CIT and nor-beta-CIT binding to serotonin transporters in rat brain
    L Reneman
    Graduate School of Neurosciences, Department of Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Synapse 34:77-80. 1999
    ....
  2. doi request reprint Incidental head and neck findings on MRI in young healthy volunteers: prevalence and clinical implications
    L Reneman
    Department of Neuroradiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    AJNR Am J Neuroradiol 33:1971-4. 2012
    ..2%). These findings suggest that a high prevalence of incidental findings is common in healthy young volunteers, though the clinical implications are negligible...
  3. doi request reprint The effects of Psychotropic drugs On Developing brain (ePOD) study: methods and design
    Marco A Bottelier
    Brain Imaging Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    BMC Psychiatry 14:48. 2014
    ..The effects of Psychotropic drugs On the Developing brain (ePOD) study is a combination of different approaches to determine whether there are related findings in humans...
  4. doi request reprint Preliminary evidence of hippocampal damage in chronic users of ecstasy
    Bjørnar den Hollander
    Graduate School of Neurosciences, Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 83:83-5. 2012
    ..032). These data provide preliminary evidence that ecstasy users may be prone to incurring hippocampal damage, in line with previous reports of acute hippocampal sclerosis and subsequent atrophy in chronic users of this drug...
  5. ncbi request reprint The acute and chronic effects of MDMA ("ecstasy") on cortical 5-HT2A receptors in rat and human brain
    Liesbeth Reneman
    Graduate School of Neurosciences, Department of Nuclear Medicine Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
    Neuropsychopharmacology 26:387-96. 2002
    ..The combined results of this study suggest a compensatory upregulation of post-synaptic 5-HT(2A) receptors in the occipital cortex of ex-MDMA users due to low synaptic 5-HT levels...
  6. ncbi request reprint Use of amphetamine by recreational users of ecstasy (MDMA) is associated with reduced striatal dopamine transporter densities: a [123I]beta-CIT SPECT study--preliminary report
    Liesbeth Reneman
    Department of Nuclear Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Psychopharmacology (Berl) 159:335-40. 2002
    ..However, little is known about the effects of ecstasy use or the combination of ecstasy and amphetamine use on dopamine (DA) neurones in the human brain...
  7. ncbi request reprint Validity of [123I]beta-CIT SPECT in detecting MDMA-induced serotonergic neurotoxicity
    Liesbeth Reneman
    Department of Nuclear Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
    Synapse 46:199-205. 2002
    ....
  8. ncbi request reprint Neuroimaging findings with MDMA/ecstasy: technical aspects, conceptual issues and future prospects
    Liesbeth Reneman
    Graduate School of Neurosciences, Department of Radiology, Academic Medical Centre, University of Amsterdam, The Netherlands
    J Psychopharmacol 20:164-75. 2006
    ..Because most studies have had a retrospective design, in which evidence is indirect and differs in the degree to which any causal links can be implied, longitudinal studies in human ecstasy users are needed to draw definite conclusions...
  9. ncbi request reprint Memory function and serotonin transporter promoter gene polymorphism in ecstasy (MDMA) users
    Liesbeth Reneman
    Graduate School of Neurosciences, Department of Radiology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Psychopharmacol 20:389-99. 2006
    ..No effect of 5-HTTLPR or gender on memory function or MDMA use was observed...
  10. ncbi request reprint Effects of dose, sex, and long-term abstention from use on toxic effects of MDMA (ecstasy) on brain serotonin neurons
    L Reneman
    Departments of Nuclear Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, Netherlands
    Lancet 358:1864-9. 2001
    ..We investigated the effects of moderate and heavy MDMA use, sex differences, and long-term effects of MDMA use on serotonin neurons in different brain regions...
  11. ncbi request reprint Cortical serotonin transporter density and verbal memory in individuals who stopped using 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy"): preliminary findings
    L Reneman
    Department of Nuclear Medicine, F2 210, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Arch Gen Psychiatry 58:901-6. 2001
    ..We investigated the long-term effects of MDMA use on cortical 5-HT neurons in humans and memory function, because brain 5-HT has been implicated in memory function...
  12. ncbi request reprint Addition of a 5-HT receptor agonist to methylphenidate potentiates the reduction of [123I]FP-CIT binding to dopamine transporters in rat frontal cortex and hippocampus
    L Reneman
    Graduate School of Neurosciences, Department of Nuclear Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
    Synapse 39:193-200. 2001
    ..These findings suggest potential harmful effects of concomitant use of drugs directly activating 5-HT2 receptors in patients using methylphenidate...
  13. ncbi request reprint Effects of ecstasy (MDMA) on the brain in abstinent users: initial observations with diffusion and perfusion MR imaging
    L Reneman
    Graduate School of Neurosciences, Department of Nuclear Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Radiology 220:611-7. 2001
    ..To evaluate the effects of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) on the human brain by using diffusion and perfusion magnetic resonance (MR) imaging...
