A F Moorman

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. pmc Development of the pulmonary vein and the systemic venous sinus: an interactive 3D overview
    Gert van den Berg
    Department of Anatomy, Embryology and Physiology, Academic Medical Center, Amsterdam, The Netherlands
    PLoS ONE 6:e22055. 2011
  2. pmc Concepts of cardiac development in retrospect
    Gert van den Berg
    Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands
    Pediatr Cardiol 30:580-7. 2009
  3. ncbi request reprint Development of the building plan of the heart
    Antoon F M Moorman
    Experimental and Molecular Cardiology Group, Department of Anatomy and Embryology, Academic Medical Centre, Amsterdam, The Netherlands
    Ann N Y Acad Sci 1015:171-81. 2004
  4. pmc The heart-forming fields: one or multiple?
    Antoon F M Moorman
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Philos Trans R Soc Lond B Biol Sci 362:1257-65. 2007
  5. ncbi request reprint Cardiac chamber formation: development, genes, and evolution
    Antoon F M Moorman
    Department of Anatomy and Embryology, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Physiol Rev 83:1223-67. 2003
  6. ncbi request reprint Sensitive nonradioactive detection of mRNA in tissue sections: novel application of the whole-mount in situ hybridization protocol
    A F Moorman
    Experimental and Molecular Cardiology Group, Academic Medical Center, Amsterdam, The Netherlands
    J Histochem Cytochem 49:1-8. 2001
  7. ncbi request reprint Presence of functional sarcoplasmic reticulum in the developing heart and its confinement to chamber myocardium
    A F Moorman
    Experimental and Molecular Cardiology Group, Cardiovascular Research Institute Amsterdam, Academic Medical Center, Amsterdam, 1105 AZ, The Netherlands
    Dev Biol 223:279-90. 2000
  8. ncbi request reprint Development of the conduction system of the heart
    A F Moorman
    Department of Anatomy and Embryology, University of Amsterdam, The Netherlands
    Pacing Clin Electrophysiol 20:2087-92. 1997
  9. ncbi request reprint Multiple transcriptional domains, with distinct left and right components, in the atrial chambers of the developing heart
    D Franco
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circ Res 87:984-91. 2000
  10. ncbi request reprint Chamber formation and morphogenesis in the developing mammalian heart
    V M Christoffels
    Department of Anatomy and Embryology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105, The Netherlands
    Dev Biol 223:266-78. 2000

Detail Information

Publications112 found, 100 shown here

  1. pmc Development of the pulmonary vein and the systemic venous sinus: an interactive 3D overview
    Gert van den Berg
    Department of Anatomy, Embryology and Physiology, Academic Medical Center, Amsterdam, The Netherlands
    PLoS ONE 6:e22055. 2011
    ..We discuss our model with respect to normal formation of the heart, congenital cardiac malformations, and the phylogeny of the venous tributaries...
  2. pmc Concepts of cardiac development in retrospect
    Gert van den Berg
    Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands
    Pediatr Cardiol 30:580-7. 2009
    ..In this communication we present excerpts of important embryological studies of the pioneers of experimental cardiac embryology of the previous century, to relate insights from the past to current observations...
  3. ncbi request reprint Development of the building plan of the heart
    Antoon F M Moorman
    Experimental and Molecular Cardiology Group, Department of Anatomy and Embryology, Academic Medical Centre, Amsterdam, The Netherlands
    Ann N Y Acad Sci 1015:171-81. 2004
    ..With the exception of the outflow tract that becomes incorporated into the ventricles, these regions contribute to the cardiac conduction system...
  4. pmc The heart-forming fields: one or multiple?
    Antoon F M Moorman
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Philos Trans R Soc Lond B Biol Sci 362:1257-65. 2007
    ....
  5. ncbi request reprint Cardiac chamber formation: development, genes, and evolution
    Antoon F M Moorman
    Department of Anatomy and Embryology, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Physiol Rev 83:1223-67. 2003
    ..This view on the development of cardiac design unfolds fascinating possibilities for future research...
  6. ncbi request reprint Sensitive nonradioactive detection of mRNA in tissue sections: novel application of the whole-mount in situ hybridization protocol
    A F Moorman
    Experimental and Molecular Cardiology Group, Academic Medical Center, Amsterdam, The Netherlands
    J Histochem Cytochem 49:1-8. 2001
    ..The radioactive ISH procedure scarcely permitted detection of these sequences, underscoring the value of this novel method...
  7. ncbi request reprint Presence of functional sarcoplasmic reticulum in the developing heart and its confinement to chamber myocardium
    A F Moorman
    Experimental and Molecular Cardiology Group, Cardiovascular Research Institute Amsterdam, Academic Medical Center, Amsterdam, 1105 AZ, The Netherlands
    Dev Biol 223:279-90. 2000
    ..iii) The pattern of SERCA2a expression underscores a manner of chamber development by differentiation at the outer curvature, rather than by segmentation of the linear heart tube...
