M Peppelenbosch

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. doi request reprint d-Asb11 is an essential mediator of canonical Delta-Notch signalling
    Sander H Diks
    Deptartment of Cell Biology, University Medical Center Groningen, University of Groningen, A Deusinglaan 1, NL 9713 AV Groningen, The Netherlands
    Nat Cell Biol 10:1190-8. 2008
  2. ncbi request reprint Bone morphogenetic protein 4 expressed in esophagitis induces a columnar phenotype in esophageal squamous cells
    Francesca Milano
    Laboratory of Experimental Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Gastroenterology 132:2412-21. 2007
  3. doi request reprint The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers
    Liudmila L Kodach
    Department of Gastroenterology, Leiden University Medical Center, Leiden, The Netherlands
    Gastroenterology 134:1332-41. 2008
  4. ncbi request reprint Multiple signal transduction pathways regulate TNF-induced actin reorganization in macrophages: inhibition of Cdc42-mediated filopodium formation by TNF
    M Peppelenbosch
    Ludwig Institute for Cancer Research, London, United Kingdom
    J Immunol 162:837-45. 1999
  5. ncbi request reprint Type I diabetes: a role for tissue factor in pancreatic islet transplantation?
    Maikel P Peppelenbosch
    Laboratory for Experimental Internal Medicine, Academic Medical Centre, NL 1105 AZ Amsterdam, Netherlands
    Lancet 360:1999-2000. 2002
  6. ncbi request reprint Cell biology of tissue factor, an unusual member of the cytokine receptor family
    M P Peppelenbosch
    Laboratory for Experimental Internal Medicine, Academic Medical Centre, Amsterdam, The Netherlands
    Trends Cardiovasc Med 11:335-9. 2001
  7. ncbi request reprint Macrophages present pinocytosed exogenous antigen via MHC class I whereas antigen ingested by receptor-mediated endocytosis is presented via MHC class II
    M P Peppelenbosch
    Laboratory for Experimental Internal Medicine, Academic Medical Centre, Amsterdam, The Netherlands
    J Immunol 165:1984-91. 2000
  8. ncbi request reprint Lipopolysaccharide regulates macrophage fluid phase pinocytosis via CD14-dependent and CD14-independent pathways
    M P Peppelenbosch
    Laboratory for Experimental Internal Medicine, G2 130 Academic Medical Centre, Amsterdam, The Netherlands
    Blood 93:4011-8. 1999
  9. ncbi request reprint Bone morphogenetic protein signaling suppresses tumorigenesis at gastric epithelial transition zones in mice
    Sylvia A Bleuming
    Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Cancer Res 67:8149-55. 2007
  10. ncbi request reprint An ex vivo readout for evaluation of dendritic cell-induced autologous cytotoxic T lymphocyte responses against esophageal cancer
    Francesca Milano
    Department of Experimental Internal Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Cancer Immunol Immunother 56:1967-77. 2007

Collaborators

Detail Information

Publications66

  1. doi request reprint d-Asb11 is an essential mediator of canonical Delta-Notch signalling
    Sander H Diks
    Deptartment of Cell Biology, University Medical Center Groningen, University of Groningen, A Deusinglaan 1, NL 9713 AV Groningen, The Netherlands
    Nat Cell Biol 10:1190-8. 2008
    ..We conclude that d-Asb11 is a component in the regulation of Delta-Notch signalling, important in fine-tuning the lateral inhibition gradients between DeltaA and Notch through a cell non-autonomous mechanism...
  2. ncbi request reprint Bone morphogenetic protein 4 expressed in esophagitis induces a columnar phenotype in esophageal squamous cells
    Francesca Milano
    Laboratory of Experimental Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Gastroenterology 132:2412-21. 2007
    ..In this study, the role of the BMP pathway in the metaplastic transformation of normal squamous cells into columnar cells was examined...
  3. doi request reprint The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers
    Liudmila L Kodach
    Department of Gastroenterology, Leiden University Medical Center, Leiden, The Netherlands
    Gastroenterology 134:1332-41. 2008
    ..The finding of bone morphogenetic protein (BMP) receptor 1a mutations in juvenile polyposis suggests that BMPs are important in colorectal cancer (CRC). We investigated the BMP pathway in sporadic CRC...
