Martijn A Nolte

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. pmc The price of the CD27-CD70 costimulatory axis: you can't have it all
    Martijn A Nolte
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Netherlands
    J Exp Med 203:2405-8. 2006
  2. ncbi request reprint CD70-driven chronic immune activation is protective against atherosclerosis
    Ronald W van Olffen
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Innate Immun 2:344-52. 2010
  3. doi request reprint Protective CD8 T cell memory is impaired during chronic CD70-driven costimulation
    Klaas P J M van Gisbergen
    Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
    J Immunol 182:5352-62. 2009
  4. doi request reprint Chronic CD70-driven costimulation impairs IgG responses by instructing T cells to inhibit germinal center B cell formation through FasL-Fas interactions
    Cathrien R L Beishuizen
    Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
    J Immunol 183:6442-51. 2009
  5. doi request reprint BH3-only protein Noxa regulates apoptosis in activated B cells and controls high-affinity antibody formation
    Felix M Wensveen
    Department of Experimental Immunology, Academic Medical Center, Meibergdreef 9, Amsterdam, The Netherlands
    Blood 119:1440-9. 2012
  6. ncbi request reprint Immune activation modulates hematopoiesis through interactions between CD27 and CD70
    Martijn A Nolte
    Department of Hematology, F4 224, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    Nat Immunol 6:412-8. 2005
  7. pmc BH3-only protein Noxa contributes to apoptotic control of stress-erythropoiesis
    Felix M Wensveen
    Department of Experimental Immunology, Academic Medical Center, Meibergdreef 8, 1105 AZ, Amsterdam, The Netherlands
    Apoptosis 18:1306-18. 2013
  8. ncbi request reprint Signaling through CD70 regulates B cell activation and IgG production
    Ramon Arens
    Department of Hematology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Immunol 173:3901-8. 2004
  9. doi request reprint The costimulatory molecule CD27 maintains clonally diverse CD8(+) T cell responses of low antigen affinity to protect against viral variants
    Klaas P J M van Gisbergen
    Department of Experimental Immunology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Immunity 35:97-108. 2011
  10. doi request reprint GITR triggering induces expansion of both effector and regulatory CD4+ T cells in vivo
    Ronald W van Olffen
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 182:7490-500. 2009