  8. ncbi request reprint Development of the conduction system of the heart
    A F Moorman
    Department of Anatomy and Embryology, University of Amsterdam, The Netherlands
    Pacing Clin Electrophysiol 20:2087-92. 1997
    ..In this review we will summarize recent immunohistochemical studies that have permitted this appreciation...
  9. ncbi request reprint Multiple transcriptional domains, with distinct left and right components, in the atrial chambers of the developing heart
    D Franco
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circ Res 87:984-91. 2000
    ..Furthermore, this work will allow the contribution of each of these myocardial components to be studied in congenitally malformed hearts, such as those with abnormal venous return...
  10. ncbi request reprint Chamber formation and morphogenesis in the developing mammalian heart
    V M Christoffels
    Department of Anatomy and Embryology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105, The Netherlands
    Dev Biol 223:266-78. 2000
    ....
  11. ncbi request reprint Molecular pathway for the localized formation of the sinoatrial node
    Mathilda T M Mommersteeg
    Center for Heart Failure Research, Academic Medical Centre, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    Circ Res 100:354-62. 2007
    ....
  12. ncbi request reprint Patterning the embryonic heart: identification of five mouse Iroquois homeobox genes in the developing heart
    V M Christoffels
    Experimental and Molecular Cardiology Group, University of Amsterdam, The Netherlands
    Dev Biol 224:263-74. 2000
    ....
  13. ncbi request reprint Gene and cluster-specific expression of the Iroquois family members during mouse development
    A C Houweling
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Mech Dev 107:169-74. 2001
    ..The results indicate that the Irx genes are coordinately regulated at the level of the cluster...
  14. ncbi request reprint MLC3F transgene expression in iv mutant mice reveals the importance of left-right signalling pathways for the acquisition of left and right atrial but not ventricular compartment identity
    D Franco
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Dev Dyn 221:206-15. 2001
    ..These data suggest that molecular specification of left and right atrial but not ventricular chambers is dependent on left-right axial cues...
  15. ncbi request reprint Divergent expression of delayed rectifier K(+) channel subunits during mouse heart development
    D Franco
    Experimental Molecular Cardiology Group, AMC, University of Amsterdam, Amsterdam, The Netherlands
    Cardiovasc Res 52:65-75. 2001
    ....
  16. ncbi request reprint Pitx2c and Nkx2-5 are required for the formation and identity of the pulmonary myocardium
    Mathilda T M Mommersteeg
    Heart Failure Research Center, Academic Medical Centre, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    Circ Res 101:902-9. 2007
    ..In conclusion, our data suggest a cellular mechanism for pulmonary myocardium formation and highlight the key roles played by Pitx2c and Nkx2-5 in its formation and identity...
  17. ncbi request reprint Isolation and characterization of the rat gene encoding glutamate dehydrogenase
    A T Das
    Department of Anatomy and Embryology, University of Amsterdam, The Netherlands
    Eur J Biochem 211:795-803. 1993
    ..In addition, consensus sequences for the binding sites of the transcription factors Sp1 and Zif268 are present in the G + C-rich upstream region...
  18. ncbi request reprint Myosin light chain 2a and 2v identifies the embryonic outflow tract myocardium in the developing rodent heart
    D Franco
    Department of Anatomy and Embryology, Academic Medical Center, University of Amsterdam, The Netherlands
    Anat Rec 254:135-46. 1999
    ..These findings demonstrate the contribution of the outflow tract to the definitive ventricles and demonstrate that the outlet septum is derived from outflow tract myocardium...
  19. doi request reprint Formation of the sinus node head and differentiation of sinus node myocardium are independently regulated by Tbx18 and Tbx3
    Cornelia Wiese
    Center for Heart Failure Research, Academic Medical Centre, Meibergdreef 15, 1105AZ Amsterdam, The Netherlands
    Circ Res 104:388-97. 2009
    ..Our data establish a functional order for Tbx18 and Tbx3 in SAN formation, in which Tbx18 controls the formation of the SAN head from mesenchymal precursors, on which Tbx3 subsequently imposes the pacemaker gene program...
  20. pmc A caudal proliferating growth center contributes to both poles of the forming heart tube
    Gert van den Berg
    Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands
    Circ Res 104:179-88. 2009
    ..These data show how a proliferating growth center in the caudal coelomic wall elongates the heart tube at both its venous and arterial pole, providing a morphological mechanism for early heart formation...
  21. ncbi request reprint Developmental changes of connexin40 and connexin43 mRNA distribution patterns in the rat heart
    M J van Kempen
    Department of Anatomy and Embryology, University of Amsterdam, Netherlands
    Cardiovasc Res 32:886-900. 1996
    ..We investigated therefore the distribution of their mRNAs with more sensitive techniques...