  4. ncbi request reprint Multiple signal transduction pathways regulate TNF-induced actin reorganization in macrophages: inhibition of Cdc42-mediated filopodium formation by TNF
    M Peppelenbosch
    Ludwig Institute for Cancer Research, London, United Kingdom
    J Immunol 162:837-45. 1999
    ..We conclude that different domains of TNFR-1 mediate distinct changes in the Mphi cytoskeleton, and that the ability of TNF to inhibit Mphi chemotaxis may be due to decreased filopodium formation downstream of Cdc42...
  5. ncbi request reprint Type I diabetes: a role for tissue factor in pancreatic islet transplantation?
    Maikel P Peppelenbosch
    Laboratory for Experimental Internal Medicine, Academic Medical Centre, NL 1105 AZ Amsterdam, Netherlands
    Lancet 360:1999-2000. 2002
  6. ncbi request reprint Cell biology of tissue factor, an unusual member of the cytokine receptor family
    M P Peppelenbosch
    Laboratory for Experimental Internal Medicine, Academic Medical Centre, Amsterdam, The Netherlands
    Trends Cardiovasc Med 11:335-9. 2001
    ..In this review we focus on FVIIa/TF-induced intracellular signaling and its possible role in physiology...
  7. ncbi request reprint Macrophages present pinocytosed exogenous antigen via MHC class I whereas antigen ingested by receptor-mediated endocytosis is presented via MHC class II
    M P Peppelenbosch
    Laboratory for Experimental Internal Medicine, Academic Medical Centre, Amsterdam, The Netherlands
    J Immunol 165:1984-91. 2000
    ....
  8. ncbi request reprint Lipopolysaccharide regulates macrophage fluid phase pinocytosis via CD14-dependent and CD14-independent pathways
    M P Peppelenbosch
    Laboratory for Experimental Internal Medicine, G2 130 Academic Medical Centre, Amsterdam, The Netherlands
    Blood 93:4011-8. 1999
    ..Furthermore, as addition of LPS to macrophages effected pinocytosis but not Fc receptor-mediated endocytosis, these two processes are independently regulated in macrophages...
  9. ncbi request reprint Bone morphogenetic protein signaling suppresses tumorigenesis at gastric epithelial transition zones in mice
    Sylvia A Bleuming
    Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Cancer Res 67:8149-55. 2007
    ..Our data show that BMP signaling through Bmpr1a suppresses tumorigenesis at gastric epithelial junctional zones that are distinct from the adjacent gastric epithelium in both cellular differentiation and proliferation...
  10. ncbi request reprint An ex vivo readout for evaluation of dendritic cell-induced autologous cytotoxic T lymphocyte responses against esophageal cancer
    Francesca Milano
    Department of Experimental Internal Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Cancer Immunol Immunother 56:1967-77. 2007
    ..Additionally, we demonstrated that the use of autologous tumor RNA as a strategy for raising cytotoxic responses against multiple tumor antigens could be effective for treating esophageal cancer...
  11. ncbi request reprint Coagulation factor Xa drives tumor cells into apoptosis through BH3-only protein Bim up-regulation
    Keren S Borensztajn
    Center for Experimental and Molecular Medicine, Academic Medical Center, Meibergdreef 9, Amsterdam, The Netherlands
    Exp Cell Res 313:2622-33. 2007
    ..We thus provide evidence that beyond its role in blood coagulation, FXa plays a key role in cellular processes in which Bim is the central player in determining cell survival...
  12. ncbi request reprint Profiling of the renal kinome: a novel tool to identify protein kinases involved in angiotensin II-dependent hypertensive renal damage
    Martin H de Borst
    Dept of Pathology, University of Groningen, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Am J Physiol Renal Physiol 293:F428-37. 2007
    ..Array-based profiling of tissue kinase activities in ANG II-mediated renal damage provides a powerful tool for identification of relevant kinase pathways in vivo and may lead to novel strategies for therapy...
  13. ncbi request reprint Efficient automated assessment of genetic abnormalities detected by fluorescence in situ hybridization on brush cytology in a Barrett esophagus surveillance population
    Agnieszka M Rygiel
    Department of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Cancer 109:1980-8. 2007
    ....
