W A Paxton

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. pmc HIV-1 autologous antibody neutralization associates with mother to child transmission
    Elly Baan
    Laboratory of Experimental Virology, Department of Medical Microbiology, Centre for Infection and Immunity Amsterdam CINIMA, Academic Medical Centre of the University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 8:e69274. 2013
  2. pmc HIV-1 disease progression is associated with bile-salt stimulated lipase (BSSL) gene polymorphism
    Martijn J Stax
    Laboratory of Experimental Virology, Department of Medical Microbiology, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e32534. 2012
  3. pmc Binding of human milk to pathogen receptor DC-SIGN varies with bile salt-stimulated lipase (BSSL) gene polymorphism
    Martijn J Stax
    Laboratory of Experimental Virology, Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 6:e17316. 2011
  4. pmc Statins disrupt CCR5 and RANTES expression levels in CD4(+) T lymphocytes in vitro and preferentially decrease infection of R5 versus X4 HIV-1
    Alexey A Nabatov
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 2:e470. 2007
  5. pmc Effect of chloroquine on reducing HIV-1 replication in vitro and the DC-SIGN mediated transfer of virus to CD4+ T-lymphocytes
    Marloes A Naarding
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Retrovirology 4:6. 2007
  6. pmc The carbohydrate at asparagine 386 on HIV-1 gp120 is not essential for protein folding and function but is involved in immune evasion
    Rogier W Sanders
    Laboratory of Experimental Virology, Dept, Medical Microbiology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands
    Retrovirology 5:10. 2008
  7. pmc Varied sensitivity to therapy of HIV-1 strains in CD4+ lymphocyte sub-populations upon ART initiation
    Edwin J Heeregrave
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center of the University of Amsterdam, The Netherlands
    AIDS Res Ther 7:42. 2010
  8. ncbi request reprint RANTES production from CD4+ lymphocytes correlates with host genotype and rates of human immunodeficiency virus type 1 disease progression
    W A Paxton
    Department of Human Retrovirology, Academic Medical Center, Amsterdam, 1105 AZ, The Netherlands
    J Infect Dis 183:1678-81. 2001
  9. ncbi request reprint HIV-1 infectability of CD4+ lymphocytes with relation to beta-chemokines and the CCR5 coreceptor
    W A Paxton
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Netherlands
    Immunol Lett 66:71-5. 1999
  10. ncbi request reprint N-linked glycosylation of the HIV type-1 gp120 envelope glycoprotein as a major determinant of CCR5 and CXCR4 coreceptor utilization
    G Pollakis
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Biol Chem 276:13433-41. 2001

Collaborators

Detail Information

Publications10

  1. pmc HIV-1 autologous antibody neutralization associates with mother to child transmission
    Elly Baan
    Laboratory of Experimental Virology, Department of Medical Microbiology, Centre for Infection and Immunity Amsterdam CINIMA, Academic Medical Centre of the University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 8:e69274. 2013
    ..Although the number of HIV-1 transmitting pairs is low our results indicate that autologous NAb responses in mothers and infants do not protect against MTCT and may in fact be detrimental when considering IU HIV-1 transmissions. ..
  2. pmc HIV-1 disease progression is associated with bile-salt stimulated lipase (BSSL) gene polymorphism
    Martijn J Stax
    Laboratory of Experimental Virology, Department of Medical Microbiology, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e32534. 2012
    ..Furthermore, BSSL binds to HIV-1 co-receptor CXCR4. We hypothesized that BSSL modulates HIV-1 disease progression and emergence of CXCR4 using HIV-1 (X4) variants...
  3. pmc Binding of human milk to pathogen receptor DC-SIGN varies with bile salt-stimulated lipase (BSSL) gene polymorphism
    Martijn J Stax
    Laboratory of Experimental Virology, Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 6:e17316. 2011
    ..Objective was to study variation in DC-SIGN binding properties and the relation between DC-SIGN binding capacity of milk and BSSL gene polymorphisms...
  4. pmc Statins disrupt CCR5 and RANTES expression levels in CD4(+) T lymphocytes in vitro and preferentially decrease infection of R5 versus X4 HIV-1
    Alexey A Nabatov
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 2:e470. 2007
    ....
  5. pmc Effect of chloroquine on reducing HIV-1 replication in vitro and the DC-SIGN mediated transfer of virus to CD4+ T-lymphocytes
    Marloes A Naarding
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Retrovirology 4:6. 2007
    ..These activities indicate that the compound can be used not only as an effective HIV-1 therapeutic agent but also as a modulator of the gp120 envelope protein structure enabling for the production of broader neutralizing Ab responses...
  6. pmc The carbohydrate at asparagine 386 on HIV-1 gp120 is not essential for protein folding and function but is involved in immune evasion
    Rogier W Sanders
    Laboratory of Experimental Virology, Dept, Medical Microbiology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands
    Retrovirology 5:10. 2008
    ..Here we studied the role of the carbohydrate at position 386. We identified a virus variant that had lost the 386 glycan in an evolution study of a mutant virus lacking the disulfide bond at the base of the V4 domain...
  7. pmc Varied sensitivity to therapy of HIV-1 strains in CD4+ lymphocyte sub-populations upon ART initiation
    Edwin J Heeregrave
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center of the University of Amsterdam, The Netherlands
    AIDS Res Ther 7:42. 2010
    ..In this study we analyzed the sensitivity to ART of HIV-1 strains in naïve, central memory and effector memory CD4+ lymphocyte subsets...
  8. ncbi request reprint RANTES production from CD4+ lymphocytes correlates with host genotype and rates of human immunodeficiency virus type 1 disease progression
    W A Paxton
    Department of Human Retrovirology, Academic Medical Center, Amsterdam, 1105 AZ, The Netherlands
    J Infect Dis 183:1678-81. 2001
    ..These results further support the hypothesis that chemokine production levels are associated with HIV-1 replication in vivo...
  9. ncbi request reprint HIV-1 infectability of CD4+ lymphocytes with relation to beta-chemokines and the CCR5 coreceptor
    W A Paxton
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Netherlands
    Immunol Lett 66:71-5. 1999
    ..These results suggest that the CCR5 phenotype is important in determining the replicative capacity of M-tropic HIV-1 in vitro. The implications of these results with relation to HIV-1 transmission and disease progression are discussed...
  10. ncbi request reprint N-linked glycosylation of the HIV type-1 gp120 envelope glycoprotein as a major determinant of CCR5 and CXCR4 coreceptor utilization
    G Pollakis
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Biol Chem 276:13433-41. 2001
    ..These results demonstrate that the N-linked glycosylation pattern of the HIV-1 envelope can strongly influence viral coreceptor utilization and the R5 to X4 switch...