Research Topics
Species | Pieter G PostemaSummaryAffiliation: Academic Medical Center Country: The Netherlands Publications
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Publications
Accurate electrocardiographic assessment of the QT interval: teach the tangentPieter G Postema
Cardiology Department, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Heart Rhythm 5:1015-8. 2008..Conversely, almost 40% of patients referred to specialized centers with a presumed diagnosis of LQTS have a normal QT...- Familial Brugada syndrome uncovered by hyperkalaemic diabetic ketoacidosisPieter G Postema
Department of Cardiology, Academic Medical Center, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands
Europace 13:1509-10. 2011..Diabetic ketoacidosis with hyperkalaemia may uncover an inheritable arrhythmia syndrome that may put the patient and his/her next of kin at risk for a sudden death, irrespective of diabetes mellitus... 
Pneumococcal aortitis: an insidious diagnosisP G Postema
Department of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
Neth J Med 69:31-4. 2011..Although emergency surgery was performed when aortic rupture occurred, the patient did not survive. Infectious arteritis of large vessels is a diagnosis often made late and associated with high mortality...
Drugs and Brugada syndrome patients: review of the literature, recommendations, and an up-to-date website (www.brugadadrugs.org)Pieter G Postema
Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Heart Rhythm 6:1335-41. 2009..Importantly, many drugs have been reported to induce the characteristic Brugada syndrome-linked ECG abnormalities and/or (fatal) ventricular tachyarrhythmias...- Mechanism of right precordial ST-segment elevation in structural heart disease: excitation failure by current-to-load mismatchMark G Hoogendijk
Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Heart Rhythm 7:238-48. 2010..The Brugada sign has been associated with mutations in SCN5A and with right ventricular structural abnormalities. Their role in the Brugada sign and the associated ventricular arrhythmias is unknown... - [Premature sudden death--consider serious familial heart rhythm disturbances]Pieter G Postema
Academisch Medisch Centrum, afd Cardiologie, Hartfaal Centrum, Amsterdam, The Netherlands
Ned Tijdschr Geneeskd 155:A3391. 2011..Timely recognition of persons affected allows appropriate treatment and may implicate an implantable cardioverter defibrillator... - Sodium channelopathies: do we really understand what's going on?Pieter G Postema
Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Cardiovasc Electrophysiol 22:590-3. 2011..One son who carried the ΔKPQ mutation but not the I1660V mutation did not show the expected Long-QT phenotype but, unexpectedly, showed a conduction disease/Brugada phenotype... - Fever-induced life-threatening arrhythmias in children harboring an SCN5A mutationPriya Chockalingam
Department of Cardiology, Heart Failure Research Centre, Academic Medical Centre, Meibergdreef 9, 1105AZ Amsterdam, Netherlands
Pediatrics 127:e239-44. 2011..Management consisted of prompt antipyretic measures, hospitalization with vigorous monitoring during immunization and febrile episodes, and prevention of tachycardia-induced conduction disturbance with β-blockers... - The pathophysiological mechanism underlying Brugada syndrome: depolarization versus repolarizationArthur A M Wilde
Department of Cardiology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands
J Mol Cell Cardiol 49:543-53. 2010..depolarization hypothesis... - Local depolarization abnormalities are the dominant pathophysiologic mechanism for type 1 electrocardiogram in brugada syndrome a study of electrocardiograms, vectorcardiograms, and body surface potential maps during ajmaline provocationPieter G Postema
Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
J Am Coll Cardiol 55:789-97. 2010.... - Slow and discontinuous conduction conspire in Brugada syndrome: a right ventricular mapping and stimulation studyPieter G Postema
Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Circ Arrhythm Electrophysiol 1:379-86. 2008..The pathophysiological basis of the arrhythmias and type-1 BrS-ECG is unresolved. We studied the electrophysiological characteristics of the RV endocardium in BrS... - Haplotype-sharing analysis implicates chromosome 7q36 harboring DPP6 in familial idiopathic ventricular fibrillationMarielle Alders
Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands
Am J Hum Genet 84:468-76. 2009..Penetrance of IVF was high; 50% of risk-haplotype carriers experienced (aborted) sudden cardiac death before the age of 58 years. We propose DPP6 as a gene for IVF and increased DPP6 expression as the likely pathogenetic mechanism... - Do patients with long QT syndrome remain at risk for sudden cardiac death after 40 years of age?Pieter G Postema
Department of Clinical and Experimental Cardiology at the Academic Medical Centre, Amsterdam, The Netherlands
Nat Clin Pract Cardiovasc Med 5:602-3. 2008..65-9.92). Clearly, patients with LQTS remain at increased risk of lethal events after 40 years of age, indicating that continuous, age-independent awareness for QT prolongation is essential...