Collaborators

Detail Information

Publications25

  1. pmc The price of the CD27-CD70 costimulatory axis: you can't have it all
    Martijn A Nolte
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Netherlands
    J Exp Med 203:2405-8. 2006
    ..Thus, while being crucial for the induction of some adaptive effector pathways, costimulation may block the development of others. Pathogens may exploit this Achilles' heal to achieve persistence...
  2. ncbi request reprint CD70-driven chronic immune activation is protective against atherosclerosis
    Ronald W van Olffen
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Innate Immun 2:344-52. 2010
    ..This unexpected outcome provides a new insight into the consequences of costimulatory signals and their impact on innate immunity...
  3. doi request reprint Protective CD8 T cell memory is impaired during chronic CD70-driven costimulation
    Klaas P J M van Gisbergen
    Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
    J Immunol 182:5352-62. 2009
    ..We conclude that constitutive expression of CD70 is sufficient to deregulate the CD8 T cell differentiation pathway of acute infection reminiscent of events in chronic infection...
  4. doi request reprint Chronic CD70-driven costimulation impairs IgG responses by instructing T cells to inhibit germinal center B cell formation through FasL-Fas interactions
    Cathrien R L Beishuizen
    Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
    J Immunol 183:6442-51. 2009
    ..Because CD70 is expressed constitutively in chronic viral infections such as HIV-1 infection, this mechanism may also contribute to defects in humoral immunity associated with this disease...
  5. doi request reprint BH3-only protein Noxa regulates apoptosis in activated B cells and controls high-affinity antibody formation
    Felix M Wensveen
    Department of Experimental Immunology, Academic Medical Center, Meibergdreef 9, Amsterdam, The Netherlands
    Blood 119:1440-9. 2012
    ..Manipulation of this process may alter the breadth of antibody responses after immunization...
  6. ncbi request reprint Immune activation modulates hematopoiesis through interactions between CD27 and CD70
    Martijn A Nolte
    Department of Hematology, F4 224, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    Nat Immunol 6:412-8. 2005
    ..As CD70 is expressed only on activated immune cells, we suggest that CD27 triggering on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation...
  7. pmc BH3-only protein Noxa contributes to apoptotic control of stress-erythropoiesis
    Felix M Wensveen
    Department of Experimental Immunology, Academic Medical Center, Meibergdreef 8, 1105 AZ, Amsterdam, The Netherlands
    Apoptosis 18:1306-18. 2013
    ....
  8. ncbi request reprint Signaling through CD70 regulates B cell activation and IgG production
    Ramon Arens
    Department of Hematology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Immunol 173:3901-8. 2004
    ..Together, the in vitro and in vivo data demonstrate that CD70 has potent reverse signaling properties in B cells, initiating a signaling cascade that regulates expansion and differentiation...
  9. doi request reprint The costimulatory molecule CD27 maintains clonally diverse CD8(+) T cell responses of low antigen affinity to protect against viral variants
    Klaas P J M van Gisbergen
    Department of Experimental Immunology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Immunity 35:97-108. 2011
    ..We propose that CD27-driven costimulation is a strategy to generate memory clones that have potential reactivity to a wide array of mutable pathogens...
  10. doi request reprint GITR triggering induces expansion of both effector and regulatory CD4+ T cells in vivo
    Ronald W van Olffen
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 182:7490-500. 2009
    ..These data indicate that GITR regulates the balance between regulatory and effector CD4(+) T cells by enhancing proliferation of both populations in parallel...
  11. doi request reprint Function of CD27 in helper T cell differentiation
    Sten Libregts
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Immunol Lett 136:177-86. 2011
    ..In summary, this study indicates that CD27 signalling does influence T(H) cell differentiation, but that it is highly dependent on the conditions and genetic background...
  12. doi request reprint Interferon-γ impairs proliferation of hematopoietic stem cells in mice
    Alexander M de Bruin
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Blood 121:3578-85. 2013
    ....
  13. doi request reprint Timing and tuning of CD27-CD70 interactions: the impact of signal strength in setting the balance between adaptive responses and immunopathology
    Martijn A Nolte
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Immunol Rev 229:216-31. 2009
    ....
  14. doi request reprint Eosinophil differentiation in the bone marrow is inhibited by T cell-derived IFN-gamma
    Alexander M de Bruin
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Blood 116:2559-69. 2010
    ....
  15. doi request reprint Chronic IFN-γ production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU.1 axis
    Sten F Libregts
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Blood 118:2578-88. 2011
    ..Notably, down-regulation of either IRF-1 or PU.1 expression is sufficient to overcome IFN-γ-induced inhibition of erythropoiesis. These findings reveal a molecular mechanism by which chronic exposure to IFN-γ induces anemia...
  16. ncbi request reprint CD27 contributes to the early systemic immune response to Mycobacterium tuberculosis infection but does not affect outcome
    Catharina W Wieland
    Center of Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Int Immunol 18:1531-9. 2006
    ..Our data suggest that CD27 does not contribute to the local IFNgamma-mediated response and long-term protection against M. tuberculosis...
  17. pmc Tumor rejection induced by CD70-mediated quantitative and qualitative effects on effector CD8+ T cell formation
    Ramon Arens
    Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Netherlands
    J Exp Med 199:1595-605. 2004
    ..Thus, CD70 costimulation enhances both the expansion and per cell activity of antigen-specific CD8+ T cells...
  18. ncbi request reprint B cells are crucial for both development and maintenance of the splenic marginal zone
    Martijn A Nolte
    Department of Molecular Cell Biology, Vrije Universiteit Medical Center, Academic Medical Center, Amsterdam, The Netherlands
    J Immunol 172:3620-7. 2004
    ..This direct correlation between circulating B cells and the function of the spleen implies an increased risk for B cell lymphopenic patients with bacterial infections...
  19. pmc A conduit system distributes chemokines and small blood-borne molecules through the splenic white pulp
    Martijn A Nolte
    Department of Molecular Cell Biology, VUMC, Amsterdam, Netherlands
    J Exp Med 198:505-12. 2003
    ..Therefore, the conduit plays a role in distribution of both blood-borne and locally produced molecules and provides a framework for directing lymphocyte migration and organization of the splenic white pulp...
  20. pmc Dendritic cell quiescence during systemic inflammation driven by LPS stimulation of radioresistant cells in vivo
    Martijn A Nolte
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, London WC2A 3PX, England, UK
    J Exp Med 204:1487-501. 2007
    ..Thus, inflammatory mediators originating from nonhematopoietic tissues and from radioresistant hematopoietic cells are neither sufficient nor required for DC activation in vivo...
  21. ncbi request reprint Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins
    Neil C Rogers
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Immunity 22:507-17. 2005
    ..These results identify a novel signaling pathway involved in pattern recognition by C type lectins and suggest a potential role for Syk kinase in regulation of innate immunity...
  22. ncbi request reprint Development and function of the splenic marginal zone
    Reina E Mebius
    VU Medical Center, Department of Molecular Cell Biology and Immunology, Amsterdam, The Netherlands
    Crit Rev Immunol 24:449-64. 2004
    ..The developmental pathways that lead to the formation of the marginal zone are described, and the function of the marginal zone is discussed in relation to the function of the spleen as the major blood-filtering organ of the body...
  23. ncbi request reprint Autologous cytomegalovirus-specific T cells as effector cells in immunotherapy of B cell chronic lymphocytic leukaemia
    Arnon P Kater
    Department of Haematology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Br J Haematol 126:512-6. 2004
    ..Directing virus-specific T cells to B-CLL may overcome the inadequate immunostimulatory capacity of these cells, which could be exploited for T-cell mediated immunotherapy...
  24. pmc Arginine deficiency affects early B cell maturation and lymphoid organ development in transgenic mice
    Wouter J de Jonge
    Department of Anatomy and Embryology, University of Amsterdam, The Netherlands
    J Clin Invest 110:1539-48. 2002
    ..We conclude that arginine deficiency impairs early B cell maturation...
  25. pmc The strict regulation of lymphocyte migration to splenic white pulp does not involve common homing receptors
    Martijn A Nolte
    Department of Molecular Cell Biology, VU University Medical Centre, Amsterdam, The Netherlands
    Immunology 106:299-307. 2002
    ....