  14. ncbi request reprint An improved protocol for generation of immuno-potent dendritic cells through direct electroporation of CD14+ monocytes
    Francesca Milano
    Department of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Immunol Methods 321:94-106. 2007
    ..This improved method may represent an attractive approach for RNA-based DC immunotherapy...
  15. ncbi request reprint Transgenic probiotica as drug delivery systems: the golden bullet?
    Saravanan Yuvaraj
    Expert Opin Drug Deliv 4:1-3. 2007
    ..This methodology opens up an alternative method for local delivery of therapeutic proteins to various mucosal tissues...
  16. ncbi request reprint Comparison of kinome profiles of Barrett's esophagus with normal squamous esophagus and normal gastric cardia
    Jantine W P M van Baal
    Department of Cell Biology, University of Groningen, Groningen, The Netherlands
    Cancer Res 66:11605-12. 2006
    ..These unique findings provide novel insight in the pathogenesis of Barrett's esophagus that will ultimately help to resolve the increasing problem of Barrett's esophagus and prevention of esophageal adenocarcinoma...
  17. pmc Bone morphogenetic protein-2 is a negative regulator of hepatocyte proliferation downregulated in the regenerating liver
    Cui ping Xu
    Department of Digestive Diseases, First Clinical College, Shanxi Medical University, 85 Jiefang Nanlu, Taiyuan 030001, Shanxi Province, China
    World J Gastroenterol 12:7621-5. 2006
    ....
  18. ncbi request reprint Phosphatidyl inositol-3-phosphate kinase mediates CD14 dependent signaling
    Tom O'Toole
    Laboratory of Experimental Medicine, G2 130, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Mol Immunol 44:2362-9. 2007
    ..Moreover, we show the PI3 kinase effectors PKB and PKC(zeta) are also activated by PI3 kinase in a CD14 dependent manner in LPS stimulated human PBMC. Thus, PI3 kinase appears to be an essential component in LPS signal transduction...
  19. pmc Prediction of antitumour necrosis factor clinical efficacy by real-time visualisation of apoptosis in patients with Crohn's disease
    Jan M H Van Den Brande
    Laboratory for Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Gut 56:509-17. 2007
    ..The human anti-tumour necrosis factor (TNF) antibody infliximab binds to the membrane TNF and subsequently induces apoptosis of activated lamina propria T lymphocytes in patients with Crohn's disease in vitro...
  20. ncbi request reprint Immunology of Crohn's disease
    Henri Braat
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, NL 1105 AZ Amsterdam, The Netherlands
    Ann N Y Acad Sci 1072:135-54. 2006
    ....
  21. ncbi request reprint Phosphoprotein levels, MAPK activities and NFkappaB expression are affected by fisetin
    Roberta R Ruela de Sousa
    Department of Biochemistry, State University of Campinas, Campinas, SP, Brazil
    J Enzyme Inhib Med Chem 22:439-44. 2007
    ....
  22. ncbi request reprint Early bacterial dependent induction of inducible nitric oxide synthase (iNOS) in epithelial cells upon transfer of CD45RB(high) CD4(+) T cells in a model for experimental colitis
    Gerard Dijkstra
    Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, The Netherlands
    Inflamm Bowel Dis 13:1467-74. 2007
    ..Both the role of inducible nitric oxide synthase (iNOS) in the development of inflammatory bowel disease (IBD) as well as the molecular details governing its mucosal induction remain unclear...
  23. ncbi request reprint Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites
    Maarten F Bijlsma
    Center for Experimental and Molecular Medicine, Room G2 105, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Cell Signal 19:2596-604. 2007
    ....
  24. pmc The ubiquitin-proteasome pathway mediates gelsolin protein downregulation in pancreatic cancer
    Xiao Guang Ni
    Department of Endoscopy, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Mol Med 14:582-9. 2008
    ..In conclusion, gelsolin levels are actively downregulated in pancreatic cancer and enhanced targeting of gelsolin to the ubiquitin-proteasome pathway is an important contributing factor for this effect...