  22. ncbi request reprint Differential expression of KvLQT1 and its regulator IsK in mouse epithelia
    S Demolombe
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Am J Physiol Cell Physiol 280:C359-72. 2001
    ..The high level of KvLQT1 expression in epithelial tissues is consistent with its potential role in K+ secretion and recycling, in maintaining the resting potential, and in regulating Cl- secretion and/or Na+ absorption...
  23. ncbi request reprint Pitx2 expression defines a left cardiac lineage of cells: evidence for atrial and ventricular molecular isomerism in the iv/iv mice
    M Campione
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Dev Biol 231:252-64. 2001
    ..Furthermore, altered Pitx2 expression correlated with the occurrence of DORV. Our data reveal the existence of molecular isomerism not only in the atrial, but also in the ventricular compartment of the heart...
  24. pmc Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation
    Petra E M H Habets
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Genes Dev 16:1234-46. 2002
    ..5 on the ANF TBE-NKE, and was able to repress ANF promoter activity. Our data provide a potential mechanism for chamber-restricted gene activity in which the cooperative action of Tbx2 and Nkx2.5 inhibits expression in the AVC...
  25. pmc Epicardium and myocardium separate from a common precursor pool by crosstalk between bone morphogenetic protein- and fibroblast growth factor-signaling pathways
    Bram van Wijk
    Academic Medical Center, Department Anatomy and Embryology, Meibergdreef 15, 1105AZ Amsterdam, The Netherlands
    Circ Res 105:431-41. 2009
    ..Not much is known about the relation between the myocardial and epicardial lineage during development, whereas insights into these embryonic mechanisms could facilitate the design of future regenerative strategies...
  26. ncbi request reprint The sinus venosus progenitors separate and diversify from the first and second heart fields early in development
    Mathilda T M Mommersteeg
    Heart Failure Research Center, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Cardiovasc Res 87:92-101. 2010
    ....
  27. ncbi request reprint Spatial distribution of "tissue-specific" antigens in the developing human heart and skeletal muscle. I. An immunohistochemical analysis of creatine kinase isoenzyme expression patterns
    A Wessels
    Department of Anatomy and Embryology, University of Amsterdam, The Netherlands
    Anat Rec 228:163-76. 1990
    ....
  28. pmc Age-dependent changes in myosin composition correlate with enhanced economy of contraction in guinea-pig hearts
    J van der Velden
    Laboratory for Physiology, Institute for Cardiovascular Research, Free University, Amsterdam, The Netherlands
    J Physiol 507:497-510. 1998
    ..The pronounced dependence of cardiac energetics on MHC composition should be taken into account in long-term studies of cardiac overload...
  29. ncbi request reprint Sox4-deficiency syndrome in mice is an animal model for common trunk
    J Ya
    Department of Anatomy and Embryology, Academic Medical Center, University of Amsterdam, and the Department of Immunology, University of Utrecht, The Netherlands
    Circ Res 83:986-94. 1998
    ....
  30. ncbi request reprint A single regulatory module of the carbamoylphosphate synthetase I gene executes its hepatic program of expression
    V M Christoffels
    Department of Anatomy and Embryology and the Genetically Modified Mice Facility, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Biol Chem 275:40020-7. 2000
    ....
  31. ncbi request reprint Development of the ornithine cycle in rat liver: zonation of a metabolic pathway
    M A Dingemanse
    Department of Anatomy and Embryology, University of Amsterdam, The Netherlands
    Hepatology 24:407-11. 1996
    ....
  32. doi request reprint Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system
    Martijn L Bakker
    Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands
    Circ Res 102:1340-9. 2008
    ..Our data suggest a mechanism in which Tbx3 represses differentiation into ventricular working myocardium, thereby imposing the conduction system phenotype on cells within its expression domain...
  33. pmc Nucleotide sequence of rat glutamine synthetase mRNA
    L van de Zande
    Department of Anatomy and Embryology, University of Amsterdam, The Netherlands
    Nucleic Acids Res 16:7726. 1988
  34. ncbi request reprint Diet- and hormone-induced reversal of the carbamoylphosphate synthetase mRNA gradient in the rat liver lobulus
    A F Moorman
    Department of Anatomy and Embryology, University of Amsterdam, The Netherlands
    FEBS Lett 276:9-13. 1990
    ..It is concluded that blood-borne factors constitute the major determinants for the expression patterns of CPS mRNA within the context of the architecture of the liver lobulus...
  35. ncbi request reprint Developmental pattern of ANF gene expression reveals a strict localization of cardiac chamber formation in chicken
    Arjan C Houweling
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Anat Rec 266:93-102. 2002
    ..We conclude that differentiation of chamber myocardium takes place already at HH9 at the ventral side of the linear heart tube, possibly preceded by latero-medial signals in the unfused cardiac sheets...
