W A Paxton

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. pmc Effect of chloroquine on reducing HIV-1 replication in vitro and the DC-SIGN mediated transfer of virus to CD4+ T-lymphocytes
    Marloes A Naarding
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Retrovirology 4:6. 2007
  2. pmc The carbohydrate at asparagine 386 on HIV-1 gp120 is not essential for protein folding and function but is involved in immune evasion
    Rogier W Sanders
    Laboratory of Experimental Virology, Dept, Medical Microbiology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands
    Retrovirology 5:10. 2008
  3. pmc Varied sensitivity to therapy of HIV-1 strains in CD4+ lymphocyte sub-populations upon ART initiation
    Edwin J Heeregrave
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center of the University of Amsterdam, The Netherlands
    AIDS Res Ther 7:42. 2010
  4. ncbi request reprint HIV-1 infectability of CD4+ lymphocytes with relation to beta-chemokines and the CCR5 coreceptor
    W A Paxton
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Netherlands
    Immunol Lett 66:71-5. 1999
  5. ncbi request reprint RANTES production from CD4+ lymphocytes correlates with host genotype and rates of human immunodeficiency virus type 1 disease progression
    W A Paxton
    Department of Human Retrovirology, Academic Medical Center, Amsterdam, 1105 AZ, The Netherlands
    J Infect Dis 183:1678-81. 2001
  6. ncbi request reprint N-linked glycosylation of the HIV type-1 gp120 envelope glycoprotein as a major determinant of CCR5 and CXCR4 coreceptor utilization
    G Pollakis
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Biol Chem 276:13433-41. 2001

Collaborators

  • J Goudsmit
  • A U Neumann
  • T R Gingeras
  • L Wu
  • Edwin J Heeregrave
  • Georgios Pollakis
  • Elly Baan
  • Rogier W Sanders
  • Marloes A Naarding
  • G Pollakis
  • Renee M van der Sluis
  • Mark J Geels
  • Ineke Braakman
  • Ilja Bontjer
  • Alexei A Nabatov
  • Martijn M Dankers
  • Els Busser
  • Ben Berkhout
  • I Marije Liscaljet
  • Mark Melchers
  • Dirk Eggink
  • Fedde Groot
  • Eelco van Anken
  • M I Chalaby
  • A Kliphuis
  • S Kang

Detail Information

Publications6

  1. pmc Effect of chloroquine on reducing HIV-1 replication in vitro and the DC-SIGN mediated transfer of virus to CD4+ T-lymphocytes
    Marloes A Naarding
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Retrovirology 4:6. 2007
    ..These activities indicate that the compound can be used not only as an effective HIV-1 therapeutic agent but also as a modulator of the gp120 envelope protein structure enabling for the production of broader neutralizing Ab responses...
  2. pmc The carbohydrate at asparagine 386 on HIV-1 gp120 is not essential for protein folding and function but is involved in immune evasion
    Rogier W Sanders
    Laboratory of Experimental Virology, Dept, Medical Microbiology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands
    Retrovirology 5:10. 2008
    ..Here we studied the role of the carbohydrate at position 386. We identified a virus variant that had lost the 386 glycan in an evolution study of a mutant virus lacking the disulfide bond at the base of the V4 domain...
  3. pmc Varied sensitivity to therapy of HIV-1 strains in CD4+ lymphocyte sub-populations upon ART initiation
    Edwin J Heeregrave
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center of the University of Amsterdam, The Netherlands
    AIDS Res Ther 7:42. 2010
    ..In this study we analyzed the sensitivity to ART of HIV-1 strains in naïve, central memory and effector memory CD4+ lymphocyte subsets...
  4. ncbi request reprint HIV-1 infectability of CD4+ lymphocytes with relation to beta-chemokines and the CCR5 coreceptor
    W A Paxton
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Netherlands
    Immunol Lett 66:71-5. 1999
    ..These results suggest that the CCR5 phenotype is important in determining the replicative capacity of M-tropic HIV-1 in vitro. The implications of these results with relation to HIV-1 transmission and disease progression are discussed...
  5. ncbi request reprint RANTES production from CD4+ lymphocytes correlates with host genotype and rates of human immunodeficiency virus type 1 disease progression
    W A Paxton
    Department of Human Retrovirology, Academic Medical Center, Amsterdam, 1105 AZ, The Netherlands
    J Infect Dis 183:1678-81. 2001
    ..These results further support the hypothesis that chemokine production levels are associated with HIV-1 replication in vivo...
  6. ncbi request reprint N-linked glycosylation of the HIV type-1 gp120 envelope glycoprotein as a major determinant of CCR5 and CXCR4 coreceptor utilization
    G Pollakis
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Biol Chem 276:13433-41. 2001
    ..These results demonstrate that the N-linked glycosylation pattern of the HIV-1 envelope can strongly influence viral coreceptor utilization and the R5 to X4 switch...