M Nieuwdorp

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Hypercoagulability in the metabolic syndrome
    Max Nieuwdorp
    Department of Vascular Medicine, AMC, Meibergdreef 9 room F4 159 2, 1100 DD Amsterdam, The Netherlands
    Curr Opin Pharmacol 5:155-9. 2005
  2. doi request reprint Fecal transplant: a safe and sustainable clinical therapy for restoring intestinal microbial balance in human disease?
    A Vrieze
    Department of Internal Medicine, AMC, University of Amsterdam, The Netherlands
    Best Pract Res Clin Gastroenterol 27:127-37. 2013
  3. pmc The environment within: how gut microbiota may influence metabolism and body composition
    A Vrieze
    Department of Internal and Vascular Medicine, Academic Medical Centre, Meibergdreef 9, Room F4 159 2, 1105, AZ Amsterdam, The Netherlands
    Diabetologia 53:606-13. 2010
  4. ncbi request reprint Role of the microbiome in energy regulation and metabolism
    Max Nieuwdorp
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Wallenberg Laboratory, Sahlgrenska Center for Cardiovascular and Metabolic Research, University of Goteborg, Goteborg, Sweden Electronic address
    Gastroenterology 146:1525-33. 2014
  5. pmc Identification of candidate genes linking systemic inflammation to atherosclerosis; results of a human in vivo LPS infusion study
    Suthesh Sivapalaratnam
    Department of Vascular Medicine, Academic Medical Center, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    BMC Med Genomics 4:64. 2011
  6. pmc Perturbation of hyaluronan metabolism predisposes patients with type 1 diabetes mellitus to atherosclerosis
    M Nieuwdorp
    Department of Internal Medicine, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Diabetologia 50:1288-93. 2007
  7. doi request reprint The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus
    R S Kootte
    Department of Vascular Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Diabetes Obes Metab 14:112-20. 2012
  8. pmc Effect of sulodexide on endothelial glycocalyx and vascular permeability in patients with type 2 diabetes mellitus
    L N Broekhuizen
    Department of Vascular Medicine, Academic Medical Centre, Room F4 211, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Diabetologia 53:2646-55. 2010
  9. doi request reprint Obesity, non-alcoholic fatty liver disease, and atherothrombosis: a role for the intestinal microbiota?
    M Knaapen
    Department of Vascular Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Clin Microbiol Infect 19:331-7. 2013
  10. doi request reprint Tumor necrosis factor-alpha inhibition protects against endotoxin-induced endothelial glycocalyx perturbation
    M Nieuwdorp
    Department of Vascular Medicine, Academic Medical Centre, University of Amsterdam, The Netherlands
    Atherosclerosis 202:296-303. 2009

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Hypercoagulability in the metabolic syndrome
    Max Nieuwdorp
    Department of Vascular Medicine, AMC, Meibergdreef 9 room F4 159 2, 1100 DD Amsterdam, The Netherlands
    Curr Opin Pharmacol 5:155-9. 2005
    ..In view of the rising incidence of metabolic syndrome even at a young age, both the incidence of venous thromboembolism and the effect of intervention on markers of hypercoagulability in metabolic syndrome call for further studies...
  2. doi request reprint Fecal transplant: a safe and sustainable clinical therapy for restoring intestinal microbial balance in human disease?
    A Vrieze
    Department of Internal Medicine, AMC, University of Amsterdam, The Netherlands
    Best Pract Res Clin Gastroenterol 27:127-37. 2013
    ....
  3. pmc The environment within: how gut microbiota may influence metabolism and body composition
    A Vrieze
    Department of Internal and Vascular Medicine, Academic Medical Centre, Meibergdreef 9, Room F4 159 2, 1105, AZ Amsterdam, The Netherlands
    Diabetologia 53:606-13. 2010
    ..This review discusses the relationships between the following: composition of gut microbiota, energy extracted from diet, synthesis of gut hormones involved in energy homeostasis, production of butyrate and the regulation of fat storage...
  4. ncbi request reprint Role of the microbiome in energy regulation and metabolism
    Max Nieuwdorp
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Wallenberg Laboratory, Sahlgrenska Center for Cardiovascular and Metabolic Research, University of Goteborg, Goteborg, Sweden Electronic address
    Gastroenterology 146:1525-33. 2014
    ..We discuss how controlled studies involving direct perturbations of microbial communities in human and animal models are required to identify effective therapeutic targets in the microbiota...
  5. pmc Identification of candidate genes linking systemic inflammation to atherosclerosis; results of a human in vivo LPS infusion study
    Suthesh Sivapalaratnam
    Department of Vascular Medicine, Academic Medical Center, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    BMC Med Genomics 4:64. 2011
    ..Such differentially expressed genes in circulating monocytes would be strong candidates for further investigation in disease association studies...
  6. pmc Perturbation of hyaluronan metabolism predisposes patients with type 1 diabetes mellitus to atherosclerosis
    M Nieuwdorp
    Department of Internal Medicine, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Diabetologia 50:1288-93. 2007
    ..In the present study, we evaluated the relationship between hyaluronan and hyaluronidase with carotid intima-media thickness (cIMT), an established surrogate marker for cardiovascular disease...