  14. ncbi request reprint Memory disturbances in "Ecstasy" users are correlated with an altered brain serotonin neurotransmission
    L Reneman
    Graduate School of Neurosciences, Department of Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Psychopharmacology (Berl) 148:322-4. 2000
    ..Since loss of 5-HT neurons has been implicated in memory loss, it is important to establish whether MDMA use may produce changes in postsynaptic 5-HT receptors and memory function in humans...
  15. ncbi request reprint Dopamine transporter density in young patients with schizophrenia assessed with [123]FP-CIT SPECT
    J Lavalaye
    Department of Psychiatry, Academic Medical Center, Tafelbergweg 25, 1105 BC Amsterdam, The Netherlands
    Schizophr Res 47:59-67. 2001
    ..56, p=0.014).Concluding, functional changes in the dopaminergic system in schizophrenia are not likely to be reflected in a change in DA transporter density. Moreover, DA transporter density does not seem to be altered by AP medication...
  16. ncbi request reprint Dopamine D2 receptor occupancy by olanzapine or risperidone in young patients with schizophrenia
    J Lavalaye
    Department of Psychiatry, Academic Medical Centre, Amsterdam, The Netherlands
    Psychiatry Res 92:33-44. 1999
    ..The lower incidence of prolactin elevation with olanzapine, compared to risperidone, may not be attributed to a lower D2 receptor occupancy...
  17. ncbi request reprint Effect of age and gender on dopamine transporter imaging with [123I]FP-CIT SPET in healthy volunteers
    J Lavalaye
    Graduate School of Neurosciences Amsterdam, Department of Nuclear Medicine, Academic Medical Center, The Netherlands
    Eur J Nucl Med 27:867-9. 2000
    ..The intriguing finding of a higher dopamine transporter density in females than in males is in line with findings from animal studies...
  18. doi request reprint Mapping serotonergic dysfunction in MDMA (ecstasy) users using pharmacological MRI
    M L J Schouw
    Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 22:537-45. 2012
    ..MDMA users had higher impulsivity scores and felt more uncomfortable after citalopram infusion, compared with control subjects. Our findings indicate that phMRI is very well suited for in-vivo assessment of 5-HT dysfunction...
  19. doi request reprint Mapping the hemodynamic response in human subjects to a dopaminergic challenge with dextroamphetamine using ASL-based pharmacological MRI
    M L J Schouw
    Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neuroimage 72:1-9. 2013
    ..Our observations are in line with literature and provide further evidence that ASL-based phMRI with dAMPH is a promising technique to assess DAergic function in human subjects...
  20. ncbi request reprint Prefrontal N-acetylaspartate is strongly associated with memory performance in (abstinent) ecstasy users: preliminary report
    L Reneman
    Graduate School of Neurosciences, Department of Nuclear Medicine, Academic Medical Center, 1105 AZ, Amsterdam, The Netherlands
    Biol Psychiatry 50:550-4. 2001
    ..76, p =.01). CONCLUSIONS: Greater decrements in memory function predicted lower NAA/Cr levels-and by inference greater neuronal dysfunction-in the prefrontal cortex of MDMA users...
  21. ncbi request reprint Dopamine transporter density in patients with tardive dyskinesia: a single photon emission computed tomography study
    J Lavalaye
    Department of Nuclear Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Psychopharmacology (Berl) 155:107-9. 2001
    ..Tardive dyskinesia occurs frequently in schizophrenic patients chronically treated with classical antipsychotic medication. It may be caused by loss of dopaminergic cells, due to free radicals as a product of high synaptic dopamine levels...
  22. doi request reprint Dopaminergic dysfunction in abstinent dexamphetamine users: results from a pharmacological fMRI study using a reward anticipation task and a methylphenidate challenge
    M L J Schouw
    Department of Radiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Drug Alcohol Depend 130:52-60. 2013
    ..Preclinical studies have shown that even relatively low doses of d-amphetamine (dAMPH) (equivalent to doses used in clinical Practice) can lead to DA neurotoxicity in rodents and non-human primates (Ricaurte et al., 2005)...
  23. doi request reprint Test-retest reliability of task-related pharmacological MRI with a single-dose oral citalopram challenge
    A Klomp
    Brain Imaging Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neuroimage 75:108-16. 2013
    ..This latter finding validates previous studies indicating a role for 5-HT in suppression of the task-negative network during goal-directed behavior...
  24. doi request reprint Monoaminergic dysfunction in recreational users of dexamphetamine
    M L J Schouw
    Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Brain Imaging Center at the Academic Medical Centre, Amsterdam, The Netherlands Electronic address
    Eur Neuropsychopharmacol 23:1491-502. 2013
    ....