  36. ncbi request reprint The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart
    Willem M H Hoogaars
    Experimental and Molecular Cardiology Group, AMC, University of Amsterdam, Amsterdam, The Netherlands
    Cardiovasc Res 62:489-99. 2004
    ..We studied the developmental expression pattern and functional aspects of the T-box transcription factor Tbx3, a novel marker for the murine central conduction system (CCS)...
  37. ncbi request reprint Lineage and morphogenetic analysis of the cardiac valves
    Frederik J de Lange
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circ Res 95:645-54. 2004
    ..The tricuspid septal leaflet then delaminates from the muscular ventricular septum late in development...
  38. ncbi request reprint Cardiomyocytes purified from differentiated embryonic stem cells exhibit characteristics of early chamber myocardium
    Arnoud C Fijnvandraat
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Mol Cell Cardiol 35:1461-72. 2003
    ....
  39. ncbi request reprint Expression of muscle segment homeobox genes in the developing myocardium
    Cornelis J J Boogerd
    Heart Failure Research Center, Academic Medical Center of Amsterdam, Amsterdam, The Netherlands
    Anat Rec (Hoboken) 293:998-1001. 2010
    ..In Msx2-null mice, Msx1 is not ectopically expressed in the myocardium. The absence of myocardial defects in the Msx2 knock-out can therefore not be attributed to a redundant action of Msx1 in the myocardium...
  40. ncbi request reprint Trabeculated right ventricular free wall in the chicken heart forms by ventricularization of the myocardium initially forming the outflow tract
    M Sameer Rana
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, The Netherlands
    Circ Res 100:1000-7. 2007
    ..Taken together, we show, as opposed to some current beliefs, the development of the arterial pole is similar in mammals and birds...
  41. ncbi request reprint Cardiac expression of Gal4 causes cardiomyopathy in a dose-dependent manner
    Petra E M H Habets
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Muscle Res Cell Motil 24:205-9. 2003
    ..Our results indicate that expression of a transgene in the heart may non-specifically cause HF in a dose-dependent manner...
  42. ncbi request reprint Regionalized sequence of myocardial cell growth and proliferation characterizes early chamber formation
    Alexandre T Soufan
    Molecular and Experimental Cardiology Group, Academic Medical Centre, University of Amsterdam, The Netherlands
    Circ Res 99:545-52. 2006
    ..The significance of these observations is 2-fold. First, they support a model of early cardiac morphogenesis in 2 stages. Second, they demonstrate that regional increase in size of myocytes contributes significantly to chamber formation...
  43. doi request reprint The Tbx2+ primary myocardium of the atrioventricular canal forms the atrioventricular node and the base of the left ventricle
    Wim T J Aanhaanen
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circ Res 104:1267-74. 2009
    ..These findings imply that errors in the development of the early atrioventricular canal may affect a much larger region than previously anticipated, including the ventricular base...
  44. doi request reprint Msx1 and Msx2 are functional interacting partners of T-box factors in the regulation of Connexin43
    Kees Jan Boogerd
    Department of Anatomy and Embryology, Heart Failure Research Centre, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands
    Cardiovasc Res 78:485-93. 2008
    ..Discovering protein partners of Tbx2 and Tbx3 will shed light on the mechanisms by which these factors regulate these gene programs...
  45. pmc Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria
    Willem M H Hoogaars
    Department of Anatomy and Embryology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Genes Dev 21:1098-112. 2007
    ..These data identify a Tbx3-dependent pathway for the specification and formation of the sinoatrial node, and show that Tbx3 regulates the pacemaker gene expression program and phenotype...
  46. ncbi request reprint Species-specific differences of myosin content in the developing cardiac chambers of fish, birds, and mammals
    Diego Franco
    Experimental and Molecular Cardiology Group, Cardiovascular Research Institute Amsterdam, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Anat Rec 268:27-37. 2002
    ..canicula), mouse (M. musculus), rat (R. norvegicus), and chicken (G. gallus)). These observations indicate that in the adult heart of vertebrates the atrial myocardium contains more myosin than the ventricular myocardium...
  47. pmc Nucleotide sequence of rat liver glutamate dehydrogenase cDNA
    A T Das
    Department of Anatomy and Embryology, University of Amsterdam, The Netherlands
    Nucleic Acids Res 17:2355. 1989
  48. ncbi request reprint Patterns of expression of the Follistatin and Follistatin-like1 genes during chicken heart development: a potential role in valvulogenesis and late heart muscle cell formation
    Gert van den Berg
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Anat Rec (Hoboken) 290:783-7. 2007
    ..Follistatin-like3 is not expressed in the heart. Taken together, these observations are suggestive for a role for Follistatin in cardiac valvulogenesis and a role for Follistatin-like1 in controlling late heart muscle cell formation...