  25. doi request reprint Endogenous hedgehog expression contributes to myocardial ischemia-reperfusion-induced injury
    Maarten F Bijlsma
    Center for Experimental and Molecular Medicine, Academic Medical Center, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands
    Exp Biol Med (Maywood) 233:989-96. 2008
    ..Thus, Hh seems to exert a dualistic action in cardiac ischemia in which high exogenous levels are able to foster tissue repair and endogenous Hh seems to be deleterious...
  26. doi request reprint Ferruginol suppresses survival signaling pathways in androgen-independent human prostate cancer cells
    Marcelo Bispo de Jesus
    Departamento de Bioquimica, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, Cidade Universitaria, Zeferino Vaz, Barao Geraldo, 13083 970 Campinas, SP, Brazil
    Biochimie 90:843-54. 2008
    ..This study supports further examination of ferruginol as a potential agent for both the prevention and treatment of prostate cancer...
  27. doi request reprint Leukotriene synthesis is required for hedgehog-dependent neurite projection in neuralized embryoid bodies but not for motor neuron differentiation
    Maarten F Bijlsma
    Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Stem Cells 26:1138-45. 2008
    ..These data establish a function for the previously described arachidonic acid-dependent Hh pathway in a developmentally relevant model system...
  28. doi request reprint Cyclooxygenase-2 inhibition inhibits c-Met kinase activity and Wnt activity in colon cancer
    Jurriaan B Tuynman
    Laboratory of Experimental Oncology, Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands
    Cancer Res 68:1213-20. 2008
    ....
  29. doi request reprint Assessment of chromosomal gains as compared to DNA content changes is more useful to detect dysplasia in Barrett's esophagus brush cytology specimens
    Agnieszka M Rygiel
    Center for Experimental Molecular Medicine, Academic Medical Center, The Netherlands
    Genes Chromosomes Cancer 47:396-404. 2008
    ..FISH detects chromosomal gains in early stages of BE and represents a valuable adjunct to conventional cytology to detect dysplasia or EAC...
  30. doi request reprint Cytokeratin and CDX-2 expression in Barrett's esophagus
    Jantine W P M van Baal
    Center for Experimental Molecular Medicine in Amsterdam, University Medical Center Utrecht, The Netherlands
    Scand J Gastroenterol 43:132-40. 2008
    ..The objective of this study was to determine the specificity of CDX-2 and a set of cytokeratins (CKs) as specific markers for BE as compared with normal squamous esophageal and gastric cardia tissue...
  31. ncbi request reprint A comparative analysis by SAGE of gene expression profiles of esophageal adenocarcinoma and esophageal squamous cell carcinoma
    Jantine W P M van Baal
    Center for Experimental and Molecular Medicine, Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Cell Oncol 30:63-75. 2008
    ..The results could suggest that the BE expression profile is closer related to normal squamous esophagus then to EA. In addition, several uniquely expressed genes are identified...
  32. pmc Factor Xa stimulates proinflammatory and profibrotic responses in fibroblasts via protease-activated receptor-2 activation
    Keren Borensztajn
    Center for Experimental and Molecular Medicine, Academic Medical Center, Meibergdreef 9, NL 1105 AZ, Amsterdam, The Netherlands
    Am J Pathol 172:309-20. 2008
    ..Taken together, these results support the notion that, beyond its role in coagulation, FXa-dependent PAR-2 cleavage might play a role in the progression of tissue fibrosis and remodeling...
  33. ncbi request reprint The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer
    Liudmila L Kodach
    Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Cancer 112:300-6. 2008
    ..Bone morphogenetic proteins (BMPs), a subgroup within the TGFbeta superfamily, recently also have been implicated in CRC, but their precise role in CRC has yet to be investigated...
  34. ncbi request reprint The effect of statins in colorectal cancer is mediated through the bone morphogenetic protein pathway
    Liudmila L Kodach
    Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Gastroenterology 133:1272-81. 2007
    ..Statins induce bone morphogenetic protein (BMP) expression in bone cells. We have previously shown that BMPs act as tumor suppressors in CRC. We hypothesized that the action of statins in CRC involves the induction of BMPs...