  25. doi request reprint Feasibility of ASL-based phMRI with a single dose of oral citalopram for repeated assessment of serotonin function
    A Klomp
    Brain Imaging Centre, Academic Medical Centre, Amsterdam, The Netherlands
    Neuroimage 63:1695-700. 2012
    ..We therefore conclude that the test-retest reliability of PASL phMRI with an oral citalopram challenge is low, limiting the technique's sensitivity to time-dependent changes and consequently its use as a (clinical) research tool...
  26. doi request reprint Lasting effects of chronic fluoxetine treatment on the late developing rat brain: age-dependent changes in the serotonergic neurotransmitter system assessed by pharmacological MRI
    A Klomp
    Department of Radiology, Academic Medical Centre Amsterdam, Netherlands
    Neuroimage 59:218-26. 2012
    ..e. during adolescence...
  27. ncbi request reprint Higher occupancy of muscarinic receptors by olanzapine than risperidone in patients with schizophrenia. A[123I]-IDEX SPECT study
    J Lavalaye
    Department of Psychiatry, Academic Medical Center, Amsterdam, The Netherlands
    Psychopharmacology (Berl) 156:53-7. 2001
    ..Substantial occupancy of muscarinic receptors may be an explanation for the low incidence of extrapyramidal side effects induced by olanzapine...
  28. ncbi request reprint The Netherlands XTC Toxicity (NeXT) study: objectives and methods of a study investigating causality, course, and clinical relevance
    Maartje M L de Win
    Department of Radiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Int J Methods Psychiatr Res 14:167-85. 2005
    ..The combined results will lead to conclusions that can be used in prevention messages, clinical decision making, and the development of an (inter)national ecstasy policy...
  29. ncbi request reprint Reduced N-acetylaspartate levels in the frontal cortex of 3,4-methylenedioxymethamphetamine (Ecstasy) users: preliminary results
    Liesbeth Reneman
    Academic Medical Center, Department of Nuclear Medicine F2 210, Graduate School of Neurosciences, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    AJNR Am J Neuroradiol 23:231-7. 2002
    ..Few data are available about the effects of MDMA on the human brain. This study was designed to evaluate MDMA-related alterations in metabolite ratios with single-voxel proton ((1)H) MR spectroscopy...
  30. ncbi request reprint Ecstasy in the brain: a model for neuroimaging
    Robin A Hurley
    Mental Health Care Line, Houston Veterans Affairs Medical Center, Houston, Texas, USA
    J Neuropsychiatry Clin Neurosci 14:125-9. 2002
  31. doi request reprint Cerebral impairment in chronic solvent-induced encephalopathy
    Ieke Visser
    Academic Psychiatric Center AMC, Amsterdam, The Netherlands
    Ann Neurol 63:572-80. 2008
    ..To detect preclinical, solvent-related effects, we also studied the FST circuitry in solvent-exposed, but asymptomatic workers...
  32. ncbi request reprint A prospective cohort study on sustained effects of low-dose ecstasy use on the brain in new ecstasy users
    Maartje M L de Win
    Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neuropsychopharmacology 32:458-70. 2007
    ..Additional studies are needed to replicate these findings...
  33. ncbi request reprint Mood disorders and serotonin transporter density in ecstasy users--the influence of long-term abstention, dose, and gender
    Maartje M L de Win
    Department of Radiology G1 229, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Psychopharmacology (Berl) 173:376-82. 2004
    ..Neurotoxic effects of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") on the serotonin (5-HT) system have been described in animals and humans, but little is known about long-term effects of ecstasy use on mood...
  34. ncbi request reprint Ecstasy use and self-reported depression, impulsivity, and sensation seeking: a prospective cohort study
    Maartje M L de Win
    Department of Radiology, University of Amsterdam, Academic Medical Center, The Netherlands
    J Psychopharmacol 20:226-35. 2006
    ..However, low level ecstasy use may increase (certain aspects of) sensation seeking...
  35. ncbi request reprint Validation of [(123)I]beta-CIT SPECT to assess serotonin transporters in vivo in humans: a double-blind, placebo-controlled, crossover study with the selective serotonin reuptake inhibitor citalopram
    Maartje M L de Win
    Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neuropsychopharmacology 30:996-1005. 2005
    ..Although we provide some evidence that [(123)I]beta-CIT SPECT may be used to measure SERTs in SERT-low cortical areas, these measurements must be interpreted with caution...
  36. ncbi request reprint Validity of in vivo [123I]beta-CIT SPECT in detecting MDMA-induced neurotoxicity in rats
    Maartje M L de Win
    Department of Radiology, University of Amsterdam, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 14:185-9. 2004
    ..These data show that [(123)I]beta-CIT SPECT may be able to detect MDMA-induced loss of SERTs. Therefore, this may be a promising technique to perform serial studies on MDMA-induced serotonergic neurotoxicity in living small animals...