  7. doi request reprint The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus
    R S Kootte
    Department of Vascular Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Diabetes Obes Metab 14:112-20. 2012
    ..Ultimately, we aim to translate these findings into therapeutic pathways for obesity and T2DM in humans...
  8. pmc Effect of sulodexide on endothelial glycocalyx and vascular permeability in patients with type 2 diabetes mellitus
    L N Broekhuizen
    Department of Vascular Medicine, Academic Medical Centre, Room F4 211, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Diabetologia 53:2646-55. 2010
    ..In the present study we set out to evaluate whether: (1) glycocalyx is perturbed in individuals with type 2 diabetes mellitus, and (2) oral glycocalyx precursor treatment improves glycocalyx properties...
  9. doi request reprint Obesity, non-alcoholic fatty liver disease, and atherothrombosis: a role for the intestinal microbiota?
    M Knaapen
    Department of Vascular Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Clin Microbiol Infect 19:331-7. 2013
    ..If substantiated, this could open the arena for modulation of the intestinal microbiota as a future target in obesity-associated disease, both as a diagnostic test for personalized algorithms and for selective therapeutic strategies...
  10. doi request reprint Tumor necrosis factor-alpha inhibition protects against endotoxin-induced endothelial glycocalyx perturbation
    M Nieuwdorp
    Department of Vascular Medicine, Academic Medical Centre, University of Amsterdam, The Netherlands
    Atherosclerosis 202:296-303. 2009
    ..In the present study, we investigated whether endotoxin-induced inflammatory reactions lead to a decrease of endothelial glycocalyx thickness in humans and whether tumor necrosis factor-alpha (TNFalpha) plays a role in this process...
  11. doi request reprint Pathophysiology of hypertriglyceridemia
    H C Hassing
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Biochim Biophys Acta 1821:826-32. 2012
    ..Finally we will shortly discuss future perspectives for novel therapies aiming at improving triglyceride homeostasis. This article is part of a Special Issue entitled Triglyceride Metabolism and Disease...
  12. ncbi request reprint Normalization of metabolic syndrome using fenofibrate, metformin or their combination
    M Nieuwdorp
    Department of Vascular Medicine, Academic Medical Centre, Amsterdam, The Netherlands
    Diabetes Obes Metab 9:869-78. 2007
    ..The aim of this study was to evaluate whether and to what extent fenofibrate (F), metformin (M) or a combination of these drugs improve characteristics of the metabolic syndrome (MetS)...
  13. doi request reprint Metabolic modulation of inflammation-induced activation of coagulation
    Marcel Levi
    Department of Vascular Medicine Internal Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Semin Thromb Hemost 34:26-32. 2008
    ..There are indications that this modulatory role of metabolic factors in inflammation and coagulation may also have an impact on clinical outcome in various disease states...
  14. ncbi request reprint Intestinal microbiota and faecal transplantation as treatment modality for insulin resistance and type 2 diabetes mellitus
    S D Udayappan
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Clin Exp Immunol 177:24-9. 2014
    ....
  15. ncbi request reprint Cardiovascular metabolic syndrome - an interplay of, obesity, inflammation, diabetes and coronary heart disease
    J S Rana
    Department of Vascular Medicine, Academic Medical Center Amsterdam, The Netherlands
    Diabetes Obes Metab 9:218-32. 2007
    ....
  16. ncbi request reprint Metabolic syndrome and risk of coronary, cerebral, and peripheral vascular disease in a large Dutch population with familial hypercholesterolemia
    Jamal S Rana
    Department of Vascular Medicine, Academic Medical Center, Meibergdreef 9, Room F4 159 2, 1105 AZ Amsterdam, Netherlands
    Diabetes Care 29:1125-7. 2006
  17. ncbi request reprint Endothelial glycocalyx damage coincides with microalbuminuria in type 1 diabetes
    Max Nieuwdorp
    Department of Vascular Medicine, Academic Medical Center University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Diabetes 55:1127-32. 2006
    ..In conclusion, type 1 diabetic patients are characterized by endothelial glycocalyx damage, the severity of which is increased in presence of microalbuminuria...
  18. ncbi request reprint Loss of endothelial glycocalyx during acute hyperglycemia coincides with endothelial dysfunction and coagulation activation in vivo
    Max Nieuwdorp
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, Netherlands
    Diabetes 55:480-6. 2006
    ..4 +/- 0.1 to 1.1 +/- 0.2 nmol/l; d-dimer: from 0.27 +/- 0.1 to 0.55 +/- 0.2 g/l; P < 0.05). Taken together, these data indicate a potential role for glycocalyx perturbation in mediating vascular dysfunction during hyperglycemia...
  19. ncbi request reprint Measuring endothelial glycocalyx dimensions in humans: a potential novel tool to monitor vascular vulnerability
    Max Nieuwdorp
    Department of Vascular Medicine, Academic Medical Center, Amsterdam
    J Appl Physiol (1985) 104:845-52. 2008
    ..It remains to be tested whether glycocalyx dimension can be used as an early marker of vascular damage and whether therapies aimed at glycocalyx repair can protect the vasculature against pathogenic challenges...