  35. pmc Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion
    Maarten F Bijlsma
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef, Amsterdam, Netherlands
    PLoS Biol 4:e232. 2006
    ....
  36. pmc The novel gene asb11: a regulator of the size of the neural progenitor compartment
    Sander H Diks
    Department of Cell Biology, University Medical Center Groningen, University of Groningen, NL 9713 AV Groningen, Netherlands
    J Cell Biol 174:581-92. 2006
    ..We conclude that d-Asb11 is a novel regulator of the neuronal progenitor compartment size by maintaining the neural precursors in the proliferating undifferentiated state possibly through the control of SoxB1 transcription factors...
  37. ncbi request reprint Impaired innate immunity in Crohn's disease
    Monica Comalada
    Department of Pharmacology, School of Pharmacy, University of Granada, Campus Universitario La Cartuja s n, Granada 18071, Spain
    Trends Mol Med 12:397-9. 2006
    ..Importantly, Marks and colleagues have recently investigated the immune response of Crohn's disease patients directly, convincingly showing impaired innate immunity...
  38. ncbi request reprint Coagulation factors VIIa and Xa inhibit apoptosis and anoikis
    Henri H Versteeg
    Laboratory for Experimental Internal Medicine, G2 105, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Oncogene 23:410-7. 2004
    ..Finally, TF:FVIIa-induced FXa generation dramatically increased cell survival. We propose that FVIIa-induced cell survival may explain why overexpression of TF is associated with successful metastasis...
  39. ncbi request reprint Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon
    James C H Hardwick
    Department of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Gastroenterology 126:111-21. 2004
    ..We investigated the role of BMP2 in the colon...
  40. ncbi request reprint Dichotomy between Lactobacillus rhamnosus and Klebsiella pneumoniae on dendritic cell phenotype and function
    Henri Braat
    Academic Medical Center, Department of Experimental Internal Medicine, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    J Mol Med (Berl) 82:197-205. 2004
    ..Thus our results strongly support the concept that differential modulation of DC explains the differences in the immune response to various bacterial strains and indicates that K. pneumoniae induces Th1 immune responses via DC...
  41. ncbi request reprint Activation of the canonical beta-catenin pathway by histamine
    Sander H Diks
    Laboratory for Experimental Internal Medicine, Academic Medical Center, Meibergdreef 9, The Netherlands
    J Biol Chem 278:52491-6. 2003
    ..The observation that inflammatory molecules, like histamine, activate the beta-catenin pathway may provide a molecular explanation for a possible link between inflammation and cancer...
  42. ncbi request reprint Interleukin-10-based therapy for inflammatory bowel disease
    Henri Braat
    Department of Experimental Internal Medicine, Academic Medical Center, Meiberdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Expert Opin Biol Ther 3:725-31. 2003
    ..In conclusion, it can be said that despite the disappointing results of IL-10 therapy so far, there is still enough rationale for the use of IL-10 as an anti-inflammatory biological treatment in chronic IBD...
  43. ncbi request reprint Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn's disease
    Jan M H Van Den Brande
    Laboratory for Experimental Internal Medicine, G2 133, Academic Medical Center, Meibergdreef 9, NL 1105 AZ Amsterdam, The Netherlands
    Gastroenterology 124:1774-85. 2003
    ..Because both infliximab and etanercept are TNF-alpha-neutralizing drugs, we investigated the differences in TNF-alpha-neutralizing capacity and human lymphocyte binding and apoptosis-inducing capacity of both molecules...
  44. pmc Farnesyl protein transferase inhibition interferes with activation of MAP kinase family members in human peripheral blood monocytes
    Walter L Vervenne
    Department of Medical Oncology, Academic Medical Center, Amsterdam, The Netherlands
    Mol Med 8:857-62. 2002
    ..Nevertheless, the importance for farnesyl protein transferase enzymatic activity for cellular physiology of untransformed cells remains poorly investigated...
  45. ncbi request reprint Inhibition of coagulation, fibrinolysis, and endothelial cell activation by a p38 mitogen-activated protein kinase inhibitor during human endotoxemia
    Judith Branger
    Department of Infectious Disease, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Blood 101:4446-8. 2003
    ..Activation of p38 MAPK plays an important role in the procoagulant and endothelial cell response after in vivo exposure to LPS...