  49. ncbi request reprint Cardiomyocytes derived from embryonic stem cells resemble cardiomyocytes of the embryonic heart tube
    Arnoud C Fijnvandraat
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    Cardiovasc Res 58:399-409. 2003
    ..To assess whether this program is recapitulated in in vitro differentiated embryonic stem cells, we performed qualitative and quantitative analyses of cardiogenesis in vivo and in vitro...
  50. ncbi request reprint Heart defects in connexin43-deficient mice
    J Ya
    Department of Anatomy and Embryology, Academic Medical Center, University of Amsterdam, The Netherlands
    Circ Res 82:360-6. 1998
    ....
  51. ncbi request reprint Architectural plan for the heart: early patterning and delineation of the chambers and the nodes
    Vincent M Christoffels
    Department of Anatomy and Embryology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Trends Cardiovasc Med 14:301-7. 2004
    ....
  52. doi request reprint Developmental basis for electrophysiological heterogeneity in the ventricular and outflow tract myocardium as a substrate for life-threatening ventricular arrhythmias
    Bastiaan J D Boukens
    Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands
    Circ Res 104:19-31. 2009
    ..Understanding the developmental origins of electrophysiological heterogeneity contributing to ventricular arrhythmias may give rise to new therapies...
  53. doi request reprint Protein interactions at the heart of cardiac chamber formation
    Cornelis J J Boogerd
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Ann Anat 191:505-17. 2009
    ..In this review we focus, in a morphologically integrated fashion, on the molecular interactions that govern the intricate cardiac design...
  54. ncbi request reprint T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers
    Vincent M Christoffels
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Dev Dyn 229:763-70. 2004
    ..These findings provide the first evidence that Tbx2 is a determinant in the local repression of chamber-specific gene expression and chamber differentiation...
  55. ncbi request reprint Reconstruction of the patterns of gene expression in the developing mouse heart reveals an architectural arrangement that facilitates the understanding of atrial malformations and arrhythmias
    Alexandre T Soufan
    Experimental and Molecular Cardiology Group, Academic Medical Centre, University of Amsterdam, The Netherlands
    Circ Res 95:1207-15. 2004
    ..All these regions are derived from primary myocardium, providing a molecular basis for the observed nonrandom distribution of focal right atrial tachycardias...
  56. ncbi request reprint Development of heart muscle-cell diversity: a help or a hindrance for phenotyping embryonic stem cell-derived cardiomyocytes
    Arnoud C Fijnvandraat
    Experimental and Molecular Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Cardiovasc Res 58:303-12. 2003
    ..Although for the phenotyping of ESDCs a comparison should be made with the phenotypes of the developing heart, so far none of the currently available markers allow unequivocal assignment of subtypes...
  57. pmc Sox4 mediates Tbx3 transcriptional regulation of the gap junction protein Cx43
    C J J Boogerd
    Heart Failure Research Centre, Academic Medical Centre, University of Amsterdam, The Netherlands
    Cell Mol Life Sci 68:3949-61. 2011
    ..Mechanistically, we postulate that Sox4 is a mediator of Tbx3 transcriptional activity...
  58. ncbi request reprint Isolation and characterization of the rat glutamine synthetase-encoding gene
    L van de Zande
    Department of Anatomy and Embryology, University of Amsterdam, The Netherlands
    Gene 87:225-32. 1990
    ..The position of the transcription start point was mapped. Within the first 118 bp of promoter sequence, a (T)ATAA-box, a CCAAT-box and an SP1-binding site were identified...
  59. ncbi request reprint Development of the myocardium of the atrioventricular canal and the vestibular spine in the human heart
    J S Kim
    Department of Anatomy and Embryology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circ Res 88:395-402. 2001
    ..The atrioventricular node develops from that part of the canal myocardium that retains its continuity with the ventricular myocardium...
  60. ncbi request reprint Formation of myocardium after the initial development of the linear heart tube
    M J van den Hoff
    Experimental and Molecular Cardiology Group, Cardiovascular Research Institute Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    Dev Biol 240:61-76. 2001
    ....
  61. ncbi request reprint Glutamine synthetase expression in perinatal spiny mouse liver
    W H Lamers
    Department of Anatomy and Embryology, Academic Medical Center, University of Amsterdam, The Netherlands
    Eur J Biochem 262:803-9. 1999
    ..The kinetics of GS protein accumulation, in conjunction with GS mRNA content, are consistent with an approximately sixfold increase in its rate of synthesis at birth as the result of a corresponding stimulation of the rate of elongation...