  46. ncbi request reprint From extracellular to intracellular targets, inhibiting MAP kinases in treatment of Crohn's disease
    Bernt van den Blink
    Laboratory for Experimental Internal Medicine Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
    Ann N Y Acad Sci 973:349-58. 2002
    ..We will discuss our current understanding of the molecular pathophysiology of Crohn's disease and also novel therapies that specifically target members of the MAPK pathway...
  47. ncbi request reprint Treating Crohn's disease by inducing T lymphocyte apoptosis
    Jan M H Van Den Brande
    Department of Experimental Internal Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
    Ann N Y Acad Sci 973:166-80. 2002
    ..We will also discuss the fascinating new results of cytokine-targeted therapy in animal models of Crohn's disease and the effects of these drugs in patients with Crohn's disease...
  48. pmc Dichotomal effect of the coumadin derivative warfarin on inflammatory signal transduction
    Arnon P Kater
    Laboratory for Experimental Internal Medicine, Academic Medical Centre, 1105 AZ Amsterdam, The Netherlands
    Clin Diagn Lab Immunol 9:1396-7. 2002
    ..Thus, warfarin inhibits inflammatory signal transduction, and this may contribute to clinical effects of warfarin...
  49. ncbi request reprint VIIa/tissue factor interaction results in a tissue factor cytoplasmic domain-independent activation of protein synthesis, p70, and p90 S6 kinase phosphorylation
    Henri H Versteeg
    Laboratory for Experimental Internal Medicine and the Department of Oncology, Academic Medical Center, Meibergdreef 9, AZ Amsterdam NL 1105, The Netherlands
    J Biol Chem 277:27065-72. 2002
    ..We propose that a TF cytoplasmic domain-independent stimulation of protein synthesis via activation of S6 kinase contributes to FVIIa effects in pathophysiology...
  50. ncbi request reprint Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia
    Judith Branger
    Department of Infectious Diseases, Tropical Medicine, and AIDS, Academic Medical Center, and CLB and Laboratory for Clinical and Experimental Immunology, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 168:4070-7. 2002
    ..Furthermore, the anti-inflammatory potential of an oral p38 MAPK inhibitor in humans in vivo suggests that p38 MAPK inhibitors may provide a new therapeutic option in the treatment of inflammatory diseases...
  51. ncbi request reprint Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation
    Gijs R van den Brink
    Department of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Nat Genet 36:277-82. 2004
    ..These data identify a new Wnt-Hh axis in colonic epithelial renewal...
  52. ncbi request reprint DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1
    James C H Hardwick
    Department of Experimental Internal Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Carcinogenesis 25:1293-8. 2004
    ..Furthermore, they point towards a role for Rac1 in the action of aspirin in colon cancer...
  53. pmc Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN
    Mark Lowenberg
    Laboratory of Experimental Internal Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    EMBO Rep 7:1023-9. 2006
    ..These observations support a model for nongenomic GC-induced immunosuppression on the basis of dissolution of membrane-bound GC-receptor multiprotein complexes after GC-receptor ligation...
  54. ncbi request reprint Protein phosphatase 2A is required for mesalazine-dependent inhibition of Wnt/beta-catenin pathway activity
    Carina L Bos
    Laboratory of Experimental Oncology and Radiobiology, Department of Oncology, University of Amsterdam, The Netherlands
    Carcinogenesis 27:2371-82. 2006
    ..This study shows, using concentrations of mesalazine identical to concentrations seen in patients with inflammatory bowel disease, that mesalazine inhibits the Wnt/beta-catenin pathway via inhibition of PP2A...
  55. ncbi request reprint Violacein synergistically increases 5-fluorouracil cytotoxicity, induces apoptosis and inhibits Akt-mediated signal transduction in human colorectal cancer cells
    Liudmila L Kodach
    Laboratory for Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Carcinogenesis 27:508-16. 2006
    ..Taken together, our findings suggest that violacein will be active in the treatment of colorectal tumors and offers new prospects for overcoming 5-FU resistance...
  56. ncbi request reprint A comparative analysis by SAGE of gene expression profiles of Barrett's esophagus, normal squamous esophagus, and gastric cardia
    Jantine W P M van Baal
    Laboratory of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Gastroenterology 129:1274-81. 2005
    ....
  57. ncbi request reprint Infliximab induced T lymphocyte apoptosis in Crohn's disease
    Jan van den Brande
    Department of Gastroenterology, Academic Medical Centre, Amsterdam, The Netherlands
    J Rheumatol Suppl 74:26-30. 2005
    ..This brief review considers the question of whether this disparity can be explained by the different structure of the proteins, their different binding affinities, or the subsequent effects on T lymphocytes...
  58. pmc Tissue factor and cancer metastasis: the role of intracellular and extracellular signaling pathways
    Henri H Versteeg
    Laboratory of Experimental Internal Medicine, Academic Medical Center, Meibergdreef 9, 1106 AZ Amsterdam, The Netherlands
    Mol Med 10:6-11. 2004
    ..In this review, we will discuss these phenomena in more detail and hypothesize on their role in TF-driven metastasis...
  59. ncbi request reprint Kinome profiling for studying lipopolysaccharide signal transduction in human peripheral blood mononuclear cells
    Sander H Diks
    Department of Cell Biology, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Biol Chem 279:49206-13. 2004
    ..We conclude that this first metabolic array is a useful method to determine the enzymatic activities of a large group of kinases, offering high throughput analysis of cellular metabolism and signal transduction...
  60. ncbi request reprint LPS signal transduction: the picture is becoming more complex
    Sander H Diks
    Laboratory for Experimental Internal Medicine, G2 105, Academic Medical Center, University of Amsterdam, Meibergdreef 9, NL 1105 AZ Amsterdam, The Netherlands
    Curr Top Med Chem 4:1115-26. 2004
    ..Further insight into LPS-dependent signal transduction will assist the development of novel rational therapy...
  61. ncbi request reprint Molecular mechanism of violacein-mediated human leukemia cell death
    Carmen Verissima Ferreira
    Departamento de Bioquimica, Universidade Estadual de Campinas, Sao Paulo, Brazil
    Blood 104:1459-64. 2004
    ..Hence, violacein represents the first member of a novel class of cytotoxic drugs mediating apoptosis of HL60 cells by way of the specific activation of TNF receptor 1...
  62. ncbi request reprint Prostanoids and prostanoid receptors in signal transduction
    Carina L Bos
    Laboratory for Experimental Internal Medicine, G2 130, Academic Medical Center, Meibergdreef 9, NL 1105 AZ Amsterdam, The Netherlands
    Int J Biochem Cell Biol 36:1187-205. 2004
    ..The final cellular reaction to prostaglandin stimulation will most likely depend on combined effects of the above-mentioned levels of interaction between prostaglandins and their cellular receptors...
  63. ncbi request reprint Hedgehog: an unusual signal transducer
    Maarten F Bijlsma
    Laboratory for Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Bioessays 26:387-94. 2004
    ..These atypical features make Hedgehog physiology unique in biology and may explain why this field has attracted such significant attention...
  64. ncbi request reprint FVIIa:TF induces cell survival via G12/G13-dependent Jak/STAT activation and BclXL production
    Henri H Versteeg
    Laboratory of Experimental Internal Medicine, G2 131, Academic Medical Center, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands
    Circ Res 94:1032-40. 2004
    ..Finally, we demonstrated for the first time that TF/FVIIa-signal transduction is dependent on G12/G13 class G proteins...
  65. ncbi request reprint P38 mitogen activated protein kinase is involved in the downregulation of granulocyte CXC chemokine receptors 1 and 2 during human endotoxemia
    Bernt van den Blink
    Laboratory for Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Clin Immunol 24:37-41. 2004
    ..These results indicate a principal role for p38 MAPK in regulating factors essential for neutrophil activation and chemotaxis in vivo...
  66. pmc Feed a cold, starve a fever?
    Gijs R van den Brink
    Laboratory for Experimental Internal Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Clin Diagn Lab Immunol 9:182-3. 2002
    ..Food intake resulted in increased levels of gamma interferon production, whereas food deprivation stimulated interleukin-4 release...