  62. pmc Role of the 5' enhancer of the glutamine synthetase gene in its organ-specific expression
    H Lie-Venema
    Department of Anatomy and Embryology, University of Amsterdam, Academic Medical Centre, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Biochem J 323:611-9. 1997
    ..Furthermore, CAT expression in the brain did not co-localize with that of GS, showing that the 5' regulatory region of the GS gene does not direct its expression to the astrocytes...
  63. ncbi request reprint Atrial and ventricular myosin heavy-chain expression in the developing chicken heart: strengths and limitations of non-radioactive in situ hybridization
    Semir Somi
    Academic Medical Center, Department of Anatomy and Embryology, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Histochem Cytochem 54:649-64. 2006
    ..This manuscript contains online supplemental material at http://www.jhc.org. Please visit this article online to view these materials...
  64. ncbi request reprint Sensitivity and accuracy of quantitative real-time polymerase chain reaction using SYBR green I depends on cDNA synthesis conditions
    Ronald H Lekanne Deprez
    Experimental and Molecular Cardiology Group, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Anal Biochem 307:63-9. 2002
    ..Finally, accurate quantification of mRNAs by real-time PCR using SYBR green I requires verification of the specificity of PCR by both melting curve and gel analysis...
  65. ncbi request reprint Development of the cardiac conduction system: a matter of chamber development
    Antoon F M Moorman
    Molecular and Experimental Cardiology Group, Academic Medical Centre, University of Amsterdam, Meibergdreef 15, Amsterdam, 1105 AZ, The Netherlands
    Novartis Found Symp 250:25-34; discussion 34-43, 276-9. 2003
    ..The possibility that during evolution and ontogenesis of the heat, this development is achieved by localized growth of cardiac chambers rather than of a conduction system is discussed here...
  66. ncbi request reprint Formation of the venous pole of the heart from an Nkx2-5-negative precursor population requires Tbx18
    Vincent M Christoffels
    Department of Experimental and Molecular Cardiology Group, Academic Medical Center, Amsterdam, The Netherlands
    Circ Res 98:1555-63. 2006
    ....
  67. ncbi request reprint BMP and FGF regulate the differentiation of multipotential pericardial mesoderm into the myocardial or epicardial lineage
    Boudewijn P T Kruithof
    Experimental and Molecular Cardiology Group, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Dev Biol 295:507-22. 2006
    ..We conclude that the epicardial/myocardial lineage decisions are mediated by an extrinsic, inductive mechanism, which is determined by the position of the cells in the pericardial mesoderm...
  68. ncbi request reprint Two distinct pools of mesenchyme contribute to the development of the atrial septum
    Mathilda T M Mommersteeg
    Molecular and Experimental Cardiology Group, Academic Medical Centre, University of Amsterdam, The Netherlands
    Circ Res 99:351-3. 2006
    ..From the stance of morphological description, therefore, there is little thus far to substantiate the existence of an atrial spine...
  69. ncbi request reprint Role of bone morphogenetic proteins in cardiac differentiation
    Bram van Wijk
    Molecular and Experimental Cardiology Group, Department of Anatomy and Embryology, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Cardiovasc Res 74:244-55. 2007
    ..Finally, the effects of BMPs in stem cell biology and cardiac regeneration are discussed...
  70. ncbi request reprint Marked differences in tissue-specific expression of chitinases in mouse and man
    Rolf G Boot
    Department of Biochemistry, University of Amsterdam Academic Medical Center, The Netherlands
    J Histochem Cytochem 53:1283-92. 2005
    ..In conclusion, the pattern of expression of chitinases in the lung differs between mouse and man. The implications for the development of anti-asthma drugs with chitinases as targets are discussed...
  71. ncbi request reprint Cardiac septation: a late contribution of the embryonic primary myocardium to heart morphogenesis
    Wouter H Lamers
    Department of Anatomy and Embryology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circ Res 91:93-103. 2002
    ....
  72. doi request reprint Development of the pacemaker tissues of the heart
    Vincent M Christoffels
    Heart Failure Research Center, Academic Medical Centre, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Circ Res 106:240-54. 2010
    ..It will also shed light on the etiology of inborn and acquired errors of nodal tissues...
  73. ncbi request reprint Expression analysis of subtractively enriched libraries (EASEL): a widely applicable approach to the identification of differentially expressed genes
    M Paola Lombardi
    Experimental and Molecular Cardiology Group, Cardiovascular Research Institute Amsterdam, Academic Medical Centre, Amsterdam, The Netherlands
    J Biochem Biophys Methods 57:17-33. 2003
    ....
  74. ncbi request reprint TBX5 overexpression stimulates differentiation of chamber myocardium in P19C16 embryonic carcinoma cells
    Arnoud C Fijnvandraat
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Muscle Res Cell Motil 24:211-8. 2003
    ..This indicates that Tbx5 enhances cardiac maturation within this system rather than cardiogenesis...
  75. ncbi request reprint Making more heart muscle
    Maurice J B van den Hoff
    Molecular and Experimental Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Bioessays 26:248-61. 2004
    ..In this review, the relative late additions of heart muscle cells to the linear heart tube are described and the potential underlying molecular mechanisms are discussed...
  76. ncbi request reprint Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data
    Christian Ramakers
    Department of Anatomy and Embryology K2 283, Experimental and Molecular Cardiology Group, Academic Medical Centre, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    Neurosci Lett 339:62-6. 2003
    ..A computer program to perform this calculation is available on request (e-mail: bioinfo@amc.uva.nl; subject: LinRegPCR)...
  77. doi request reprint The cardiac pacemaker and conduction system develops from embryonic myocardium that retains its primitive phenotype
    Martijn L Bakker
    Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands
    J Cardiovasc Pharmacol 56:6-15. 2010
    ....
  78. ncbi request reprint Developmental and genetic aspects of atrial fibrillation
    Alex V Postma
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, The Netherlands
    Trends Cardiovasc Med 19:123-30. 2009
    ..In this review, it is our aim to discuss the possible underlying causes of AF from a combined genetic and cardiac developmental view...
  79. ncbi request reprint Molecular imaging of the embryonic heart: Fables and facts on 3D imaging of gene expression patterns
    Jan M Ruijter
    Department of Anatomy and Embryology, Experimental and Molecular Cardiology Group, Academic Medical Center, Amsterdam, The Netherlands
    Birth Defects Res C Embryo Today 72:224-40. 2004
    ..Other methods can be used very efficiently in rapid evaluation of biological experiments and high-throughput screens of large-scale gene expression profiling efforts when high spatial resolution is not required...
  80. ncbi request reprint Recruitment of intra- and extracardiac cells into the myocardial lineage during mouse development
    Boudewijn P T Kruithof
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Anat Rec A Discov Mol Cell Evol Biol 271:303-14. 2003
    ..We show that prior to the expression of myocardial markers, alpha-Sma is expressed in these regions, which suggests that these mesodermal cells become recruited into the cardiac lineage after formation of the linear heart tube...
  81. doi request reprint A gain-of-function TBX5 mutation is associated with atypical Holt-Oram syndrome and paroxysmal atrial fibrillation
    Alex V Postma
    Heart Failure Research Center, L2 108 1, Academic Medical Center, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    Circ Res 102:1433-42. 2008
    ....
  82. ncbi request reprint Malformations of the axial skeleton in Museum Vrolik I: homeotic transformations and numerical anomalies
    Roelof Jan Oostra
    Department of Anatomy and Embryology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Am J Med Genet A 134:268-81. 2005
    ..Of the various etiological possibilities, explaining their frequent but mostly sporadic occurrence, maternal hyperthermia seems an attractive candidate...
  83. ncbi request reprint Increased cardiac workload by closure of the ductus arteriosus leads to hypertrophy and apoptosis rather than to hyperplasia in the late fetal period
    Maurice J B van den Hoff
    Experimental and Molecular Cardiology Group, Department of Anatomy and Embryology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Naunyn Schmiedebergs Arch Pharmacol 370:193-202. 2004
    ..It is concluded that pressure-overload imposed on the late-fetal heart induces limited proliferative growth complemented by extensive hypertrophic growth...
  84. ncbi request reprint cDNA sequence of the long mRNA for human glutamine synthase
    M J van den Hoff
    Department of Anatomy and Embryology, University of Amsterdam, The Netherlands
    Biochim Biophys Acta 1090:249-51. 1991
    ..The longest clone was completely sequenced and consists of a 109 bp 5' untranslated region, a 1119 bp protein coding region, a 1498 bp 3' untranslated region and a poly(A) tract of 12 bp...
  85. ncbi request reprint Arginine-metabolizing enzymes in the developing rat small intestine
    W J de Jonge
    Department of Anatomy and Embryology, Academical Medical Center, University of Amsterdam, The Netherlands
    Pediatr Res 43:442-51. 1998
    ....
  86. doi request reprint Three-dimensional and molecular analysis of the venous pole of the developing human heart
    Aleksander Sizarov
    Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands
    Circulation 122:798-807. 2010
    ....
  87. doi request reprint Developmental origin, growth, and three-dimensional architecture of the atrioventricular conduction axis of the mouse heart
    Wim T J Aanhaanen
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, The Netherlands
    Circ Res 107:728-36. 2010
    ..The clinically important atrioventricular conduction axis is structurally complex and heterogeneous, and its molecular composition and developmental origin are uncertain...
  88. ncbi request reprint Non-radioactive in situ detection of mRNA in ES cell-derived cardiomyocytes and in the developing heart
    Arnoud C Fijnvandraat
    Experimental and Molecular Cardiology Group, Academic Medical Center, Amsterdam, The Netherlands
    Microsc Res Tech 58:387-94. 2002
    ....
  89. doi request reprint Generation of mice with a conditional null allele for Tbx2
    Vincent Wakker
    Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands
    Genesis 48:195-9. 2010
    ..This Tbx2 conditional null allele will be a valuable tool to uncover tissue-specific roles of Tbx2 in development and disease...
  90. ncbi request reprint Regulatory modules in the developing heart
    Petra E M H Habets
    Experimental and Molecular Cardiology Group, Department of Anatomy and Embryology, Academic Medical Center L2 255, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    Cardiovasc Res 58:246-63. 2003
    ..Most of the regulatory modules show a domain of activity broader than the morphological boundary of a cardiac compartment and seem to respond to a patterning program along the antero-posterior axis...
  91. ncbi request reprint Expression of cVg1 mRNA during chicken embryonic development
    Semir Somi
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Anat Rec A Discov Mol Cell Evol Biol 273:603-8. 2003
    ..In the heart, cVg1 is initially expressed through the linear heart tube, but becomes restricted to the forming chamber myocardium, in an expression domain similar to that of atrial natriuretic factor (ANF) mRNA...
  92. ncbi request reprint Comparative analysis of the natriuretic peptide precursor gene cluster in vertebrates reveals loss of ANF and retention of CNP-3 in chicken
    Arjan C Houweling
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Dev Dyn 233:1076-82. 2005
    ..These results show that, in chicken, the Nppa gene has been lost from the natriuretic peptide precursor gene cluster, whereas the CNP-3 gene has been retained...
  93. ncbi request reprint Anatomic substrates for cardiac conduction
    Antoon F M Moorman
    Department of Anatomy and Embryology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Heart Rhythm 2:875-86. 2005
  94. ncbi request reprint Expression and regulation of the atrial natriuretic factor encoding gene Nppa during development and disease
    Arjan C Houweling
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Cardiovasc Res 67:583-93. 2005
    ..Here we review current knowledge on the transcriptional regulation of the Nppa gene...
  95. ncbi request reprint Genomic organisation and chromosomal localisation of two members of the KCND ion channel family, KCND2 and KCND3
    A V Postma
    Experimental and Molecular Cardiology Group, Cardiovascular Research Institute Amsterdam, The Netherlands
    Hum Genet 106:614-9. 2000
    ..2, respectively. This information should facilitate the systematic screening of KCND2 and KCND3 exons for mutations in (inherited) arrhythmia syndromes, such as LQTS and Brugada...
  96. ncbi request reprint Distribution of the nuclear thyroid-hormone receptor in extraocular and skeletal muscles
    E D Schmidt
    Department of Ophthalmology, University of Amsterdam, The Netherlands
    J Endocrinol 133:67-74. 1992
    ..The different susceptibilities of these muscles to Graves' hyperthyroidism may relate to the quantitative differences in T3 hormone-receptor distribution...
  97. ncbi request reprint Interleukin-15 expression in atherosclerotic plaques: an alternative pathway for T-cell activation in atherosclerosis?
    M A Houtkamp
    Department of Cardiovascular Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
    Arterioscler Thromb Vasc Biol 21:1208-13. 2001
    ..Moreover, plaque-derived T-cell lines were highly responsive to IL-15. Hence, IL-15 could provide a pathway for antigen-independent T-cell activation...
  98. ncbi request reprint [Stem cells: biology and possible application to myocardial infarct]
    A C Fijnvandraat
    Academisch Medisch Centrum Universiteit van Amsterdam, afd Anatomie en Embryologie, Meibergdreef 15, 1105 AZ Amsterdam
    Ned Tijdschr Geneeskd 148:1186-91. 2004
    ....
  99. doi request reprint TBX3 and its splice variant TBX3 + exon 2a are functionally similar
    Willem M H Hoogaars
    Center for Heart Failure Research, Academic Medical Centre, Amsterdam, The Netherlands
    Pigment Cell Melanoma Res 21:379-87. 2008
    ..The results suggest that in the assays used, Tbx3 and Tbx3 + 2a are functionally equivalent and that like Tbx2, Tbx3 may also function as an anti-senescence factor in melanoma...
  100. ncbi request reprint Cardiac muscle cell formation after development of the linear heart tube
    Boudewijn P T Kruithof
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Dev Dyn 227:1-13. 2003
    ..We determined that this potential is stage- and mesenchyme-dependent. This latter finding suggests an important role for mesenchyme in myocardium formation after the development of the linear heart tube...
  101. ncbi request reprint Development of the pulmonary vein
    Antoon F M Moorman
    Anat Rec (Hoboken) 290:1046-9. 2007